KEGG   PATHWAY: omc04261
Entry
omc04261                    Pathway                                
Name
Adrenergic signaling in cardiomyocytes - Onychostoma macrolepis
Description
Cardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, and alpha-1C). In the human heart the beta-1-AR is the pre- dominate receptor. Acute sympathetic stimulation of cardiac beta-1-ARs induces positive inotropic and chronotropic effects, the most effective mechanism to acutely increase output of the heart, by coupling to Gs, formation of cAMP by adenylyl cyclase (AC), and PKA- dependent phosphorylation of various target proteins (e.g., ryanodine receptor [RyR]; phospholamban [PLB], troponin I [TnI], and the L-type Ca2+ channel [LTCC]). Chronic beta-1-AR stimulation is detrimental and induces cardiomyocyte hypertrophy and apoptosis. beta-2-AR coupled to Gs exerts a proapoptotic action as well as beta-1-AR, while beta-2-AR coupled to Gi exerts an antiapoptotic action.
Class
Organismal Systems; Circulatory system
Pathway map
omc04261  Adrenergic signaling in cardiomyocytes
omc04261

Other DBs
GO: 0001997
Organism
Onychostoma macrolepis [GN:omc]
Gene
131550695  adrb1; beta-1 adrenergic receptor [KO:K04141]
131528269  adrb2b; adrenoceptor beta 2, surface b isoform X1 [KO:K04142]
131553702  adrb2a; adrenoceptor beta 2, surface a [KO:K04142]
131542089  gnas; guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
131550870  adcy1b; adenylate cyclase type 1b isoform X1 [KO:K08041] [EC:4.6.1.1]
131527742  adcy1a; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
131525946  adcy2b; adenylate cyclase type 2b isoform X1 [KO:K08042] [EC:4.6.1.1]
131521759  adcy2a; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
131526673  adenylate cyclase type 3-like isoform X1 [KO:K08043] [EC:4.6.1.1]
131522138  adcy3a; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
131546935  adcy5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
131531959  adcy6b; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
131532212  adcy6a; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
131544254  adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
131523720  si:ch211-132f19.7; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
131526680  si:dkey-206f10.1; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
131551343  adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
131534865  adenylate cyclase type 9-like [KO:K08049] [EC:4.6.1.1]
131529841  adcy9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
131522152  bves; blood vessel epicardial substance isoform X1 [KO:K21108]
131547305  popdc2; popeye domain-containing 2 isoform X1 [KO:K26206]
131522153  popdc3; popeye domain-containing protein 3 [KO:K26207]
131522947  kcnk2a; potassium channel subfamily K member 2 [KO:K04913]
131527241  kcnk2b; potassium channel subfamily K member 2b [KO:K04913]
131540829  prkacab; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
131524516  prkacbb; protein kinase, cAMP-dependent, catalytic, beta b [KO:K04345] [EC:2.7.11.11]
131549854  prkacba; protein kinase, cAMP-dependent, catalytic, beta a [KO:K04345] [EC:2.7.11.11]
131536154  prkacaa; LOW QUALITY PROTEIN: protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a [KO:K04345] [EC:2.7.11.11]
131531947  atp1a1a.3; sodium/potassium-transporting ATPase subunit alpha-1a.3 [KO:K01539] [EC:7.2.2.13]
131525364  atp1a3a; sodium/potassium-transporting ATPase subunit alpha-3a isoform X1 [KO:K01539] [EC:7.2.2.13]
131521306  atp1a3b; sodium/potassium-transporting ATPase subunit alpha-3b [KO:K01539] [EC:7.2.2.13]
131538102  atp1a1a.1; sodium/potassium-transporting ATPase subunit alpha-1a.1 isoform X1 [KO:K01539] [EC:7.2.2.13]
131538119  atp1a1a.4; LOW QUALITY PROTEIN: sodium/potassium-transporting ATPase subunit alpha-1a.4 [KO:K01539] [EC:7.2.2.13]
131553198  atp1a2a; sodium/potassium-transporting ATPase subunit alpha-2 isoform X1 [KO:K01539] [EC:7.2.2.13]
131546812  atp1a1b; sodium/potassium-transporting ATPase subunit alpha-1b [KO:K01539] [EC:7.2.2.13]
131530404  sodium/potassium-transporting ATPase subunit alpha-1-like isoform X1 [KO:K01539] [EC:7.2.2.13]
131531675  atp1b2a; sodium/potassium-transporting ATPase subunit beta-2a [KO:K01540]
131541625  atp1b2b; sodium/potassium-transporting ATPase subunit beta-2b [KO:K01540]
131542379  atp1b1a; sodium/potassium-transporting ATPase subunit beta-1a [KO:K01540]
131550503  atp1b1b; sodium/potassium-transporting ATPase subunit beta-1b [KO:K01540]
131520424  atp1b3b; sodium/potassium-transporting ATPase subunit beta-3b [KO:K01540]
131553339  atp1b4; protein ATP1B4 isoform X1 [KO:K01540]
131529573  atp1b3a; sodium/potassium-transporting ATPase subunit beta-3a [KO:K01540]
131540742  fxyd2; sodium/potassium-transporting ATPase subunit gamma [KO:K01538]
131525995  slc9a1b; sodium/hydrogen exchanger 1b isoform X1 [KO:K05742]
131521599  slc9a1a; sodium/hydrogen exchanger 1 [KO:K05742]
131534447  kcnq1.2; potassium voltage-gated channel subfamily KQT member 1 isoform X1 [KO:K04926]
131544006  kcnq1.1; potassium voltage-gated channel subfamily KQT member 1.1 isoform X1 [KO:K04926]
131547217  uncharacterized protein LOC131547217 [KO:K04894]
131532043  atp2b3b; plasma membrane calcium-transporting ATPase 3b isoform X1 [KO:K05850] [EC:7.2.2.10]
131549167  atp2b2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
131549637  atp2b4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
131533855  plasma membrane calcium-transporting ATPase 1-like [KO:K05850] [EC:7.2.2.10]
131545219  atp2b3a; plasma membrane calcium-transporting ATPase 3a isoform X1 [KO:K05850] [EC:7.2.2.10]
131539340  atp2b1a; plasma membrane calcium-transporting ATPase 1a isoform X1 [KO:K05850] [EC:7.2.2.10]
131523126  slc8a1b; sodium/calcium exchanger 1b isoform X1 [KO:K05849]
131540989  slc8a2a; sodium/calcium exchanger 2a isoform X1 [KO:K05849]
131548935  slc8a1a; sodium/calcium exchanger 1a isoform X1 [KO:K05849]
131544764  slc8a4b; solute carrier family 8 member 4b [KO:K05849]
131520791  slc8a2b; sodium/calcium exchanger 2b isoform X1 [KO:K05849]
131552694  slc8a3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
131528552  slc8a4a; solute carrier family 8 member 4a [KO:K05849]
131533204  scn5lab; sodium channel, voltage gated, type V-like, alpha b [KO:K04838]
131525512  scn12aa; sodium channel, voltage gated, type XII, alpha a [KO:K04838]
131525667  scn1bb; sodium channel, voltage-gated, type I, beta b [KO:K04845]
131522284  scn1ba; sodium channel, voltage-gated, type I, beta a isoform X1 [KO:K04845]
131522387  si:ch211-225p5.8; sodium channel subunit beta-1 [KO:K04845]
131541631  scn4bb; sodium channel, voltage-gated, type IV, beta b [KO:K04848]
131520407  scn4ba; sodium channel, voltage-gated, type IV, beta a [KO:K04848]
131538945  cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
131549742  cacna1da; calcium channel, voltage-dependent, L type, alpha 1D subunit, a isoform X1 [KO:K04851]
131546233  cacna1db; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
131546303  cacna1fb; calcium channel, voltage-dependent, L type, alpha 1F subunit [KO:K04853]
131546383  cacna1fa; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04853]
131531222  cacna1sa; LOW QUALITY PROTEIN: calcium channel, voltage-dependent, L type, alpha 1S subunit, a [KO:K04857]
131545431  cacna1sb; calcium channel, voltage-dependent, L type, alpha 1S subunit, b [KO:K04857]
131536337  cacnb1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
131544229  cacnb2a; voltage-dependent L-type calcium channel subunit beta-2a isoform X1 [KO:K04863]
131531922  cacnb3b; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit beta-4 [KO:K04864]
131532216  cacnb3a; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit beta-3a [KO:K04864]
131547319  cacnb4a; voltage-dependent L-type calcium channel subunit beta-4a [KO:K04865]
131542555  cacnb4b; voltage-dependent L-type calcium channel subunit beta-4b isoform X1 [KO:K04865]
131524152  voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
131538580  cacna2d1a; voltage-dependent calcium channel subunit alpha-2/delta-1a [KO:K04858]
131530733  cacna2d2b; voltage-dependent calcium channel subunit alpha-2/delta-2b isoform X1 [KO:K04859]
131541863  cacna2d2a; voltage-dependent calcium channel subunit alpha-2/delta-2a isoform X1 [KO:K04859]
131549743  cacna2d3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
131546144  cacna2d3a; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
131534182  cacna2d4b; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
131538522  cacna2d4a; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
131542966  cacng1a; calcium channel, voltage-dependent, gamma subunit 1a [KO:K04866]
131537820  cacng1b; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
131543041  cacng2b; calcium channel, voltage-dependent, gamma subunit 2b [KO:K04867]
131538104  cacng2a; calcium channel, voltage-dependent, gamma subunit 2a [KO:K04867]
131543370  cacng3a; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
131538056  cacng3b; voltage-dependent calcium channel gamma-3 subunit isoform X1 [KO:K04868]
131542965  cacng4a; LOW QUALITY PROTEIN: voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
131536998  cacng4b; calcium channel, voltage-dependent, gamma subunit 4b [KO:K04869]
131542553  cacng5a; calcium channel, voltage-dependent, gamma subunit 5a [KO:K04870]
131535945  cacng5b; voltage-dependent calcium channel gamma-5 subunit isoform X1 [KO:K04870]
131525937  cacng6a; calcium channel, voltage-dependent, gamma subunit 6a [KO:K04871]
131522452  cacng6b; uncharacterized protein cacng6b [KO:K04871]
131525167  cacng7a; calcium channel, voltage-dependent, gamma subunit 7a [KO:K04872]
131521207  cacng7b; voltage-dependent calcium channel gamma-7 subunit isoform X1 [KO:K04872]
131525834  cacng8a; calcium channel, voltage-dependent, gamma subunit 8a [KO:K04873]
131521585  cacng8b; voltage-dependent calcium channel gamma-4 subunit isoform X1 [KO:K04873]
131522864  calm1a; calmodulin-1a [KO:K02183]
131534460  calml4b; calmodulin-like protein 4 isoform X1 [KO:K02183]
131543599  calml4a; calmodulin-like protein 4a [KO:K02183]
131551280  calm2b; calmodulin 2b, (phosphorylase kinase, delta) [KO:K02183]
131527089  calm1b; calmodulin-1b [KO:K02183]
131552238  calm2a; calmodulin 2a (phosphorylase kinase, delta) [KO:K02183]
131528884  calm3b; calmodulin 3b (phosphorylase kinase, delta) [KO:K02183]
131554150  calm3a; calmodulin 3a (phosphorylase kinase, delta) [KO:K02183]
131548567  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
131543242  camk2d2; calcium/calmodulin-dependent protein kinase type II delta 2 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
131551127  camk2g1; calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 1 isoform X1 [KO:K04515] [EC:2.7.11.17]
131544919  camk2d1; calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
131552748  camk2g2; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
131528727  camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
131540475  camk2b1; calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 1 isoform X1 [KO:K04515] [EC:2.7.11.17]
131523200  ryr2b; ryanodine receptor 2 [KO:K04962]
131551579  ryr2a; LOW QUALITY PROTEIN: ryanodine receptor 2 [KO:K04962]
131548163  ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
131528991  ppp2cab; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
131553797  ppp2caa; protein phosphatase 2 catalytic subunit alpha a [KO:K04382] [EC:3.1.3.16]
131541088  ppp2r1ba; protein phosphatase 2, regulatory subunit A, beta a [KO:K03456]
131520784  ppp2r1bb; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
131548093  ppp2r2ab; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
131543085  ppp2r2ca; protein phosphatase 2, regulatory subunit B, gamma a isoform X1 [KO:K04354]
131551185  ppp2r2d; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354]
131528584  ppp2r2bb; protein phosphatase 2, regulatory subunit B, beta b isoform X1 [KO:K04354]
131553090  ppp2r2cb; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
131546109  ppp2r2aa; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
131553252  ppp2r2ba; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform [KO:K04354]
131523440  ppp2r3c; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma [KO:K11583]
131553562  ppp2r3a; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
131546871  ppp2r3b; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
131523149  ppp2r5ca; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
131526858  ppp2r5a; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform X1 [KO:K11584]
131527021  ppp2r5cb; protein phosphatase 2, regulatory subunit B', gamma b isoform X1 [KO:K11584]
131527102  ppp2r5ea; protein phosphatase 2, regulatory subunit B', epsilon isoform X1 [KO:K11584]
131544523  ppp2r5b; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
131552108  ppp2r5eb; protein phosphatase 2, regulatory subunit B', epsilon isoform X1 [KO:K11584]
131552142  ppp2r5d; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
131523354  ppp1cb; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
131541330  ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit A [KO:K06269] [EC:3.1.3.16]
131543468  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
131551297  ppp1cab; protein phosphatase 1, catalytic subunit, alpha isozyme b [KO:K06269] [EC:3.1.3.16]
131537308  ppp1caa; protein phosphatase 1, catalytic subunit, alpha isozyme a [KO:K06269] [EC:3.1.3.16]
131531871  tnnc1b; troponin C type 1b (slow) [KO:K05865]
131532665  tnnc1a; troponin C type 1a (slow) [KO:K05865]
131531557  tnnt2a; troponin T type 2a (cardiac) [KO:K12045]
131542174  tnnt2b; troponin T, cardiac muscle isoforms [KO:K12045]
131534270  tnnt2d; troponin T2d, cardiac [KO:K12045]
131539610  tnnt2c; troponin T2c, cardiac [KO:K12045]
131539622  tnnt2e; troponin T2e, cardiac isoform X1 [KO:K12045]
131548108  tpm2; tropomyosin beta chain isoform X1 [KO:K10373]
131525536  tpm3; tropomyosin alpha-3 chain isoform X1 [KO:K10373]
131533898  tpm1; tropomyosin alpha-1 chain isoform X1 [KO:K10373]
131543992  tpma; tropomyosin alpha-1 chain [KO:K10373]
131550832  tpm4b; tropomyosin 4b isoform X1 [KO:K10375]
131529971  tpm4a; tropomyosin 4a isoform X1 [KO:K10375]
131522880  actc1b; actin, alpha cardiac muscle 1b [KO:K12314]
131549108  acta1a; actin alpha 1, skeletal muscle a [KO:K12314]
131533870  acte1; beta-actin-like protein 2 [KO:K12314]
131552312  acta1b; actin alpha 1, skeletal muscle b [KO:K12314]
131527718  actc1a; actin, alpha cardiac muscle 1a [KO:K12314]
131527778  actc2; actin, alpha, cardiac muscle 2 isoform X1 [KO:K12314]
131532810  myosin-7-like [KO:K17751]
131533692  myosin-7-like isoform X1 [KO:K17751]
131526903  myh6; myosin-6 [KO:K17751]
131529898  myosin-7-like isoform X1 [KO:K17751]
131529910  myh7; myosin-7 [KO:K17751]
131541642  myl2a; myosin regulatory light chain 2a [KO:K10351]
131545696  myl2b; myosin, light chain 2b, regulatory, cardiac, slow [KO:K10351]
131540894  cmlc1; cardiac myosin light chain-1 [KO:K12750]
131540931  myosin light chain 4-like [KO:K12750]
131551467  zgc:163073; myosin light chain 4 [KO:K12750]
131537148  myl4; myosin light chain 4 isoform X1 [KO:K12750]
131526707  pln; cardiac phospholamban [KO:K05852]
131522803  cardiac phospholamban-like [KO:K05852]
131551336  atp2a1l; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1, like isoform X1 [KO:K05853] [EC:7.2.2.10]
131536270  atp2a1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
131545542  atp2a2a; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
131528557  atp2a2b; sarcoplasmic/endoplasmic reticulum calcium ATPase 2b [KO:K05853] [EC:7.2.2.10]
131540379  atp2a3; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
131554110  si:dkey-28b4.8; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
131552323  agt; angiotensinogen [KO:K09821]
131533539  agtr1b; type-1 angiotensin II receptor A [KO:K04166]
131522147  agtr1a; type-1 angiotensin II receptor B [KO:K04166]
131540122  agtr2; type-2 angiotensin II receptor isoform X1 [KO:K04167]
131548301  adra1ab; alpha-1A adrenergic receptor [KO:K04135]
131545167  adra1aa; adrenoceptor alpha 1Aa [KO:K04135]
131528994  adra1ba; alpha-1A adrenergic receptor [KO:K04136]
131553446  adra1bb; adrenoceptor alpha 1Bb [KO:K04136]
131550397  adra1d; alpha-1D adrenergic receptor [KO:K04137]
131541350  gnaq; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
131522892  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
131543713  plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
131527425  plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
131527426  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
131522772  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
131522774  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
131542168  prkcaa; protein kinase C, alpha, a isoform X1 [KO:K02677] [EC:2.7.11.13]
131535943  prkcab; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
131540661  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
131536056  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
131523014  rps6ka5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
131547446  creb1b; cyclic AMP-responsive element-binding protein 1b [KO:K05870]
131546836  creb1a; cyclic AMP-responsive element-binding protein 1a isoform X1 [KO:K05870]
131546731  atf2; cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
131542936  atf4a; cyclic AMP-dependent transcription factor ATF-4 isoform X1 [KO:K04374]
131538058  atf4b; activating transcription factor 4b [KO:K04374]
131530832  creb3l3a; cyclic AMP-responsive element-binding protein 3-like protein 3-A isoform X1 [KO:K09048]
131531960  creb3l3b; LOW QUALITY PROTEIN: cyclic AMP-responsive element-binding protein 3-like protein 3-A [KO:K09048]
131544157  creb3l1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
131521337  creb3l4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
131545704  creb3l3l; cAMP responsive element binding protein 3-like 3 like [KO:K09048]
131538578  creb3l2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
131525218  creb5a; cyclic AMP-responsive element-binding protein 5 [KO:K09047]
131522181  creb5b; LOW QUALITY PROTEIN: cyclic AMP-responsive element-binding protein 5 [KO:K09047]
131525451  atf6b; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
131533046  cremb; cAMP responsive element modulator b isoform X1 [KO:K09052]
131551860  crema; cAMP-responsive element modulator isoform X1 [KO:K09052]
131533091  bcl2a; apoptosis regulator Bcl-2a [KO:K02161]
131521209  bcl2b; apoptosis regulator Bcl-2 [KO:K02161]
131532333  rapgef3; rap guanine nucleotide exchange factor 3 isoform X1 [KO:K08014]
131542994  rapgef4b; rap guanine nucleotide exchange factor 4-like isoform X1 [KO:K04351]
131547186  rapgef4a; rap guanine nucleotide exchange factor 4 isoform X1 [KO:K04351]
131532537  zgc:171775; STKc_p38 domain-containing protein isoform X1 [KO:K04441] [EC:2.7.11.24]
131524817  mapk12a; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
131549668  mapk14b; mitogen-activated protein kinase 14B isoform X1 [KO:K04441] [EC:2.7.11.24]
131545795  mapk13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
131539074  mapk12b; mitogen-activated protein kinase 12b [KO:K04441] [EC:2.7.11.24]
131539076  mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
131546272  mapk14a; mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
131541907  gnai2b; guanine nucleotide-binding protein G(i) subunit alpha-2b [KO:K04630]
131549022  gnai2a; guanine nucleotide-binding protein G(i) subunit alpha-2a [KO:K04630]
131534479  gnaia; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a [KO:K04630]
131545465  gnai3; guanine nucleotide-binding protein G(i) subunit alpha isoform X1 [KO:K04630]
131538867  gnai1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
131531999  si:rp71-17i16.5; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289] [EC:2.7.1.153]
131539559  pik3cg; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
131542065  pik3r5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
131542066  phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
131536893  pik3r6b; phosphoinositide 3-kinase regulatory subunit 6 isoform X1 [KO:K21290]
131523076  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
131548207  akt2l; v-akt murine thymoma viral oncogene homolog 2, like [KO:K04456] [EC:2.7.11.1]
131548459  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
131524297  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
131527534  RAC-alpha serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
131552423  akt3a; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
Compound
C00076  Calcium cation
C00080  H+
C00165  Diacylglycerol
C00238  Potassium cation
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00788  L-Adrenaline
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C07056  Isoproterenol
Reference
PMID:19883653
  Authors
Grimm M, Brown JH
  Title
Beta-adrenergic receptor signaling in the heart: role of CaMKII.
  Journal
J Mol Cell Cardiol 48:322-30 (2010)
DOI:10.1016/j.yjmcc.2009.10.016
Reference
PMID:21212391
  Authors
Yang JH, Saucerman JJ
  Title
Computational models reduce complexity and accelerate insight into cardiac signaling networks.
  Journal
Circ Res 108:85-97 (2011)
DOI:10.1161/CIRCRESAHA.110.223602
Reference
PMID:16765984
  Authors
Schaub MC, Hefti MA, Zaugg M
  Title
Integration of calcium with the signaling network in cardiac myocytes.
  Journal
J Mol Cell Cardiol 41:183-214 (2006)
DOI:10.1016/j.yjmcc.2006.04.005
Reference
PMID:22022314
  Authors
Taggart P, Boyett MR, Logantha S, Lambiase PD
  Title
Anger, emotion, and arrhythmias: from brain to heart.
  Journal
Front Physiol 2:67 (2011)
DOI:10.3389/fphys.2011.00067
Reference
PMID:17988210
  Authors
Bers DM
  Title
Calcium cycling and signaling in cardiac myocytes.
  Journal
Annu Rev Physiol 70:23-49 (2008)
DOI:10.1146/annurev.physiol.70.113006.100455
Reference
PMID:20923637
  Authors
Soltis AR, Saucerman JJ
  Title
Synergy between CaMKII substrates and beta-adrenergic signaling in regulation of cardiac myocyte Ca(2+) handling.
  Journal
Biophys J 99:2038-47 (2010)
DOI:10.1016/j.bpj.2010.08.016
Reference
PMID:12439640
  Authors
Wallukat G
  Title
The beta-adrenergic receptors.
  Journal
Herz 27:683-90 (2002)
DOI:10.1007/s00059-002-2434-z
Reference
PMID:11604549
  Authors
Xiao RP
  Title
Beta-adrenergic signaling in the heart: dual coupling of the beta2-adrenergic receptor to G(s) and G(i) proteins.
  Journal
Sci STKE 2001:re15 (2001)
DOI:10.1126/stke.2001.104.re15
Reference
PMID:10571541
  Authors
Xiao RP, Cheng H, Zhou YY, Kuschel M, Lakatta EG
  Title
Recent advances in cardiac beta(2)-adrenergic signal transduction.
  Journal
Circ Res 85:1092-100 (1999)
DOI:10.1161/01.RES.85.11.1092
Reference
PMID:15979723
  Authors
Zheng M, Zhu W, Han Q, Xiao RP
  Title
Emerging concepts and therapeutic implications of beta-adrenergic receptor subtype signaling.
  Journal
Pharmacol Ther 108:257-68 (2005)
DOI:10.1016/j.pharmthera.2005.04.006
Reference
PMID:17826821
  Authors
Kuzumoto M, Takeuchi A, Nakai H, Oka C, Noma A, Matsuoka S
  Title
Simulation analysis of intracellular Na+ and Cl- homeostasis during beta 1-adrenergic stimulation of cardiac myocyte.
  Journal
Prog Biophys Mol Biol 96:171-86 (2008)
DOI:10.1016/j.pbiomolbio.2007.07.005
Reference
PMID:11805843
  Authors
Bers DM
  Title
Cardiac excitation-contraction coupling.
  Journal
Nature 415:198-205 (2002)
DOI:10.1038/415198a
Reference
PMID:20658186
  Authors
Ho D, Yan L, Iwatsubo K, Vatner DE, Vatner SF
  Title
Modulation of beta-adrenergic receptor signaling in heart failure and longevity: targeting adenylyl cyclase type 5.
  Journal
Heart Fail Rev 15:495-512 (2010)
DOI:10.1007/s10741-010-9183-5
Reference
PMID:15142747
  Authors
Saucerman JJ, McCulloch AD
  Title
Mechanistic systems models of cell signaling networks: a case study of myocyte adrenergic regulation.
  Journal
Prog Biophys Mol Biol 85:261-78 (2004)
DOI:10.1016/j.pbiomolbio.2004.01.005
Reference
PMID:15765137
  Authors
Yano M, Ikeda Y, Matsuzaki M
  Title
Altered intracellular Ca2+ handling in heart failure.
  Journal
J Clin Invest 115:556-64 (2005)
DOI:10.1172/JCI24159
Reference
PMID:15232578
  Authors
Wehrens XH, Marks AR
  Title
Novel therapeutic approaches for heart failure by normalizing calcium cycling.
  Journal
Nat Rev Drug Discov 3:565-73 (2004)
DOI:10.1038/nrd1440
Reference
PMID:19874988
  Authors
Triposkiadis F, Karayannis G, Giamouzis G, Skoularigis J, Louridas G, Butler J
  Title
The sympathetic nervous system in heart failure physiology, pathophysiology, and clinical implications.
  Journal
J Am Coll Cardiol 54:1747-62 (2009)
DOI:10.1016/j.jacc.2009.05.015
Reference
PMID:18407781
  Authors
Barry SP, Davidson SM, Townsend PA
  Title
Molecular regulation of cardiac hypertrophy.
  Journal
Int J Biochem Cell Biol 40:2023-39 (2008)
DOI:10.1016/j.biocel.2008.02.020
Related
pathway
omc04020  Calcium signaling pathway
omc04260  Cardiac muscle contraction
KO pathway
ko04261   
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