KEGG   PATHWAY: ncar04146
Entry
ncar04146                   Pathway                                
Name
Peroxisome - Sciurus carolinensis (gray squirrel)
Description
Peroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ether lipids and free radical detoxification. The biogenesis of peroxisomes starts with the early peroxins PEX3, PEX16 and PEX19 and proceeds via several steps. The import of membrane proteins into peroxisomes needs PEX19 for recognition, targeting and insertion via docking at PEX3. Matrix proteins in the cytosol are recognized by peroxisomal targeting signals (PTS) and transported to the docking complex at the peroxisomal membrane. Peroxisomes' deficiencies lead to severe and often fatal inherited peroxisomal disorders (PD). PDs are usually classified in two groups. The first group is disorders of peroxisome biogenesis which include Zellweger syndrome, and the second group is single peroxisomal enzyme deficiencies.
Class
Cellular Processes; Transport and catabolism
Pathway map
ncar04146  Peroxisome
ncar04146

Other DBs
GO: 0005777
Organism
Sciurus carolinensis (gray squirrel) [GN:ncar]
Gene
124958399  peroxisomal membrane protein PEX16 [KO:K13335]
124988497  peroxisomal biogenesis factor 3 [KO:K13336]
124983825  peroxisomal biogenesis factor 19 [KO:K13337]
124986804  ATP-binding cassette sub-family D member 3 isoform X1 [KO:K05677] [EC:7.6.2.4]
124991496  peroxisome biogenesis factor 1 isoform X1 [KO:K13338]
124988151  peroxisome assembly factor 2 isoform X1 [KO:K13339]
124983605  peroxisome assembly protein 26-like [KO:K13340]
124989590  peroxisomal targeting signal 2 receptor isoform X1 [KO:K13341]
124992697  PEX5-related protein isoform X1 [KO:K13342]
124982615  peroxisomal targeting signal 1 receptor isoform X1 [KO:K13342]
124989713  peroxisomal membrane protein PEX14 isoform X1 [KO:K13343]
124962982  LOW QUALITY PROTEIN: peroxisomal membrane protein PEX13-like [KO:K13344]
124978863  peroxisome assembly protein 12 [KO:K13345]
124963067  peroxisome biogenesis factor 10 [KO:K13346]
124966505  peroxisome biogenesis factor 2 isoform X1 [KO:K06664]
124991033  LOW QUALITY PROTEIN: peroxisomal membrane protein 2-like [KO:K13347]
124969338  mpv17-like protein 2 [KO:K13348]
124962788  protein Mpv17 isoform X1 [KO:K13348]
124970400  mpv17-like protein isoform X1 [KO:K13349]
124977226  peroxisomal membrane protein 4 [KO:K13350]
124977616  peroxisomal membrane protein 11A-like [KO:K13351]
124979181  peroxisomal membrane protein 11B isoform X1 [KO:K13352]
124969273  peroxisomal membrane protein 11C-like [KO:K13353]
124983680  peroxisomal membrane protein PMP34 isoform X1 [KO:K13354]
124968501  2-hydroxyacyl-CoA lyase 1 isoform X1 [KO:K12261] [EC:4.1.2.63]
124987483  alpha-methylacyl-CoA racemase-like [KO:K01796] [EC:5.1.99.4]
124961617  phytanoyl-CoA dioxygenase, peroxisomal [KO:K00477] [EC:1.14.11.18]
124962141  phytanoyl-CoA dioxygenase, peroxisomal-like [KO:K00477] [EC:1.14.11.18]
124994493  peroxisomal acyl-coenzyme A oxidase 3-like isoform X1 [KO:K00232] [EC:1.3.3.6]
124980496  peroxisomal acyl-coenzyme A oxidase 1 isoform X1 [KO:K00232] [EC:1.3.3.6]
124969525  peroxisomal acyl-coenzyme A oxidase 2-like isoform X1 [KO:K10214] [EC:1.17.99.3]
124986751  peroxisomal multifunctional enzyme type 2 [KO:K12405] [EC:1.1.1.- 4.2.1.107 4.2.1.119]
124976523  sterol carrier protein 2 isoform X1 [KO:K08764] [EC:2.3.1.176]
124964800  LOW QUALITY PROTEIN: acyl-coenzyme A amino acid N-acyltransferase 2-like [KO:K00659] [EC:2.3.1.65 3.1.2.2]
124964957  bile acid-CoA:amino acid N-acyltransferase-like [KO:K00659] [EC:2.3.1.65 3.1.2.2]
124993621  LOW QUALITY PROTEIN: peroxisomal bifunctional enzyme-like [KO:K07514] [EC:4.2.1.17 1.1.1.35 5.3.3.8]
124992302  peroxisomal bifunctional enzyme-like [KO:K07514] [EC:4.2.1.17 1.1.1.35 5.3.3.8]
124968529  3-ketoacyl-CoA thiolase B, peroxisomal [KO:K07513] [EC:2.3.1.16]
124968830  3-ketoacyl-CoA thiolase B, peroxisomal-like isoform X1 [KO:K07513] [EC:2.3.1.16]
124967365  delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial-like [KO:K12663] [EC:5.3.3.21]
124971781  ATP-binding cassette sub-family D member 1 [KO:K05675] [EC:7.6.2.4]
124984037  ATP-binding cassette sub-family D member 2 [KO:K05676] [EC:7.6.2.4]
124994117  LOW QUALITY PROTEIN: lysosomal cobalamin transporter ABCD4-like [KO:K05678] [EC:7.6.2.8]
124977786  lysosomal cobalamin transporter ABCD4 isoform X1 [KO:K05678] [EC:7.6.2.8]
124978105  very long-chain acyl-CoA synthetase isoform X1 [KO:K08746] [EC:6.2.1.- 6.2.1.3]
124986745  long-chain-fatty-acid--CoA ligase 6 isoform X1 [KO:K01897] [EC:6.2.1.3]
124984668  long-chain-fatty-acid--CoA ligase 5 isoform X1 [KO:K01897] [EC:6.2.1.3]
124979847  fatty acid CoA ligase Acsl3 [KO:K01897] [EC:6.2.1.3]
124972059  long-chain-fatty-acid--CoA ligase 4 isoform X1 [KO:K01897] [EC:6.2.1.3]
124982371  long-chain-fatty-acid--CoA ligase 1 isoform X1 [KO:K01897] [EC:6.2.1.3]
124981236  peroxisomal trans-2-enoyl-CoA reductase-like [KO:K07753] [EC:1.3.1.38]
124988578  enoyl-CoA delta isomerase 2-like isoform X1 [KO:K13239] [EC:5.3.3.8]
124967098  peroxisomal coenzyme A diphosphatase NUDT7-like isoform X1 [KO:K17879] [EC:3.6.1.77]
124987405  NAD-capped RNA hydrolase NUDT12 isoform X1 [KO:K03426] [EC:3.6.1.22]
124985935  NAD(P)H pyrophosphatase NUDT13, mitochondrial-like isoform X1 [KO:K03426] [EC:3.6.1.22]
124966327  acyl-coenzyme A diphosphatase NUDT19-like isoform X1 [KO:K13355] [EC:3.6.1.77]
124975916  acyl-coenzyme A thioesterase 8 [KO:K11992] [EC:3.1.2.27]
124964858  carnitine O-acetyltransferase isoform X1 [KO:K00624] [EC:2.3.1.7]
124990758  peroxisomal carnitine O-octanoyltransferase isoform X1 [KO:K05940] [EC:2.3.1.137]
124967129  malonyl-CoA decarboxylase, mitochondrial [KO:K01578] [EC:4.1.1.9]
124994786  LOW QUALITY PROTEIN: dihydroxyacetone phosphate acyltransferase-like [KO:K00649] [EC:2.3.1.42]
124961653  LOW QUALITY PROTEIN: dihydroxyacetone phosphate acyltransferase-like [KO:K00649] [EC:2.3.1.42]
124982828  LOW QUALITY PROTEIN: dihydroxyacetone phosphate acyltransferase-like [KO:K00649] [EC:2.3.1.42]
124980016  alkyldihydroxyacetonephosphate synthase, peroxisomal isoform X1 [KO:K00803] [EC:2.5.1.26]
124958575  fatty acyl-CoA reductase 1 isoform X1 [KO:K13356] [EC:1.2.1.84]
124982114  fatty acyl-CoA reductase 2 isoform X1 [KO:K13356] [EC:1.2.1.84]
124990556  mevalonate kinase isoform X1 [KO:K00869] [EC:2.7.1.36]
124978166  phosphomevalonate kinase isoform X1 [KO:K13273] [EC:2.7.4.2]
124981140  serine--pyruvate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
124991921  D-amino-acid oxidase-like isoform X1 [KO:K00273] [EC:1.4.3.3]
124988564  D-aspartate oxidase-like isoform X1 [KO:K00272] [EC:1.4.3.1]
124978198  isocitrate dehydrogenase [NADP], mitochondrial [KO:K00031] [EC:1.1.1.42]
124980554  isocitrate dehydrogenase [NADP] cytoplasmic [KO:K00031] [EC:1.1.1.42]
124974917  peroxisomal N(1)-acetyl-spermine/spermidine oxidase isoform X1 [KO:K00308] [EC:1.5.3.13]
124980821  peroxisomal sarcosine oxidase-like isoform X1 [KO:K00306] [EC:1.5.3.1 1.5.3.7]
124988691  3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic [KO:K01640] [EC:4.1.3.4]
124960719  hydroxymethylglutaryl-CoA lyase, mitochondrial isoform X1 [KO:K01640] [EC:4.1.3.4]
124991732  2-Hydroxyacid oxidase 2-like [KO:K11517] [EC:1.1.3.15]
124977253  2-Hydroxyacid oxidase 1 [KO:K11517] [EC:1.1.3.15]
124959884  catalase [KO:K03781] [EC:1.11.1.6]
124959016  peroxiredoxin-5, mitochondrial-like [KO:K11187] [EC:1.11.1.24]
124992482  superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
124988793  superoxide dismutase [Mn], mitochondrial [KO:K04564] [EC:1.15.1.1]
124979775  nitric oxide synthase, inducible isoform X1 [KO:K13241] [EC:1.14.13.39]
124985475  peroxiredoxin-1 isoform X1 [KO:K13279] [EC:1.11.1.24]
124976958  peroxiredoxin-1-like [KO:K13279] [EC:1.11.1.24]
124982494  bifunctional epoxide hydrolase 2-like isoform X1 [KO:K08726] [EC:3.3.2.10 3.1.3.76]
124991836  glutathione S-transferase kappa 1-like isoform X1 [KO:K13299] [EC:2.5.1.18]
124963278  xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
124976831  dehydrogenase/reductase SDR family member 4-like isoform X1 [KO:K11147] [EC:1.1.-.-]
Reference
PMID:17055078
  Authors
Wanders RJ, Waterham HR
  Title
Peroxisomal disorders: the single peroxisomal enzyme deficiencies.
  Journal
Biochim Biophys Acta 1763:1707-20 (2006)
DOI:10.1016/j.bbamcr.2006.08.010
Reference
PMID:17055079
  Authors
Steinberg SJ, Dodt G, Raymond GV, Braverman NE, Moser AB, Moser HW
  Title
Peroxisome biogenesis disorders.
  Journal
Biochim Biophys Acta 1763:1733-48 (2006)
DOI:10.1016/j.bbamcr.2006.09.010
Reference
PMID:17010456
  Authors
Rottensteiner H, Theodoulou FL
  Title
The ins and outs of peroxisomes: co-ordination of membrane transport and peroxisomal metabolism.
  Journal
Biochim Biophys Acta 1763:1527-40 (2006)
DOI:10.1016/j.bbamcr.2006.08.012
Reference
PMID:16631601
  Authors
Iida R, Yasuda T, Tsubota E, Takatsuka H, Matsuki T, Kishi K
  Title
Human Mpv17-like protein is localized in peroxisomes and regulates expression of antioxidant enzymes.
  Journal
Biochem Biophys Res Commun 344:948-54 (2006)
DOI:10.1016/j.bbrc.2006.04.008
Related
pathway
ncar00071  Fatty acid degradation
ncar00120  Primary bile acid biosynthesis
ncar00230  Purine metabolism
ncar00564  Glycerophospholipid metabolism
ncar00565  Ether lipid metabolism
ncar00830  Retinol metabolism
ncar00900  Terpenoid backbone biosynthesis
ncar03320  PPAR signaling pathway
KO pathway
ko04146   
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