KEGG   PATHWAY: oda04972
Entry
oda04972                    Pathway                                
Name
Pancreatic secretion - Oryx dammah (scimitar-horned oryx)
Description
The pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesize and secrete digestive enzymes. Stimulation of the cell by secretagogues such as acetylcholine (ACh) and cholecystokinin (CCK) causes the generation of an intracellular Ca2+ signal. This signal, in turn, triggers the fusion of the zymogen granules with the apical plasma membrane, leading to the polarised secretion of the enzymes. The major task of pancreatic duct cells is the secretion of fluid and bicarbonate ions (HCO3-), which neutralize the acidity of gastric contents that enter the duodenum. An increase in intracellular cAMP by secretin is one of the major signals of pancreatic HCO3- secretion. Activation of the CFTR Cl- channel and the CFTR-dependent Cl-/HCO3- exchange activities is responsible for cAMP-induced HCO3- secretion.
Class
Organismal Systems; Digestive system
Pathway map
oda04972  Pancreatic secretion
oda04972

Other DBs
GO: 0030157
Organism
Oryx dammah (scimitar-horned oryx) [GN:oda]
Gene
120860471  muscarinic acetylcholine receptor M3 [KO:K04131]
120865400  muscarinic acetylcholine receptor M3 [KO:K04131]
120867765  CCK; cholecystokinin [KO:K05226]
120862006  CCKAR; cholecystokinin receptor type A isoform X1 [KO:K04194]
120875860  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
120853216  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
120869193  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
120869195  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
120874626  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
120866588  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
120876193  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
120871941  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
120859727  ras-related protein Rab-3D-like [KO:K07884]
120863942  RAB3D; ras-related protein Rab-3D [KO:K07884]
120864186  RAB8A; ras-related protein Rab-8A [KO:K07901]
120852533  RAB11A; ras-related protein Rab-11A [KO:K07904]
120880971  RAB27B; ras-related protein Rab-27B [KO:K07886]
120856682  RAP1A; ras-related protein Rap-1A [KO:K04353]
120857713  RAP1B; ras-related protein Rap-1b [KO:K07836]
120868267  RHOA; transforming protein RhoA [KO:K04513]
120856144  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
120856773  alpha-amylase 2B-like [KO:K01176] [EC:3.2.1.1]
120856774  alpha-amylase 2B [KO:K01176] [EC:3.2.1.1]
120877556  cationic trypsin [KO:K01312] [EC:3.4.21.4]
120877677  anionic trypsin [KO:K01312] [EC:3.4.21.4]
120877680  cationic trypsin-like [KO:K01312] [EC:3.4.21.4]
120861142  chymotrypsinogen A-like isoform X1 [KO:K01310] [EC:3.4.21.1]
120872853  chymotrypsinogen B-like [KO:K01310] [EC:3.4.21.1]
120872854  chymotrypsinogen B [KO:K01310] [EC:3.4.21.1]
120873342  chymotrypsinogen A [KO:K01310] [EC:3.4.21.1]
120879819  chymotrypsin-like elastase family member 2A [KO:K01346] [EC:3.4.21.71]
120855015  proproteinase E [KO:K01345] [EC:3.4.21.70]
120877545  carboxypeptidase A1-like [KO:K08779] [EC:3.4.17.1]
120858402  CPA3; LOW QUALITY PROTEIN: mast cell carboxypeptidase A [KO:K08780] [EC:3.4.17.1]
120858396  CPB1; carboxypeptidase B [KO:K01291] [EC:3.4.17.2]
120883212  CPB2; carboxypeptidase B2 [KO:K01300] [EC:3.4.17.20]
120873966  pancreatic triacylglycerol lipase isoform X1 [KO:K14073] [EC:3.1.1.3]
120873967  PNLIPRP1; LOW QUALITY PROTEIN: inactive pancreatic lipase-related protein 1 [KO:K14074] [EC:3.1.1.3]
120873958  pancreatic lipase-related protein 2 [KO:K14075] [EC:3.1.1.3]
120852129  CEL; bile salt-activated lipase [KO:K12298] [EC:3.1.1.13 3.1.1.3]
120875035  group 10 secretory phospholipase A2-like isoform X1 [KO:K01047] [EC:3.1.1.4]
120861729  PLA2G12A; group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
120854985  PLA2G2E; group IIE secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
120854986  phospholipase A2, membrane associated [KO:K01047] [EC:3.1.1.4]
120854987  phospholipase A2, membrane associated-like [KO:K01047] [EC:3.1.1.4]
120854988  phospholipase A2, membrane associated-like [KO:K01047] [EC:3.1.1.4]
120854989  PLA2G5; phospholipase A2 group V isoform X1 [KO:K01047] [EC:3.1.1.4]
120854990  PLA2G2D; group IID secretory phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
120854991  PLA2G2F; group IIF secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
120854994  PLA2G2C; putative inactive group IIC secretory phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
120871150  PLA2G1B; phospholipase A2 [KO:K01047] [EC:3.1.1.4]
120871258  PLA2G3; group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
120865302  PLA2G12B; group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
120867669  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
120858499  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
120869823  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
120860476  ryanodine receptor 2-like [KO:K04962]
120865404  ryanodine receptor 2-like [KO:K04962]
120861630  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
120861770  BST1; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 isoform X1 [KO:K18152] [EC:3.2.2.6 2.4.99.20]
120874141  TPCN2; two pore calcium channel protein 2 [KO:K14077]
120876547  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
120871032  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
120866166  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
120856913  CLCA1; calcium-activated chloride channel regulator 1 [KO:K05027]
120856915  CLCA2; calcium-activated chloride channel regulator 2 [KO:K05028]
120856909  calcium-activated chloride channel regulator 1-like [KO:K05030]
120856911  calcium-activated chloride channel regulator 1 [KO:K05030]
120856912  CLCA4; calcium-activated chloride channel regulator 4 [KO:K05030]
120858210  TRPC1; short transient receptor potential channel 1 isoform X1 [KO:K04964]
120864720  SLC12A2; solute carrier family 12 member 2 isoform X1 [KO:K10951]
120855582  ATP1A2; sodium/potassium-transporting ATPase subunit alpha-2 [KO:K01539] [EC:7.2.2.13]
120855583  ATP1A4; sodium/potassium-transporting ATPase subunit alpha-4 [KO:K01539] [EC:7.2.2.13]
120856023  ATP1A1; sodium/potassium-transporting ATPase subunit alpha-1 isoform X1 [KO:K01539] [EC:7.2.2.13]
120872368  ATP1A3; sodium/potassium-transporting ATPase subunit alpha-3 [KO:K01539] [EC:7.2.2.13]
120880280  ATP1B1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540]
120881515  ATP1B4; protein ATP1B4 isoform X1 [KO:K01540]
120853069  LOW QUALITY PROTEIN: sodium/potassium-transporting ATPase subunit beta-3-like [KO:K01540]
120866038  ATP1B2; sodium/potassium-transporting ATPase subunit beta-2 [KO:K01540]
120858125  ATP1B3; sodium/potassium-transporting ATPase subunit beta-3 [KO:K01540]
120876304  FXYD2; sodium/potassium-transporting ATPase subunit gamma isoform X1 [KO:K01538]
120874163  KCNQ1; potassium voltage-gated channel subfamily KQT member 1 [KO:K04926]
120865253  KCNMA1; calcium-activated potassium channel subunit alpha-1 isoform X1 [KO:K04936]
120881802  ATP2B3; plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
120868133  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
120858399  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
120855120  SLC9A1; sodium/hydrogen exchanger 1 isoform X1 [KO:K05742]
120877874  SLC4A2; anion exchange protein 2 [KO:K13855]
120874217  SCT; secretin [KO:K05263]
120854123  SCTR; secretin receptor [KO:K04588]
120869377  guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
120869379  neuroendocrine secretory protein 55 [KO:K04632]
120877473  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
120879368  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
120851596  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
120853482  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
120870754  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
120861292  adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
120858160  adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
120872811  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
120878868  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
120874335  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
120877516  CFTR; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
120878189  SLC26A3; chloride anion exchanger isoform X1 [KO:K14078]
120861416  SLC4A4; electrogenic sodium bicarbonate cotransporter 1 isoform X1 [KO:K13575]
120878526  CA2; carbonic anhydrase 2 [KO:K18245] [EC:4.2.1.1]
Compound
C00001  H2O
C00011  CO2
C00076  Calcium cation
C00080  H+
C00165  Diacylglycerol
C00238  Potassium cation
C00288  HCO3-
C00575  3',5'-Cyclic AMP
C00698  Cl-
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C01353  Carbonic acid
C01996  Acetylcholine
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:17850212
  Authors
Petersen OH, Tepikin AV
  Title
Polarized calcium signaling in exocrine gland cells.
  Journal
Annu Rev Physiol 70:273-99 (2008)
DOI:10.1146/annurev.physiol.70.113006.100618
Reference
PMID:20625287
  Authors
Williams JA
  Title
Regulation of acinar cell function in the pancreas.
  Journal
Curr Opin Gastroenterol 26:478-83 (2010)
DOI:10.1097/MOG.0b013e32833d11c6
Reference
PMID:16891880
  Authors
Williams JA
  Title
Regulation of pancreatic acinar cell function.
  Journal
Curr Opin Gastroenterol 22:498-504 (2006)
DOI:10.1097/01.mog.0000239863.96833.c0
Reference
PMID:15689674
  Authors
Bi Y, Williams JA
  Title
Receptor biology and signal transduction in pancreatic acinar cells.
  Journal
Curr Opin Gastroenterol 20:427-34 (2004)
DOI:10.1097/00001574-200409000-00002
Reference
PMID:14660554
  Authors
Yamasaki M, Masgrau R, Morgan AJ, Churchill GC, Patel S, Ashcroft SJ, Galione A
  Title
Organelle selection determines agonist-specific Ca2+ signals in pancreatic acinar and beta cells.
  Journal
J Biol Chem 279:7234-40 (2004)
DOI:10.1074/jbc.M311088200
Reference
PMID:9548666
  Authors
Kanno T
  Title
Ca2+ signaling in the pancreatic acinus.
  Journal
Pancreas 16:273-6 (1998)
Reference
PMID:18626068
  Authors
Heitzmann D, Warth R
  Title
Physiology and pathophysiology of potassium channels in gastrointestinal epithelia.
  Journal
Physiol Rev 88:1119-82 (2008)
DOI:10.1152/physrev.00020.2007
Reference
PMID:14637169
  Authors
Konturek SJ, Zabielski R, Konturek JW, Czarnecki J
  Title
Neuroendocrinology of the pancreas; role of brain-gut axis in pancreatic secretion.
  Journal
Eur J Pharmacol 481:1-14 (2003)
DOI:10.1016/j.ejphar.2003.08.042
Reference
PMID:16888148
  Authors
Chu JY, Yung WH, Chow BK
  Title
Secretin: a pleiotrophic hormone.
  Journal
Ann N Y Acad Sci 1070:27-50 (2006)
DOI:10.1196/annals.1317.013
Reference
PMID:16930743
  Authors
Siu FK, Lam IP, Chu JY, Chow BK
  Title
Signaling mechanisms of secretin receptor.
  Journal
Regul Pept 137:95-104 (2006)
DOI:10.1016/j.regpep.2006.02.011
Reference
PMID:15709963
  Authors
Steward MC, Ishiguro H, Case RM
  Title
Mechanisms of bicarbonate secretion in the pancreatic duct.
  Journal
Annu Rev Physiol 67:377-409 (2005)
DOI:10.1146/annurev.physiol.67.031103.153247
Reference
PMID:20224219
  Authors
Kim D, Steward MC
  Title
The role of CFTR in bicarbonate secretion by pancreatic duct and airway epithelia.
  Journal
J Med Invest 56 Suppl:336-42 (2009)
DOI:10.2152/jmi.56.336
Reference
PMID:17205399
  Authors
Whitcomb DC, Lowe ME
  Title
Human pancreatic digestive enzymes.
  Journal
Dig Dis Sci 52:1-17 (2007)
DOI:10.1007/s10620-006-9589-z
Reference
PMID:10835353
  Authors
Cancela JM, Gerasimenko OV, Gerasimenko JV, Tepikin AV, Petersen OH
  Title
Two different but converging messenger pathways to intracellular Ca(2+) release: the roles of nicotinic acid adenine dinucleotide phosphate, cyclic ADP-ribose and inositol trisphosphate.
  Journal
EMBO J 19:2549-57 (2000)
DOI:10.1093/emboj/19.11.2549
Reference
PMID:10078532
  Authors
Cancela JM, Churchill GC, Galione A
  Title
Coordination of agonist-induced Ca2+-signalling patterns by NAADP in pancreatic acinar cells.
  Journal
Nature 398:74-6 (1999)
DOI:10.1038/18032
Reference
PMID:11087843
  Authors
Parekh AB
  Title
Calcium signaling and acute pancreatitis: specific response to a promiscuous messenger.
  Journal
Proc Natl Acad Sci U S A 97:12933-4 (2000)
DOI:10.1073/pnas.97.24.12933
Reference
PMID:19088252
  Authors
Williams JA, Chen X, Sabbatini ME
  Title
Small G proteins as key regulators of pancreatic digestive enzyme secretion.
  Journal
Am J Physiol Endocrinol Metab 296:E405-14 (2009)
DOI:10.1152/ajpendo.90874.2008
Related
pathway
oda04020  Calcium signaling pathway
oda04530  Tight junction
oda04973  Carbohydrate digestion and absorption
oda04974  Protein digestion and absorption
oda04975  Fat digestion and absorption
oda04977  Vitamin digestion and absorption
KO pathway
ko04972   
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