KEGG   PATHWAY: mcc04120
Entry
mcc04120                    Pathway                                
Name
Ubiquitin mediated proteolysis - Macaca mulatta (rhesus monkey)
Description
Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
mcc04120  Ubiquitin mediated proteolysis
mcc04120

Other DBs
GO: 0016567
Organism
Macaca mulatta (rhesus monkey) [GN:mcc]
Gene
696110  UBB; polyubiquitin-B [KO:K04551]
712934  UBC; LOW QUALITY PROTEIN: polyubiquitin-C [KO:K08770]
720243  UBA52; ubiquitin-60S ribosomal protein L40 [KO:K02927]
708161  ubiquitin-like isoform X2 [KO:K02927]
704498  ubiquitin [KO:K02927]
718909  RPS27A; 40S ribosomal protein S27a [KO:K02977]
106992282  RPS27A; ubiquitin-40S ribosomal protein S27a [KO:K02977]
706324  UBA1; ubiquitin-like modifier-activating enzyme 1 isoform X1 [KO:K03178] [EC:6.2.1.45]
717918  SAE1; SUMO-activating enzyme subunit 1 isoform X1 [KO:K10684] [EC:6.2.1.45]
705808  UBA2; SUMO-activating enzyme subunit 2 isoform X1 [KO:K10685] [EC:6.2.1.45]
696493  UBA3; NEDD8-activating enzyme E1 catalytic subunit [KO:K10686] [EC:6.2.1.64]
704875  UBA7; ubiquitin-like modifier-activating enzyme 7 [KO:K10698] [EC:6.2.1.45]
711751  UBA6; ubiquitin-like modifier-activating enzyme 6 isoform X1 [KO:K10699] [EC:6.2.1.45]
693716  UBE2A; ubiquitin-conjugating enzyme E2 A [KO:K10573] [EC:2.3.2.23]
710678  UBE2B; ubiquitin-conjugating enzyme E2 B [KO:K10574] [EC:2.3.2.23]
714349  ubiquitin-conjugating enzyme E2 C [KO:K06688] [EC:2.3.2.23]
709380  UBE2C; ubiquitin-conjugating enzyme E2 C isoform X1 [KO:K06688] [EC:2.3.2.23]
693688  ubiquitin-conjugating enzyme E2 C [KO:K06688] [EC:2.3.2.23]
707320  ubiquitin-conjugating enzyme E2 C [KO:K06688] [EC:2.3.2.23]
694667  UBE2D2; ubiquitin-conjugating enzyme E2 D2 isoform X1 [KO:K06689] [EC:2.3.2.23]
701491  UBE2D1; ubiquitin-conjugating enzyme E2 D1 [KO:K06689] [EC:2.3.2.23]
707831  UBE2D4; ubiquitin-conjugating enzyme E2 D4 isoform X3 [KO:K06689] [EC:2.3.2.23]
710772  UBE2D3; ubiquitin-conjugating enzyme E2 D3 [KO:K06689] [EC:2.3.2.23]
699101  UBE2E2; ubiquitin-conjugating enzyme E2 E2 [KO:K20217] [EC:2.3.2.23]
701036  UBE2E1; ubiquitin-conjugating enzyme E2 E1 isoform X2 [KO:K20217] [EC:2.3.2.23]
704530  UBE2E3; ubiquitin-conjugating enzyme E2 E3 [KO:K20217] [EC:2.3.2.23]
695394  UBE2F; NEDD8-conjugating enzyme UBE2F [KO:K10687] [EC:2.3.2.34]
721528  UBE2G1; ubiquitin-conjugating enzyme E2 G1 isoform X2 [KO:K10575] [EC:2.3.2.23]
710862  UBE2G2; ubiquitin-conjugating enzyme E2 G2 [KO:K04555] [EC:2.3.2.23]
702056  UBE2H; ubiquitin-conjugating enzyme E2 H [KO:K10576] [EC:2.3.2.23]
722434  UBE2I; SUMO-conjugating enzyme UBC9 [KO:K10577]
701100  UBE2J1; ubiquitin-conjugating enzyme E2 J1 isoform X1 [KO:K10578] [EC:2.3.2.23]
700798  UBE2J2; ubiquitin-conjugating enzyme E2 J2 isoform X1 [KO:K04554] [EC:2.3.2.23]
699734  UBE2K; ubiquitin-conjugating enzyme E2 K [KO:K04649] [EC:2.3.2.23]
697675  UBE2L3; ubiquitin-conjugating enzyme E2 L3 [KO:K04552] [EC:2.3.2.23]
705561  UBE2L6; ubiquitin/ISG15-conjugating enzyme E2 L6 isoform X1 [KO:K04553] [EC:2.3.2.23]
712206  UBE2M; NEDD8-conjugating enzyme Ubc12 [KO:K10579] [EC:2.3.2.34]
715437  UBE2N; ubiquitin-conjugating enzyme E2 N [KO:K10580] [EC:2.3.2.23]
703337  ubiquitin-conjugating enzyme E2 N [KO:K10580] [EC:2.3.2.23]
698894  ubiquitin-conjugating enzyme E2 N-like [KO:K10580] [EC:2.3.2.23]
106995043  ubiquitin-conjugating enzyme E2 N-like [KO:K10580] [EC:2.3.2.23]
696017  ubiquitin-conjugating enzyme E2 N-like [KO:K10580] [EC:2.3.2.23]
710529  UBE2O; (E3-independent) E2 ubiquitin-conjugating enzyme isoform X1 [KO:K10581] [EC:2.3.2.24]
718733  UBE2Q1; ubiquitin-conjugating enzyme E2 Q1 [KO:K10582] [EC:2.3.2.23]
100428498  UBE2Q2; ubiquitin-conjugating enzyme E2 Q2 isoform X14 [KO:K10582] [EC:2.3.2.23]
100426423  UBE2QL1; ubiquitin-conjugating enzyme E2Q-like protein 1 isoform X1 [KO:K10582] [EC:2.3.2.23]
100424232  ubiquitin-conjugating enzyme E2 Q2-like isoform X1 [KO:K10582] [EC:2.3.2.23]
701507  UBE2R2; ubiquitin-conjugating enzyme E2 R2 isoform X1 [KO:K02207] [EC:2.3.2.23]
100425016  CDC34; ubiquitin-conjugating enzyme E2 R1 [KO:K02207] [EC:2.3.2.23]
700592  UBE2S; ubiquitin-conjugating enzyme E2 S [KO:K10583] [EC:2.3.2.23]
697545  UBE2U; ubiquitin-conjugating enzyme E2 U isoform X1 [KO:K10584] [EC:2.3.2.23]
696276  UBE2W; ubiquitin-conjugating enzyme E2 W [KO:K10688] [EC:2.3.2.23 2.3.2.25]
699906  UBE2Z; ubiquitin-conjugating enzyme E2 Z [KO:K10585] [EC:2.3.2.23]
709443  BIRC6; baculoviral IAP repeat-containing protein 6 isoform X1 [KO:K10586] [EC:2.3.2.23]
711270  UBE3A; ubiquitin-protein ligase E3A [KO:K10587] [EC:2.3.2.26]
707324  UBE3B; ubiquitin-protein ligase E3B isoform X1 [KO:K10588] [EC:2.3.2.26]
719956  UBE3C; ubiquitin-protein ligase E3C isoform X1 [KO:K10589] [EC:2.3.2.26]
717902  SMURF2; E3 ubiquitin-protein ligase SMURF2 isoform X1 [KO:K04678] [EC:2.3.2.26]
718616  SMURF1; E3 ubiquitin-protein ligase SMURF1 [KO:K04678] [EC:2.3.2.26]
707640  ITCH; E3 ubiquitin-protein ligase Itchy homolog isoform X1 [KO:K05632] [EC:2.3.2.26]
694098  WWP1; NEDD4-like E3 ubiquitin-protein ligase WWP1 [KO:K05633] [EC:2.3.2.26]
705464  WWP2; NEDD4-like E3 ubiquitin-protein ligase WWP2 [KO:K05630] [EC:2.3.2.26]
710560  TRIP12; E3 ubiquitin-protein ligase TRIP12 isoform X1 [KO:K10590] [EC:2.3.2.26]
699550  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
700282  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
700136  HUWE1; E3 ubiquitin-protein ligase HUWE1 [KO:K10592] [EC:2.3.2.26]
707163  UBR5; E3 ubiquitin-protein ligase UBR5 isoform X3 [KO:K10593] [EC:2.3.2.26]
706308  HERC1; probable E3 ubiquitin-protein ligase HERC1 isoform X7 [KO:K10594] [EC:2.3.2.26]
712294  E3 ubiquitin-protein ligase HERC2 isoform X1 [KO:K10595] [EC:2.3.2.26]
703108  HERC3; probable E3 ubiquitin-protein ligase HERC3 [KO:K10614] [EC:2.3.2.26]
695571  HERC4; probable E3 ubiquitin-protein ligase HERC4 [KO:K10615] [EC:2.3.2.26]
699836  UBE4A; ubiquitin conjugation factor E4 A [KO:K10596] [EC:2.3.2.27]
713348  UBE4B; ubiquitin conjugation factor E4 B [KO:K10597] [EC:2.3.2.27]
697105  STUB1; E3 ubiquitin-protein ligase CHIP [KO:K09561] [EC:2.3.2.27]
700024  PPIL2; LOW QUALITY PROTEIN: RING-type E3 ubiquitin-protein ligase PPIL2 [KO:K10598] [EC:5.2.1.8]
696170  PRPF19; pre-mRNA-processing factor 19 [KO:K10599] [EC:2.3.2.27]
717166  UBOX5; RING finger protein 37 isoform X3 [KO:K10600]
718284  MDM2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
704311  CBL; E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
703879  CBLB; E3 ubiquitin-protein ligase CBL-B isoform X1 [KO:K22517] [EC:2.3.2.27]
713112  CBLC; E3 ubiquitin-protein ligase CBL-C isoform X2 [KO:K22518] [EC:2.3.2.27]
710899  PRKN; E3 ubiquitin-protein ligase parkin isoform X1 [KO:K04556] [EC:2.3.2.31]
716629  SIAH1; E3 ubiquitin-protein ligase SIAH1 [KO:K04506] [EC:2.3.2.27]
694921  E3 ubiquitin-protein ligase SIAH1 [KO:K04506] [EC:2.3.2.27]
700379  PML; protein PML [KO:K10054] [EC:2.3.2.-]
716907  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
710979  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
708802  COP1; E3 ubiquitin-protein ligase COP1 [KO:K10143] [EC:2.3.2.27]
701580  RCHY1; RING finger and CHY zinc finger domain-containing protein 1 [KO:K10144] [EC:2.3.2.27]
702592  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
702468  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
698057  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
697671  BIRC7; baculoviral IAP repeat-containing protein 7 isoform X1 [KO:K16061]
693445  PIAS1; E3 SUMO-protein ligase PIAS1 [KO:K04706] [EC:2.3.2.-]
696737  PIAS2; E3 SUMO-protein ligase PIAS2 isoform X4 [KO:K16063] [EC:2.3.2.-]
706775  PIAS3; LOW QUALITY PROTEIN: E3 SUMO-protein ligase PIAS3 [KO:K16064] [EC:2.3.2.-]
714328  PIAS4; E3 SUMO-protein ligase PIAS4 isoform X2 [KO:K16065] [EC:2.3.2.27]
716698  SYVN1; E3 ubiquitin-protein ligase synoviolin [KO:K10601] [EC:2.3.2.27]
704451  NHLRC1; E3 ubiquitin-protein ligase NHLRC1 [KO:K10602] [EC:2.3.2.27]
712858  AIRE; autoimmune regulator isoform X1 [KO:K10603]
709272  MGRN1; E3 ubiquitin-protein ligase MGRN1 isoform X1 [KO:K10604] [EC:2.3.2.27]
712634  BRCA1; breast cancer type 1 susceptibility protein homolog [KO:K10605] [EC:2.3.2.27]
717528  FANCL; E3 ubiquitin-protein ligase FANCL isoform X2 [KO:K10606] [EC:2.3.2.27]
709683  MID1; E3 ubiquitin-protein ligase Midline-1 isoform X1 [KO:K08285] [EC:2.3.2.27]
702595  TRIM32; E3 ubiquitin-protein ligase TRIM32 [KO:K10607] [EC:2.3.2.27]
710934  TRIM37; E3 ubiquitin-protein ligase TRIM37 [KO:K10608] [EC:2.3.2.27]
710252  RBX1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
710581  CUL1; cullin-1 [KO:K03347]
100423634  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
708990  FBXW11; F-box/WD repeat-containing protein 11 [KO:K03362]
711843  BTRC; F-box/WD repeat-containing protein 1A isoform X2 [KO:K03362]
700617  SKP2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
695101  FBXW7; F-box/WD repeat-containing protein 7 [KO:K10260]
722738  FBXO2; F-box only protein 2 [KO:K10099]
697007  FBXO4; F-box only protein 4 isoform X1 [KO:K10291]
698384  CUL2; cullin-2 [KO:K03870]
698922  ELOC; transcription elongation factor B polypeptide 1 [KO:K03872]
100428355  elongin-C-like [KO:K03872]
715218  elongin-B [KO:K03873]
700034  ELOB; elongin-B [KO:K03873]
106996285  VHL; von Hippel-Lindau disease tumor suppressor isoform X1 [KO:K03871]
707550  CUL3; cullin-3 [KO:K03869]
720514  KEAP1; kelch-like ECH-associated protein 1 [KO:K10456]
710546  KLHL13; kelch-like protein 13 isoform X3 [KO:K10447]
710804  KLHL9; kelch-like protein 9 [KO:K10447]
716607  RHOBTB2; rho-related BTB domain-containing protein 2 isoform X1 [KO:K07868]
699132  RHOBTB1; rho-related BTB domain-containing protein 1 [KO:K07868]
696410  CUL4B; cullin-4B isoform X2 [KO:K10609]
714302  CUL4A; cullin-4A isoform X2 [KO:K10609]
694253  DDB1; DNA damage-binding protein 1 isoform X1 [KO:K10610]
713813  DDB2; DNA damage-binding protein 2 [KO:K10140]
114672263  LOW QUALITY PROTEIN: DNA damage-binding protein 2-like [KO:K10140]
693362  ERCC8; DNA excision repair protein ERCC-8 isoform X1 [KO:K10570]
697994  DET1; DET1 homolog [KO:K10571]
714961  RNF7; RING-box protein 2 [KO:K10611]
707559  CUL5; LOW QUALITY PROTEIN: cullin-5 [KO:K10612]
711180  SOCS1; suppressor of cytokine signaling 1 [KO:K04694]
715680  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
699545  CUL7; cullin-7 isoform X2 [KO:K10613]
693388  FBXW8; F-box/WD repeat-containing protein 8 isoform X1 [KO:K10264]
714909  ANAPC11; anaphase-promoting complex subunit 11 [KO:K03358]
706384  ANAPC2; anaphase-promoting complex subunit 2 [KO:K03349]
702317  CDC20; cell division cycle protein 20 homolog [KO:K03363]
721711  FZR1; fizzy-related protein homolog [KO:K03364]
698073  ANAPC1; anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
717321  CDC27; cell division cycle protein 27 homolog isoform X1 [KO:K03350]
694006  ANAPC4; anaphase-promoting complex subunit 4 [KO:K03351]
699821  ANAPC5; anaphase-promoting complex subunit 5 isoform X1 [KO:K03352]
699089  CDC16; cell division cycle protein 16 homolog [KO:K03353]
709012  ANAPC7; anaphase-promoting complex subunit 7 isoform X1 [KO:K03354]
714000  CDC23; cell division cycle protein 23 homolog [KO:K03355]
701694  ANAPC10; anaphase-promoting complex subunit 10 isoform X4 [KO:K03357]
706165  CDC26; anaphase-promoting complex subunit CDC26 [KO:K03359]
717294  ANAPC13; anaphase-promoting complex subunit 13 [KO:K12456]
718333  ANAPC15; anaphase-promoting complex subunit 15 [KO:K25228]
709147  ANAPC16; anaphase-promoting complex subunit 16 [KO:K25229]
Reference
PMID:16922370
  Authors
Kamura T.
  Title
[Cullin-based E3 family]
  Journal
Tanpakushitsu Kakusan Koso 51:1167-72 (2006)
Reference
PMID:16922408
  Authors
Matsuda N.
  Title
[Overview: hereditary disorders caused by dysfunction of ubiquitylation]
  Journal
Tanpakushitsu Kakusan Koso 51:1402-7 (2006)
Reference
PMID:16922367
  Authors
Tokunaga F.
  Title
[E2 ubiquitin-conjugating enzymes: structures and functions]
  Journal
Tanpakushitsu Kakusan Koso 51:1150-6 (2006)
Reference
PMID:16816840
  Authors
Nalepa G, Rolfe M, Harper JW.
  Title
Drug discovery in the ubiquitin-proteasome system.
  Journal
Nat Rev Drug Discov 5:596-613 (2006)
DOI:10.1038/nrd2056
Reference
PMID:16405856
  Authors
Hsu YJ, Goodman SR.
  Title
Spectrin and ubiquitination: a review.
  Journal
Cell Mol Biol (Noisy-le-grand) Suppl 51:OL801-7 (2005)
Reference
PMID:12944364
  Authors
Hatakeyama S, Nakayama KI.
  Title
Ubiquitylation as a quality control system for intracellular proteins.
  Journal
J Biochem 134:1-8 (2003)
DOI:10.1093/jb/mvg106
Reference
PMID:17588513
  Authors
Lee J, Zhou P.
  Title
DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase.
  Journal
Mol Cell 26:775-80 (2007)
DOI:10.1016/j.molcel.2007.06.001
Related
pathway
mcc03050  Proteasome
KO pathway
ko04120   
LinkDB

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