KEGG   PATHWAY: oda04020
Entry
oda04020                    Pathway                                
Name
Calcium signaling pathway - Oryx dammah (scimitar-horned oryx)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
oda04020  Calcium signaling pathway
oda04020

Other DBs
GO: 0019722
Organism
Oryx dammah (scimitar-horned oryx) [GN:oda]
Gene
120851705  SLC8A1; sodium/calcium exchanger 1 isoform X1 [KO:K05849]
120852763  SLC8A3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
120872225  SLC8A2; sodium/calcium exchanger 2 [KO:K05849]
120881802  ATP2B3; plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
120868133  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
120858399  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
120874592  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
120860471  muscarinic acetylcholine receptor M3 [KO:K04131]
120865400  muscarinic acetylcholine receptor M3 [KO:K04131]
120853254  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
120871308  ADORA2A; adenosine receptor A2a [KO:K04266]
120867417  ADORA2B; adenosine receptor A2b [KO:K04267]
120873913  ADRB1; beta-1 adrenergic receptor [KO:K04141]
120863437  ADRB2; beta-2 adrenergic receptor [KO:K04142]
120865655  ADRB3; beta-3 adrenergic receptor [KO:K04143]
120860970  D(1A) dopamine receptor [KO:K04144]
120853592  D(1A) dopamine receptor-like [KO:K04144]
120862215  DRD5; D(1B) dopamine receptor [KO:K05840]
120860973  histamine H2 receptor-like [KO:K04150]
120853594  histamine H2 receptor-like [KO:K04150]
120864464  HTR4; 5-hydroxytryptamine receptor 4 [KO:K04160]
120877757  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
120854740  5-hydroxytryptamine receptor 5B [KO:K04161]
120854980  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
120873807  HTR7; 5-hydroxytryptamine receptor 7 [KO:K04163]
120869377  guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
120869379  neuroendocrine secretory protein 55 [KO:K04632]
120880820  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha [KO:K04633]
120862548  guanine nucleotide-binding protein G(s) subunit alpha-like [KO:K04633]
120877473  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
120879368  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
120851596  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
120853482  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
120872811  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
120878868  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
120874335  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
120864090  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
120856949  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
120862443  PLN; cardiac phospholamban [KO:K05852]
120876208  SLN; sarcolipin [KO:K22642]
120860511  uncharacterized protein LOC120860511 isoform X1 [KO:K22643]
120865376  uncharacterized protein LOC120865376 isoform X1 [KO:K22643]
120861680  CUNH4orf3; uncharacterized protein C4orf3 homolog [KO:K26467]
120866782  SMIM6; small integral membrane protein 6 [KO:K26468]
120876547  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
120871032  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
120866166  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
120872151  HRC; LOW QUALITY PROTEIN: sarcoplasmic reticulum histidine-rich calcium-binding protein [KO:K23450]
120876706  STIM1; stromal interaction molecule 1 isoform X1 [KO:K16059]
120862008  STIM2; stromal interaction molecule 2 isoform X1 [KO:K18196]
120871068  ORAI1; calcium release-activated calcium channel protein 1 [KO:K16056]
120878808  ORAI2; protein orai-2 [KO:K16057]
120877584  ORAI3; protein orai-3 [KO:K16058]
120857839  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
120868392  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
120881638  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
120880100  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
120864066  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
120852240  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
120880491  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
120867316  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
120872782  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
120857616  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
120875517  neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
120852162  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
120855629  glutamate receptor ionotropic, NMDA 2A [KO:K05209]
120858879  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
120866712  GRIN2C; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
120872196  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
120861634  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
120863718  GRIN3B; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
120866173  P2RX1; P2X purinoceptor 1 [KO:K05215]
120871536  P2RX2; P2X purinoceptor 2 isoform X1 [KO:K05216]
120877067  P2RX3; P2X purinoceptor 3 [KO:K05217]
120871053  P2RX4; P2X purinoceptor 4 [KO:K05218]
120866171  P2RX5; P2X purinoceptor 5 isoform X1 [KO:K05219]
120871338  P2RX6; P2X purinoceptor 6 isoform X1 [KO:K05221]
120871097  P2RX7; P2X purinoceptor 7 [KO:K05220]
120873294  RYR1; ryanodine receptor 1 [KO:K04961]
120860476  ryanodine receptor 2-like [KO:K04962]
120865404  ryanodine receptor 2-like [KO:K04962]
120853265  RYR3; ryanodine receptor 3 [KO:K04963]
120862866  triadin-like [KO:K23449]
120855585  CASQ1; calsequestrin-1 [KO:K23468]
120856031  CASQ2; calsequestrin-2 [KO:K23445]
120878611  ASPH; aspartyl/asparaginyl beta-hydroxylase isoform X1 [KO:K00476] [EC:1.14.11.16]
120881937  CYSLTR1; cysteinyl leukotriene receptor 1 [KO:K04322]
120883042  CYSLTR2; cysteinyl leukotriene receptor 2 isoform X1 [KO:K04323]
120877623  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
120860293  alpha-1A adrenergic receptor isoform X1 [KO:K04135]
120866027  ADRA1A; alpha-1A adrenergic receptor isoform X1 [KO:K04135]
120863360  ADRA1B; alpha-1B adrenergic receptor [KO:K04136]
120868909  ADRA1D; alpha-1D adrenergic receptor [KO:K04137]
120858385  AGTR1; type-1 angiotensin II receptor [KO:K04166]
120871459  EDNRA; endothelin-1 receptor [KO:K04197]
120883031  EDNRB; endothelin receptor type B [KO:K04198]
120852599  proteinase-activated receptor 1-like [KO:K03914]
120860948  proteinase-activated receptor 1 [KO:K03914]
120862584  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
120874853  GRM5; metabotropic glutamate receptor 5 [KO:K04604]
120882550  GRPR; gastrin-releasing peptide receptor [KO:K04169]
120868129  HRH1; histamine H1 receptor [KO:K04149]
120883032  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
120881410  HTR2C; 5-hydroxytryptamine receptor 2C [KO:K04157]
120854266  HTR2B; 5-hydroxytryptamine receptor 2B isoform X1 [KO:K04157]
120852247  LHCGR; lutropin-choriogonadotropic hormone receptor [KO:K04248]
120868811  NTSR1; neurotensin receptor type 1 [KO:K04211]
120867684  OXTR; oxytocin receptor [KO:K04229]
120857536  AVPR1A; vasopressin V1a receptor isoform X1 [KO:K04226]
120879944  AVPR1B; vasopressin V1b receptor [KO:K04227]
120853479  LTB4R2; leukotriene B4 receptor 2 [KO:K04297]
120855141  PTAFR; platelet-activating factor receptor [KO:K04279]
120864100  PTGER1; prostaglandin E2 receptor EP1 subtype isoform X1 [KO:K04258]
120857002  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X1 [KO:K04260]
120856966  PTGFR; prostaglandin F2-alpha receptor [KO:K04262]
120875299  BDKRB1; B1 bradykinin receptor [KO:K03915]
120875298  BDKRB2; B2 bradykinin receptor [KO:K03916]
120851228  TACR1; substance-P receptor [KO:K04222]
120865187  TACR2; substance-K receptor [KO:K04223]
120861864  TACR3; neuromedin-K receptor [KO:K04224]
120864807  TBXA2R; thromboxane A2 receptor isoform X1 [KO:K04264]
120879077  thyrotropin-releasing hormone receptor [KO:K04282]
120860680  thyrotropin-releasing hormone receptor [KO:K04282]
120869424  LOW QUALITY PROTEIN: thyrotropin-releasing hormone receptor-like [KO:K04282]
120862006  CCKAR; cholecystokinin receptor type A isoform X1 [KO:K04194]
120876556  CCKBR; gastrin/cholecystokinin type B receptor [KO:K04195]
120854493  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
120875860  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
120864791  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
120875700  GNA14; guanine nucleotide-binding protein subunit alpha-14 [KO:K04636]
120864792  GNA15; guanine nucleotide-binding protein subunit alpha-15 [KO:K04637]
120862277  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
120851642  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
120882986  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
120857626  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
120876152  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
120871511  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
120863516  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
120871375  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
120882958  FGF9; fibroblast growth factor 9 [KO:K04358]
120879448  FGF10; fibroblast growth factor 10 [KO:K04358]
120879682  FGF18; fibroblast growth factor 18 [KO:K04358]
120881943  FGF16; fibroblast growth factor 16 [KO:K04358]
120852969  FGF7; fibroblast growth factor 7 [KO:K04358]
120861494  FGF5; fibroblast growth factor 5 [KO:K04358]
120863735  FGF22; fibroblast growth factor 22 [KO:K04358]
120865280  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
120865787  FGF20; fibroblast growth factor 20 [KO:K04358]
120873551  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
120857882  FGF6; fibroblast growth factor 6 [KO:K04358]
120874109  FGF3; fibroblast growth factor 3 [KO:K04358]
120874146  FGF4; fibroblast growth factor 4 [KO:K04358]
120874107  FGF19; fibroblast growth factor 19 [KO:K22603]
120872173  FGF21; fibroblast growth factor 21 [KO:K22429]
120857881  FGF23; fibroblast growth factor 23 [KO:K22428]
120870090  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
120874692  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
120882562  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
120860535  vascular endothelial growth factor C [KO:K05449]
120865839  vascular endothelial growth factor C-like [KO:K05449]
120856034  NGF; beta-nerve growth factor [KO:K02582]
120878117  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
120868233  MST1; hepatocyte growth factor-like protein isoform X1 [KO:K23441]
120879354  GDNF; glial cell line-derived neurotrophic factor [KO:K05452]
120867903  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
120867212  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
120857431  ERBB3; LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
120854102  receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
120862113  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
120863403  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
120865665  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
120873875  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
120861835  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
120863866  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
120882914  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
120864345  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
120862130  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
120855667  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
120866819  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
120875661  NTRK3; NT-3 growth factor receptor isoform X1 [KO:K05101] [EC:2.7.10.1]
120878210  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
120868284  MST1R; macrophage-stimulating protein receptor isoform X1 [KO:K05100] [EC:2.7.10.1]
120860461  proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
120865390  proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
120867828  PLCD1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 [KO:K05857] [EC:3.1.4.11]
120854371  PLCD4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1 [KO:K05857] [EC:3.1.4.11]
120867002  PLCD3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X1 [KO:K05857] [EC:3.1.4.11]
120853216  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
120869193  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
120869195  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
120874626  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
120869330  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
120873247  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
120873713  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
120857989  PLCZ1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 [KO:K05861] [EC:3.1.4.11]
120867669  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
120858499  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
120869823  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
120861630  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
120871124  TPCN1; two pore calcium channel protein 1 isoform X1 [KO:K16896]
120874141  TPCN2; two pore calcium channel protein 2 [KO:K14077]
120863913  MCOLN1; mucolipin-1 isoform X1 [KO:K04992]
120856936  MCOLN2; mucolipin-2 [KO:K04993]
120856935  MCOLN3; mucolipin-3 isoform X1 [KO:K04994]
120872180  SPHK2; sphingosine kinase 2 isoform X1 [KO:K04718] [EC:2.7.1.91]
120866745  SPHK1; sphingosine kinase 1 isoform X1 [KO:K04718] [EC:2.7.1.91]
120865296  MCU; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
120863663  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
120865264  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
120853636  LOW QUALITY PROTEIN: uncharacterized protein LOC120853636 [KO:K15041]
120865850  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
120882423  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
120881444  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
120862122  ADP/ATP translocase 2-like [KO:K05863]
120870953  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
120865728  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
120865368  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
120868360  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
120869524  TNNC2; troponin C, skeletal muscle isoform X1 [KO:K12042]
120879484  calmodulin-1-like [KO:K02183]
120879826  CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
120851742  CALM2; calmodulin-2 [KO:K02183]
120852515  calmodulin-like protein 4 isoform X1 [KO:K02183]
120860890  calmodulin-like protein 4 isoform X1 [KO:K02183]
120853084  calmodulin-1 [KO:K02183]
120869481  calmodulin-like [KO:K02183]
120853545  CALM1; calmodulin-1 isoform X1 [KO:K02183]
120872248  CALM3; calmodulin-3 [KO:K02183]
120858425  calmodulin-1-like [KO:K02183]
120876938  PHKG2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform [KO:K00871] [EC:2.7.11.19]
120877899  PHKG1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform [KO:K00871] [EC:2.7.11.19]
120882529  PHKA2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
120881977  PHKA1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
120872913  PHKB; phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
120868758  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
120869929  myosin light chain kinase family member 4-like [KO:K00907] [EC:2.7.11.18]
120870611  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
120872918  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
120880019  CAMK1G; calcium/calmodulin-dependent protein kinase type 1G [KO:K08794] [EC:2.7.11.17]
120867742  CAMK1; calcium/calmodulin-dependent protein kinase type 1 [KO:K08794] [EC:2.7.11.17]
120869259  CAMK1D; calcium/calmodulin-dependent protein kinase type 1D isoform X1 [KO:K08794] [EC:2.7.11.17]
120877497  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
120861703  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
120863412  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
120865286  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
120863455  CAMK4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
120861873  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
120865288  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
120865483  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
120851376  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
120864045  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
120870138  TFEB; transcription factor EB [KO:K15590]
120880955  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
120869072  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
120872701  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
120853486  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
120871573  NOS1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
120866313  NOS2; nitric oxide synthase, inducible isoform X1 [KO:K13241] [EC:1.14.13.39]
120877875  NOS3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
120877386  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
120853992  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
120858306  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
120860357  protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
120866066  protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
120880329  ITPKB; inositol-trisphosphate 3-kinase B isoform X1 [KO:K00911] [EC:2.7.1.127]
120853178  ITPKA; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
120872383  ITPKC; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
120866588  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
120876193  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
120871941  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
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Berridge MJ, Bootman MD, Roderick HL.
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Calcium signalling: dynamics, homeostasis and remodelling.
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Nat Rev Mol Cell Biol 4:517-29 (2003)
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PMID:11413485
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The versatility and universality of calcium signalling.
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Nat Rev Mol Cell Biol 1:11-21 (2000)
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PMID:15111104
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Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
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Am J Physiol Cell Physiol 281:C1743-56 (2001)
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Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
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J Biol Chem 269:7390-6 (1994)
Reference
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J Bioenerg Biomembr 35:577-98 (2003)
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Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
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Neurosci Res 38:3-17 (2000)
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Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
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J Biol Chem 272:19125-32 (1997)
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Reference
PMID:7861177
  Authors
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Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
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J Neurochem 64:953-60 (1995)
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Reference
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Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
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Cell Calcium 34:431-44 (2003)
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Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
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Mol Cell Biochem 193:89-98 (1999)
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Reference
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J Physiol 529 Pt 1:11-21 (2000)
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Extracellular-signal-regulated kinase signalling in neurons.
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Curr Opin Neurobiol 9:544-53 (1999)
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Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
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Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
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Acta Physiol (Oxf) 204:151-7 (2012)
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Reference
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Immunodeficiency due to defects in store-operated calcium entry.
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Ann N Y Acad Sci 1238:74-90 (2011)
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Reference
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Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
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STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
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Seikagaku 80:1123-8 (2008)
Reference
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The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
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Pflugers Arch 458:869-76 (2009)
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Reference
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Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
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Eur Biophys J 39:27-36 (2009)
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Reference
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Marty I
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Triadin regulation of the ryanodine receptor complex.
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J Physiol 593:3261-6 (2015)
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Reference
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Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
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Related
pathway
oda04010  MAPK signaling pathway
oda04070  Phosphatidylinositol signaling system
oda04210  Apoptosis
oda04720  Long-term potentiation
oda04730  Long-term depression
KO pathway
ko04020   
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