KEGG   PATHWAY: pfor04144
Entry
pfor04144                   Pathway                                
Name
Endocytosis - Poecilia formosa (Amazon molly)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
pfor04144  Endocytosis
pfor04144

Other DBs
GO: 0006897
Organism
Poecilia formosa (Amazon molly) [GN:pfor]
Gene
103138717  arf6; ADP-ribosylation factor 6 [KO:K07941]
103152670  ADP-ribosylation factor 6 [KO:K07941]
103155185  phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
103151221  phosphatidylinositol 4-phosphate 5-kinase type-1 gamma-like isoform X1 [KO:K00889] [EC:2.7.1.68]
103130968  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha-like isoform X2 [KO:K00889] [EC:2.7.1.68]
103140821  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha-like isoform X1 [KO:K00889] [EC:2.7.1.68]
103154527  pip5k1b; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
103142964  phosphatidylinositol 4-phosphate 5-kinase type-1 beta-like isoform X2 [KO:K00889] [EC:2.7.1.68]
103153974  phosphatidylinositol 4-phosphate 5-kinase-like protein 1 [KO:K13712] [EC:2.7.1.68]
103141943  phosphatidylinositol 4-phosphate 5-kinase-like protein 1 [KO:K13712] [EC:2.7.1.68]
103130056  phospholipase D1-like [KO:K01115] [EC:3.1.4.4]
103146532  pld1; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
103145637  phospholipase D1-like [KO:K01115] [EC:3.1.4.4]
103140038  dynamin-3-like [KO:K01528] [EC:3.6.5.5]
103156292  dynamin-1-like isoform X2 [KO:K01528] [EC:3.6.5.5]
103149917  dnm1; dynamin-1 isoform X1 [KO:K01528] [EC:3.6.5.5]
103137059  dnm3; dynamin-3 isoform X1 [KO:K01528] [EC:3.6.5.5]
103151998  dnm2; dynamin-2 isoform X5 [KO:K23484] [EC:3.6.5.5]
103154155  dynamin-2-like isoform X1 [KO:K23484] [EC:3.6.5.5]
103148743  clathrin light chain A isoform X1 [KO:K04644]
103144534  cltb; clathrin light chain B isoform X3 [KO:K04645]
103145869  clathrin heavy chain 1-like isoform X4 [KO:K04646]
103145870  clathrin heavy chain 1-like isoform X4 [KO:K04646]
103154595  clathrin heavy chain 1 isoform X4 [KO:K04646]
103142087  cltc; clathrin heavy chain 1 isoform X3 [KO:K04646]
103131521  AP-2 complex subunit alpha-2-like isoform X1 [KO:K11824]
103149205  AP-2 complex subunit alpha-2 isoform X2 [KO:K11824]
103130815  AP-1 complex subunit beta-1 [KO:K11825]
103147009  ap2m1; AP-2 complex subunit mu isoform X2 [KO:K11826]
103136270  ap2s1; AP-2 complex subunit sigma [KO:K11827]
103138223  ehd2; EH domain-containing protein 2 isoform X1 [KO:K12469]
103152918  EH domain-containing protein 2-like [KO:K12469]
103130834  TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
103144447  tgfbr2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
103136959  TGF-beta receptor type-2-like isoform X1 [KO:K04388] [EC:2.7.11.30]
103151759  zinc finger FYVE domain-containing protein 16 [KO:K04679]
103148570  zfyve9; zinc finger FYVE domain-containing protein 9 isoform X1 [KO:K04679]
103142563  zinc finger FYVE domain-containing protein 9-like isoform X1 [KO:K04679]
103152383  mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
103146727  mothers against decapentaplegic homolog 2-like [KO:K04500]
103146174  mothers against decapentaplegic homolog 3 [KO:K23605]
103140049  tfrc; transferrin receptor protein 1 [KO:K06503]
103140536  transferrin receptor protein 1-like isoform X1 [KO:K06503]
103135727  egfr; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
103156750  melanoma receptor tyrosine-protein kinase isoform X1 [KO:K04361] [EC:2.7.10.1]
103137117  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
103137630  fibroblast growth factor receptor 2-like isoform X1 [KO:K05093] [EC:2.7.10.1]
103149422  fgfr3; fibroblast growth factor receptor 3 isoform X2 [KO:K05094] [EC:2.7.10.1]
103131912  fibroblast growth factor receptor 4-like isoform X1 [KO:K05095] [EC:2.7.10.1]
103133810  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
103149868  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
103145535  E3 ubiquitin-protein ligase CBL-like [KO:K04707] [EC:2.3.2.27]
103136255  cbl; E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
103139241  E3 ubiquitin-protein ligase CBL isoform X3 [KO:K22518] [EC:2.3.2.27]
103140537  sh3kbp1; SH3 domain-containing kinase-binding protein 1 isoform X1 [KO:K12470]
103151233  sh3gl1; endophilin-A2 isoform X1 [KO:K11247]
103130753  endophilin-A1-like isoform X1 [KO:K11247]
103148646  sh3gl3; endophilin-A3 isoform X1 [KO:K11247]
103142547  endophilin-A2-like [KO:K11247]
103129331  endophilin-A1 [KO:K11247]
103146545  endophilin-B1-like [KO:K11248]
103147999  endophilin-B1 [KO:K11248]
103141914  endophilin-B2-like isoform X6 [KO:K21269]
103153975  sh3glb2; endophilin-B2 [KO:K21269]
103154120  myc box-dependent-interacting protein 1-like isoform X7 [KO:K12562]
103156547  myc box-dependent-interacting protein 1-like isoform X1 [KO:K12562]
103151815  epn2; epsin-2 isoform X1 [KO:K12471]
103146421  epsin-1-like isoform X1 [KO:K12471]
103140912  epn3; epsin-3 isoform X1 [KO:K12471]
103156326  epsin-3-like isoform X1 [KO:K12471]
103136688  epsin-1-like isoform X2 [KO:K12471]
103138471  epidermal growth factor receptor substrate 15 isoform X1 [KO:K12472]
103132514  uncharacterized protein LOC103132514 isoform X1 [KO:K12472]
103146064  epidermal growth factor receptor substrate 15-like 1 isoform X4 [KO:K12472]
103139919  spg20; spartin isoform X1 [KO:K19366]
103140009  spartin-like isoform X1 [KO:K19366]
103149456  LOW QUALITY PROTEIN: spartin-like [KO:K19366]
103149462  LOW QUALITY PROTEIN: spartin-like [KO:K19366]
103153810  nedd4; E3 ubiquitin-protein ligase NEDD4 isoform X3 [KO:K10591] [EC:2.3.2.26]
103142784  nedd4l; E3 ubiquitin-protein ligase NEDD4-like [KO:K13305] [EC:2.3.2.26]
103154036  mdm2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
103153578  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
103139134  rnf41; E3 ubiquitin-protein ligase NRDP1 [KO:K11981] [EC:2.3.2.27]
103156105  E3 ubiquitin-protein ligase Itchy-like [KO:K05632] [EC:2.3.2.26]
103150133  itch; E3 ubiquitin-protein ligase Itchy homolog [KO:K05632] [EC:2.3.2.26]
103130484  smurf2; E3 ubiquitin-protein ligase SMURF2 [KO:K04678] [EC:2.3.2.26]
103153444  smurf1; E3 ubiquitin-protein ligase SMURF1 isoform X2 [KO:K04678] [EC:2.3.2.26]
103143671  E3 ubiquitin-protein ligase SMURF2 [KO:K04678] [EC:2.3.2.26]
103143359  wwp1; NEDD4-like E3 ubiquitin-protein ligase WWP1 [KO:K05633] [EC:2.3.2.26]
103137717  low-density lipoprotein receptor-like [KO:K12473]
103143695  ldlr; low-density lipoprotein receptor [KO:K12473]
103137560  uncharacterized protein LOC103137560 isoform X1 [KO:K12474]
103138648  low density lipoprotein receptor adapter protein 1-B-like isoform X1 [KO:K12474]
103146039  low density lipoprotein receptor adapter protein 1-A-like isoform X2 [KO:K12474]
103146051  low density lipoprotein receptor adapter protein 1-A-like [KO:K12474]
103153652  ldlrap1; low density lipoprotein receptor adapter protein 1 isoform X1 [KO:K12474]
103135869  dab2; disabled homolog 2 isoform X1 [KO:K12475]
103156732  C-C chemokine receptor type 5-like isoform X1 [KO:K04180]
103138160  C-X-C chemokine receptor type 2-like [KO:K05050]
103138162  C-X-C chemokine receptor type 2-like [KO:K05050]
103138174  C-X-C chemokine receptor type 1-like [KO:K05050]
103151916  C-X-C chemokine receptor type 1-like [KO:K05050]
103150653  cxcr4; C-X-C chemokine receptor type 4 [KO:K04189]
103138353  C-X-C chemokine receptor type 4-like isoform X1 [KO:K04189]
103138356  C-X-C chemokine receptor type 4-like [KO:K04189]
103139383  grk1; rhodopsin kinase [KO:K00909] [EC:2.7.11.14]
103145650  rhodopsin kinase-like [KO:K00909] [EC:2.7.11.14]
103146304  rhodopsin kinase 2-like [KO:K00909] [EC:2.7.11.14]
103140333  rhodopsin kinase-like [KO:K00909] [EC:2.7.11.14]
103149510  grk7; rhodopsin kinase [KO:K00909] [EC:2.7.11.14]
103151765  adrbk2; beta-adrenergic receptor kinase 2 [KO:K00910] [EC:2.7.11.15]
103156162  beta-adrenergic receptor kinase 2 [KO:K00910] [EC:2.7.11.15]
103151736  G protein-coupled receptor kinase 6-like [KO:K08291] [EC:2.7.11.16]
103132125  grk4; G protein-coupled receptor kinase 4 isoform X4 [KO:K08291] [EC:2.7.11.16]
103146590  G protein-coupled receptor kinase 5-like isoform X1 [KO:K08291] [EC:2.7.11.16]
103147243  grk6; G protein-coupled receptor kinase 6 [KO:K08291] [EC:2.7.11.16]
103152990  beta-arrestin-1 [KO:K04439]
103156624  arrb2; beta-arrestin-2 isoform X1 [KO:K04439]
103143267  wiskott-Aldrich syndrome protein-like [KO:K23612]
103129169  neural Wiskott-Aldrich syndrome protein-like isoform X5 [KO:K23612]
103152710  wasl; neural Wiskott-Aldrich syndrome protein isoform X1 [KO:K23612]
103152452  actin-related protein 2-B isoform X2 [KO:K17260]
103145931  actin-related protein 2-like isoform X1 [KO:K17260]
103133049  actin-related protein 2-like isoform X1 [KO:K17260]
103156868  actin-related protein 3B-like [KO:K18584]
103130230  actr3; actin-related protein 3 [KO:K18584]
103139192  actin-related protein 3 [KO:K18584]
103132644  actin-related protein 2/3 complex subunit 1B-like [KO:K05757]
103154812  actin-related protein 2/3 complex subunit 1A [KO:K05757]
103154813  actin-related protein 2/3 complex subunit 1B-like [KO:K05757]
103156812  actin-related protein 2/3 complex subunit 1A-like isoform X1 [KO:K05757]
103151917  arpc2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
103147492  arpc3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
103145794  actin-related protein 2/3 complex subunit 4 [KO:K05755]
103143224  actin-related protein 2/3 complex subunit 4-like [KO:K05755]
103129992  actin-related protein 2/3 complex subunit 5-like [KO:K05754]
103137250  actin-related protein 2/3 complex subunit 5-like [KO:K05754]
103137252  actin-related protein 2/3 complex subunit 5-like [KO:K05754]
103145279  WAS/WASL-interacting protein family member 3-like isoform X1 [KO:K19475]
103153074  WAS/WASL-interacting protein family member 2-like isoform X1 [KO:K19475]
103153643  wipf2; WAS/WASL-interacting protein family member 2 [KO:K19475]
103154314  wipf1; WAS/WASL-interacting protein family member 1 [KO:K19475]
103130283  hspa8; heat shock cognate 71 kDa protein [KO:K03283]
103151051  heat shock 70 kDa protein-like [KO:K03283]
103132027  heat shock 70 kDa protein 1 [KO:K03283]
103139657  heat shock cognate 71 kDa protein-like [KO:K03283]
103139658  heat shock cognate 71 kDa protein-like [KO:K03283]
103137282  putative tyrosine-protein phosphatase auxilin [KO:K09526]
103137228  putative tyrosine-protein phosphatase auxilin isoform X1 [KO:K09526]
103144403  kiaa1033; WASH complex subunit 7 [KO:K18465]
103135215  kiaa0196; WASH complex subunit strumpellin [KO:K18464]
103147708  WASH complex subunit FAM21-like isoform X3 [KO:K18462]
103133793  WAS protein family homolog 1 [KO:K18461]
103156926  ccdc53; WASH complex subunit CCDC53 [KO:K18463]
103149399  capza2; F-actin-capping protein subunit alpha-2 [KO:K10364]
103129858  capza3; F-actin-capping protein subunit alpha-3 [KO:K10364]
103129832  capzb; F-actin-capping protein subunit beta isoform X1 [KO:K10365]
103156996  vps29; vacuolar protein sorting-associated protein 29 isoform X1 [KO:K18467]
103139649  vps26b; vacuolar protein sorting-associated protein 26B [KO:K18466]
103141044  vacuolar protein sorting-associated protein 26B-like [KO:K18466]
103136517  vps26a; vacuolar protein sorting-associated protein 26A [KO:K18466]
103130319  vps35; vacuolar protein sorting-associated protein 35 [KO:K18468]
103138694  sorting nexin-12 isoform X1 [KO:K17918]
103134585  snx3; sorting nexin-3 isoform X1 [KO:K17918]
103143588  usp8; ubiquitin carboxyl-terminal hydrolase 8 isoform X2 [KO:K11839] [EC:3.4.19.12]
103134877  STAM-binding protein-like A [KO:K11866] [EC:3.4.19.12]
103145773  ras-related protein Rab-7a-like [KO:K07897]
103147350  ras-related protein Rab-7a-like [KO:K07897]
103143223  ras-related protein Rab-7a [KO:K07897]
103140906  hgs; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X3 [KO:K12182]
103134831  stam2; signal transducing adapter molecule 2 [KO:K04705]
103135679  stam; signal transducing adapter molecule 1 [KO:K04705]
103151605  tsg101; tumor susceptibility gene 101 protein [KO:K12183]
103151610  tumor susceptibility gene 101 protein-like [KO:K12183]
103131093  multivesicular body subunit 12B-like [KO:K12186]
103146935  multivesicular body subunit 12B-like isoform X1 [KO:K12186]
103147257  multivesicular body subunit 12B-like [KO:K12186]
103154143  multivesicular body subunit 12A [KO:K12186]
103135115  vps28; vacuolar protein sorting-associated protein 28 homolog [KO:K12184]
103131279  vacuolar protein sorting-associated protein 37B-like [KO:K12185]
103152807  vps37b; vacuolar protein sorting-associated protein 37B [KO:K12185]
103153632  vacuolar protein sorting-associated protein 37C-like [KO:K12185]
103148734  vps37a; vacuolar protein sorting-associated protein 37A [KO:K12185]
103152211  snf8; vacuolar-sorting protein SNF8 [KO:K12188]
103140643  vps36; vacuolar protein-sorting-associated protein 36 [KO:K12190]
103151561  vps25; vacuolar protein-sorting-associated protein 25 [KO:K12189]
103153009  charged multivesicular body protein 6-like [KO:K12195]
103147035  charged multivesicular body protein 6-like [KO:K12195]
103140929  charged multivesicular body protein 6-like [KO:K12195]
103152539  charged multivesicular body protein 4b-like [KO:K12194]
103156040  chmp4b; charged multivesicular body protein 4b [KO:K12194]
103156962  charged multivesicular body protein 4b-like [KO:K12194]
103140471  charged multivesicular body protein 4c-like [KO:K24782]
103154767  chmp3; charged multivesicular body protein 3 isoform X1 [KO:K12193]
103152233  chmp2a; charged multivesicular body protein 2a [KO:K12191]
103141466  chmp2b; charged multivesicular body protein 2b [KO:K12192]
103148395  charged multivesicular body protein 7-like isoform X1 [KO:K15053]
103148399  charged multivesicular body protein 7-like isoform X1 [KO:K15053]
103152541  vacuolar protein sorting-associated protein 4A [KO:K12196]
103142423  vps4a; vacuolar protein sorting-associated protein 4A [KO:K12196]
103143024  vps4b; vacuolar protein sorting-associated protein 4B isoform X1 [KO:K12196]
103137085  vacuolar protein sorting-associated protein 4B-like [KO:K12196]
103146820  vta1; vacuolar protein sorting-associated protein VTA1 homolog [KO:K12199]
107836548  charged multivesicular body protein 1b-like [KO:K12197]
103139900  charged multivesicular body protein 1b-like [KO:K12197]
103133966  chmp1b; charged multivesicular body protein 1b [KO:K12197]
103129247  chmp1a; charged multivesicular body protein 1a [KO:K12197]
103135691  chmp5; charged multivesicular body protein 5 [KO:K12198]
103149800  charged multivesicular body protein 5 [KO:K12198]
103139326  ist1; IST1 homolog isoform X1 [KO:K19476]
103135062  pdcd6ip; programmed cell death 6-interacting protein isoform X1 [KO:K12200]
103149185  spg21; maspardin [KO:K19367]
103129229  igf2r; cation-independent mannose-6-phosphate receptor [KO:K06564]
103152618  snx2; sorting nexin-2 isoform X1 [KO:K17917]
103134532  sorting nexin-1-like [KO:K17917]
103135963  sorting nexin-1 [KO:K17917]
103134149  snx5; sorting nexin-5 [KO:K17920]
103147629  sorting nexin-6-like [KO:K17920]
103156178  snx6; sorting nexin-6 isoform X1 [KO:K17920]
103152501  proto-oncogene tyrosine-protein kinase Src-like isoform X2 [KO:K05704] [EC:2.7.10.2]
103134564  proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
103151608  GTPase HRas-like [KO:K02833]
103151612  hras; GTPase HRas [KO:K02833]
103147374  interleukin-2 receptor subunit beta-like isoform X2 [KO:K05069]
103156074  interleukin-2 receptor subunit beta-like isoform X1 [KO:K05069]
103156075  uncharacterized protein LOC103156075 [KO:K05069]
103133209  cytokine receptor common subunit gamma-like [KO:K05070]
103141865  cytokine receptor common subunit gamma isoform X1 [KO:K05070]
103138302  transforming protein RhoA [KO:K04513]
103154003  rho-related GTP-binding protein RhoA-B-like [KO:K04513]
103154017  rho-related GTP-binding protein RhoA-B-like [KO:K04513]
103154239  rho-related GTP-binding protein RhoA-C isoform X1 [KO:K04513]
103134577  rho-related GTP-binding protein RhoC-like [KO:K04513]
103149604  rho-related GTP-binding protein RhoA-D isoform X2 [KO:K04513]
103149647  rho-related GTP-binding protein RhoA-A-like [KO:K04513]
103133221  class I histocompatibility antigen, Gogo-C*0203 alpha chain-like [KO:K06751]
103133238  class I histocompatibility antigen, Gogo-C*0203 alpha chain-like [KO:K06751]
103146387  H-2 class I histocompatibility antigen, Q9 alpha chain-like isoform X1 [KO:K06751]
103146389  H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751]
103146390  major histocompatibility complex class I-related gene protein-like [KO:K06751]
107832861  H-2 class I histocompatibility antigen, Q9 alpha chain-like isoform X1 [KO:K06751]
103146391  LOW QUALITY PROTEIN: H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751]
103146392  H-2 class I histocompatibility antigen, Q9 alpha chain-like isoform X3 [KO:K06751]
103146393  major histocompatibility complex class I-related gene protein-like [KO:K06751]
103146409  major histocompatibility complex class I-related gene protein-like [KO:K06751]
103146410  major histocompatibility complex class I-related gene protein-like isoform X2 [KO:K06751]
103146414  major histocompatibility complex class I-related gene protein-like [KO:K06751]
103146415  major histocompatibility complex class I-related gene protein-like [KO:K06751]
103146462  major histocompatibility complex class I-related gene protein-like [KO:K06751]
103146413  major histocompatibility complex class I-related gene protein-like [KO:K06751]
103146460  major histocompatibility complex class I-related gene protein-like [KO:K06751]
107837608  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
103146412  zinc-alpha-2-glycoprotein-like [KO:K06751]
103146458  major histocompatibility complex class I-related gene protein-like [KO:K06751]
103146459  LOW QUALITY PROTEIN: zinc-alpha-2-glycoprotein-like [KO:K06751]
103149767  uncharacterized protein LOC103149767 [KO:K06751]
103149742  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
103149743  HLA class I histocompatibility antigen, B-38 alpha chain-like isoform X2 [KO:K06751]
103146277  folr2; folate receptor beta [KO:K13649]
103143699  riboflavin-binding protein-like [KO:K13649]
103150612  cav1; caveolin-1 [KO:K06278]
103150613  cav2; caveolin-2 [KO:K12958]
103150700  caveolin-2-like [KO:K12958]
103151330  caveolin-2-like [KO:K12958]
103137395  caveolin-2-like [KO:K12958]
103150699  cav3; caveolin-3 [KO:K12959]
103144161  EH domain-containing protein 3 [KO:K12476]
103156172  EH domain-containing protein 4-like isoform X1 [KO:K12477]
103133682  eea1; early endosome antigen 1 isoform X2 [KO:K12478]
103153896  rab5a; ras-related protein Rab-5A [KO:K07887]
103135088  ras-related protein Rab-5A [KO:K07887]
103156738  ras-related protein Rab-5B-like [KO:K07888]
103156740  ras-related protein Rab-5B-like [KO:K07888]
103142193  rab5c; ras-related protein Rab-5C [KO:K07889]
103142197  ras-related protein Rab-5C [KO:K07889]
103155714  ras-related protein Rab-5C-like [KO:K07889]
103146133  rabep1; rab GTPase-binding effector protein 1 isoform X1 [KO:K12480]
103145030  rbsn; rabenosyn-5 isoform X1 [KO:K12481]
103136493  rab4a; ras-related protein Rab-4A [KO:K07879]
103144530  rufy1; RUN and FYVE domain-containing protein 1 [KO:K12482]
103136506  rufy2; LOW QUALITY PROTEIN: RUN and FYVE domain-containing protein 2 [KO:K12482]
103136898  EH domain-containing protein 1-like [KO:K12483]
103147945  vps45; vacuolar protein sorting-associated protein 45 isoform X1 [KO:K12479]
103131760  sorting nexin-4-like isoform X1 [KO:K17919]
103133084  sorting nexin-4-like [KO:K17919]
103156543  sorting nexin-4-like [KO:K17919]
103146325  rab31; ras-related protein Rab-31 [KO:K07891]
103134558  ras-related protein Rab-22A [KO:K07891]
103134560  ras-related protein Rab-22A [KO:K07891]
103135097  ras-related protein Rab-10-like [KO:K07903]
103153996  ras-related protein Rab-10 [KO:K07903]
103138449  ras-related protein Rab-8A [KO:K07901]
103146060  ras-related protein Rab-8A [KO:K07901]
103156891  ras-related protein Rab-8A-like [KO:K07901]
103155910  ras-related protein Rab-35-like [KO:K07876]
103152411  rab35; ras-related protein Rab-35 isoform X1 [KO:K07876]
103150818  ras-related protein Rab-11A-like [KO:K07904]
103131161  ras-related protein Rab-11A [KO:K07904]
103147000  ras-related protein Rab-11B-like [KO:K07905]
103155165  ras-related protein Rab-11B-like [KO:K07905]
103155167  ras-related protein Rab-11B [KO:K07905]
103145996  rab11 family-interacting protein 1-like isoform X1 [KO:K12484]
103148235  rab11fip2; rab11 family-interacting protein 2 [KO:K12484]
103148761  rab11fip1; LOW QUALITY PROTEIN: rab11 family-interacting protein 1 [KO:K12484]
103149589  rab11 family-interacting protein 1-like isoform X1 [KO:K12484]
103150076  uncharacterized protein LOC103150076 isoform X1 [KO:K12484]
103150563  zfyve27; protrudin isoform X3 [KO:K19368]
103138015  kinesin-1 heavy chain [KO:K10396]
103132717  kinesin heavy chain-like [KO:K10396]
103139009  kinesin heavy chain-like [KO:K10396]
103152093  kif5c; kinesin heavy chain [KO:K10396]
103143946  kinesin-1 heavy chain isoform X1 [KO:K10396]
103135827  kif5a; kinesin heavy chain isoform X2 [KO:K10396]
103137745  rab11fip4; rab11 family-interacting protein 4 isoform X1 [KO:K12485]
103154374  rab11 family-interacting protein 4A-like [KO:K12485]
103156079  rab11fip3; rab11 family-interacting protein 3 isoform X3 [KO:K12485]
103129117  partitioning defective 3 homolog isoform X1 [KO:K04237]
103143381  pard3; partitioning defective 3 homolog isoform X2 [KO:K04237]
103130160  partitioning defective 6 homolog alpha-like isoform X1 [KO:K06093]
103135162  partitioning defective 6 homolog gamma [KO:K06093]
103156112  pard6b; partitioning defective 6 homolog beta [KO:K06093]
103150454  prkcz; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
103146080  prkci; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
103144004  cell division control protein 42 homolog isoform X1 [KO:K04393]
103144092  cell division control protein 42 homolog [KO:K04393]
103146449  cell division control protein 42 homolog [KO:K04393]
103136751  cell division control protein 42 homolog [KO:K04393]
103136753  cell division control protein 42 homolog isoform X1 [KO:K04393]
103136754  cell division control protein 42 homolog isoform X1 [KO:K04393]
103137613  stromal membrane-associated protein 1-like isoform X1 [KO:K12486]
103133460  stromal membrane-associated protein 1-like [KO:K12486]
103131348  stromal membrane-associated protein 1-like [KO:K12486]
103145250  stromal membrane-associated protein 2-like [KO:K12486]
103148125  git1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
103149222  ARF GTPase-activating protein GIT2-like isoform X6 [KO:K12487]
103142882  git2; ARF GTPase-activating protein GIT2 isoform X6 [KO:K12487]
103144225  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 [KO:K12488]
103146801  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2-like isoform X1 [KO:K12488]
103147271  asap2; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X4 [KO:K12488]
103134691  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2-like isoform X2 [KO:K12488]
103149780  asap1; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12488]
103137521  acap1; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 [KO:K12489]
103150918  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3-like [KO:K12489]
103150983  acap3; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12489]
103130490  acap2; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X2 [KO:K12489]
103139499  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3-like isoform X1 [KO:K12489]
103146283  arap1; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K18439]
103137544  arap2; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 [KO:K18440]
103141071  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1-like [KO:K18440]
103155966  arap3; LOW QUALITY PROTEIN: arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 [KO:K12490]
103150926  agap1; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X5 [KO:K12491]
103135768  agap3; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12491]
103130460  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1-like isoform X1 [KO:K17848]
103129588  agap2; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 [KO:K17848]
103144310  arfgap1; ADP-ribosylation factor GTPase-activating protein 1 isoform X2 [KO:K12492]
103151130  arfgap2; ADP-ribosylation factor GTPase-activating protein 2 isoform X2 [KO:K12493]
103156933  arfgap3; ADP-ribosylation factor GTPase-activating protein 3 [KO:K12493]
103155334  uncharacterized protein LOC103155334 isoform X1 [KO:K12494]
103153124  PH and SEC7 domain-containing protein 1-like isoform X2 [KO:K12494]
103149273  PH and SEC7 domain-containing protein 2-like isoform X2 [KO:K12494]
103149731  PH and SEC7 domain-containing protein 2-like [KO:K12494]
103145094  IQ motif and SEC7 domain-containing protein 1 isoform X1 [KO:K12495]
103139168  IQ motif and SEC7 domain-containing protein 2-like [KO:K12495]
103146224  IQ motif and SEC7 domain-containing protein 3-like isoform X1 [KO:K12495]
103152742  IQ motif and SEC7 domain-containing protein 1-like isoform X2 [KO:K12495]
103133798  IQ motif and SEC7 domain-containing protein 3 isoform X1 [KO:K12495]
103153489  IQ motif and SEC7 domain-containing protein 2-like isoform X1 [KO:K12495]
103145155  cytohesin-1 isoform X2 [KO:K18441]
103145156  cytohesin-1-like isoform X2 [KO:K18441]
103140956  cytohesin-1 isoform X1 [KO:K18441]
103141618  cytohesin-3-like [KO:K18441]
103141729  cytohesin-3-like [KO:K18441]
103156058  cyth4; cytohesin-4 [KO:K18441]
103136465  cytohesin-3-like [KO:K18441]
103143117  cytohesin-3 [KO:K18441]
103136639  cytohesin-2 isoform X1 [KO:K18441]
103153102  cytohesin-2-like [KO:K18441]
103139706  arfgef1; brefeldin A-inhibited guanine nucleotide-exchange protein 1 isoform X1 [KO:K18442]
103156113  arfgef2; brefeldin A-inhibited guanine nucleotide-exchange protein 2 [KO:K18442]
103155784  gbf1; Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X1 [KO:K18443]
103154467  ADP-ribosylation factor 1-like [KO:K07937]
103151023  ADP-ribosylation factor 1 [KO:K07937]
103135756  arf1; ADP-ribosylation factor 1 isoform X1 [KO:K07937]
103142236  ADP-ribosylation factor 1-like [KO:K07937]
103141121  ADP-ribosylation factor 3 isoform X2 [KO:K07938]
103143203  ADP-ribosylation factor 3 [KO:K07938]
103140198  ADP-ribosylation factor 4 [KO:K07939]
103133752  ADP-ribosylation factor 4-like [KO:K07939]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
PMID:19007773
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
PMID:18647649
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
PMID:15261671
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
PMID:19325624
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
PMID:20110990
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
PMID:15687999
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
PMID:19924646
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
PMID:16203612
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
PMID:19696797
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
PMID:22193161
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
Related
pathway
pfor04060  Cytokine-cytokine receptor interaction
pfor04070  Phosphatidylinositol signaling system
pfor04130  SNARE interactions in vesicular transport
pfor04142  Lysosome
pfor04350  TGF-beta signaling pathway
KO pathway
ko04144   
LinkDB

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