KEGG   PATHWAY: morg04120
Entry
morg04120                   Pathway                                
Name
Ubiquitin mediated proteolysis - Microtus oregoni (creeping vole)
Description
Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
morg04120  Ubiquitin mediated proteolysis
morg04120

Other DBs
GO: 0016567
Organism
Microtus oregoni (creeping vole) [GN:morg]
Gene
121456703  Ubb; polyubiquitin-B isoform X1 [KO:K08770]
121465926  polyubiquitin-B-like [KO:K08770]
121445927  Ubc; polyubiquitin-C [KO:K08770]
121461891  ubiquitin-60S ribosomal protein L40-like [KO:K02927]
121462490  Uba52; ubiquitin-60S ribosomal protein L40 [KO:K02927]
121455938  ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
121459610  Rps27a; ubiquitin-40S ribosomal protein S27a [KO:K02977]
121445279  ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
121446349  ubiquitin-40S ribosomal protein S27a [KO:K02977]
121434872  ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
121441777  ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
121443689  ubiquitin-like modifier-activating enzyme 1 [KO:K03178] [EC:6.2.1.45]
121443747  ubiquitin-like modifier-activating enzyme 1 [KO:K03178] [EC:6.2.1.45]
121450149  Sae1; SUMO-activating enzyme subunit 1 isoform X1 [KO:K10684] [EC:6.2.1.45]
121449740  Uba2; SUMO-activating enzyme subunit 2 [KO:K10685] [EC:6.2.1.45]
121439310  Uba3; NEDD8-activating enzyme E1 catalytic subunit isoform X1 [KO:K10686] [EC:6.2.1.64]
121464409  Uba7; ubiquitin-like modifier-activating enzyme 7 [KO:K10698] [EC:6.2.1.45]
121460733  Uba6; ubiquitin-like modifier-activating enzyme 6 [KO:K10699] [EC:6.2.1.45]
121444720  Ube2a; ubiquitin-conjugating enzyme E2 A [KO:K10573] [EC:2.3.2.23]
121441653  ubiquitin-conjugating enzyme E2 A-like [KO:K10573] [EC:2.3.2.23]
121456279  Ube2b; ubiquitin-conjugating enzyme E2 B [KO:K10574] [EC:2.3.2.23]
121462414  ubiquitin-conjugating enzyme E2 C-like isoform X1 [KO:K06688] [EC:2.3.2.23]
121458734  ubiquitin-conjugating enzyme E2 C-like isoform X1 [KO:K06688] [EC:2.3.2.23]
121458735  ubiquitin-conjugating enzyme E2 C-like isoform X1 [KO:K06688] [EC:2.3.2.23]
121460438  Ube2c; ubiquitin-conjugating enzyme E2 C [KO:K06688] [EC:2.3.2.23]
121442799  ubiquitin-conjugating enzyme E2 C-like isoform X1 [KO:K06688] [EC:2.3.2.23]
121443509  ubiquitin-conjugating enzyme E2 C-like [KO:K06688] [EC:2.3.2.23]
121440482  ubiquitin-conjugating enzyme E2 D2-like [KO:K06689] [EC:2.3.2.23]
121459517  Ube2d3; ubiquitin-conjugating enzyme E2 D3 [KO:K06689] [EC:2.3.2.23]
121453406  ubiquitin-conjugating enzyme E2 D2 [KO:K06689] [EC:2.3.2.23]
121459893  Ube2d4; ubiquitin-conjugating enzyme E2 D4 isoform X1 [KO:K06689] [EC:2.3.2.23]
121450956  Ube2d1; ubiquitin-conjugating enzyme E2 D1 [KO:K06689] [EC:2.3.2.23]
121447261  ubiquitin-conjugating enzyme E2 D3-like [KO:K06689] [EC:2.3.2.23]
121433705  ubiquitin-conjugating enzyme E2 D2B [KO:K06689] [EC:2.3.2.23]
121443016  ubiquitin-conjugating enzyme E2 D2 [KO:K06689] [EC:2.3.2.23]
121454870  ubiquitin-conjugating enzyme E2 E2 [KO:K20217] [EC:2.3.2.23]
121454926  Ube2e1; ubiquitin-conjugating enzyme E2 E1 isoform X1 [KO:K20217] [EC:2.3.2.23]
121462164  ubiquitin-conjugating enzyme E2 E1-like [KO:K20217] [EC:2.3.2.23]
121439284  Ube2e3; ubiquitin-conjugating enzyme E2 E3 [KO:K20217] [EC:2.3.2.23]
121446858  Ube2f; NEDD8-conjugating enzyme UBE2F isoform X1 [KO:K10687] [EC:2.3.2.34]
121456280  Ube2g1; ubiquitin-conjugating enzyme E2 G1 [KO:K10575] [EC:2.3.2.23]
121435167  Ube2g2; ubiquitin-conjugating enzyme E2 G2 [KO:K04555] [EC:2.3.2.23]
121463317  Ube2h; ubiquitin-conjugating enzyme E2 H isoform X1 [KO:K10576] [EC:2.3.2.23]
121455860  SUMO-conjugating enzyme UBC9 [KO:K10577]
121463657  Ube2i; SUMO-conjugating enzyme UBC9 [KO:K10577]
121443588  SUMO-conjugating enzyme UBC9-like [KO:K10577]
121441205  SUMO-conjugating enzyme UBC9-like [KO:K10577]
121442003  SUMO-conjugating enzyme UBC9-B-like [KO:K10577]
121442069  SUMO-conjugating enzyme UBC9-like [KO:K10577]
121448699  SUMO-conjugating enzyme UBC9-like [KO:K10577]
121458393  Ube2j1; ubiquitin-conjugating enzyme E2 J1 isoform X1 [KO:K10578] [EC:2.3.2.23]
121443596  ubiquitin-conjugating enzyme E2 J2 isoform X1 [KO:K04554] [EC:2.3.2.23]
121448916  ubiquitin-conjugating enzyme E2 J2 isoform X1 [KO:K04554] [EC:2.3.2.23]
121460621  Ube2k; ubiquitin-conjugating enzyme E2 K [KO:K04649] [EC:2.3.2.23]
121462663  ubiquitin-conjugating enzyme E2 K-like [KO:K04649] [EC:2.3.2.23]
121455128  ubiquitin-conjugating enzyme E2 L3 [KO:K04552] [EC:2.3.2.23]
121461499  ubiquitin-conjugating enzyme E2 L3-like [KO:K04552] [EC:2.3.2.23]
121462984  ubiquitin-conjugating enzyme E2 L3 [KO:K04552] [EC:2.3.2.23]
121457160  ubiquitin-conjugating enzyme E2 L3-like isoform X1 [KO:K04552] [EC:2.3.2.23]
121457312  ubiquitin-conjugating enzyme E2 L3-like [KO:K04552] [EC:2.3.2.23]
121464796  Ube2l3; ubiquitin-conjugating enzyme E2 L3 [KO:K04552] [EC:2.3.2.23]
121453006  ubiquitin-conjugating enzyme E2 L3-like [KO:K04552] [EC:2.3.2.23]
121443675  ubiquitin-conjugating enzyme E2 L3-like isoform X1 [KO:K04552] [EC:2.3.2.23]
121444303  ubiquitin-conjugating enzyme E2 L3-like [KO:K04552] [EC:2.3.2.23]
121444368  ubiquitin-conjugating enzyme E2 L3-like [KO:K04552] [EC:2.3.2.23]
121439044  ubiquitin-conjugating enzyme E2 L3-like isoform X1 [KO:K04552] [EC:2.3.2.23]
121433094  ubiquitin-conjugating enzyme E2 L3-like isoform X1 [KO:K04552] [EC:2.3.2.23]
121441222  ubiquitin-conjugating enzyme E2 L3-like isoform X1 [KO:K04552] [EC:2.3.2.23]
121439127  ubiquitin/ISG15-conjugating enzyme E2 L6-like isoform X1 [KO:K04553] [EC:2.3.2.23]
121439338  Ube2l6; ubiquitin/ISG15-conjugating enzyme E2 L6 isoform X1 [KO:K04553] [EC:2.3.2.23]
121449398  Ube2m; NEDD8-conjugating enzyme Ubc12 [KO:K10579] [EC:2.3.2.34]
121464068  ubiquitin-conjugating enzyme E2 N-like [KO:K10580] [EC:2.3.2.23]
121452447  ubiquitin-conjugating enzyme E2 N-like [KO:K10580] [EC:2.3.2.23]
121459183  Ube2n; ubiquitin-conjugating enzyme E2 N [KO:K10580] [EC:2.3.2.23]
121440844  ubiquitin-conjugating enzyme E2 N-like [KO:K10580] [EC:2.3.2.23]
121436151  Ube2o; (E3-independent) E2 ubiquitin-conjugating enzyme isoform X1 [KO:K10581] [EC:2.3.2.24]
121444910  ubiquitin-conjugating enzyme E2 Q2-like [KO:K10582] [EC:2.3.2.23]
121451114  Ube2q1; ubiquitin-conjugating enzyme E2 Q1 isoform X1 [KO:K10582] [EC:2.3.2.23]
121438282  Ube2q2; ubiquitin-conjugating enzyme E2 Q2 isoform X1 [KO:K10582] [EC:2.3.2.23]
121433722  Ube2ql1; ubiquitin-conjugating enzyme E2Q-like protein 1 [KO:K10582] [EC:2.3.2.23]
121443503  ubiquitin-conjugating enzyme E2 Q2-like [KO:K10582] [EC:2.3.2.23]
121458326  Ube2r2; ubiquitin-conjugating enzyme E2 R2 [KO:K02207] [EC:2.3.2.23]
121459212  Cdc34; ubiquitin-conjugating enzyme E2 R1 isoform X1 [KO:K02207] [EC:2.3.2.23]
121450782  ubiquitin-conjugating enzyme E2 R2-like [KO:K02207] [EC:2.3.2.23]
121450955  ubiquitin-conjugating enzyme E2 R2-like isoform X1 [KO:K02207] [EC:2.3.2.23]
121449427  Ube2s; ubiquitin-conjugating enzyme E2 S [KO:K10583] [EC:2.3.2.23]
121447879  Ube2u; ubiquitin-conjugating enzyme E2 U [KO:K10584] [EC:2.3.2.23]
121458295  Ube2w; ubiquitin-conjugating enzyme E2 W [KO:K10688] [EC:2.3.2.23 2.3.2.25]
121456246  Ube2z; ubiquitin-conjugating enzyme E2 Z [KO:K10585] [EC:2.3.2.23]
121432966  Birc6; baculoviral IAP repeat-containing protein 6 isoform X1 [KO:K10586] [EC:2.3.2.23]
121453370  Ube3a; ubiquitin-protein ligase E3A isoform X1 [KO:K10587] [EC:2.3.2.26]
121445699  Ube3b; ubiquitin-protein ligase E3B [KO:K10588] [EC:2.3.2.26]
121439951  Ube3c; ubiquitin-protein ligase E3C [KO:K10589] [EC:2.3.2.26]
121464863  Smurf1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
121436046  Smurf2; E3 ubiquitin-protein ligase SMURF2 [KO:K04678] [EC:2.3.2.26]
121460097  Itch; E3 ubiquitin-protein ligase Itchy homolog [KO:K05632] [EC:2.3.2.26]
121451494  Wwp1; NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X1 [KO:K05633] [EC:2.3.2.26]
121447050  Wwp2; NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform X1 [KO:K05630] [EC:2.3.2.26]
121447038  Trip12; E3 ubiquitin-protein ligase TRIP12 isoform X1 [KO:K10590] [EC:2.3.2.26]
121465993  Nedd4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
121438846  Nedd4l; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
121440679  E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
121445565  Huwe1; E3 ubiquitin-protein ligase HUWE1 isoform X1 [KO:K10592] [EC:2.3.2.26]
121443059  E3 ubiquitin-protein ligase HUWE1-like [KO:K10592] [EC:2.3.2.26]
121437583  Ubr5; E3 ubiquitin-protein ligase UBR5 isoform X1 [KO:K10593] [EC:2.3.2.26]
121466167  Herc1; probable E3 ubiquitin-protein ligase HERC1 isoform X1 [KO:K10594] [EC:2.3.2.26]
121451076  Herc2; E3 ubiquitin-protein ligase HERC2 [KO:K10595] [EC:2.3.2.26]
121443010  Herc3; probable E3 ubiquitin-protein ligase HERC3 isoform X1 [KO:K10614] [EC:2.3.2.26]
121451032  Herc4; probable E3 ubiquitin-protein ligase HERC4 isoform X1 [KO:K10615] [EC:2.3.2.26]
121438255  Ube4a; ubiquitin conjugation factor E4 A [KO:K10596] [EC:2.3.2.27]
121448227  ubiquitin conjugation factor E4 B isoform X1 [KO:K10597] [EC:2.3.2.27]
121441790  ubiquitin conjugation factor E4 B isoform X1 [KO:K10597] [EC:2.3.2.27]
121463700  Stub1; E3 ubiquitin-protein ligase CHIP [KO:K09561] [EC:2.3.2.27]
121464842  Ppil2; RING-type E3 ubiquitin-protein ligase PPIL2 isoform X1 [KO:K10598] [EC:5.2.1.8]
121454798  Prpf19; pre-mRNA-processing factor 19 [KO:K10599] [EC:2.3.2.27]
121460116  Ubox5; RING finger protein 37 [KO:K10600]
121460179  Mdm2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
121438406  Cbl; E3 ubiquitin-protein ligase CBL isoform X1 [KO:K04707] [EC:2.3.2.27]
121461747  Cblb; E3 ubiquitin-protein ligase CBL-B isoform X1 [KO:K22517] [EC:2.3.2.27]
121450183  Cblc; E3 ubiquitin-protein ligase CBL-C isoform X1 [KO:K22518] [EC:2.3.2.27]
121466547  Prkn; E3 ubiquitin-protein ligase parkin isoform X1 [KO:K04556] [EC:2.3.2.31]
121447388  Siah1; E3 ubiquitin-protein ligase SIAH1 [KO:K04506] [EC:2.3.2.27]
121466108  Pml; protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
121465651  Traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
121440550  TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
121455832  Map3k1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
121455286  Cop1; E3 ubiquitin-protein ligase COP1 isoform X1 [KO:K10143] [EC:2.3.2.27]
121460710  Rchy1; RING finger and CHY zinc finger domain-containing protein 1 [KO:K10144] [EC:2.3.2.27]
121451815  baculoviral IAP repeat-containing protein 2 [KO:K16060]
121451487  baculoviral IAP repeat-containing protein 3-like [KO:K16060]
121439471  E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
121440885  Birc7; baculoviral IAP repeat-containing protein 7 isoform X1 [KO:K16061]
121465990  Pias1; E3 SUMO-protein ligase PIAS1 isoform X1 [KO:K04706] [EC:2.3.2.-]
121438760  Pias2; E3 SUMO-protein ligase PIAS2 isoform X1 [KO:K16063] [EC:2.3.2.-]
121438023  Pias3; E3 SUMO-protein ligase PIAS3 isoform X1 [KO:K16064] [EC:2.3.2.-]
121459706  Pias4; E3 SUMO-protein ligase PIAS4 [KO:K16065] [EC:2.3.2.27]
121454249  Syvn1; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase synoviolin [KO:K10601] [EC:2.3.2.27]
121433927  Nhlrc1; E3 ubiquitin-protein ligase NHLRC1 [KO:K10602] [EC:2.3.2.27]
121443253  E3 ubiquitin-protein ligase NHLRC1 [KO:K10602] [EC:2.3.2.27]
121435533  Aire; autoimmune regulator isoform X1 [KO:K10603]
121463578  Mgrn1; E3 ubiquitin-protein ligase MGRN1 isoform X1 [KO:K10604] [EC:2.3.2.27]
121442452  Brca1; breast cancer type 1 susceptibility protein isoform X1 [KO:K10605] [EC:2.3.2.27]
121459687  Fancl; E3 ubiquitin-protein ligase FANCL isoform X1 [KO:K10606] [EC:2.3.2.27]
121444458  E3 ubiquitin-protein ligase Midline-1 [KO:K08285] [EC:2.3.2.27]
121443080  E3 ubiquitin-protein ligase Midline-1-like [KO:K08285] [EC:2.3.2.27]
121433775  Trim32; E3 ubiquitin-protein ligase TRIM32 [KO:K10607] [EC:2.3.2.27]
121456401  Trim37; E3 ubiquitin-protein ligase TRIM37 isoform X1 [KO:K10608] [EC:2.3.2.27]
121461000  Rbx1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
121444018  E3 ubiquitin-protein ligase RBX1-like [KO:K03868] [EC:2.3.2.32]
121433638  Cul1; cullin-1 [KO:K03347]
121460492  S-phase kinase-associated protein 1-like [KO:K03094]
121456270  Skp1; S-phase kinase-associated protein 1 [KO:K03094]
121463665  Fbxw11; F-box/WD repeat-containing protein 11 isoform X1 [KO:K03362]
121453901  Btrc; F-box/WD repeat-containing protein 1A isoform X1 [KO:K03362]
121445087  S-phase kinase-associated protein 2-like [KO:K03875]
121445657  S-phase kinase-associated protein 2-like [KO:K03875]
121445658  S-phase kinase-associated protein 2-like [KO:K03875]
121439825  S-phase kinase-associated protein 2-like [KO:K03875]
121433099  Skp2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
121452734  Fbxw7; F-box/WD repeat-containing protein 7 isoform X1 [KO:K10260]
121448122  F-box only protein 2-like isoform X1 [KO:K10099]
121441783  Fbxo2; F-box only protein 2 [KO:K10099]
121444558  F-box only protein 4 isoform X1 [KO:K10291]
121432999  F-box only protein 4-like [KO:K10291]
121440750  Cul2; cullin-2 [KO:K03870]
121462395  elongin-C-like [KO:K03872]
121458568  Eloc; elongin-C [KO:K03872]
121432494  elongin-C-like [KO:K03872]
121455609  elongin-B-like [KO:K03873]
121463606  Elob; elongin-B [KO:K03873]
121465562  elongin-B-like [KO:K03873]
121453567  elongin-B-like [KO:K03873]
121443682  elongin-B-like [KO:K03873]
121443704  elongin-B-like [KO:K03873]
121443712  elongin-B-like [KO:K03873]
121443714  elongin-B-like [KO:K03873]
121448873  elongin-B-like [KO:K03873]
121448875  elongin-B-like [KO:K03873]
121448876  elongin-B-like [KO:K03873]
121448877  elongin-B-like [KO:K03873]
121448878  elongin-B-like [KO:K03873]
121448879  elongin-B-like [KO:K03873]
121448880  elongin-B-like [KO:K03873]
121448881  elongin-B-like [KO:K03873]
121448883  elongin-B-like [KO:K03873]
121441314  Vhl; von Hippel-Lindau disease tumor suppressor [KO:K03871]
121446938  Cul3; cullin-3 isoform X1 [KO:K03869]
121451759  Keap1; kelch-like ECH-associated protein 1 [KO:K10456]
121439861  kelch-like protein 13 isoform X1 [KO:K10447]
121448018  Klhl9; kelch-like protein 9 [KO:K10447]
121441694  kelch-like protein 13 isoform X1 [KO:K10447]
121458144  Rhobtb2; rho-related BTB domain-containing protein 2 [KO:K07868]
121450945  Rhobtb1; rho-related BTB domain-containing protein 1 [KO:K07868]
121462217  Cul4a; cullin-4A [KO:K10609]
121432309  cullin-4B-like [KO:K10609]
121439485  Cul4b; cullin-4B isoform X1 [KO:K10609]
121454244  Ddb1; DNA damage-binding protein 1 [KO:K10610]
121437671  Ddb2; DNA damage-binding protein 2 [KO:K10140]
121437682  LOW QUALITY PROTEIN: DNA damage-binding protein 2-like [KO:K10140]
121455755  Ercc8; DNA excision repair protein ERCC-8 isoform X1 [KO:K10570]
121447436  Det1; DET1 homolog isoform X1 [KO:K10571]
121464388  Rnf7; RING-box protein 2 isoform X1 [KO:K10611]
121438270  Cul5; cullin-5 isoform X1 [KO:K10612]
121463807  Socs1; suppressor of cytokine signaling 1 [KO:K04694]
121435989  Socs3; suppressor of cytokine signaling 3 [KO:K04696]
121450831  Cul7; cullin-7 isoform X1 [KO:K10613]
121446023  Fbxw8; F-box/WD repeat-containing protein 8 [KO:K10264]
121444045  anaphase-promoting complex subunit 11 [KO:K03358]
121444615  anaphase-promoting complex subunit 11 [KO:K03358]
121462918  Anapc2; anaphase-promoting complex subunit 2 [KO:K03349]
121448551  Cdc20; cell division cycle protein 20 homolog [KO:K03363]
121459355  Fzr1; fizzy-related protein homolog [KO:K03364]
121460067  Anapc1; anaphase-promoting complex subunit 1 [KO:K03348]
121436111  Cdc27; cell division cycle protein 27 homolog isoform X1 [KO:K03350]
121442278  Anapc4; anaphase-promoting complex subunit 4 isoform X1 [KO:K03351]
121445984  Anapc5; anaphase-promoting complex subunit 5 isoform X1 [KO:K03352]
121462431  Cdc16; cell division cycle protein 16 homolog isoform X1 [KO:K03353]
121446583  Anapc7; anaphase-promoting complex subunit 7 isoform X1 [KO:K03354]
121453125  cell division cycle protein 23 homolog [KO:K03355]
121443025  cell division cycle protein 23 homolog [KO:K03355]
121455729  Anapc10; anaphase-promoting complex subunit 10 isoform X1 [KO:K03357]
121451121  anaphase-promoting complex subunit CDC26-like [KO:K03359]
121433835  Cdc26; anaphase-promoting complex subunit CDC26 [KO:K03359]
121464313  Anapc13; anaphase-promoting complex subunit 13 [KO:K12456]
121463686  Anapc15; anaphase-promoting complex subunit 15 isoform X1 [KO:K25228]
121450583  Anapc16; anaphase-promoting complex subunit 16 [KO:K25229]
Reference
PMID:16922370
  Authors
Kamura T.
  Title
[Cullin-based E3 family]
  Journal
Tanpakushitsu Kakusan Koso 51:1167-72 (2006)
Reference
PMID:16922408
  Authors
Matsuda N.
  Title
[Overview: hereditary disorders caused by dysfunction of ubiquitylation]
  Journal
Tanpakushitsu Kakusan Koso 51:1402-7 (2006)
Reference
PMID:16922367
  Authors
Tokunaga F.
  Title
[E2 ubiquitin-conjugating enzymes: structures and functions]
  Journal
Tanpakushitsu Kakusan Koso 51:1150-6 (2006)
Reference
PMID:16816840
  Authors
Nalepa G, Rolfe M, Harper JW.
  Title
Drug discovery in the ubiquitin-proteasome system.
  Journal
Nat Rev Drug Discov 5:596-613 (2006)
DOI:10.1038/nrd2056
Reference
PMID:16405856
  Authors
Hsu YJ, Goodman SR.
  Title
Spectrin and ubiquitination: a review.
  Journal
Cell Mol Biol (Noisy-le-grand) Suppl 51:OL801-7 (2005)
Reference
PMID:12944364
  Authors
Hatakeyama S, Nakayama KI.
  Title
Ubiquitylation as a quality control system for intracellular proteins.
  Journal
J Biochem 134:1-8 (2003)
DOI:10.1093/jb/mvg106
Reference
PMID:17588513
  Authors
Lee J, Zhou P.
  Title
DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase.
  Journal
Mol Cell 26:775-80 (2007)
DOI:10.1016/j.molcel.2007.06.001
Related
pathway
morg03050  Proteasome
KO pathway
ko04120   
LinkDB

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