Entry Name ECM-receptor interaction - Mus musculus (house mouse)
Description The extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell and tissue structure and function. Specific interactions between cells and the ECM are mediated by transmembrane molecules, mainly integrins and perhaps also proteoglycans, CD36, or other cell-surface-associated components. These interactions lead to a direct or indirect control of cellular activities such as adhesion, migration, differentiation, proliferation, and apoptosis. In addition, integrins function as mechanoreceptors and provide a force-transmitting physical link between the ECM and the cytoskeleton. Integrins are a family of glycosylated, heterodimeric transmembrane adhesion receptors that consist of noncovalently bound alpha- and beta-subunits.
Class Environmental Information Processing; Signaling molecules and interactionBRITE hierarchy
Pathway map Ortholog table Other DBs Organism Mus musculus (house mouse) [GN:
mmu ]
Gene 12845 Comp; cartilage oligomeric matrix protein [KO:K04659 ]
231470 Fras1; Fraser extracellular matrix complex subunit 1 [KO:K23379 ]
242022 Frem2; Fras1 related extracellular matrix protein 2 [KO:K23380 ]
329872 Frem1; Fras1 related extracellular matrix protein 1 [KO:K23380 ]
15530 Hspg2; perlecan (heparan sulfate proteoglycan 2) [KO:K06255 ]
16402 Itga5; integrin alpha 5 (fibronectin receptor alpha) [KO:K06484 ]
16412 Itgb1; integrin beta 1 (fibronectin receptor beta) [KO:K05719 ]
64051 Sv2a; synaptic vesicle glycoprotein 2 a [KO:K06258 ]
64176 Sv2b; synaptic vesicle glycoprotein 2 b [KO:K06258 ]
75209 Sv2c; synaptic vesicle glycoprotein 2c [KO:K06258 ]
14723 Gp1ba; glycoprotein 1b, alpha polypeptide [KO:K06261 ]
14724 Gp1bb; glycoprotein Ib, beta polypeptide [KO:K06262 ]
16423 Cd47; CD47 antigen (Rh-related antigen, integrin-associated signal transducer) [KO:K06266 ]
15366 Hmmr; hyaluronan mediated motility receptor (RHAMM) [KO:K06267 ]
Compound Reference Authors van der Flier A, Sonnenberg A.
Title Function and interactions of integrins.
Journal Reference Authors Reddy KV, Mangale SS.
Title Integrin receptors: the dynamic modulators of endometrial function.
Journal Reference Authors Milner R, Campbell IL.
Title The integrin family of cell adhesion molecules has multiple functions within the CNS.
Journal Reference Authors Cichy J, Pure E.
Title The liberation of CD44.
Journal Reference Authors Elenius K, Jalkanen M.
Title Function of the syndecans--a family of cell surface proteoglycans.
Journal J Cell Sci 107 ( Pt 11):2975-82 (1994)
Reference Authors Son YJ, Scranton TW, Sunderland WJ, Baek SJ, Miner JH, Sanes JR, Carlson SS.
Title The synaptic vesicle protein SV2 is complexed with an alpha5-containing laminin on the nerve terminal surface.
Journal Reference Authors Sid B, Sartelet H, Bellon G, El Btaouri H, Rath G, Delorme N, Haye B, Martiny L.
Title Thrombospondin 1: a multifunctional protein implicated in the regulation of tumor growth.
Journal Reference Authors Canobbio I, Balduini C, Torti M.
Title Signalling through the platelet glycoprotein Ib-V-IX complex.
Journal Reference Authors Nieswandt B, Brakebusch C, Bergmeier W, Schulte V, Bouvard D, Mokhtari-Nejad R, Lindhout T, Heemskerk JW, Zirngibl H, Fassler R.
Title Glycoprotein VI but not alpha2beta1 integrin is essential for platelet interaction with collagen.
Journal Reference Authors Martin PT.
Title Dystroglycan glycosylation and its role in matrix binding in skeletal muscle.
Journal Reference Authors Toole BP.
Title Hyaluronan: from extracellular glue to pericellular cue.
Journal Reference Authors Bosman FT, Stamenkovic I.
Title Functional structure and composition of the extracellular matrix.
Journal Reference Authors van der Ven AT, Vivante A, Hildebrandt F
Title Novel Insights into the Pathogenesis of Monogenic Congenital Anomalies of the Kidney and Urinary Tract.
Journal Related KO pathway LinkDB All DBs
