KEGG   PATHWAY: mmu04512
Entry
mmu04512                    Pathway                                
Name
ECM-receptor interaction - Mus musculus (house mouse)
Description
The extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell and tissue structure and function. Specific interactions between cells and the ECM are mediated by transmembrane molecules, mainly integrins and perhaps also proteoglycans, CD36, or other cell-surface-associated components. These interactions lead to a direct or indirect control of cellular activities such as adhesion, migration, differentiation, proliferation, and apoptosis. In addition, integrins function as mechanoreceptors and provide a force-transmitting physical link between the ECM and the cytoskeleton. Integrins are a family of glycosylated, heterodimeric transmembrane adhesion receptors that consist of noncovalently bound alpha- and beta-subunits.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
mmu04512  ECM-receptor interaction
mmu04512

Other DBs
GO: 0005201
Organism
Mus musculus (house mouse) [GN:mmu]
Gene
104099  Itga9; integrin alpha-9 isoform a precursor [KO:K06585]
109700  Itga1; integrin alpha-1 precursor [KO:K06480]
114249  Npnt; nephronectin isoform b precursor [KO:K06824]
11603  Agrn; agrin isoform 2 [KO:K06254]
12491  Cd36; platelet glycoprotein 4 [KO:K06259]
12505  Cd44; CD44 antigen isoform b precursor [KO:K06256]
12643  Chad; chondroadherin precursor [KO:K06248]
12824  Col2a1; collagen alpha-1(II) chain isoform 1 preproprotein [KO:K19719]
12826  Col4a1; collagen alpha-1(IV) chain precursor [KO:K06237]
12827  Col4a2; collagen alpha-2(IV) chain precursor [KO:K06237]
12828  Col4a3; collagen alpha-3(IV) chain precursor [KO:K06237]
12829  Col4a4; collagen alpha-4(IV) chain precursor [KO:K06237]
12830  Col4a5; collagen alpha-5(IV) chain isoform 1 precursor [KO:K06237]
12833  Col6a1; collagen alpha-1(VI) chain precursor [KO:K06238]
12834  Col6a2; collagen alpha-2(VI) chain isoform 1 precursor [KO:K06238]
12835  Col6a3; collagen alpha-3(VI) chain isoform 1 precursor [KO:K06238]
12839  Col9a1; collagen alpha-1(IX) chain isoform 2 precursor [KO:K08131]
12840  Col9a2; collagen alpha-2(IX) chain precursor [KO:K08131]
12841  Col9a3; collagen alpha-3(IX) chain isoform 1 precursor [KO:K08131]
12842  Col1a1; collagen alpha-1(I) chain preproprotein [KO:K06236]
12843  Col1a2; collagen alpha-2(I) chain preproprotein [KO:K06236]
12845  Comp; cartilage oligomeric matrix protein precursor [KO:K04659]
13138  Dag1; dystroglycan 1 preproprotein [KO:K06265]
13406  Dmp1; dentin matrix acidic phosphoprotein 1 precursor [KO:K23328]
14268  Fn1; fibronectin isoform a precursor [KO:K05717]
14723  Gp1ba; platelet glycoprotein Ib alpha chain precursor [KO:K06261]
14724  Gp1bb; platelet glycoprotein Ib beta chain isoform 2 precursor [KO:K06262]
14729  Gp5; platelet glycoprotein V precursor [KO:K06260]
15366  Hmmr; hyaluronan mediated motility receptor [KO:K06267]
15530  Hspg2; basement membrane-specific heparan sulfate proteoglycan core protein precursor [KO:K06255]
15891  Ibsp; bone sialoprotein 2 precursor [KO:K06253]
16398  Itga2; integrin alpha-2 precursor [KO:K06481]
16399  Itga2b; integrin alpha-IIb precursor [KO:K06476]
16400  Itga3; integrin alpha-3 isoform 1 preproprotein [KO:K06482]
16401  Itga4; integrin alpha-4 precursor [KO:K06483]
16402  Itga5; integrin alpha-5 isoform 1 preproprotein [KO:K06484]
16403  Itga6; integrin alpha-6 isoform 2 precursor [KO:K06485]
16404  Itga7; integrin alpha-7 isoform 2 precursor [KO:K06583]
16410  Itgav; integrin alpha-V isoform 1 precursor [KO:K06487]
16412  Itgb1; integrin beta-1 precursor [KO:K05719]
16416  Itgb3; integrin beta-3 precursor [KO:K06493]
16419  Itgb5; integrin beta-5 isoform 1 precursor [KO:K06588]
16420  Itgb6; integrin beta-6 precursor [KO:K06589]
16421  Itgb7; integrin beta-7 precursor [KO:K06590]
16423  Cd47; leukocyte surface antigen CD47 isoform 1 precursor [KO:K06266]
16772  Lama1; laminin subunit alpha-1 precursor [KO:K05637]
16773  Lama2; laminin subunit alpha-2 precursor [KO:K05637]
16774  Lama3; laminin subunit alpha-3 isoform 3B precursor [KO:K06240]
16775  Lama4; laminin subunit alpha-4 precursor [KO:K06241]
16776  Lama5; laminin subunit alpha-5 precursor [KO:K06240]
16777  Lamb1; laminin subunit beta-1 precursor [KO:K05636]
16779  Lamb2; laminin subunit beta-2 precursor [KO:K06243]
16780  Lamb3; laminin subunit beta-3 precursor [KO:K06244]
16782  Lamc2; laminin subunit gamma-2 precursor [KO:K06246]
192897  Itgb4; integrin beta-4 isoform 1 precursor [KO:K06525]
19699  Reln; reelin isoform 1 precursor [KO:K06249] [EC:3.4.21.-]
20750  Spp1; osteopontin isoform 4 precursor [KO:K06250]
20969  Sdc1; syndecan-1 precursor [KO:K06257]
20971  Sdc4; syndecan-4 precursor [KO:K16338]
213119  Itga10; integrin alpha-10 precursor [KO:K06586]
21825  Thbs1; thrombospondin-1 isoform 2 precursor [KO:K16857]
21826  Thbs2; thrombospondin-2 precursor [KO:K04659]
21827  Thbs3; thrombospondin-3 precursor [KO:K04659]
21828  Thbs4; thrombospondin-4 precursor [KO:K04659]
21923  Tnc; tenascin isoform 1 precursor [KO:K06252]
21960  Tnr; tenascin-R precursor [KO:K06252]
22370  Vtn; vitronectin precursor [KO:K06251]
22371  Vwf; von Willebrand factor precursor [KO:K03900]
226519  Lamc1; laminin subunit gamma-1 precursor [KO:K05635]
231470  Fras1; extracellular matrix organizing protein FRAS1 precursor [KO:K23379]
23928  Lamc3; laminin subunit gamma-3 precursor [KO:K06247]
241226  Itga8; integrin alpha-8 isoform 1 preproprotein [KO:K06584]
242022  Frem2; FRAS1-related extracellular matrix protein 2 precursor [KO:K23380]
243816  Gp6; platelet glycoprotein VI precursor [KO:K06264]
245026  Col6a6; collagen alpha-6(VI) chain isoform 1 precursor [KO:K06238]
319480  Itga11; integrin alpha-11 precursor [KO:K06587]
320910  Itgb8; integrin beta-8 precursor [KO:K06591]
329278  Tnn; tenascin-N precursor [KO:K06252]
329872  Frem1; FRAS1-related extracellular matrix protein 1 isoform 1 precursor [KO:K23380]
54368  Gp9; platelet glycoprotein IX precursor [KO:K06263]
64051  Sv2a; synaptic vesicle glycoprotein 2A [KO:K06258]
64176  Sv2b; synaptic vesicle glycoprotein 2B [KO:K06258]
665033  Col6a5; collagen alpha-5(VI) chain precursor [KO:K06238]
666279  Dspp; dentin sialophosphoprotein preproprotein [KO:K23573]
68553  Col6a4; collagen alpha-4(VI) chain precursor [KO:K06238]
75209  Sv2c; synaptic vesicle glycoprotein 2C [KO:K06258]
81877  Tnxb; tenascin-X precursor [KO:K06252]
94111  Mepe; matrix extracellular phosphoglycoprotein precursor [KO:K26442]
94216  Col4a6; collagen alpha-6(IV) chain precursor [KO:K06237]
Compound
G10505  Hyaluronic acid
Reference
PMID:11572082
  Authors
van der Flier A, Sonnenberg A.
  Title
Function and interactions of integrins.
  Journal
Cell Tissue Res 305:285-98 (2001)
DOI:10.1007/s004410100417
Reference
PMID:12921709
  Authors
Reddy KV, Mangale SS.
  Title
Integrin receptors: the dynamic modulators of endometrial function.
  Journal
Tissue Cell 35:260-73 (2003)
DOI:10.1016/S0040-8166(03)00039-9
Reference
PMID:12125070
  Authors
Milner R, Campbell IL.
  Title
The integrin family of cell adhesion molecules has multiple functions within the CNS.
  Journal
J Neurosci Res 69:286-91 (2002)
DOI:10.1002/jnr.10321
Reference
PMID:12796473
  Authors
Cichy J, Pure E.
  Title
The liberation of CD44.
  Journal
J Cell Biol 161:839-43 (2003)
DOI:10.1083/jcb.200302098
Reference
PMID:7698997
  Authors
Elenius K, Jalkanen M.
  Title
Function of the syndecans--a family of cell surface proteoglycans.
  Journal
J Cell Sci 107 ( Pt 11):2975-82 (1994)
Reference
PMID:10617638
  Authors
Son YJ, Scranton TW, Sunderland WJ, Baek SJ, Miner JH, Sanes JR, Carlson SS.
  Title
The synaptic vesicle protein SV2 is complexed with an alpha5-containing laminin on the nerve terminal surface.
  Journal
J Biol Chem 275:451-60 (2000)
DOI:10.1074/jbc.275.1.451
Reference
PMID:15036264
  Authors
Sid B, Sartelet H, Bellon G, El Btaouri H, Rath G, Delorme N, Haye B, Martiny L.
  Title
Thrombospondin 1: a multifunctional protein implicated in the regulation of tumor growth.
  Journal
Crit Rev Oncol Hematol 49:245-58 (2004)
DOI:10.1016/j.critrevonc.2003.09.009
Reference
PMID:15381249
  Authors
Canobbio I, Balduini C, Torti M.
  Title
Signalling through the platelet glycoprotein Ib-V-IX complex.
  Journal
Cell Signal 16:1329-44 (2004)
DOI:10.1016/j.cellsig.2004.05.008
Reference
PMID:11331578
  Authors
Nieswandt B, Brakebusch C, Bergmeier W, Schulte V, Bouvard D, Mokhtari-Nejad R, Lindhout T, Heemskerk JW, Zirngibl H, Fassler R.
  Title
Glycoprotein VI but not alpha2beta1 integrin is essential for platelet interaction with collagen.
  Journal
EMBO J 20:2120-30 (2001)
DOI:10.1093/emboj/20.9.2120
Reference
PMID:12736199
  Authors
Martin PT.
  Title
Dystroglycan glycosylation and its role in matrix binding in skeletal muscle.
  Journal
Glycobiology 13:55R-66R (2003)
DOI:10.1093/glycob/cwg076
Reference
PMID:15229478
  Authors
Toole BP.
  Title
Hyaluronan: from extracellular glue to pericellular cue.
  Journal
Nat Rev Cancer 4:528-39 (2004)
DOI:10.1038/nrc1391
Reference
PMID:12845610
  Authors
Bosman FT, Stamenkovic I.
  Title
Functional structure and composition of the extracellular matrix.
  Journal
J Pathol 200:423-8 (2003)
DOI:10.1002/path.1437
Reference
PMID:29079659
  Authors
van der Ven AT, Vivante A, Hildebrandt F
  Title
Novel Insights into the Pathogenesis of Monogenic Congenital Anomalies of the Kidney and Urinary Tract.
  Journal
J Am Soc Nephrol 29:36-50 (2018)
DOI:10.1681/ASN.2017050561
Related
pathway
mmu04510  Focal adhesion
KO pathway
ko04512   

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