KEGG   PATHWAY: mpah03015
Entry
mpah03015                   Pathway                                
Name
mRNA surveillance pathway - Mus pahari (shrew mouse)
Description
The mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go decay (NGD). NMD is a mechanism that eliminates mRNAs containing premature translation-termination codons (PTCs). In vertebrates, PTCs trigger efficient NMD when located upstream of an exon junction complex (EJC). Upf3, together with Upf1 and Upf2, may signal the presence of the PTC to the 5'end of the transcript, resulting in decapping and rapid exonucleolytic digestion of the mRNA. In the NSD pathway, which targets mRNAs lacking termination codons, the ribosome is believed to translate through the 3' untranslated region and stall at the end of the poly(A) tail. NSD involves an eRF3-like protein, Ski7p, which is hypothesized to bind the empty A site of the ribosome and recruit the exosome to degrade the mRNA from the 3' end. NGD targets mRNAs with stalls in translation elongation for endonucleolytic cleavage in a process involving the Dom34 and Hbs1 proteins.
Class
Genetic Information Processing; Translation
Pathway map
mpah03015  mRNA surveillance pathway
mpah03015

Other DBs
GO: 0071028
Organism
Mus pahari (shrew mouse) [GN:mpah]
Gene
110322910  Ncbp1; nuclear cap-binding protein subunit 1 [KO:K12882]
110329642  Ncbp2; nuclear cap-binding protein subunit 2 isoform X1 [KO:K12883]
110313486  Upf3b; regulator of nonsense transcripts 3B isoform X1 [KO:K14328]
110336733  Upf3a; regulator of nonsense transcripts 3A [KO:K14328]
110320325  Rbm8a; RNA-binding protein 8A isoform X1 [KO:K12876]
110316567  Magohb; protein mago nashi homolog 2 isoform X1 [KO:K12877]
110323400  Magoh; protein mago nashi homolog [KO:K12877]
110332485  Casc3; LOW QUALITY PROTEIN: protein CASC3 [KO:K14323]
110331127  Eif4a3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
110325550  Sap18; histone deacetylase complex subunit SAP18 [KO:K14324]
110324457  Pnn; pinin [KO:K13114]
110325592  Acin1; apoptotic chromatin condensation inducer in the nucleus isoform X1 [KO:K12875]
110337927  Rnps1; RNA-binding protein with serine-rich domain 1 isoform X1 [KO:K14325]
110322222  aly/REF export factor 2 [KO:K12881]
110321368  aly/REF export factor 2-like [KO:K12881]
110321369  THO complex subunit 4-like [KO:K12881]
110315425  LOW QUALITY PROTEIN: THO complex subunit 4-like [KO:K12881]
110331971  Alyref; THO complex subunit 4 [KO:K12881]
110337354  ATP-dependent RNA helicase DDX19A [KO:K18655] [EC:5.6.2.7]
110337355  ATP-dependent RNA helicase DDX19B-like [KO:K18655] [EC:5.6.2.7]
110317690  Gle1; nucleoporin GLE1 [KO:K18723]
110321944  Nxf1; nuclear RNA export factor 1 isoform X1 [KO:K14284]
110314122  Nxf3; nuclear RNA export factor 3 [KO:K14284]
110313920  nuclear RNA export factor 2-like [KO:K14284]
110313921  nuclear RNA export factor 1-like isoform X1 [KO:K14284]
110313965  Nxt2; NTF2-related export protein 2 [KO:K14285]
110318880  Nxt1; NTF2-related export protein 1 [KO:K14285]
110335097  NTF2-related export protein 1-like [KO:K14285]
110335531  Ddx39b; spliceosome RNA helicase DDX39B [KO:K12812] [EC:5.6.2.7]
110326694  Pym1; partner of Y14 and mago isoform X1 [KO:K14294]
110322803  Srrm1; serine/arginine repetitive matrix protein 1 isoform X1 [KO:K13171]
110338665  Rngtt; mRNA-capping enzyme isoform X1 [KO:K13917] [EC:2.7.7.50 3.6.1.74]
110333253  Rnmt; mRNA cap guanine-N7 methyltransferase isoform X1 [KO:K00565] [EC:2.1.1.56]
110320507  Fus; RNA-binding protein FUS isoform X1 [KO:K13098]
110323474  Tardbp; TAR DNA-binding protein 43 isoform X1 [KO:K23600]
110325304  Pabpn1; polyadenylate-binding protein 2 [KO:K14396]
110337683  Pabpn1l; embryonic polyadenylate-binding protein 2 isoform X1 [KO:K14396]
110337428  Nudt21; cleavage and polyadenylation specificity factor subunit 5 [KO:K14397]
110316140  Cpsf7; cleavage and polyadenylation specificity factor subunit 7 isoform X1 [KO:K14398]
110326107  Cpsf6; cleavage and polyadenylation specificity factor subunit 6 [KO:K14398]
110312782  Papolb; poly(A) polymerase beta [KO:K14376] [EC:2.7.7.19]
110330194  Papolg; poly(A) polymerase gamma [KO:K14376] [EC:2.7.7.19]
110323997  Papola; poly(A) polymerase alpha isoform X1 [KO:K14376] [EC:2.7.7.19]
110318689  Clp1; polyribonucleotide 5'-hydroxyl-kinase Clp1 isoform X1 [KO:K14399] [EC:2.7.1.78]
110333172  Pcf11; pre-mRNA cleavage complex 2 protein Pcf11 isoform X1 [KO:K14400]
110334446  Cpsf1; cleavage and polyadenylation specificity factor subunit 1 isoform X1 [KO:K14401]
110324215  Cpsf2; cleavage and polyadenylation specificity factor subunit 2 [KO:K14402]
110324958  Cpsf3; cleavage and polyadenylation specificity factor subunit 3 [KO:K14403] [EC:3.1.27.-]
110313220  Cpsf4; cleavage and polyadenylation specificity factor subunit 4 isoform X1 [KO:K14404]
110332573  Cpsf4l; LOW QUALITY PROTEIN: putative cleavage and polyadenylation specificity factor subunit 4-like protein [KO:K14404]
110331031  Fip1l1; pre-mRNA 3'-end-processing factor FIP1 isoform X1 [KO:K14405]
110332884  Wdr33; pre-mRNA 3' end processing protein WDR33 isoform X1 [KO:K15542]
110327980  Wdr82; WD repeat-containing protein 82 [KO:K14962]
110312794  Ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
110317198  Ppp1ca; serine/threonine-protein phosphatase PP1-alpha catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
110324329  Ppp1cb; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
110323073  Ssu72; RNA polymerase II subunit A C-terminal domain phosphatase SSU72 [KO:K15544] [EC:3.1.3.16]
110318300  Cstf1; cleavage stimulation factor subunit 1 [KO:K14406]
110313070  Cstf2t; cleavage stimulation factor subunit 2 tau variant isoform X1 [KO:K14407]
110313285  Cstf2; cleavage stimulation factor subunit 2 isoform X1 [KO:K14407]
110318477  Cstf3; cleavage stimulation factor subunit 3 [KO:K14408]
110336469  Sympk; symplekin [KO:K06100]
110331369  Msi2; RNA-binding protein Musashi homolog 2 isoform X1 [KO:K14411]
110312825  Msi1; RNA-binding protein Musashi homolog 1 isoform X1 [KO:K14411]
110326396  Dazap1; DAZ-associated protein 1 isoform X1 [KO:K14411]
110334482  Pabpc1; polyadenylate-binding protein 1 [KO:K13126]
110318873  Pabpc1l; polyadenylate-binding protein 1-like [KO:K13126]
110322835  Pabpc4; polyadenylate-binding protein 4 isoform X1 [KO:K13126]
110313999  polyadenylate-binding protein 1-like 2 [KO:K13126]
110320461  Pabpc4l; polyadenylate-binding protein 4-like [KO:K13126]
110313904  Pabpc5; polyadenylate-binding protein 5 isoform X1 [KO:K13126]
110332929  Etf1; eukaryotic peptide chain release factor subunit 1 isoform X1 [KO:K03265]
110313606  eukaryotic peptide chain release factor GTP-binding subunit ERF3B [KO:K03267]
110329334  Gspt1; eukaryotic peptide chain release factor GTP-binding subunit ERF3A isoform X1 [KO:K03267]
110336868  Upf1; regulator of nonsense transcripts 1 isoform X1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
110333635  Upf2; regulator of nonsense transcripts 2 isoform X1 [KO:K14327]
110318746  Smg1; serine/threonine-protein kinase SMG1 [KO:K08873] [EC:2.7.11.1]
110322315  Smg7; protein SMG7 isoform X1 [KO:K14409]
110319882  Smg5; protein SMG5 isoform X1 [KO:K11125]
110331441  Smg6; telomerase-binding protein EST1A [KO:K11124] [EC:3.1.-.-]
110336304  Ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform isoform X1 [KO:K04382] [EC:3.1.3.16]
110331422  Ppp2ca; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
110328279  Ppp2r1b; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
110337932  Ppp2r1a; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X1 [KO:K03456]
110325313  Ppp2r2a; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
110330369  Ppp2r2c; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
110332843  Ppp2r2b; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform [KO:K04354]
110318923  Ppp2r2d; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
110324355  Ppp2r3c; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma [KO:K11583]
110327434  Ppp2r3a; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
110321572  Ppp2r5a; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
110321059  Ppp2r5b; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1 [KO:K11584]
110324840  Ppp2r5e; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
110324283  Ppp2r5c; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
110335699  Ppp2r5d; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X1 [KO:K11584]
110337873  Hbs1l; HBS1-like protein isoform X1 [KO:K14416]
110328854  Pelo; protein pelota homolog [KO:K06965]
Reference
PMID:15040442
  Authors
Maquat LE
  Title
Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics.
  Journal
Nat Rev Mol Cell Biol 5:89-99 (2004)
DOI:10.1038/nrm1310
Reference
PMID:16723977
  Authors
Amrani N, Sachs MS, Jacobson A
  Title
Early nonsense: mRNA decay solves a translational problem.
  Journal
Nat Rev Mol Cell Biol 7:415-25 (2006)
DOI:10.1038/nrm1942
Reference
PMID:17183357
  Authors
Eulalio A, Behm-Ansmant I, Izaurralde E
  Title
P bodies: at the crossroads of post-transcriptional pathways.
  Journal
Nat Rev Mol Cell Biol 8:9-22 (2007)
DOI:10.1038/nrm2080
Reference
PMID:18158581
  Authors
Mandel CR, Bai Y, Tong L
  Title
Protein factors in pre-mRNA 3'-end processing.
  Journal
Cell Mol Life Sci 65:1099-122 (2008)
DOI:10.1007/s00018-007-7474-3
Reference
PMID:16715045
  Authors
Clement SL, Lykke-Andersen J
  Title
No mercy for messages that mess with the ribosome.
  Journal
Nat Struct Mol Biol 13:299-301 (2006)
DOI:10.1038/nsmb0406-299
Related
pathway
mpah03013  Nucleocytoplasmic transport
mpah03018  RNA degradation
mpah03040  Spliceosome
KO pathway
ko03015   
LinkDB

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