Entry
Name
ECM-receptor interaction - Mus musculus (house mouse)
Description
The extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell and tissue structure and function. Specific interactions between cells and the ECM are mediated by transmembrane molecules, mainly integrins and perhaps also proteoglycans, CD36, or other cell-surface-associated components. These interactions lead to a direct or indirect control of cellular activities such as adhesion, migration, differentiation, proliferation, and apoptosis. In addition, integrins function as mechanoreceptors and provide a force-transmitting physical link between the ECM and the cytoskeleton. Integrins are a family of glycosylated, heterodimeric transmembrane adhesion receptors that consist of noncovalently bound alpha- and beta-subunits.
Class
Environmental Information Processing; Signaling molecules and interaction
BRITE hierarchy
Pathway map
Other DBs
Organism
Mus musculus (house mouse) [GN:
mmu ]
Gene
12845 Comp; cartilage oligomeric matrix protein [KO:K04659 ]
14723 Gp1ba; glycoprotein 1b, alpha polypeptide [KO:K06261 ]
14724 Gp1bb; glycoprotein Ib, beta polypeptide [KO:K06262 ]
15366 Hmmr; hyaluronan mediated motility receptor (RHAMM) [KO:K06267 ]
15530 Hspg2; perlecan (heparan sulfate proteoglycan 2) [KO:K06255 ]
16402 Itga5; integrin alpha 5 (fibronectin receptor alpha) [KO:K06484 ]
16412 Itgb1; integrin beta 1 (fibronectin receptor beta) [KO:K05719 ]
16423 Cd47; CD47 antigen (Rh-related antigen, integrin-associated signal transducer) [KO:K06266 ]
231470 Fras1; Fraser extracellular matrix complex subunit 1 [KO:K23379 ]
242022 Frem2; Fras1 related extracellular matrix protein 2 [KO:K23380 ]
329872 Frem1; Fras1 related extracellular matrix protein 1 [KO:K23380 ]
64051 Sv2a; synaptic vesicle glycoprotein 2a [KO:K06258 ]
64176 Sv2b; synaptic vesicle glycoprotein 2b [KO:K06258 ]
75209 Sv2c; synaptic vesicle glycoprotein 2c [KO:K06258 ]
94111 Mepe; matrix extracellular phosphoglycoprotein with ASARM motif (bone) [KO:K26442 ]
Compound
Reference
Authors
van der Flier A, Sonnenberg A.
Title
Function and interactions of integrins.
Journal
Reference
Authors
Reddy KV, Mangale SS.
Title
Integrin receptors: the dynamic modulators of endometrial function.
Journal
Reference
Authors
Milner R, Campbell IL.
Title
The integrin family of cell adhesion molecules has multiple functions within the CNS.
Journal
Reference
Authors
Cichy J, Pure E.
Title
The liberation of CD44.
Journal
Reference
Authors
Elenius K, Jalkanen M.
Title
Function of the syndecans--a family of cell surface proteoglycans.
Journal
J Cell Sci 107 ( Pt 11):2975-82 (1994)
Reference
Authors
Son YJ, Scranton TW, Sunderland WJ, Baek SJ, Miner JH, Sanes JR, Carlson SS.
Title
The synaptic vesicle protein SV2 is complexed with an alpha5-containing laminin on the nerve terminal surface.
Journal
Reference
Authors
Sid B, Sartelet H, Bellon G, El Btaouri H, Rath G, Delorme N, Haye B, Martiny L.
Title
Thrombospondin 1: a multifunctional protein implicated in the regulation of tumor growth.
Journal
Reference
Authors
Canobbio I, Balduini C, Torti M.
Title
Signalling through the platelet glycoprotein Ib-V-IX complex.
Journal
Reference
Authors
Nieswandt B, Brakebusch C, Bergmeier W, Schulte V, Bouvard D, Mokhtari-Nejad R, Lindhout T, Heemskerk JW, Zirngibl H, Fassler R.
Title
Glycoprotein VI but not alpha2beta1 integrin is essential for platelet interaction with collagen.
Journal
Reference
Authors
Martin PT.
Title
Dystroglycan glycosylation and its role in matrix binding in skeletal muscle.
Journal
Reference
Authors
Toole BP.
Title
Hyaluronan: from extracellular glue to pericellular cue.
Journal
Reference
Authors
Bosman FT, Stamenkovic I.
Title
Functional structure and composition of the extracellular matrix.
Journal
Reference
Authors
van der Ven AT, Vivante A, Hildebrandt F
Title
Novel Insights into the Pathogenesis of Monogenic Congenital Anomalies of the Kidney and Urinary Tract.
Journal
Related pathway
KO pathway