KEGG   PATHWAY: omc04010
Entry
omc04010                    Pathway                                
Name
MAPK signaling pathway - Onychostoma macrolepis
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
omc04010  MAPK signaling pathway
omc04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Onychostoma macrolepis [GN:omc]
Gene
131520546  nf1a; neurofibromin isoform X1 [KO:K08052]
131520569  pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
131520702  [KO:K04723]
131520745  ppp5c; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
131520783  relb; transcription factor RelB isoform X1 [KO:K09253]
131520886  tgfb1a; transforming growth factor, beta 1a [KO:K13375]
131520971  [KO:K04392]
131521017  ppm1na; protein phosphatase, Mg2+/Mn2+ dependent, 1Na (putative) [KO:K04457] [EC:3.1.3.16]
131521184  [KO:K05465]
131521207  cacng7b; voltage-dependent calcium channel gamma-7 subunit isoform X1 [KO:K04872]
131521212  prkcg; protein kinase C alpha type isoform X1 [KO:K19663] [EC:2.7.11.13]
131521349  jund; transcription factor jun-D [KO:K04449]
131521472  nradd; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
131521476  si:ch211-1i11.3; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
131521510  cdc42l; cell division cycle 42, like [KO:K04393]
131521555  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
131521577  ntrk1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
131521585  cacng8b; voltage-dependent calcium channel gamma-4 subunit isoform X1 [KO:K04873]
131521750  tgfbr2b; LOW QUALITY PROTEIN: TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
131521827  mycb; transcriptional regulator Myc-B [KO:K04377]
131522136  tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
131522141  vegfaa; vascular endothelial growth factor A-A isoform X1 [KO:K05448]
131522286  tgfbr1a; TGF-beta receptor type-1a [KO:K04674] [EC:2.7.11.30]
131522452  cacng6b; uncharacterized protein cacng6b [KO:K04871]
131522483  efna3b; ephrin-A3b isoform X1 [KO:K05462]
131522530  si:dkey-246i14.3; ephrin-A4 isoform X1 [KO:K05462]
131522619  efna1b; ephrin-A1b [KO:K05462]
131522620  stmn1b; stathmin 1b [KO:K04381]
131522768  pla2g4f.2; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
131522924  map4k3b; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
131522954  rasgrp3; ras guanyl-releasing protein 3 [KO:K12362]
131522970  pgfb; placenta growth factor [KO:K16859]
131523014  rps6ka5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
131523017  efna2a; ephrin-A2 [KO:K05462]
131523045  rps6ka1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
131523076  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
131523087  egfra; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
131523266  pla2g4f.1; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
131523270  fosaa; protein c-Fos [KO:K04379]
131523556  tgfb3; LOW QUALITY PROTEIN: transforming growth factor beta-3 proprotein [KO:K13377]
131523876  hgfb; hepatocyte growth factor isoform X1 [KO:K05460]
131524117  pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
131524139  map3k10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
131524152  [KO:K04858]
131524230  igf1ra; insulin-like growth factor 1a receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
131524282  rasgrp4; RAS guanyl-releasing protein 4 isoform X1 [KO:K04350]
131524297  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
131524327  rasa2; ras GTPase-activating protein 2 [KO:K08053]
131524475  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
131524488  fgf7; fibroblast growth factor 7 [KO:K04358]
131524512  gadd45aa; growth arrest and DNA-damage-inducible, alpha, a [KO:K04402]
131524516  prkacbb; protein kinase, cAMP-dependent, catalytic, beta b [KO:K04345] [EC:2.7.11.11]
131524536  rasgrf1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
131524705  pla2g4aa; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
131524731  mapk8ip2; C-Jun-amino-terminal kinase-interacting protein 2 isoform X1 [KO:K04435]
131524817  mapk12a; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
131524878  gadd45bb; growth arrest and DNA-damage-inducible, beta b [KO:K04402]
131525167  cacng7a; calcium channel, voltage-dependent, gamma subunit 7a [KO:K04872]
131525429  efna1a; ephrin-A1a [KO:K05462]
131525430  efna3a; ephrin-A3 isoform X1 [KO:K05462]
131525456  angpt1; angiopoietin-1 [KO:K05465]
131525460  tnfa; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156]
131525642  cacna1eb; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
131525652  [KO:K16342] [EC:3.1.1.4]
131525741  angpt2b; angiopoietin-2b [KO:K05466]
131525834  cacng8a; calcium channel, voltage-dependent, gamma subunit 8a [KO:K04873]
131525937  cacng6a; calcium channel, voltage-dependent, gamma subunit 6a [KO:K04871]
131526084  nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
131526223  daxx; death domain-associated protein 6 isoform X1 [KO:K02308]
131526345  stk3; serine/threonine-protein kinase 3 [KO:K04412]
131526361  stmn1a; stathmin 1a [KO:K04381]
131526386  [KO:K03156]
131526674  fosab; v-fos FBJ murine osteosarcoma viral oncogene homolog Ab [KO:K04379]
131526675  si:ch211-153j24.3; protein c-Fos isoform X1 [KO:K04379]
131526712  tab2; LOW QUALITY PROTEIN: TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
131526934  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
131526972  pgfa; placenta growth factor [KO:K16859]
131527039  map3k5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
131527222  pla2g4ab; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
131527339  max; protein max isoform X1 [KO:K04453]
131527360  kdr; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
131527369  faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
131527390  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
131527450  ppm1ab; LOW QUALITY PROTEIN: protein phosphatase, Mg2+/Mn2+ dependent, 1Ab [KO:K04457] [EC:3.1.3.16]
131527494  kita; mast/stem cell growth factor receptor kita isoform X1 [KO:K05091] [EC:2.7.10.1]
131527534  [KO:K04456] [EC:2.7.11.1]
131527592  dusp10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
131527636  jun; transcription factor AP-1 [KO:K04448]
131528161  gadd45gb.1; growth arrest and DNA-damage-inducible, gamma b, tandem duplicate 1 [KO:K04402]
131528190  dusp4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
131528511  mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
131528658  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
131528699  ppm1nb; protein phosphatase, Mg2+/Mn2+ dependent, 1Nb (putative) [KO:K04457] [EC:3.1.3.16]
131528700  tgfb1b; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
131528958  ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
131529034  fgf10a; fibroblast growth factor 10a [KO:K04358]
131529050  fgf1b; fibroblast growth factor 1b [KO:K18496]
131529073  csf1rb; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
131529115  map4k6; mitogen-activated protein kinase kinase kinase kinase 6 isoform X1 [KO:K04414] [EC:2.7.11.1]
131529150  crkl; crk-like protein [KO:K04438]
131529165  fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
131529312  rasgrp2; RAS guanyl-releasing protein 2 [KO:K12361]
131529404  efna5a; ephrin-A5b [KO:K05462]
131529438  cacna1bb; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
131529522  taok1b; serine/threonine-protein kinase TAO1-B [KO:K04429] [EC:2.7.11.1]
131529623  dusp5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
131529879  mknk2a; MAP kinase-interacting serine/threonine-protein kinase 2a [KO:K04372] [EC:2.7.11.1]
131530048  fgf22; fibroblast growth factor 22 [KO:K04358]
131530059  insrb; insulin receptor b [KO:K04527] [EC:2.7.10.1]
131530260  srfa; serum response factor a isoform X1 [KO:K04378]
131530277  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
131530324  mrasb; ras-related protein M-Ras [KO:K07831]
131530560  pdgfaa; platelet-derived growth factor alpha polypeptide a isoform X1 [KO:K04359]
131530733  cacna2d2b; voltage-dependent calcium channel subunit alpha-2/delta-2b isoform X1 [KO:K04859]
131530842  pak2b; serine/threonine-protein kinase PAK 2b isoform X1 [KO:K04410] [EC:2.7.11.1]
131530877  [KO:K25416]
131531130  [KO:K25414]
131531222  cacna1sa; LOW QUALITY PROTEIN: calcium channel, voltage-dependent, L type, alpha 1S subunit, a [KO:K04857]
131531329  pdgfba; platelet-derived growth factor beta polypeptide a [KO:K17386]
131531530  cdc42l2; cell division cycle 42 like 2 [KO:K04393]
131531922  cacnb3b; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit beta-4 [KO:K04864]
131531944  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
131531969  flna; filamin-A [KO:K04437]
131532074  epha2b; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
131532211  ngfa; neurotrophin-7 isoform X1 [KO:K02582]
131532216  cacnb3a; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit beta-3a [KO:K04864]
131532462  kitb; KIT proto-oncogene, receptor tyrosine kinase b [KO:K05091] [EC:2.7.10.1]
131532475  erbb3b; receptor tyrosine-protein kinase erbB-3b isoform X1 [KO:K05084] [EC:2.7.10.1]
131532537  zgc:171775; STKc_p38 domain-containing protein isoform X1 [KO:K04441] [EC:2.7.11.24]
131532646  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
131532651  nr4a1; nuclear receptor subfamily 4 group A member 1 isoform X1 [KO:K04465]
131532794  myca; transcriptional regulator Myc-A [KO:K04377]
131532892  flt1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
131532893  flt3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
131532913  map3k22; mitogen-activated protein kinase kinase kinase 22 isoform X1 [KO:K04421] [EC:2.7.11.25]
131532978  [KO:K04466] [EC:2.7.11.25]
131533057  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
131533107  tgfbr1b; TGF-beta receptor type-1b [KO:K04674] [EC:2.7.11.30]
131533164  rps6ka3b; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
131533491  [KO:K04361] [EC:2.7.10.1]
131533942  met; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
131534047  hrasa; HRas proto-oncogene, GTPase a [KO:K02833]
131534121  fgf6a; fibroblast growth factor 6a [KO:K04358]
131534182  cacna2d4b; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
131534196  irak4; LOW QUALITY PROTEIN: interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
131534236  kras; GTPase KRas isoform X1 [KO:K07827]
131534250  dusp8a; dual specificity protein phosphatase 8 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
131534262  igf2b; insulin-like growth factor 2b [KO:K13769]
131534292  nfatc3b; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
131534903  dusp6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
131534917  kitlga; kit ligand a isoform X1 [KO:K05461]
131534954  mapk8ip1a; C-Jun-amino-terminal kinase-interacting protein 1a [KO:K04434]
131535921  cacna1ia; voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04856]
131535943  prkcab; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
131535945  cacng5b; voltage-dependent calcium channel gamma-5 subunit isoform X1 [KO:K04870]
131535991  fgf21; fibroblast growth factor 21 [KO:K22429]
131536056  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
131536154  prkacaa; LOW QUALITY PROTEIN: protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a [KO:K04345] [EC:2.7.11.11]
131536183  pdgfbb; uncharacterized protein pdgfbb [KO:K04359]
131536187  map3k14a; mitogen-activated protein kinase kinase kinase 14 isoform X1 [KO:K04466] [EC:2.7.11.25]
131536221  taok2a; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
131536236  nlk1; nemo-like kinase, type 1 [KO:K04468] [EC:2.7.11.24]
131536243  ngfra; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
131536267  dusp3b; dual specificity protein phosphatase 3b isoform X1 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
131536337  cacnb1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
131536340  [KO:K04407] [EC:2.7.11.1]
131536620  prkcbb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
131536680  rac1b; ras-related C3 botulinum toxin substrate 1b [KO:K04392]
131536821  zgc:55558; GTPase KRas isoform X1 [KO:K07827]
131536840  cacna1ha; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
131536939  rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
131536998  cacng4b; calcium channel, voltage-dependent, gamma subunit 4b [KO:K04869]
131537043  map2k4a; dual specificity mitogen-activated protein kinase kinase 4a isoform X1 [KO:K04430] [EC:2.7.12.2]
131537052  gna12a; guanine nucleotide-binding protein subunit alpha-12a [KO:K04346]
131537145  maptb; microtubule-associated protein tau isoform X1 [KO:K04380]
131537364  grb2b; growth factor receptor-bound protein 2b [KO:K04364]
131537410  map3k3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
131537430  rac3a; ras-related C3 botulinum toxin substrate 3a [KO:K07861]
131537454  mapk8ip3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
131537712  rras; ras-related protein R-Ras [KO:K07830]
131537713  [KO:K04526]
131537820  cacng1b; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
131537993  casp3a; caspase-3a [KO:K02187] [EC:3.4.22.56]
131537999  [KO:K03283]
131538005  pdgfab; platelet-derived growth factor alpha polypeptide b isoform X1 [KO:K04359]
131538013  cacna1aa; LOW QUALITY PROTEIN: voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
131538056  cacng3b; voltage-dependent calcium channel gamma-3 subunit isoform X1 [KO:K04868]
131538058  atf4b; activating transcription factor 4b [KO:K04374]
131538104  cacng2a; calcium channel, voltage-dependent, gamma subunit 2a [KO:K04867]
131538292  vegfab; vascular endothelial growth factor Ab isoform X1 [KO:K05448]
131538485  rapgef2a; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
131538522  cacna2d4a; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
131538580  cacna2d1a; voltage-dependent calcium channel subunit alpha-2/delta-1a [KO:K04858]
131538661  ptprr; tyrosine-protein phosphatase non-receptor type 5 isoform X1 [KO:K04458] [EC:3.1.3.48]
131538945  cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
131539039  dusp16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
131539074  mapk12b; mitogen-activated protein kinase 12b [KO:K04441] [EC:2.7.11.24]
131539076  mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
131539087  fgf23; fibroblast growth factor 23 [KO:K22428]
131539090  fgf6b; fibroblast growth factor 6b [KO:K04358]
131539107  hgfa; hepatocyte growth factor a [KO:K05460]
131539279  kitlgb; kit ligand b isoform X1 [KO:K05461]
131539332  igf1; insulin-like growth factor I [KO:K05459]
131539492  prkcba; protein kinase C, beta a isoform X1 [KO:K19662] [EC:2.7.11.13]
131539604  braf; LOW QUALITY PROTEIN: serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
131539666  rap1b; ras-related protein Rap-1b isoform X1 [KO:K07836]
131539675  ntf3; neurotrophin-3 [KO:K04356]
131540102  traf2b; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
131540116  [KO:K16342] [EC:3.1.1.4]
131540135  [KO:K16342] [EC:3.1.1.4]
131540148  [KO:K16342] [EC:3.1.1.4]
131540358  fgf5; LOW QUALITY PROTEIN: fibroblast growth factor 5 [KO:K04358]
131540395  erbb4a; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
131540439  traf2a; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
131540463  ppp3cca; protein phosphatase 3, catalytic subunit, gamma isozyme, a isoform X1 [KO:K04348] [EC:3.1.3.16]
131540535  rasa1a; ras GTPase-activating protein 1 [KO:K04352]
131540544  tek; tyrosine-protein kinase receptor Tie-2 [KO:K05121] [EC:2.7.10.1]
131540585  mef2cb; myocyte enhancer factor 2cb isoform X1 [KO:K04454]
131540645  fgf10b; fibroblast growth factor 10b [KO:K04358]
131540658  cacna1ba; calcium channel, voltage-dependent, N type, alpha 1B subunit, a isoform X1 [KO:K04849]
131540661  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
131540693  ntrk2b; neurotrophic tyrosine kinase, receptor, type 2b isoform X1 [KO:K04360] [EC:2.7.10.1]
131540710  [KO:K03173] [EC:2.3.2.27]
131540717  [KO:K16342] [EC:3.1.1.4]
131540745  rps6ka4; ribosomal protein S6 kinase alpha-4 [KO:K16510] [EC:2.7.11.1]
131540815  [KO:K16342] [EC:3.1.1.4]
131540817  [KO:K16342] [EC:3.1.1.4]
131540818  [KO:K16342] [EC:3.1.1.4]
131540829  prkacab; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
131540839  june; junE proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
131540871  taok3b; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
131540942  rasgrf2b; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
131541104  [KO:K16342] [EC:3.1.1.4]
131541107  [KO:K16342] [EC:3.1.1.4]
131541163  gdnfb; glial cell line-derived neurotrophic factor [KO:K05452]
131541218  ins; insulin [KO:K04526]
131541242  rps6ka3a; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
131541252  tp53; cellular tumor antigen p53 isoform X1 [KO:K04451]
131541377  [KO:K16342] [EC:3.1.1.4]
131541609  taok3a; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
131541618  mapkapk5; MAP kinase-activated protein kinase 5 [KO:K04442] [EC:2.7.11.1]
131541643  hspb1; heat shock protein beta-1 [KO:K04455]
131541667  araf; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
131541690  map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
131541840  tgfa; protransforming growth factor alpha isoform X1 [KO:K08774]
131541848  tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
131541863  cacna2d2a; voltage-dependent calcium channel subunit alpha-2/delta-2a isoform X1 [KO:K04859]
131541898  [KO:K25415]
131542074  gadd45ab; growth arrest and DNA-damage-inducible, alpha, b [KO:K04402]
131542155  [KO:K04856]
131542168  prkcaa; protein kinase C, alpha, a isoform X1 [KO:K02677] [EC:2.7.11.13]
131542171  si:ch73-383l1.1; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
131542212  [KO:K04424] [EC:2.7.11.25]
131542235  ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
131542332  fgf8b; fibroblast growth factor 8b isoform X1 [KO:K04358]
131542360  map3k2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
131542543  ngfb; nerve growth factor [KO:K02582]
131542553  cacng5a; calcium channel, voltage-dependent, gamma subunit 5a [KO:K04870]
131542555  cacnb4b; voltage-dependent L-type calcium channel subunit beta-4b isoform X1 [KO:K04865]
131542622  gng12b; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
131542705  grb2a; growth factor receptor-bound protein 2a [KO:K04364]
131542724  erbb3a; receptor tyrosine-protein kinase erbB-3a isoform X1 [KO:K05084] [EC:2.7.10.1]
131542936  atf4a; cyclic AMP-dependent transcription factor ATF-4 isoform X1 [KO:K04374]
131542965  cacng4a; LOW QUALITY PROTEIN: voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
131542966  cacng1a; calcium channel, voltage-dependent, gamma subunit 1a [KO:K04866]
131542978  epha2a; LOW QUALITY PROTEIN: ephrin type-A receptor 2a [KO:K05103] [EC:2.7.10.1]
131543041  cacng2b; calcium channel, voltage-dependent, gamma subunit 2b [KO:K04867]
131543225  arrb2b; arrestin, beta 2b [KO:K04439]
131543257  rras2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
131543330  [KO:K04451]
131543370  cacng3a; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
131543458  ppp3r1b; calcineurin subunit B type 1b isoform X1 [KO:K06268]
131543547  igf1rb; insulin-like growth factor 1b receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
131543591  ptpn5; tyrosine-protein phosphatase non-receptor type 5 isoform X1 [KO:K18018] [EC:3.1.3.48]
131543637  rela; transcription factor p65 [KO:K04735]
131543764  ecsit; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
131543819  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
131543822  [KO:K04419] [EC:2.7.11.25]
131543828  hrasb; HRas proto-oncogene, GTPase b [KO:K02833]
131544102  map2k5; LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
131544133  mapk8ip1b; C-Jun-amino-terminal kinase-interacting protein 1 [KO:K04434]
131544217  [KO:K12361]
131544229  cacnb2a; voltage-dependent L-type calcium channel subunit beta-2a isoform X1 [KO:K04863]
131544242  [KO:K04348] [EC:3.1.3.16]
131544263  bdnf; brain-derived neurotrophic factor isoform X1 [KO:K04355]
131544350  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
131544446  fgf3; fibroblast growth factor 3 [KO:K04358]
131544447  fgf19; fibroblast growth factor 19 [KO:K22603]
131544448  fgf4; fibroblast growth factor 4 [KO:K04358]
131544465  fgf20a; fibroblast growth factor 20a [KO:K04358]
131544629  map4k2; mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
131544710  igf2a; insulin-like growth factor 2a [KO:K13769]
131544966  nfatc3a; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
131545218  fgf17; fibroblast growth factor 17 isoform X1 [KO:K04358]
131545292  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
131545319  fgfr1a; fibroblast growth factor receptor 1-A isoform X1 [KO:K04362] [EC:2.7.10.1]
131545431  cacna1sb; calcium channel, voltage-dependent, L type, alpha 1S subunit, b [KO:K04857]
131545456  mknk2b; MAP kinase-interacting serine/threonine-protein kinase 2b [KO:K04372] [EC:2.7.11.1]
131545529  rap1aa; RAP1A, member of RAS oncogene family a [KO:K04353]
131545611  efna5b; ephrin-A5b isoform X1 [KO:K05462]
131545740  [KO:K04852]
131545764  gadd45ga; growth arrest and DNA-damage-inducible, gamma a [KO:K04402]
131545795  mapk13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
131545807  nras; GTPase NRas [KO:K07828]
131545864  hspa1b; heat shock 70 kDa protein-like [KO:K03283]
131546124  irak1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
131546137  ntrk2a; neurotrophic tyrosine kinase, receptor, type 2a isoform X1 [KO:K04360] [EC:2.7.10.1]
131546144  cacna2d3a; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
131546156  elk1; ETS domain-containing protein Elk-1 [KO:K04375]
131546233  cacna1db; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
131546272  mapk14a; mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
131546303  cacna1fb; calcium channel, voltage-dependent, L type, alpha 1F subunit [KO:K04853]
131546350  mapkapk2b; MAP kinase-activated protein kinase 2b [KO:K04443] [EC:2.7.11.1]
131546383  cacna1fa; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04853]
131546610  fgf9; fibroblast growth factor 7 isoform X1 [KO:K04358]
131546731  atf2; cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
131546765  tgfbr2l; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
131546826  map3k20a; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
131546853  zmp:0000000936; interleukin-1 receptor type 1 [KO:K04386]
131547004  [KO:K04386]
131547056  map3k12; mitogen-activated protein kinase kinase kinase 12 isoform X1 [KO:K04423] [EC:2.7.11.25]
131547098  si:ch211-45c16.2; mitogen-activated protein kinase kinase kinase 13 isoform X1 [KO:K04422] [EC:2.7.11.25]
131547319  cacnb4a; voltage-dependent L-type calcium channel subunit beta-4a [KO:K04865]
131547327  mrasa; ras-related protein M-Ras isoform X1 [KO:K07831]
131547520  [KO:K05085] [EC:2.7.10.1]
131547778  fgf18b; fibroblast growth factor 18b [KO:K04358]
131547897  map3k1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
131548111  mef2ca; myocyte enhancer factor 2ca isoform X1 [KO:K04454]
131548128  nf1b; neurofibromin isoform X1 [KO:K08052]
131548207  akt2l; v-akt murine thymoma viral oncogene homolog 2, like [KO:K04456] [EC:2.7.11.1]
131548225  il1b; interleukin-1 beta [KO:K04519]
131548345  fgfr1b; fibroblast growth factor receptor 1b [KO:K04362] [EC:2.7.10.1]
131548392  rasa1b; ras GTPase-activating protein 1 [KO:K04352]
131548457  ppp3ccb; protein phosphatase 3, catalytic subunit, gamma isozyme, b isoform X1 [KO:K04348] [EC:3.1.3.16]
131548459  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
131548586  hspa8; heat shock cognate 71 kDa protein [KO:K03283]
131548645  arrb2a; arrestin, beta 2a isoform X1 [KO:K04439]
131548758  gdnfa; LOW QUALITY PROTEIN: glial cell line-derived neurotrophic factor [KO:K05452]
131548776  rasgrf2a; LOW QUALITY PROTEIN: ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
131548892  sos1; son of sevenless homolog 1 [KO:K03099]
131548956  elk4; ETS domain-containing protein Elk-4 isoform X1 [KO:K04376]
131549034  vegfd; vascular endothelial growth factor D isoform X1 [KO:K05449]
131549071  vegfc; vascular endothelial growth factor C isoform X1 [KO:K05449]
131549089  dusp7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
131549091  map4k3a; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
131549180  nrtn; LOW QUALITY PROTEIN: neurturin [KO:K25414]
131549244  raf1b; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
131549282  cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393]
131549289  mknk1; LOW QUALITY PROTEIN: MAP kinase-interacting serine/threonine-protein kinase 1 [KO:K04372] [EC:2.7.11.1]
131549350  gadd45ba; growth arrest and DNA-damage-inducible, beta a [KO:K04402]
131549384  rap1ab; ras-related protein rap1ab [KO:K04353]
131549437  mapkapk2a; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
131549572  mapkapk3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
131549627  [KO:K05462]
131549668  mapk14b; mitogen-activated protein kinase 14B isoform X1 [KO:K04441] [EC:2.7.11.24]
131549742  cacna1da; calcium channel, voltage-dependent, L type, alpha 1D subunit, a isoform X1 [KO:K04851]
131549743  cacna2d3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
131549842  csf1a; macrophage colony-stimulating factor 1a isoform X1 [KO:K05453]
131549851  cacna1ab; calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, b isoform X1 [KO:K04344]
131549854  prkacba; protein kinase, cAMP-dependent, catalytic, beta a [KO:K04345] [EC:2.7.11.11]
131550508  map3k8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
131550610  map2k4b; dual specificity mitogen-activated protein kinase kinase 4b isoform X1 [KO:K04430] [EC:2.7.12.2]
131550671  erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
131550723  cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G [KO:K04854]
131550741  taok2b; serine/threonine-protein kinase TAO2 [KO:K04429] [EC:2.7.11.1]
131550747  ppm1bb; protein phosphatase 1bb isoform X1 [KO:K04461] [EC:3.1.3.16]
131550767  gng12a; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12a [KO:K04347]
131550800  dusp3a; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
131550853  mapk8b; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
131551015  rac1a; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
131551075  mapk7; LOW QUALITY PROTEIN: mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
131551082  rac3b; ras-related C3 botulinum toxin substrate 3b [KO:K07861]
131551136  map2k6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
131551422  ngfrb; nerve growth factor receptor b isoform X1 [KO:K02583]
131551462  mapta; microtubule-associated protein tau isoform X1 [KO:K04380]
131551755  angpt2a; angiopoietin-2a [KO:K05466]
131551792  srfb; serum response factor b isoform X1 [KO:K04378]
131551829  [KO:K04469]
131551844  map3k4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
131551948  ppp3r1a; calcineurin subunit B type 1 [KO:K06268]
131552214  map3k21; mitogen-activated protein kinase kinase kinase 21 isoform X1 [KO:K17534] [EC:2.7.11.25]
131552218  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
131552281  map2k2b; dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
131552303  fgf8a; fibroblast growth factor 8 isoform X1 [KO:K04358]
131552326  ret; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
131552343  ppm1ba; protein phosphatase 1B [KO:K04461] [EC:3.1.3.16]
131552377  fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
131552403  map3k9; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
131552423  akt3a; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
131552620  sos2; son of sevenless homolog 2 [KO:K03099]
131552635  chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
131552697  rps6ka2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
131552727  fgfr2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
131552774  cdc25b; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
131552789  lamtor3; ragulator complex protein LAMTOR3 [KO:K04370]
131552793  ppm1aa; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
131552848  [KO:K25415]
131552887  fgf18a; fibroblast growth factor 18a [KO:K04358]
131552902  egf; pro-epidermal growth factor isoform X1 [KO:K04357]
131552912  casp3b; caspase-3b isoform X1 [KO:K02187] [EC:3.4.22.56]
131552968  rps6kal; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
131552986  rapgef2b; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
131552990  csf1ra; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
131553041  si:zfos-2326c3.2; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
131553086  nfkb1; LOW QUALITY PROTEIN: nuclear factor NF-kappa-B p105 subunit [KO:K02580]
131553121  pdgfrb; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
131553262  pak2a; LOW QUALITY PROTEIN: serine/threonine-protein kinase PAK 2a [KO:K04410] [EC:2.7.11.1]
131553310  fgf2; fibroblast growth factor 2 [KO:K18497]
131553421  dusp1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
131553469  ppp3cb; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2B catalytic subunit beta isoform [KO:K04348] [EC:3.1.3.16]
131553489  fgf16; fibroblast growth factor 16 [KO:K04358]
131553494  kdrl; vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
131553575  fgf20b; LOW QUALITY PROTEIN: fibroblast growth factor 20b [KO:K04358]
131553762  fgf1a; putative fibroblast growth factor 1 isoform X1 [KO:K18496]
131553788  tgfb5; transforming growth factor beta-2 proprotein [KO:K13376]
131553823  insra; insulin receptor a isoform X1 [KO:K04527] [EC:2.7.10.1]
131553902  flt4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
131553957  insb; preproinsulin b [KO:K04526]
131553973  pdgfc; platelet-derived growth factor C isoform X1 [KO:K05450]
131554074  nlk2; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
131554078  hsc70; heat shock cognate 71 kDa protein [KO:K03283]
131554100  hspa8b; LOW QUALITY PROTEIN: heat shock protein family A (Hsp70) member 8b [KO:K03283]
131554183  taok1a; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
131554376  arrb1; beta-arrestin-1 [KO:K04439]
131554391  crk; adapter molecule crk [KO:K04438]
131554413  mecom; MDS1 and EVI1 complex locus protein EVI1-A isoform X1 [KO:K04462] [EC:2.1.1.367]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
omc04070  Phosphatidylinositol signaling system
omc04110  Cell cycle
omc04115  p53 signaling pathway
omc04210  Apoptosis
omc04310  Wnt signaling pathway
KO pathway
ko04010   

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