KEGG   PATHWAY: pmua04540
Entry
pmua04540                   Pathway                                
Name
Gap junction - Podarcis muralis (common wall lizard)
Description
Gap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels', each containing six connexins, contributed by each neighboring cell. These channels permit the direct transfer of small molecules including ions, amino acids, nucleotides, second messengers and other metabolites between adjacent cells. Gap junctional communication is essential for many physiological events, including embryonic development, electrical coupling, metabolic transport, apoptosis, and tissue homeostasis. Communication through Gap Junction is sensitive to a variety of stimuli, including changes in the level of intracellular Ca2+, pH, transjunctional applied voltage and phosphorylation/dephosphorylation processes. This figure represents the possible activation routes of different protein kinases involved in Cx43 and Cx36 phosphorylation.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
pmua04540  Gap junction
pmua04540

Other DBs
GO: 0005921
Organism
Podarcis muralis (common wall lizard) [GN:pmua]
Gene
114594100  GJA1; LOW QUALITY PROTEIN: gap junction alpha-1 protein [KO:K07372]
114593206  GJD2; gap junction delta-2 protein [KO:K07373]
114603302  gap junction delta-2 protein-like [KO:K07373]
114587543  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
114585716  lysophosphatidic acid receptor 3-like [KO:K04289]
114591516  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
114599173  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha isoform X1 [KO:K04630]
114605041  GNAI1; LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
114584301  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
114605091  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
114595668  PDGFD; platelet-derived growth factor D [KO:K05450]
114603981  PDGFC; platelet-derived growth factor C [KO:K05450]
114604055  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
114604335  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
114591343  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
114607096  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
114590607  growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
114591118  SOS2; LOW QUALITY PROTEIN: son of sevenless homolog 2 [KO:K03099]
114594815  SOS1; son of sevenless homolog 1 [KO:K03099]
114599845  HRAS; GTPase HRas isoform X1 [KO:K02833]
114608097  GTPase HRas-like [KO:K07827]
114605215  KRAS; GTPase KRas isoform X1 [KO:K07827]
114599398  NRAS; GTPase NRas [KO:K07828]
114591641  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
114584876  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
114588247  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
114586322  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
114582021  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
114599561  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
114603537  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
114584990  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
114582827  MAPK7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
114602742  tubulin alpha-1D chain [KO:K07374]
114602811  tubulin alpha-4A chain [KO:K07374]
114587623  tubulin alpha-1B chain [KO:K07374]
114587624  tubulin alpha-1A chain [KO:K07374]
114587625  tubulin alpha-1C chain-like [KO:K07374]
114587630  tubulin alpha-1C chain [KO:K07374]
114605478  TUBAL3; tubulin alpha chain-like 3 isoform X1 [KO:K07374]
114597763  tubulin alpha-3 chain isoform X1 [KO:K07374]
114597767  LOW QUALITY PROTEIN: tubulin alpha-3 chain-like [KO:K07374]
114599454  tubulin alpha-8 chain [KO:K07374]
114605600  tubulin alpha-4 chain-like [KO:K07374]
114605624  tubulin alpha-8 chain [KO:K07374]
114587477  TUBB4A; tubulin beta-4A chain [KO:K07375]
114600760  TUBB6; tubulin beta-6 chain isoform X1 [KO:K07375]
114599689  TUBB1; tubulin beta-1 chain isoform X1 [KO:K07375]
114602926  TUBB3; tubulin beta-3 chain [KO:K07375]
114600949  tubulin beta-1 chain-like [KO:K07375]
114600950  tubulin beta-1 chain-like [KO:K07375]
114600951  tubulin beta-2 chain isoform X1 [KO:K07375]
114600952  tubulin beta-1 chain-like [KO:K07375]
114591987  TUBB; tubulin beta chain [KO:K07375]
114589912  CSNK1D; casein kinase I isoform X1 [KO:K08959] [EC:2.7.11.1]
114597159  CDK1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
114584155  TJP1; tight junction protein ZO-1 isoform X1 [KO:K05701]
114597471  ADRB1; beta-1 adrenergic receptor [KO:K04141]
114591203  DRD1; D(1A) dopamine receptor [KO:K04144]
114599685  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
114585861  DRD2; D(2) dopamine receptor [KO:K04145]
114607043  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
114601220  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
114594931  adenylate cyclase type 3-like [KO:K08043] [EC:4.6.1.1]
114581737  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
114603889  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
114592965  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
114602227  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
114600245  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
114584296  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
114598815  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
114590804  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
114589285  5-hydroxytryptamine receptor 2A-like [KO:K04157]
114598199  HTR2B; 5-hydroxytryptamine receptor 2B [KO:K04157]
114594222  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
114595611  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
114588282  guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
114606268  guanine nucleotide-binding protein G(q) subunit alpha-like [KO:K04634]
114593658  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
114593659  PLCB4; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
114593800  PLCB2; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
114586167  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
114591812  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
114604922  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
114599227  ITPR3; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
114588142  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
114583925  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
114581744  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
114595672  GUCY1A2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
114603793  GUCY1A1; guanylate cyclase soluble subunit alpha-1 [KO:K12318] [EC:4.6.1.2]
114593729  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
114597802  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
114604018  GUCY1B1; guanylate cyclase soluble subunit beta-1 [KO:K12319] [EC:4.6.1.2]
114597269  PRKG1; cGMP-dependent protein kinase 1 isoform X1 [KO:K07376] [EC:2.7.11.12]
114604385  PRKG2; cGMP-dependent protein kinase 2 [KO:K19477] [EC:2.7.11.12]
114595005  cGMP-dependent protein kinase 1-like isoform X1 [KO:K19477] [EC:2.7.11.12]
Compound
C00025  L-Glutamate
C00076  Calcium cation
C00165  Diacylglycerol
C00533  Nitric oxide
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00681  1-Acyl-sn-glycerol 3-phosphate
C00780  Serotonin
C00942  3',5'-Cyclic GMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C03758  Dopamine
Reference
PMID:14506308
  Authors
Saez JC, Berthoud VM, Branes MC, Martinez AD, Beyer EC.
  Title
Plasma membrane channels formed by connexins: their regulation and functions.
  Journal
Physiol Rev 83:1359-400 (2003)
DOI:10.1152/physrev.00007.2003
Reference
PMID:15033580
  Authors
Warn-Cramer BJ, Lau AF.
  Title
Regulation of gap junctions by tyrosine protein kinases.
  Journal
Biochim Biophys Acta 1662:81-95 (2004)
DOI:10.1016/j.bbamem.2003.10.018
Reference
PMID:9535909
  Authors
Warn-Cramer BJ, Cottrell GT, Burt JM, Lau AF.
  Title
Regulation of connexin-43 gap junctional intercellular communication by mitogen-activated protein kinase.
  Journal
J Biol Chem 273:9188-96 (1998)
DOI:10.1074/jbc.273.15.9188
Reference
PMID:10751659
  Authors
Roerig B, Feller MB.
  Title
Neurotransmitters and gap junctions in developing neural circuits.
  Journal
Brain Res Brain Res Rev 32:86-114 (2000)
DOI:10.1016/S0165-0173(99)00069-7
Reference
PMID:10873290
  Authors
Hatton GI.
  Title
Synaptic modulation of neuronal coupling.
  Journal
Cell Biol Int 22:765-80 (1998)
DOI:10.1006/cbir.1998.0386
Reference
PMID:12566218
  Authors
Cruciani V, Mikalsen SO.
  Title
Connexins, gap junctional intercellular communication and kinases.
  Journal
Biol Cell 94:433-43 (2002)
DOI:10.1016/S0248-4900(02)00014-X
Reference
PMID:15094344
  Authors
Giepmans BN.
  Title
Gap junctions and connexin-interacting proteins.
  Journal
Cardiovasc Res 62:233-45 (2004)
DOI:10.1016/j.cardiores.2003.12.009
Reference
PMID:15955302
  Authors
Laird DW.
  Title
Connexin phosphorylation as a regulatory event linked to gap junction internalization and degradation.
  Journal
Biochim Biophys Acta 1711:172-82 (2005)
DOI:10.1016/j.bbamem.2004.09.009
Reference
PMID:15033579
  Authors
Peracchia C.
  Title
Chemical gating of gap junction channels; roles of calcium, pH and calmodulin.
  Journal
Biochim Biophys Acta 1662:61-80 (2004)
DOI:10.1016/j.bbamem.2003.10.020
Reference
PMID:15033578
  Authors
Bukauskas FF, Verselis VK.
  Title
Gap junction channel gating.
  Journal
Biochim Biophys Acta 1662:42-60 (2004)
DOI:10.1016/j.bbamem.2004.01.008
Related
pathway
pmua04010  MAPK signaling pathway
pmua04020  Calcium signaling pathway
pmua04060  Cytokine-cytokine receptor interaction
pmua04070  Phosphatidylinositol signaling system
pmua04080  Neuroactive ligand-receptor interaction
KO pathway
ko04540   
LinkDB

DBGET integrated database retrieval system