KEGG   PATHWAY: omc04150
Entry
omc04150                    Pathway                                
Name
mTOR signaling pathway - Onychostoma macrolepis
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
omc04150  mTOR signaling pathway
omc04150

Organism
Onychostoma macrolepis [GN:omc]
Gene
131534537  slc7a5; large neutral amino acids transporter small subunit 1 [KO:K13780]
131544236  zgc:158423; 4F2 cell-surface antigen heavy chain [KO:K06519]
131544781  slc3a2a; solute carrier family 3 member 2a [KO:K06519]
131528814  slc3a2b; solute carrier family 3 member 2b [KO:K06519]
131548270  slc38a9; neutral amino acid transporter 9 [KO:K14995]
131541243  atp6v1aa; ATPase H+ transporting V1 subunit Aa [KO:K02145] [EC:7.1.2.2]
131533231  atp6v1ab; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
131523515  atp6v1ba; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
131547966  atp6v1b2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
131523518  atp6v1c2; V-type proton ATPase subunit C 1-B isoform X1 [KO:K02148]
131526359  atp6v1c1b; V-type proton ATPase subunit C 1-B isoform X1 [KO:K02148]
131522581  atp6v1c1a; V-type proton ATPase subunit C 1-A isoform X1 [KO:K02148]
131527065  atp6v1d; V-type proton ATPase subunit D [KO:K02149]
131534936  atp6v1e1a; V-type proton ATPase subunit E 1a [KO:K02150]
131527124  V-type proton ATPase subunit E 1-like [KO:K02150]
131539089  atp6v1e1b; V-type proton ATPase subunit E 1 [KO:K02150]
131539653  atp6v1f; V-type proton ATPase subunit F [KO:K02151]
131540069  atp6v1g1; V-type proton ATPase subunit G 1 [KO:K02152]
131521527  atp6v1h; V-type proton ATPase subunit H isoform X1 [KO:K02144]
131520545  ragulator complex protein LAMTOR1-like [KO:K20397]
131520924  lamtor1; ragulator complex protein LAMTOR1 [KO:K20397]
131521659  lamtor2; ragulator complex protein LAMTOR2 [KO:K20398]
131552789  lamtor3; ragulator complex protein LAMTOR3 [KO:K04370]
131539654  lamtor4; ragulator complex protein LAMTOR4 [KO:K20399]
131546279  lamtor5; ragulator complex protein LAMTOR5 [KO:K16344]
131522259  flcn; folliculin [KO:K09594]
131528696  fnip1; folliculin-interacting protein 1 isoform X1 [KO:K20400]
131545549  fnip2; folliculin-interacting protein 2 isoform X1 [KO:K20401]
131553120  rraga; ras-related GTP-binding protein A [KO:K16185]
131523583  rragd; ras-related GTP-binding protein D [KO:K16186]
131525099  rragcb; ras-related GTP binding Cb [KO:K16186]
131521368  rragca; ras-related GTP binding Ca [KO:K16186]
131525323  sesn2; sestrin-2 [KO:K20394]
131541421  castor1; cytosolic arginine sensor for mTORC1 subunit 1 isoform X1 [KO:K23080]
131540503  castor2; cytosolic arginine sensor for mTORC1 subunit 2 [KO:K23081]
131522500  mios; GATOR complex protein MIOS [KO:K20407]
131526319  seh1l; nucleoporin SEH1 isoform X1 [KO:K14299]
131521801  nucleoporin SEH1 [KO:K14299]
131533257  wdr24; GATOR complex protein WDR24 isoform X1 [KO:K20408]
131524622  wdr59; GATOR complex protein WDR59 isoform X1 [KO:K20409]
131530728  sec13; protein SEC13 homolog [KO:K14004]
131547771  depdc5; GATOR complex protein DEPDC5 isoform X1 [KO:K20404]
131541916  nprl2; GATOR complex protein NPRL2 isoform X1 [KO:K20405]
131537422  nprl3; GATOR complex protein NPRL3 isoform X1 [KO:K20406]
131528753  skp2; S-phase kinase-associated protein 2 [KO:K03875]
131550878  rnf152; E3 ubiquitin-protein ligase rnf152 [KO:K15705] [EC:2.3.2.27]
131542747  rptor; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
131537026  akt1s1; uncharacterized protein akt1s1 [KO:K16184]
131545178  mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
131549771  si:dkeyp-97e7.9; DEP domain-containing mTOR-interacting protein [KO:K20402]
131522080  deptor; DEP domain-containing mTOR-interacting protein [KO:K20402]
131551629  mlst8; target of rapamycin complex subunit lst8 [KO:K08266]
131533721  telo2; telomere length regulation protein TEL2 homolog isoform X1 [KO:K11137]
131531964  tti1; LOW QUALITY PROTEIN: TELO2-interacting protein 1 homolog [KO:K20403]
131540674  clip1a; CAP-Gly domain-containing linker protein 1 isoform X1 [KO:K10421]
131548421  clip1b; CAP-Gly domain-containing linker protein 1 isoform X1 [KO:K10421]
131525303  grb10a; growth factor receptor-bound protein 10a isoform X1 [KO:K20064]
131521285  grb10b; growth factor receptor-bound protein 10 isoform X1 [KO:K20064]
131541957  LOW QUALITY PROTEIN: zgc:123305 [KO:K15728] [EC:3.1.3.4]
131526864  lpin1b; LOW QUALITY PROTEIN: phosphatidate phosphatase LPIN1 [KO:K15728] [EC:3.1.3.4]
131529758  lpin2; phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
131522694  lpin1a; phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
131546023  ulk1a; serine/threonine-protein kinase ULK1a isoform X1 [KO:K21357] [EC:2.7.11.1]
131528997  ulk1b; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
131520423  ulk2; serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
131528840  eif4ebp1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
131531800  eif4e2rs1; eukaryotic translation initiation factor 4E family member 2 related sequence 1 [KO:K03259]
131525768  eif4e2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
131552300  eif4e1c; eukaryotic translation initiation factor 4E family member 1c isoform X1 [KO:K03259]
131552819  eif4eb; eukaryotic translation initiation factor 4eb isoform X1 [KO:K03259]
131553449  eif4ea; eukaryotic translation initiation factor 4E-1A isoform X1 [KO:K03259]
131540388  eif4e1b; eukaryotic translation initiation factor 4E-1B isoform X1 [KO:K03259]
131548109  rps6kb1a; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
131520792  rps6kb1b; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
131531540  eif4ba; eukaryotic translation initiation factor 4Ba isoform X1 [KO:K03258]
131542396  eif4bb; eukaryotic translation initiation factor 4Bb isoform X1 [KO:K03258]
131539446  rps6; 40S ribosomal protein S6 [KO:K02991]
131537940  strada; STE20-related kinase adapter protein alpha isoform X1 [KO:K08271]
131542915  stradb; STE20-related kinase adapter protein beta [KO:K17532]
131525215  stk11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
131542239  cab39l; calcium-binding protein 39-like [KO:K08272]
131553660  cab39l1; calcium binding protein 39, like 1 [KO:K08272]
131554155  cab39; calcium-binding protein 39 [KO:K08272]
131541130  prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
131527199  prkaa2; LOW QUALITY PROTEIN: 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
131529507  tsc1b; TSC complex subunit 1b [KO:K07206]
131540183  tsc1a; TSC complex subunit 1a isoform X1 [KO:K07206]
131541038  tsc2; tuberin isoform X1 [KO:K07207]
131527287  tbc1d7; TBC1 domain family member 7 [KO:K20396]
131533638  rheb; GTP-binding protein Rheb [KO:K07208]
131542734  rhebl1; ras homolog, mTORC1 binding like 1 [KO:K07208]
131551626  ddit4; DNA damage-inducible transcript 4 protein [KO:K08270]
131531808  wnt1; protein Wnt-1 [KO:K03209]
131524582  wnt2; protein Wnt-2 isoform X1 [KO:K00182]
131542340  wnt2ba; wingless-type MMTV integration site family, member 2Ba isoform X1 [KO:K00182]
131546291  wnt2bb; wingless-type MMTV integration site family, member 2Bb isoform X1 [KO:K00182]
131551046  wnt3; proto-oncogene Wnt-3 [KO:K00312]
131551173  wnt3a; protein Wnt-3a [KO:K00312]
131549733  wnt4; protein Wnt-4a [KO:K00408]
131521461  wnt4b; wingless-type MMTV integration site family, member 4b [KO:K00408]
131546292  wnt5a; protein Wnt-5a [KO:K00444]
131542488  wnt6a; protein Wnt-6 [KO:K00445]
131546949  wnt6b; protein Wnt-6 isoform X1 [KO:K00445]
131532036  protein Wnt-7a isoform X1 [KO:K00572]
131549706  wnt7aa; wingless-type MMTV integration site family, member 7Aa isoform X1 [KO:K00572]
131534539  wnt7bb; protein Wnt-7b isoform X1 [KO:K00572]
131539121  wnt7ba; protein Wnt-7b [KO:K00572]
131552276  wnt8b; protein Wnt-8b [KO:K00714]
131553296  wnt8a; protein Wnt-8a ORF1 isoform X1 [KO:K00714]
131553298  protein Wnt-8a ORF2 [KO:K00714]
131551148  wnt9a; protein Wnt-9a [KO:K01064]
131535880  wnt9b; protein Wnt-9b [KO:K01064]
131531807  wnt10b; protein Wnt-10b [KO:K01357]
131546944  wnt10a; protein Wnt-10a [KO:K01357]
131540996  wnt11f2; protein Wnt-11 [KO:K01384]
131548259  wnt11; protein Wnt-11 [KO:K01384]
131542166  fzd7b; frizzled-7b [KO:K02432]
131546907  fzd7a; frizzled-7a [KO:K02432]
131522572  fzd1; frizzled-1 [KO:K02432]
131538064  fzd2; frizzled-2 [KO:K02235]
131523487  fzd3b; frizzled-3b isoform X1 [KO:K02329]
131526729  fzd3a; frizzled-3a isoform X1 [KO:K02329]
131520488  fzd4; LOW QUALITY PROTEIN: frizzled-4 [KO:K02354]
131533661  fzd8a; frizzled-8a [KO:K02375]
131529092  fzd8b; frizzled-8b [KO:K02375]
131546902  fzd5; frizzled-5 [KO:K02375]
131521478  fzd6; LOW QUALITY PROTEIN: frizzled-6 [KO:K02376]
131540941  fzd9a; frizzled-9 [KO:K02842]
131523887  fzd9b; LOW QUALITY PROTEIN: frizzled-9b [KO:K02842]
131545728  fzd10; frizzled-10 [KO:K02842]
131534186  lrp5; LOW QUALITY PROTEIN: low-density lipoprotein receptor-related protein 5 [KO:K03068]
131538355  lrp6; low-density lipoprotein receptor-related protein 6 [KO:K03068]
131530862  dvl3a; LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-3a [KO:K02353]
131531535  dvl1a; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
131524350  segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
131549552  dvl1b; segment polarity protein dishevelled homolog DVL-1b [KO:K02353]
131543251  dvl2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
131547336  gsk3ba; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
131547844  gsk3bb; glycogen synthase kinase 3 beta, genome duplicate b [KO:K03083] [EC:2.7.11.26]
131525460  tnfa; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156]
131526386  tumor necrosis factor-like [KO:K03156]
131521555  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
131545292  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
131541218  ins; insulin [KO:K04526]
131537713  insulin isoform X1 [KO:K04526]
131553957  insb; preproinsulin b [KO:K04526]
131539332  igf1; insulin-like growth factor I [KO:K05459]
131553823  insra; insulin receptor a isoform X1 [KO:K04527] [EC:2.7.10.1]
131530059  insrb; insulin receptor b [KO:K04527] [EC:2.7.10.1]
131524230  igf1ra; insulin-like growth factor 1a receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
131543547  igf1rb; insulin-like growth factor 1b receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
131542705  grb2a; growth factor receptor-bound protein 2a [KO:K04364]
131537364  grb2b; growth factor receptor-bound protein 2b [KO:K04364]
131548892  sos1; son of sevenless homolog 1 [KO:K03099]
131552620  sos2; son of sevenless homolog 2 [KO:K03099]
131534047  hrasa; HRas proto-oncogene, GTPase a [KO:K02833]
131543828  hrasb; HRas proto-oncogene, GTPase b [KO:K02833]
131534236  kras; GTPase KRas isoform X1 [KO:K07827]
131536821  zgc:55558; GTPase KRas isoform X1 [KO:K07827]
131545807  nras; GTPase NRas [KO:K07828]
131539604  braf; LOW QUALITY PROTEIN: serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
131531944  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
131549244  raf1b; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
131524475  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
131552281  map2k2b; dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
131530277  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
131540661  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
131536056  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
131523045  rps6ka1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
131541242  rps6ka3a; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
131533164  rps6ka3b; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
131552697  rps6ka2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
131552968  rps6kal; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
131520610  irs1; insulin receptor substrate 1-B isoform X1 [KO:K16172]
131541975  pik3r3b; phosphoinositide-3-kinase, regulatory subunit 3b (gamma) isoform X1 [KO:K02649]
131552189  pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
131540458  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
131532182  zgc:158659; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
131532482  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
131549562  pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
131554420  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
131523186  ptena; phosphatase and tensin homolog A isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
131550661  ptenb; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
131532993  pdpk1b; 3-phosphoinositide dependent protein kinase 1b isoform X1 [KO:K06276] [EC:2.7.11.1]
131536992  pdpk1a; 3-phosphoinositide-dependent protein kinase 1a isoform X1 [KO:K06276] [EC:2.7.11.1]
131523076  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
131548207  akt2l; v-akt murine thymoma viral oncogene homolog 2, like [KO:K04456] [EC:2.7.11.1]
131548459  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
131524297  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
131527534  RAC-alpha serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
131552423  akt3a; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
131552635  chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
131540711  mapkap1; target of rapamycin complex 2 subunit MAPKAP1 isoform X1 [KO:K20410]
131541110  rictora; LOW QUALITY PROTEIN: rapamycin-insensitive companion of mTOR [KO:K08267]
131528901  rictorb; rapamycin-insensitive companion of mTOR isoform X1 [KO:K08267]
131534529  prr5a; proline-rich protein 5a [KO:K20411]
131543820  proline-rich protein 5-like [KO:K20411]
131534914  prr5l; proline-rich protein 5-like [KO:K20411]
131538685  prr5b; proline-rich protein 5 isoform X1 [KO:K20411]
131531628  rhoac; rho-related GTP-binding protein RhoA-C [KO:K04513]
131542024  rhoca; ras homolog family member Ca [KO:K04513]
131545414  rhocb; rho-related GTP-binding protein RhoA-D isoform X1 [KO:K04513]
131545415  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
131545538  rhoaa; rho-related GTP-binding protein RhoA-A [KO:K04513]
131530114  rho-related GTP-binding protein RhoA-D-like [KO:K04513]
131542168  prkcaa; protein kinase C, alpha, a isoform X1 [KO:K02677] [EC:2.7.11.13]
131535943  prkcab; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
131536620  prkcbb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
131539492  prkcba; protein kinase C, beta a isoform X1 [KO:K19662] [EC:2.7.11.13]
131521212  prkcg; protein kinase C alpha type isoform X1 [KO:K19663] [EC:2.7.11.13]
131532422  sgk1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
131526179  si:ch211-195b13.1; STKc_SGK domain-containing protein [KO:K13302] [EC:2.7.11.1]
131521596  sgk2b; serine/threonine-protein kinase Sgk2b [KO:K13302] [EC:2.7.11.1]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
omc00561  Glycerolipid metabolism
omc04010  MAPK signaling pathway
omc04140  Autophagy - animal
omc04810  Regulation of actin cytoskeleton
omc04910  Insulin signaling pathway
KO pathway
ko04150   
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