KEGG   PATHWAY: pmua04060
Entry
pmua04060                   Pathway                                
Name
Cytokine-cytokine receptor interaction - Podarcis muralis (common wall lizard)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
pmua04060  Cytokine-cytokine receptor interaction
pmua04060

Organism
Podarcis muralis (common wall lizard) [GN:pmua]
Gene
114581477  [KO:K05493]
114581483  BMPR2; bone morphogenetic protein receptor type-2 [KO:K04671] [EC:2.7.11.30]
114581697  EPO; erythropoietin isoform X1 [KO:K05437]
114581752  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
114581758  [KO:K05076]
114582042  GH1; somatotropin [KO:K05438]
114582126  ACKR3; atypical chemokine receptor 3 isoform X1 [KO:K04304]
114582157  [KO:K04185]
114582297  TNFRSF12A; tumor necrosis factor receptor superfamily member 12A [KO:K05149]
114582307  CCR7; C-C chemokine receptor type 7 [KO:K04182]
114582309  [KO:K10030]
114582321  TNFSF12; tumor necrosis factor ligand superfamily member 12 [KO:K05474]
114582322  TNFSF13; tumor necrosis factor ligand superfamily member 13 [KO:K05475]
114582482  [KO:K22629]
114582638  [KO:K04185]
114582668  CCR10; C-C chemokine receptor type 10 [KO:K04185]
114582737  [KO:K10035]
114582789  TNFSF13B; tumor necrosis factor ligand superfamily member 13B [KO:K05476]
114582801  [KO:K05423]
114582810  [KO:K05505]
114582858  [KO:K24382]
114583239  IL11; interleukin-11 [KO:K05417]
114583612  IL25; interleukin-25 [KO:K05493]
114584164  IL21R; interleukin-21 receptor isoform X1 [KO:K05075]
114584165  IL4R; interleukin-4 receptor subunit alpha [KO:K05071]
114584300  IL16; pro-interleukin-16 isoform X1 [KO:K22628]
114584677  [KO:K05073]
114584949  TNFRSF13B; tumor necrosis factor receptor superfamily member 13B [KO:K05150]
114585074  [KO:K21093]
114585255  [KO:K05050]
114585260  [KO:K05050]
114585328  [KO:K05482]
114585484  CXCR5; C-X-C chemokine receptor type 5 [KO:K04190]
114585615  [KO:K04722]
114585668  [KO:K12964]
114585708  IL10RA; interleukin-10 receptor subunit alpha [KO:K05134]
114585802  [KO:K12964]
114585880  [KO:K05488]
114585881  [KO:K05483]
114585930  [KO:K05487]
114585943  NODAL; nodal homolog [KO:K04666]
114586591  [KO:K13376]
114586744  ACVRL1; serine/threonine-protein kinase receptor R3 [KO:K13594] [EC:2.7.11.30]
114586982  [KO:K05419]
114587119  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
114587681  GDF11; growth/differentiation factor 11 [KO:K22679]
114587744  IL27RA; interleukin-27 receptor subunit alpha [KO:K19598]
114587799  [KO:K03158]
114587841  EPOR; erythropoietin receptor isoform X1 [KO:K05079]
114587930  TNFSF14; tumor necrosis factor ligand superfamily member 14 [KO:K05477]
114588021  [KO:K06454]
114588052  IFNK; interferon kappa [KO:K05414]
114588057  [KO:K05442]
114588058  [KO:K05442]
114588061  [KO:K05442]
114588143  [KO:K03158]
114588436  AMH; muellerian-inhibiting factor [KO:K04665]
114588456  GDF15; growth/differentiation factor 15 [KO:K05504]
114588517  EBI3; interleukin-27 subunit beta isoform X1 [KO:K24476]
114588522  GDF1; embryonic growth/differentiation factor 1 [KO:K05495]
114588566  [KO:K21283]
114588688  IL12RB1; interleukin-12 receptor subunit beta-1 [KO:K05063]
114588695  [KO:K05060]
114588848  TNFSF8; tumor necrosis factor ligand superfamily member 8 [KO:K05471]
114589017  EDA; ectodysplasin-A isoform X1 [KO:K05480]
114589039  IL13RA1; interleukin-13 receptor subunit alpha-1 isoform X1 [KO:K05076]
114589240  TNFSF15; tumor necrosis factor ligand superfamily member 15 isoform X1 [KO:K05478]
114589346  EDA2R; tumor necrosis factor receptor superfamily member 27 [KO:K05163]
114589433  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
114589510  CD40LG; CD40 ligand [KO:K03161]
114589900  [KO:K04185]
114590094  [KO:K05050]
114590095  [KO:K05050]
114590988  IL17B; interleukin-17B [KO:K05490]
114591238  GDF9; growth/differentiation factor 9 isoform X1 [KO:K22673]
114591344  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
114591688  IL17RB; LOW QUALITY PROTEIN: interleukin-17 receptor B [KO:K05165]
114591728  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
114591932  IL17RC; interleukin-17 receptor C isoform X1 [KO:K05166]
114591935  IL17RE; interleukin-17 receptor E [KO:K05168]
114592791  [KO:K03156]
114592815  [KO:K05426]
114592861  [KO:K05425]
114592931  INHBE; inhibin beta E chain [KO:K22689]
114593047  AMHR2; anti-Muellerian hormone type-2 receptor [KO:K04672] [EC:2.7.11.30]
114593266  [KO:K05494]
114593403  [KO:K05136]
114593429  [KO:K05405]
114593430  [KO:K05405]
114593469  TNFRSF21; tumor necrosis factor receptor superfamily member 21 [KO:K05157]
114593655  BMP2; bone morphogenetic protein 2 [KO:K21283]
114593708  GDF7; growth/differentiation factor 7 [KO:K20013]
114593834  BMP5; bone morphogenetic protein 5 isoform X1 [KO:K04663]
114594178  IFNGR1; interferon gamma receptor 1 [KO:K05132]
114594334  CCR6; C-C chemokine receptor type 6 [KO:K04181]
114594660  TGFB2; transforming growth factor beta-2 proprotein [KO:K13376]
114594877  BMP4; bone morphogenetic protein 4 [KO:K04662]
114595545  RELT; tumor necrosis factor receptor superfamily member 19L [KO:K05156]
114595715  IL17D; interleukin-17D [KO:K05492]
114595730  TNFRSF19; tumor necrosis factor receptor superfamily member 19 isoform X1 [KO:K05155]
114595856  [KO:K05507]
114596047  [KO:K05131]
114596048  [KO:K05131]
114596049  [KO:K05135]
114596050  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
114596051  IFNGR2; interferon gamma receptor 2 isoform X1 [KO:K05133]
114596328  [KO:K05066]
114596332  CRLF2; cytokine receptor-like factor 2 [KO:K05078]
114596401  IL1R1; interleukin-1 receptor type 1 [KO:K04386]
114596403  [KO:K05172]
114596404  IL18R1; interleukin-18 receptor 1 [KO:K05173]
114596431  EDAR; tumor necrosis factor receptor superfamily member EDAR [KO:K05162]
114596486  IL1R2; interleukin-1 receptor type 2 [KO:K04387]
114596488  [KO:K05171]
114596489  IL18RAP; interleukin-18 receptor accessory protein [KO:K05174]
114596695  GDF2; growth/differentiation factor 2 [KO:K05503]
114596977  CXCL12; stromal cell-derived factor 1 [KO:K10031]
114597134  BMPR1A; bone morphogenetic protein receptor type-1A [KO:K04673] [EC:2.7.11.30]
114597296  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
114597818  CCL20; C-C motif chemokine 20 [KO:K14625]
114597986  TNFSF10; tumor necrosis factor ligand superfamily member 10 isoform X1 [KO:K04721]
114598050  THPO; thrombopoietin isoform X1 [KO:K06854]
114598124  IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
114598324  TNFSF18; tumor necrosis factor ligand superfamily member 18 [KO:K05479]
114598442  IL23R; interleukin-23 receptor [KO:K05065]
114598483  [KO:K05469]
114598486  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
114598875  IL12RB2; interleukin-12 receptor subunit beta-2 [KO:K05064]
114598887  LEPR; leptin receptor isoform X1 [KO:K05062]
114598952  [KO:K04722]
114599141  MPL; thrombopoietin receptor isoform X1 [KO:K05082]
114599167  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
114599330  IL10; interleukin-10 [KO:K05443]
114599408  NGF; beta-nerve growth factor [KO:K02582]
114599462  GDF5; growth/differentiation factor 5 [KO:K04664]
114599669  BMP7; bone morphogenetic protein 7 isoform X1 [KO:K16621]
114599786  TNFRSF6B; tumor necrosis factor receptor superfamily member 6B [KO:K05143]
114599900  CD40; tumor necrosis factor receptor superfamily member 5 [KO:K03160]
114600094  TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473]
114600294  TNFRSF11B; tumor necrosis factor receptor superfamily member 11B [KO:K05148]
114600402  GDF6; growth/differentiation factor 6 [KO:K20012]
114600983  TNFRSF11A; tumor necrosis factor receptor superfamily member 11A [KO:K05147]
114601102  CNTF; ciliary neurotrophic factor [KO:K05420]
114601103  RELL2; RELT-like protein 2 isoform X1 [KO:K26541]
114601367  PRL; prolactin [KO:K05439]
114601576  IFNLR1; interferon lambda receptor 1 [KO:K05140]
114601577  IL22RA1; interleukin-22 receptor subunit alpha-1 [KO:K05138]
114601738  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
114601782  CX3CL1; fractalkine [KO:K05508]
114602054  CLCF1; cardiotrophin-like cytokine factor 1 isoform X1 [KO:K05421]
114602142  [KO:K04188]
114602368  TNFRSF9; tumor necrosis factor receptor superfamily member 9 [KO:K05146]
114602505  TNFRSF18; tumor necrosis factor receptor superfamily member 18 [KO:K05154]
114602534  INHA; inhibin alpha chain [KO:K05500]
114602568  TNFRSF14; tumor necrosis factor receptor superfamily member 14 isoform X1 [KO:K05152]
114602604  TNFRSF1B; tumor necrosis factor receptor superfamily member 1B [KO:K05141]
114602722  [KO:K05481]
114602908  [KO:K16622]
114602927  IL17C; interleukin-17C [KO:K05491]
114602943  [KO:K05146]
114602991  TNFRSF8; tumor necrosis factor receptor superfamily member 8 [KO:K05145]
114603208  IL20RB; interleukin-20 receptor subunit beta [KO:K05137]
114603243  [KO:K05152]
114603286  BMP10; bone morphogenetic protein 10 [KO:K22670]
114603303  IL1B; interleukin-1 beta [KO:K04519]
114603306  TGFB1; transforming growth factor beta-1 proprotein [KO:K13375]
114603316  [KO:K21283]
114603388  [KO:K05050]
114603626  CXCR3; C-X-C chemokine receptor type 3 [KO:K04188]
114603741  INHBB; inhibin beta B chain [KO:K22687]
114603946  BMPR1B; bone morphogenetic protein receptor type-1B isoform X1 [KO:K13578] [EC:2.7.11.30]
114604090  [KO:K04388] [EC:2.7.11.30]
114604185  RELL1; RELT-like protein 1 isoform X1 [KO:K26541]
114604237  [KO:K12672]
114604313  BMP3; bone morphogenetic protein 3 [KO:K05496]
114604350  IL15; interleukin-15 [KO:K05433]
114604597  [KO:K10032]
114604641  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
114604763  [KO:K10032]
114604839  [KO:K05074]
114604914  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
114604932  ACVR2A; activin receptor type-2A isoform X1 [KO:K04670] [EC:2.7.11.30]
114605242  ACVR1C; activin receptor type-1C [KO:K13568] [EC:2.7.11.30]
114605253  ACVR1; activin receptor type-1 [KO:K04675] [EC:2.7.11.30]
114605318  LEP; leptin [KO:K05424]
114605534  [KO:K05439]
114605540  [KO:K04687]
114605541  IL22; interleukin-22 [KO:K05445]
114605570  TNFRSF13C; tumor necrosis factor receptor superfamily member 13C [KO:K05151]
114605576  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
114605882  IL17RA; interleukin-17 receptor A [KO:K05164]
114606014  CSF2RB; LOW QUALITY PROTEIN: cytokine receptor common subunit beta [KO:K04738]
114606139  GHR; growth hormone receptor isoform X1 [KO:K05080]
114606165  IL11RA; interleukin-11 receptor subunit alpha isoform X1 [KO:K05056]
114606170  [KO:K05060]
114606453  [KO:K22630]
114606653  [KO:K05057]
114606663  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
114606819  CCL19; C-C motif chemokine 19 [KO:K05512]
114606821  [KO:K05059]
114606832  [KO:K05060]
114606865  CCL28; C-C motif chemokine 28 [KO:K05513]
114606890  LIFR; leukemia inhibitory factor receptor [KO:K05058]
114607200  ACKR4; atypical chemokine receptor 4 [KO:K04186]
114607243  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
114607263  [KO:K02583]
114607355  MSTN; growth/differentiation factor 8 [KO:K05497]
114607400  CXCR6; C-X-C chemokine receptor type 6 isoform X1 [KO:K04191]
114607426  [KO:K04180]
114607494  INHBA; inhibin beta A chain [KO:K04667]
114607535  [KO:K04192]
114607541  XCR1; chemokine XC receptor 1 [KO:K04193]
114607551  ACVR2B; activin receptor type-2B isoform X1 [KO:K13596] [EC:2.7.11.30]
114607598  [KO:K04179]
114607611  [KO:K04179]
114607734  IL6; LOW QUALITY PROTEIN: interleukin-6 [KO:K05405]
114607767  [KO:K04180]
114608061  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Reference
PMID:21106488
  Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
  Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
  Journal
Hum Genomics 5:30-55 (2010)
DOI:10.1186/1479-7364-5-1-30
Reference
PMID:27577879
  Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
  Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
  Journal
J Allergy Clin Immunol 138:984-1010 (2016)
DOI:10.1016/j.jaci.2016.06.033
Reference
PMID:15500860
  Authors
Boulanger MJ, Garcia KC
  Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
  Journal
Adv Protein Chem 68:107-46 (2004)
DOI:10.1016/S0065-3233(04)68004-1
Reference
PMID:16034365
  Authors
Allan SM, Tyrrell PJ, Rothwell NJ
  Title
Interleukin-1 and neuronal injury.
  Journal
Nat Rev Immunol 5:629-40 (2005)
DOI:10.1038/nri1664
Reference
PMID:23847622
  Authors
Lopetuso LR, Chowdhry S, Pizarro TT
  Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
  Journal
Front Immunol 4:181 (2013)
DOI:10.3389/fimmu.2013.00181
Reference
PMID:21349428
  Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
  Title
Functional specialization of interleukin-17 family members.
  Journal
Immunity 34:149-62 (2011)
DOI:10.1016/j.immuni.2011.02.012
Reference
PMID:17530315
  Authors
Fischer P, Hilfiker-Kleiner D
  Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
  Journal
Basic Res Cardiol 102:279-97 (2007)
DOI:10.1007/s00395-007-0658-z
Reference
PMID:24381786
  Authors
Richards CD
  Title
The enigmatic cytokine oncostatin m and roles in disease.
  Journal
ISRN Inflamm 2013:512103 (2013)
DOI:10.1155/2013/512103
Reference
PMID:18926762
  Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
  Title
Structures and biological functions of IL-31 and IL-31 receptors.
  Journal
Cytokine Growth Factor Rev 19:347-56 (2008)
DOI:10.1016/j.cytogfr.2008.08.003
Reference
PMID:21155715
  Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
  Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
  Journal
Biochem J 434:343-51 (2011)
DOI:10.1042/BJ20101628
Reference
PMID:22410872
  Authors
de Weerd NA, Nguyen T
  Title
The interferons and their receptors--distribution and regulation.
  Journal
Immunol Cell Biol 90:483-91 (2012)
DOI:10.1038/icb.2012.9
Reference
PMID:12949498
  Authors
Aggarwal BB
  Title
Signalling pathways of the TNF superfamily: a double-edged sword.
  Journal
Nat Rev Immunol 3:745-56 (2003)
DOI:10.1038/nri1184
Reference
PMID:12189384
  Authors
Ashkenazi A
  Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
  Journal
Nat Rev Cancer 2:420-30 (2002)
DOI:10.1038/nrc821
Reference
PMID:26115564
  Authors
Seeger P, Musso T, Sozzani S
  Title
The TGF-beta superfamily in dendritic cell biology.
  Journal
Cytokine Growth Factor Rev 26:647-57 (2015)
DOI:10.1016/j.cytogfr.2015.06.002
Reference
PMID:23612460
  Authors
Wakefield LM, Hill CS
  Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
  Journal
Nat Rev Cancer 13:328-41 (2013)
DOI:10.1038/nrc3500
Reference
PMID:22710174
  Authors
Mueller TD, Nickel J
  Title
Promiscuity and specificity in BMP receptor activation.
  Journal
FEBS Lett 586:1846-59 (2012)
DOI:10.1016/j.febslet.2012.02.043
KO pathway
ko04060   

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