KEGG   PATHWAY: pcao04622
Entry
pcao04622                   Pathway                                
Name
RIG-I-like receptor signaling pathway - Phalacrocorax carbo (great cormorant)
Description
Specific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular viral replication is recognized by a family of cytosolic RNA helicases termed RIG-I-like receptors (RLRs). The RLR proteins include RIG-I, MDA5, and LGP2 and are expressed in both immune and nonimmune cells. Upon recognition of viral nucleic acids, RLRs recruit specific intracellular adaptor proteins to initiate signaling pathways that lead to the synthesis of type I interferon and other inflammatory cytokines, which are important for eliminating viruses.
Class
Organismal Systems; Immune system
Pathway map
pcao04622  RIG-I-like receptor signaling pathway
pcao04622

Organism
Phalacrocorax carbo (great cormorant) [GN:pcao]
Gene
104039496  DDX58; probable ATP-dependent RNA helicase DDX58 [KO:K12646] [EC:5.6.2.6]
104042610  IFIH1; interferon-induced helicase C domain-containing protein 1 [KO:K12647] [EC:5.6.2.6]
104039777  ZNFX1; NFX1-type zinc finger-containing protein 1 [KO:K27391]
104044683  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
104044932  TRAF family member-associated NF-kappa-B activator-like [KO:K12650]
104051869  AZI2; LOW QUALITY PROTEIN: 5-azacytidine-induced protein 2 [KO:K12651]
104047645  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
104039528  interferon epsilon-like [KO:K05414]
104050721  interferon-like [KO:K05415]
104041883  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
104041064  FADD; FAS-associated death domain protein [KO:K02373]
104049000  RIPK1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
104042978  caspase-8-like [KO:K04398] [EC:3.4.22.61]
104051994  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
104042979  CASP10; caspase-10 [KO:K04400] [EC:3.4.22.63]
104041028  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
104039708  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
104040479  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
104053716  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
104048946  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
104040114  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
104039330  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
104051671  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
104053402  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
104043989  mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
104049434  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
104048216  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
104053513  mitogen-activated protein kinase 11-like [KO:K04441] [EC:2.7.11.24]
104045500  LOW QUALITY PROTEIN: mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
104051094  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
104044191  interleukin-8-like [KO:K10030]
104051162  interleukin-8 [KO:K10030]
104051163  interleukin-8-like [KO:K10030]
104051164  LOW QUALITY PROTEIN: interleukin-8-like [KO:K10030]
104042903  IL12A; interleukin-12 subunit alpha [KO:K05406]
104053283  IL12B; interleukin-12 subunit beta [KO:K05425]
104044916  ADAR; double-stranded RNA-specific adenosine deaminase [KO:K12968] [EC:3.5.4.37]
104042399  TRIM25; E3 ubiquitin/ISG15 ligase TRIM25 [KO:K10652] [EC:2.3.2.27]
104043510  ubiquitin carboxyl-terminal hydrolase CYLD-like [KO:K08601] [EC:3.4.19.12]
104044582  ubiquitin carboxyl-terminal hydrolase CYLD-like [KO:K08601] [EC:3.4.19.12]
104040876  RNF125; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase RNF125 [KO:K12170] [EC:2.3.2.27]
104044297  ATG5; autophagy protein 5 [KO:K08339]
104045550  NLRX1; LOW QUALITY PROTEIN: NLR family member X1 [KO:K12653]
104053742  TMEM173; stimulator of interferon genes protein [KO:K12654]
104045874  SIKE1; suppressor of IKBKE 1 [KO:K12656]
104048086  ATP-dependent RNA helicase DDX3X [KO:K11594] [EC:5.6.2.7]
104042958  PIN1; peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 [KO:K09578] [EC:5.2.1.8]
Compound
C00046  RNA
Reference
PMID:15208624
  Authors
Yoneyama M, Kikuchi M, Natsukawa T, Shinobu N, Imaizumi T, Miyagishi M, Taira K, Akira S, Fujita T
  Title
The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses.
  Journal
Nat Immunol 5:730-7 (2004)
DOI:10.1038/ni1087
Reference
PMID:18272355
  Authors
Takeuchi O, Akira S
  Title
MDA5/RIG-I and virus recognition.
  Journal
Curr Opin Immunol 20:17-22 (2008)
DOI:10.1016/j.coi.2008.01.002
Reference
PMID:19120475
  Authors
Yoneyama M, Fujita T
  Title
RNA recognition and signal transduction by RIG-I-like receptors.
  Journal
Immunol Rev 227:54-65 (2009)
DOI:10.1111/j.1600-065X.2008.00727.x
Reference
PMID:19539500
  Authors
Nakhaei P, Genin P, Civas A, Hiscott J
  Title
RIG-I-like receptors: sensing and responding to RNA virus infection.
  Journal
Semin Immunol 21:215-22 (2009)
DOI:10.1016/j.smim.2009.05.001
Reference
PMID:18549796
  Authors
Moore CB, Ting JP
  Title
Regulation of mitochondrial antiviral signaling pathways.
  Journal
Immunity 28:735-9 (2008)
DOI:10.1016/j.immuni.2008.05.005
Reference
PMID:19615405
  Authors
Barral PM, Sarkar D, Su ZZ, Barber GN, DeSalle R, Racaniello VR, Fisher PB
  Title
Functions of the cytoplasmic RNA sensors RIG-I and MDA-5: key regulators of innate immunity.
  Journal
Pharmacol Ther 124:219-34 (2009)
DOI:10.1016/j.pharmthera.2009.06.012
Reference
PMID:19120476
  Authors
Schlee M, Hartmann E, Coch C, Wimmenauer V, Janke M, Barchet W, Hartmann G
  Title
Approaching the RNA ligand for RIG-I?
  Journal
Immunol Rev 227:66-74 (2009)
DOI:10.1111/j.1600-065X.2008.00724.x
Reference
PMID:18591413
  Authors
Saito T, Gale M Jr
  Title
Differential recognition of double-stranded RNA by RIG-I-like receptors in antiviral immunity.
  Journal
J Exp Med 205:1523-7 (2008)
DOI:10.1084/jem.20081210
Reference
PMID:19076341
  Authors
Kawai T, Akira S
  Title
Toll-like receptor and RIG-I-like receptor signaling.
  Journal
Ann N Y Acad Sci 1143:1-20 (2008)
DOI:10.1196/annals.1443.020
Reference
PMID:18439848
  Authors
Michallet MC, Meylan E, Ermolaeva MA, Vazquez J, Rebsamen M, Curran J, Poeck H, Bscheider M, Hartmann G, Konig M, Kalinke U, Pasparakis M, Tschopp J
  Title
TRADD protein is an essential component of the RIG-like helicase antiviral pathway.
  Journal
Immunity 28:651-61 (2008)
DOI:10.1016/j.immuni.2008.03.013
Reference
PMID:18984593
  Authors
Yoshida R, Takaesu G, Yoshida H, Okamoto F, Yoshioka T, Choi Y, Akira S, Kawai T, Yoshimura A, Kobayashi T
  Title
TRAF6 and MEKK1 play a pivotal role in the RIG-I-like helicase antiviral pathway.
  Journal
J Biol Chem 283:36211-20 (2008)
DOI:10.1074/jbc.M806576200
Reference
PMID:19224920
  Authors
Mikkelsen SS, Jensen SB, Chiliveru S, Melchjorsen J, Julkunen I, Gaestel M, Arthur JS, Flavell RA, Ghosh S, Paludan SR
  Title
RIG-I-mediated activation of p38 MAPK is essential for viral induction of interferon and activation of dendritic cells: dependence on TRAF2 and TAK1.
  Journal
J Biol Chem 284:10774-82 (2009)
DOI:10.1074/jbc.M807272200
Reference
PMID:32668226
  Authors
Liu G, Gack MU
  Title
Distinct and Orchestrated Functions of RNA Sensors in Innate Immunity.
  Journal
Immunity 53:26-42 (2020)
DOI:10.1016/j.immuni.2020.03.017
Related
pathway
pcao04010  MAPK signaling pathway
pcao04120  Ubiquitin mediated proteolysis
pcao04210  Apoptosis
KO pathway
ko04622   
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