KEGG   PATHWAY: pmua04010
Entry
pmua04010                   Pathway                                
Name
MAPK signaling pathway - Podarcis muralis (common wall lizard)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
pmua04010  MAPK signaling pathway
pmua04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Podarcis muralis (common wall lizard) [GN:pmua]
Gene
114581516  [KO:K04468] [EC:2.7.11.24]
114581569  TAOK2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
114581630  [KO:K05083] [EC:2.7.10.1]
114581680  RRAS; ras-related protein R-Ras [KO:K07830]
114581713  MAP3K3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
114581720  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
114581735  [KO:K05083] [EC:2.7.10.1]
114581744  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
114581752  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
114581835  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
114581922  [KO:K16342] [EC:3.1.1.4]
114581931  CACNG8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
114581979  [KO:K04438]
114582021  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
114582041  AREG; amphiregulin [KO:K09782]
114582060  [KO:K04355]
114582080  [KO:K16342] [EC:3.1.1.4]
114582091  CACNG7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
114582250  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
114582346  [KO:K16342] [EC:3.1.1.4]
114582363  [KO:K12457]
114582526  CACNG6; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
114582556  EREG; proepiregulin [KO:K09784]
114582576  [KO:K05454]
114582678  FGF21; fibroblast growth factor 21 [KO:K22429]
114582724  ARRB2; beta-arrestin-2 [KO:K04439]
114582760  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
114582772  [KO:K16342] [EC:3.1.1.4]
114582827  MAPK7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
114582942  [KO:K16342] [EC:3.1.1.4]
114583404  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
114583925  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
114583943  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
114583944  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
114584033  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
114584040  [KO:K16342] [EC:3.1.1.4]
114584096  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
114584301  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
114584540  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
114584544  CACNG3; voltage-dependent calcium channel gamma-3 subunit isoform X1 [KO:K04868]
114584719  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
114584851  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
114584876  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
114584984  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
114584990  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
114584997  FGF7; fibroblast growth factor 7 [KO:K04358]
114585088  [KO:K04526]
114585132  CRK; adapter molecule crk isoform X1 [KO:K04438]
114585209  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
114585296  NF1; LOW QUALITY PROTEIN: neurofibromin [KO:K08052]
114585343  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
114585620  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
114585704  HSPB1; heat shock protein beta-1 [KO:K04455]
114585725  TAOK1; serine/threonine-protein kinase TAO1 isoform X1 [KO:K04429] [EC:2.7.11.1]
114585925  [KO:K16342] [EC:3.1.1.4]
114585959  [KO:K02187] [EC:3.4.22.56]
114585984  NLK; serine/threonine-protein kinase NLK isoform X1 [KO:K04468] [EC:2.7.11.24]
114586154  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
114586239  CRKL; crk-like protein [KO:K04438]
114586284  TAOK3; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
114586322  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
114586443  MAP3K11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
114586486  [KO:K20216] [EC:3.1.3.16 3.1.3.48]
114586583  EFNA4; ephrin-A4 [KO:K05462]
114586591  [KO:K13376]
114586605  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
114586656  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
114586685  EFNA1; ephrin-A1 isoform X1 [KO:K05462]
114586719  NR4A1; nuclear receptor subfamily 4 group A member 1 isoform X1 [KO:K04465]
114586742  [KO:K03283]
114586817  [KO:K03283]
114586844  VEGFB; vascular endothelial growth factor B [KO:K05448]
114586970  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 [KO:K04414] [EC:2.7.11.1]
114587106  RELA; transcription factor p65 [KO:K04735]
114587212  RPS6KA4; ribosomal protein S6 kinase alpha-4 isoform X1 [KO:K16510] [EC:2.7.11.1]
114587359  FLNA; filamin-A isoform X1 [KO:K04437]
114587380  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
114587447  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
114587594  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
114587683  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
114587704  DUSP9; LOW QUALITY PROTEIN: dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
114587749  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
114587799  [KO:K03158]
114587816  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
114588053  TEK; LOW QUALITY PROTEIN: angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
114588086  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
114588093  PSPN; persephin [KO:K25416]
114588119  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
114588125  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
114588133  CACNG5; voltage-dependent calcium channel gamma-5 subunit isoform X1 [KO:K04870]
114588142  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
114588143  [KO:K03158]
114588195  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
114588247  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
114588248  EFNA2; ephrin-A2 [KO:K05462]
114588308  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
114588340  [KO:K16342] [EC:3.1.1.4]
114588447  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
114588471  [KO:K04449]
114588545  NRTN; neurturin [KO:K25414]
114588550  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
114588594  FGF22; fibroblast growth factor 22 [KO:K04358]
114588691  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
114588860  [KO:K05096] [EC:2.7.10.1]
114588906  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
114589344  FGF16; fibroblast growth factor 16 isoform X1 [KO:K04358]
114589436  [KO:K16342] [EC:3.1.1.4]
114589532  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
114589702  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
114589737  [KO:K05467]
114590009  [KO:K03173] [EC:2.3.2.27]
114590202  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
114590607  [KO:K04364]
114590704  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
114590804  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
114590811  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
114590816  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
114590871  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 [KO:K04859]
114591042  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
114591047  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
114591118  SOS2; LOW QUALITY PROTEIN: son of sevenless homolog 2 [KO:K03099]
114591226  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
114591317  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
114591336  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
114591343  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
114591344  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
114591436  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
114591548  MAPKAPK3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
114591583  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
114591641  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
114591684  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
114591690  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
114591728  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
114591829  FOS; proto-oncogene c-Fos [KO:K04379]
114591899  PGF; placenta growth factor [KO:K16859]
114592029  [KO:K03173] [EC:2.3.2.27]
114592544  DAXX; death domain-associated protein 6 isoform X1 [KO:K02308]
114592791  [KO:K03156]
114592937  DDIT3; DNA damage-inducible transcript 3 protein isoform X1 [KO:K04452]
114592963  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
114593051  MAP3K12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
114593501  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
114593583  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
114593638  FGF18; LOW QUALITY PROTEIN: fibroblast growth factor 18 [KO:K04358]
114593734  ANGPT2; angiopoietin-2 [KO:K05466]
114593961  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
114594175  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
114594233  [KO:K16342] [EC:3.1.1.4]
114594237  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
114594260  [KO:K16342] [EC:3.1.1.4]
114594270  [KO:K16342] [EC:3.1.1.4]
114594287  [KO:K16342] [EC:3.1.1.4]
114594296  PLA2G4F; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
114594310  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
114594329  RPS6KA2; LOW QUALITY PROTEIN: ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
114594397  MAP3K21; mitogen-activated protein kinase kinase kinase 21 isoform X1 [KO:K17534] [EC:2.7.11.25]
114594443  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
114594505  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
114594528  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
114594643  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
114594660  TGFB2; transforming growth factor beta-2 proprotein [KO:K13376]
114594735  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
114594766  SRF; serum response factor isoform X1 [KO:K04378]
114594815  SOS1; son of sevenless homolog 1 [KO:K03099]
114594816  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
114595512  [KO:K04439]
114595565  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
114595668  PDGFD; platelet-derived growth factor D [KO:K05450]
114595727  FGF9; fibroblast growth factor 9 [KO:K04358]
114595759  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
114595760  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
114596120  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
114596232  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
114596264  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
114596400  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
114596401  IL1R1; interleukin-1 receptor type 1 [KO:K04386]
114596843  DUSP16; LOW QUALITY PROTEIN: dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
114596867  FGF3; fibroblast growth factor 3 [KO:K04358]
114596868  FGF4; fibroblast growth factor 4 [KO:K04358]
114596871  FGF19; fibroblast growth factor 19 [KO:K22603]
114596912  NTF3; LOW QUALITY PROTEIN: neurotrophin-3 [KO:K04356]
114596925  FGF6; fibroblast growth factor 6 [KO:K04358]
114596926  FGF23; fibroblast growth factor 23 [KO:K22428]
114596954  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
114596969  MAPK8; LOW QUALITY PROTEIN: mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
114596983  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
114597009  NFKB2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
114597022  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
114597095  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
114597199  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
114597296  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
114597424  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
114597493  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
114597563  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
114597691  MAP3K13; mitogen-activated protein kinase kinase kinase 13 isoform X1 [KO:K04422] [EC:2.7.11.25]
114597726  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
114597829  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
114597957  MECOM; histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
114598124  IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
114598486  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
114598511  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
114598597  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
114598629  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
114598815  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
114598872  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
114598873  GADD45A; LOW QUALITY PROTEIN: growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
114598878  PTPN5; tyrosine-protein phosphatase non-receptor type 5 isoform X1 [KO:K18018] [EC:3.1.3.48]
114598927  JUN; transcription factor AP-1 [KO:K04448]
114599046  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
114599121  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
114599126  ARTN; LOW QUALITY PROTEIN: artemin [KO:K25415]
114599167  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
114599194  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
114599205  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
114599208  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
114599312  ELK4; ETS domain-containing protein Elk-4 isoform X1 [KO:K04376]
114599328  MAPKAPK2; MAP kinase-activated protein kinase 2 isoform X1 [KO:K04443] [EC:2.7.11.1]
114599344  DUSP8; dual specificity protein phosphatase 8 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
114599364  RAP1A; ras-related protein Rap-1A [KO:K04353]
114599398  NRAS; GTPase NRas [KO:K07828]
114599408  NGF; beta-nerve growth factor [KO:K02582]
114599427  PTPN7; tyrosine-protein phosphatase non-receptor type 7 isoform X1 [KO:K18019] [EC:3.1.3.48]
114599575  STK4; serine/threonine-protein kinase 4 [KO:K04411]
114599801  ANGPT4; angiopoietin-4 [KO:K05467]
114599845  HRAS; GTPase HRas isoform X1 [KO:K02833]
114600173  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
114600250  MYC; myc proto-oncogene protein [KO:K04377]
114600322  ANGPT1; angiopoietin-1 [KO:K05465]
114600383  STK3; serine/threonine-protein kinase 3 isoform X1 [KO:K04412]
114600809  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
114601173  PPM1A; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
114601490  MAP3K6; mitogen-activated protein kinase kinase kinase 6 [KO:K04425] [EC:2.7.11.25]
114601524  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
114601551  STMN1; stathmin isoform X1 [KO:K04381]
114601628  [KO:K05466]
114601905  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
114601925  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
114602294  MAX; protein max isoform X1 [KO:K04453]
114602591  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
114602632  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
114602744  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
114602774  EPHA2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
114602842  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
114602973  TGFA; protransforming growth factor alpha [KO:K08774]
114603132  PPM1N; probable protein phosphatase 1N isoform X1 [KO:K04457] [EC:3.1.3.16]
114603133  [KO:K16859]
114603188  MAP3K10; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
114603190  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
114603220  RASGRP4; RAS guanyl-releasing protein 4 [KO:K12363]
114603266  [KO:K04460] [EC:3.1.3.16]
114603303  IL1B; interleukin-1 beta [KO:K04519]
114603306  TGFB1; transforming growth factor beta-1 proprotein [KO:K13375]
114603313  RELB; LOW QUALITY PROTEIN: transcription factor RelB [KO:K09253]
114603431  [KO:K03283]
114603537  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
114603604  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
114603754  FGF5; fibroblast growth factor 5 [KO:K04358]
114603804  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
114603897  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
114603905  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
114603981  PDGFC; platelet-derived growth factor C [KO:K05450]
114603990  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
114603995  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
114604055  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
114604057  VEGFC; vascular endothelial growth factor C isoform X1 [KO:K05449]
114604090  [KO:K04388] [EC:2.7.11.30]
114604149  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
114604225  FGF20; fibroblast growth factor 20 [KO:K04358]
114604250  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
114604335  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
114604383  CDC25B; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
114604525  FGF2; fibroblast growth factor 2 [KO:K18497]
114604938  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
114604939  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
114605047  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
114605085  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
114605091  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
114605096  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04856]
114605154  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
114605162  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
114605166  KITLG; kit ligand isoform X1 [KO:K05461]
114605192  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
114605215  KRAS; GTPase KRas isoform X1 [KO:K07827]
114605252  RAP1B; ras-related protein Rap-1b isoform X1 [KO:K07836]
114605269  MET; LOW QUALITY PROTEIN: hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
114605285  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
114605404  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
114605566  PTPRR; receptor-type tyrosine-protein phosphatase R isoform X1 [KO:K04458] [EC:3.1.3.48]
114605626  CACNG2; voltage-dependent calcium channel gamma-2 subunit isoform X1 [KO:K04867]
114605640  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
114605668  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
114605675  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
114605733  IGF1; insulin-like growth factor I [KO:K05459]
114605885  [KO:K04850]
114605978  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
114606019  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
114606265  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
114606419  FGF10; fibroblast growth factor 10 [KO:K04358]
114606536  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
114606543  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
114606662  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
114606668  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
114606722  [KO:K04450]
114606733  GDNF; glial cell line-derived neurotrophic factor [KO:K05452]
114606760  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
114606766  RASA1; ras GTPase-activating protein 1 isoform X1 [KO:K04352]
114606876  MAP3K20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
114606892  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
114607096  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
114607133  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
114607243  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
114607263  [KO:K02583]
114607438  [KO:K04421] [EC:2.7.11.25]
114607585  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
114607849  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
114608061  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
114608083  TP53; cellular tumor antigen p53 [KO:K04451]
114608097  [KO:K07827]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
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Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
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MAP kinases.
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Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
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Tanoue T, Nishida E.
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Docking interactions in the mitogen-activated protein kinase cascades.
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Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
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Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
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MAPK pathways in radiation responses.
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Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
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Huang EJ, Reichardt LF.
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Trk receptors: roles in neuronal signal transduction.
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Annu Rev Biochem 72:609-42 (2003)
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Reference
PMID:11369511
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Harper SJ, LoGrasso P.
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Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
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Cell Signal 13:299-310 (2001)
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Reference
PMID:12390245
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Takeda K, Ichijo H
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Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
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Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
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Yang SH, Sharrocks AD, Whitmarsh AJ.
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Transcriptional regulation by the MAP kinase signaling cascades.
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Gene 320:3-21 (2003)
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Reference
PMID:12566928
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Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
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The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
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Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
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Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
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Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
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Lemmon MA, Schlessinger J
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Cell signaling by receptor tyrosine kinases.
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Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
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The neurotrophin family of neurotrophic factors: an overview.
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Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
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Chu WM
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Tumor necrosis factor.
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Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
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Gaestel M, Kotlyarov A, Kracht M
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Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
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Ajibade AA, Wang HY, Wang RF
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Cell type-specific function of TAK1 in innate immune signaling.
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Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
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Turner MD, Nedjai B, Hurst T, Pennington DJ
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Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
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Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
pmua04070  Phosphatidylinositol signaling system
pmua04110  Cell cycle
pmua04115  p53 signaling pathway
pmua04210  Apoptosis
pmua04310  Wnt signaling pathway
KO pathway
ko04010   

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