KEGG   ORTHOLOGY: K04351
Entry
K04351                      KO                                     
Symbol
RAPGEF4, EPAC2
Name
Rap guanine nucleotide exchange factor 4
Pathway
map04015  Rap1 signaling pathway
map04024  cAMP signaling pathway
map04072  Phospholipase D signaling pathway
map04261  Adrenergic signaling in cardiomyocytes
map04670  Leukocyte transendothelial migration
map04911  Insulin secretion
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    K04351  RAPGEF4, EPAC2; Rap guanine nucleotide exchange factor 4
   04072 Phospholipase D signaling pathway
    K04351  RAPGEF4, EPAC2; Rap guanine nucleotide exchange factor 4
   04024 cAMP signaling pathway
    K04351  RAPGEF4, EPAC2; Rap guanine nucleotide exchange factor 4
 09150 Organismal Systems
  09151 Immune system
   04670 Leukocyte transendothelial migration
    K04351  RAPGEF4, EPAC2; Rap guanine nucleotide exchange factor 4
  09152 Endocrine system
   04911 Insulin secretion
    K04351  RAPGEF4, EPAC2; Rap guanine nucleotide exchange factor 4
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K04351  RAPGEF4, EPAC2; Rap guanine nucleotide exchange factor 4
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K04351  RAPGEF4, EPAC2; Rap guanine nucleotide exchange factor 4
Membrane trafficking [BR:ko04131]
 Endoplasmic reticulum (ER) - Golgi transport
  Forward pathways
   Rab associated proteins
    K04351  RAPGEF4, EPAC2; Rap guanine nucleotide exchange factor 4
Genes
HSA: 11069(RAPGEF4)
PTR: 459744(RAPGEF4)
PPS: 100995002(RAPGEF4)
GGO: 101151388(RAPGEF4)
PON: 100189911(RAPGEF4)
NLE: 100602878(RAPGEF4)
MCC: 698148(RAPGEF4)
MCF: 101865166(RAPGEF4)
CSAB: 103217330(RAPGEF4)
CATY: 105579810(RAPGEF4)
PANU: 100997024(RAPGEF4)
TGE: 112636245(RAPGEF4)
RRO: 104673512(RAPGEF4)
RBB: 108518542(RAPGEF4)
TFN: 117094851(RAPGEF4)
PTEH: 111522172(RAPGEF4)
CJC: 100401754(RAPGEF4)
SBQ: 101043595(RAPGEF4)
CSYR: 103267141(RAPGEF4)
MMUR: 105880732(RAPGEF4)
LCAT: 123644044(RAPGEF4)
OGA: 100944201(RAPGEF4)
MMU: 56508(Rapgef4)
MCAL: 110289761(Rapgef4)
MPAH: 110318780(Rapgef4)
RNO: 252857(Rapgef4)
MCOC: 116090303(Rapgef4)
CGE: 100774346
MAUA: 101839349(Rapgef4)
PLEU: 114704477(Rapgef4)
MORG: 121433185(Rapgef4) 121439272
AAMP: 119819683(Rapgef4)
NGI: 103751742(Rapgef4)
HGL: 101706913(Rapgef4)
CPOC: 100730964(Rapgef4)
CCAN: 109687932(Rapgef4)
DORD: 105996072(Rapgef4)
DSP: 122120106(Rapgef4)
NCAR: 124978987
OCU: 100348394(RAPGEF4)
OPI: 101534512(RAPGEF4)
TUP: 102485451(RAPGEF4)
CFA: 488402(RAPGEF4)
CLUD: 112668098(RAPGEF4)
VVP: 112916400(RAPGEF4)
VLG: 121471317(RAPGEF4)
AML: 100480097(RAPGEF4)
UMR: 103659569
UAH: 113250770(RAPGEF4)
UAR: 123780680(RAPGEF4)
ELK: 111158917
LLV: 125095734
MPUF: 101683321(RAPGEF4)
ORO: 101382059(RAPGEF4)
EJU: 114223796(RAPGEF4)
ZCA: 113919486(RAPGEF4)
MLX: 118012324(RAPGEF4)
FCA: 101092955(RAPGEF4)
PYU: 121030705(RAPGEF4)
PBG: 122481463(RAPGEF4)
PTG: 102959994(RAPGEF4)
PPAD: 109273039
AJU: 106987935(RAPGEF4)
HHV: 120236410(RAPGEF4)
BTA: 537312(RAPGEF4)
BOM: 102264805(RAPGEF4)
BIU: 109566435(RAPGEF4)
BBUB: 102396497(RAPGEF4)
CHX: 102184383(RAPGEF4)
OAS: 101112196(RAPGEF4)
ODA: 120854931(RAPGEF4)
CCAD: 122453597(RAPGEF4)
SSC: 100511786(RAPGEF4)
CFR: 102519185(RAPGEF4)
CBAI: 105073438(RAPGEF4)
CDK: 105091096(RAPGEF4)
VPC: 102528724(RAPGEF4)
BACU: 103018315(RAPGEF4)
LVE: 103078675(RAPGEF4)
OOR: 101271995(RAPGEF4)
DLE: 111172871(RAPGEF4)
PCAD: 102985646(RAPGEF4)
PSIU: 116757044(RAPGEF4)
ECB: 100064121(RAPGEF4)
EPZ: 103559592(RAPGEF4)
EAI: 106834741(RAPGEF4)
MYB: 102262528(RAPGEF4)
MYD: 102765492(RAPGEF4)
MMYO: 118661427(RAPGEF4)
MLF: 102423839(RAPGEF4)
MNA: 107531114(RAPGEF4)
PKL: 118709358(RAPGEF4)
HAI: 109388735(RAPGEF4)
DRO: 112305728(RAPGEF4)
SHON: 118985700(RAPGEF4)
AJM: 119053630
PDIC: 114494369(RAPGEF4)
PHAS: 123805328(RAPGEF4)
MMF: 118625354(RAPGEF4)
RFQ: 117026182(RAPGEF4)
PALE: 102884268
PGIG: 120596952(RAPGEF4)
PVP: 105290355(RAPGEF4)
RAY: 107505164(RAPGEF4)
MJV: 108395539(RAPGEF4)
TOD: 119255936(RAPGEF4)
SARA: 101558391(RAPGEF4)
LAV: 100660747(RAPGEF4)
TMU: 101341572
DNM: 101440135(RAPGEF4)
MDO: 100025283(RAPGEF4)
GAS: 123242207(RAPGEF4)
SHR: 100933298(RAPGEF4)
PCW: 110211578(RAPGEF4)
OAA: 100084234(RAPGEF4)
GGA: 429022(RAPGEF4)
PCOC: 116232848(RAPGEF4)
CJO: 107316695(RAPGEF4)
NMEL: 110399900(RAPGEF4)
APLA: 101803499(RAPGEF4)
ACYG: 106029998(RAPGEF4)
AFUL: 116490762(RAPGEF4)
TGU: 100231316(RAPGEF4)
LSR: 110482918(RAPGEF4)
SCAN: 103814439(RAPGEF4)
PMOA: 120497563(RAPGEF4)
OTC: 121335480(RAPGEF4)
PRUF: 121356710(RAPGEF4)
GFR: 102033413(RAPGEF4)
FAB: 101808736(RAPGEF4)
PHI: 102102247(RAPGEF4)
PMAJ: 107207670(RAPGEF4)
CCAE: 111932077(RAPGEF4)
CCW: 104693870(RAPGEF4)
CBRC: 103616563(RAPGEF4)
ETL: 114054913(RAPGEF4)
ZAB: 102069630(RAPGEF4)
FPG: 101910581(RAPGEF4)
FCH: 102051155(RAPGEF4)
CLV: 102085464(RAPGEF4)
EGZ: 104128060(RAPGEF4)
NNI: 104010004(RAPGEF4)
PCRI: 104035177
ACUN: 113482011(RAPGEF4)
TALA: 104359765(RAPGEF4)
PADL: 103924207(RAPGEF4)
ACHC: 115342849(RAPGEF4)
HALD: 104322661(RAPGEF4)
CCRI: 104157562(RAPGEF4)
CSTI: 104553476(RAPGEF4)
EHS: 104511936(RAPGEF4)
CMAC: 104475986(RAPGEF4)
FGA: 104075741(RAPGEF4)
GSTE: 104262313(RAPGEF4)
LDI: 104343627(RAPGEF4)
MNB: 103775971(RAPGEF4)
OHA: 104328968(RAPGEF4)
AAM: 106499302(RAPGEF4)
AROW: 112963929(RAPGEF4)
NPD: 112950323(RAPGEF4)
DNE: 112979077(RAPGEF4)
ASN: 102376494(RAPGEF4)
AMJ: 102568614(RAPGEF4)
CPOO: 109323037(RAPGEF4)
GGN: 109301694(RAPGEF4)
PSS: 102444117(RAPGEF4)
CMY: 102944298(RAPGEF4)
CPIC: 101939565(RAPGEF4)
TST: 117884859(RAPGEF4)
CABI: 116827216(RAPGEF4)
MRV: 120374757(RAPGEF4)
ACS: 100567156(rapgef4)
PVT: 110088585(RAPGEF4)
SUND: 121928870(RAPGEF4)
PBI: 103053910(RAPGEF4)
PMUR: 107290439(RAPGEF4)
TSR: 106551336(RAPGEF4)
PGUT: 117671562(RAPGEF4)
VKO: 123017010(RAPGEF4)
PMUA: 114606886(RAPGEF4)
ZVI: 118094642(RAPGEF4)
GJA: 107107055(RAPGEF4)
STOW: 125426059(RAPGEF4)
XLA: 108701373(rapgef4.L) 108702995(rapgef4.S)
XTR: 100497690(rapgef4)
NPR: 108800352(RAPGEF4)
RTEM: 120944439(RAPGEF4)
BBUF: 121008125
BGAR: 122944653(RAPGEF4)
DRE: 559170(rapgef4)
PPRM: 120459799(rapgef4a) 120491575(rapgef4b)
MAMB: 125269808(rapgef4a) 125274151(rapgef4b)
IPU: 108266644(rapgef4a)
PHYP: 113525881(rapgef4)
SMEO: 124383164(rapgef4a)
TFD: 113654530(rapgef4a)
AMEX: 103032232 103034068(rapgef4)
EEE: 113580024 113588392(rapgef4)
TRU: 101065114(rapgef4) 101070245
LCO: 104927784(rapgef4) 104932605
CGOB: 115022857 115026764(rapgef4)
ELY: 117251637(rapgef4) 117272549
EFO: 125899934(rapgef4a) 125902486
PLEP: 121948803(rapgef4a) 121951212
SLUC: 116037213 116048428(rapgef4a)
ECRA: 117952605(rapgef4) 117953716
PFLV: 114564554(rapgef4) 114564996
GAT: 120816034 120834404(rapgef4a)
PPUG: 119209246 119228636(rapgef4a)
MSAM: 119902204 119904105(rapgef4a)
CUD: 121519779 121522485(rapgef4a)
ALAT: 119011472 119025409(rapgef4a)
ONL: 100689894 100695746(rapgef4)
OAU: 116316203 116322950(rapgef4a)
OML: 112147447 112155522(rapgef4a)
XMA: 102217330 102228535(rapgef4)
PFOR: 103134298(rapgef4) 103147034
PLAI: 106946958(rapgef4) 106961733
GAF: 122839682(rapgef4a) 122841093
CVG: 107085744 107091853(rapgef4)
CTUL: 119773841 119797528(rapgef4a)
GMU: 124869392 124871919(rapgef4a)
NFU: 107384114 107390013(rapgef4)
KMR: 108239540 108239698(rapgef4a)
NWH: 119414635 119419154(rapgef4a)
MCEP: 125011243 125017392(rapgef4a)
SSEN: 122765254(rapgef4a) 122771580
HHIP: 117755448(rapgef4) 117777823
HSP: 118118428 118120570(rapgef4a)
LCF: 108883636 108888702(rapgef4)
SDU: 111218206(rapgef4) 111228847
SLAL: 111668523(rapgef4) 111671130
XGL: 120798593 120801397(rapgef4a)
HCQ: 109507461 109507910(rapgef4)
BPEC: 110166573(rapgef4) 110173508
MALB: 109958072(rapgef4) 109969253
BSPL: 114843849 114847209(rapgef4a)
OGO: 124041551 124043170(rapgef4a) 124043863
ELS: 105007217 105016205(rapgef4)
SFM: 108920347 108920713(rapgef4)
AANG: 118223290(rapgef4)
LOC: 102688111(rapgef4)
LCM: 102366727(RAPGEF4)
CMK: 103176454(rapgef4a)
RTP: 109921268
BFO: 118424000
BBEL: 109474534
CIN: 100186896
SCLV: 120338473
SPU: 579050
APLC: 110973481
SKO: 100373735
DME: Dmel_CG34392(Epac)
DER: 6540983
DSI: Dsimw501_GD10302(Dsim_GD10302)
DSR: 110189781
DPO: 6898079
DPE: 6590280
DMN: 108160374
DWI: 6643336
DGR: 6559823
DAZ: 108614880
DNV: 108653799
DHE: 111601122
CCAT: 101451839
BOD: 106617320
MDE: 101899941
SCAC: 106087471
LCQ: 111681708
HIS: 119649168
ACOZ: 120954006
AARA: 120894130
ASTE: 118514493
AAG: 5573236
AALB: 109423294
CPII: 120423495
CNS: 116352135
BCOO: 119081367
TCA: 661613
DPA: 109539619
SOY: 115890798
ATD: 109609621
AGB: 108912795
LDC: 111506459
NVL: 108564753
PPYR: 116176076
OTU: 111419213
API: 100162065
DNX: 107163321
AGS: 114131920
RMD: 113551411
BTAB: 109044228
CLEC: 106668425
HHAL: 106682206
FOC: 113207618
TPAL: 117645704
ZNE: 110836465
CSEC: 111867584
FCD: 110846921
DMK: 116918971
PVM: 113819322
PJA: 122254571
HAME: 121860080
PCLA: 123760276
PTRU: 123503082
PPOI: 119096759
DSV: 119441883
RSAN: 119386996
RMP: 119178506
VDE: 111252027
VJA: 111269305
TUT: 107363025
DPTE: 113792243
DFR: 124499241
CSCU: 111621959
PTEP: 107457381
SDM: 118184275
CEL: CELE_T20G5.5(epac-1)
CBR: CBG_09801(Cbr-epac-1)
BMY: BM_BM5869(Bma-epac-1)
TSP: Tsp_01532
PCAN: 112564521
BGT: 106074727
GAE: 121380852
HRF: 124110717
HRJ: 124281639
CRG: 105320113
MYI: 110442375
PMAX: 117324132
OBI: 106867327
OSN: 115210368
NVE: 5508916
EPA: 110238364
ATEN: 116296698
ADF: 107350554
AMIL: 114946958
PDAM: 113675988
SPIS: 111323510
DGT: 114538354
XEN: 124441892
AQU: 100638923
 » show all
Reference
  Authors
Gloerich M, Bos JL
  Title
Epac: defining a new mechanism for cAMP action.
  Journal
Annu Rev Pharmacol Toxicol 50:355-75 (2010)
DOI:10.1146/annurev.pharmtox.010909.105714
Reference
PMID:9856955
  Authors
Kawasaki H, Springett GM, Mochizuki N, Toki S, Nakaya M, Matsuda M, Housman DE, Graybiel AM
  Title
A family of cAMP-binding proteins that directly activate Rap1.
  Journal
Science 282:2275-9 (1998)
DOI:10.1126/science.282.5397.2275
  Sequence
[hsa:11069]
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