KEGG   PATHWAY: pps04640
Entry
pps04640                    Pathway                                
Name
Hematopoietic cell lineage - Pan paniscus (bonobo)
Description
Blood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid progenitor (CLP) or a common myeloid progenitor (CMP). A CLP gives rise to the lymphoid lineage of white blood cells or leukocytes-the natural killer (NK) cells and the T and B lymphocytes. A CMP gives rise to the myeloid lineage, which comprises the rest of the leukocytes, the erythrocytes (red blood cells), and the megakaryocytes that produce platelets important in blood clotting. Cells undergoing these differentiation process express a stage- and lineage-specific set of surface markers. Therefore cellular stages are identified by the specific expression patterns of these genes.
Class
Organismal Systems; Immune system
Pathway map
pps04640  Hematopoietic cell lineage
pps04640

Organism
Pan paniscus (bonobo) [GN:pps]
Gene
100973372  KITLG; kit ligand isoform X1 [KO:K05461]
100986540  IL7; interleukin-7 isoform X1 [KO:K05431]
100988878  IL4; interleukin-4 isoform X1 [KO:K05430]
100995954  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
100991249  IL5; interleukin-5 [KO:K05428]
100972250  CSF3; granulocyte colony-stimulating factor isoform X1 [KO:K05423]
100967294  IL3; interleukin-3 [KO:K04736]
100967827  IL6; interleukin-6 isoform X2 [KO:K05405]
100982675  IL11; interleukin-11 isoform X3 [KO:K05417]
100994286  IL1A; interleukin-1 alpha [KO:K04383]
100993613  IL1B; interleukin-1 beta [KO:K04519]
100977674  TNF; tumor necrosis factor [KO:K03156]
100994576  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
100981507  EPO; erythropoietin [KO:K05437]
100980796  THPO; thrombopoietin isoform X1 [KO:K06854]
100976441  CD34; hematopoietic progenitor cell antigen CD34 isoform X1 [KO:K06474]
100989601  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
100976638  DNTT; DNA nucleotidylexotransferase [KO:K00977] [EC:2.7.7.31]
100995226  HLA class II histocompatibility antigen, DP beta 1 chain [KO:K06752]
100967723  HLA class II histocompatibility antigen, DO alpha chain isoform X3 [KO:K06752]
100968410  MHC-DMB; HLA class II histocompatibility antigen, DM beta chain isoform X1 [KO:K06752]
100972994  HLA class II histocompatibility antigen, DQ beta 1 chain isoform X2 [KO:K06752]
100973583  HLA class II histocompatibility antigen, DQ alpha 2 chain [KO:K06752]
100986750  HLA class II histocompatibility antigen, DRB1 beta chain [KO:K06752]
100987081  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
100995577  HLA class II histocompatibility antigen, DP alpha 1 chain isoform X1 [KO:K06752]
100968989  HLA class II histocompatibility antigen, DM alpha chain isoform X3 [KO:K06752]
100970847  HLA class II histocompatibility antigen, DO beta chain [KO:K06752]
100979649  HLA class II histocompatibility antigen, DQ alpha 1 chain [KO:K06752]
100972641  HLA class II histocompatibility antigen, DQ beta 2 chain isoform X3 [KO:K06752]
134730587  HLA class II histocompatibility antigen, DR beta 5 chain [KO:K06752]
100985935  KIT; mast/stem cell growth factor receptor Kit isoform X7 [KO:K05091] [EC:2.7.10.1]
100974407  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
100981232  IL7R; interleukin-7 receptor subunit alpha isoform X1 [KO:K05072]
100986593  TFRC; transferrin receptor protein 1 [KO:K06503]
100974952  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
100978316  CD7; T-cell antigen CD7 [KO:K06457]
100972744  CD2; T-cell surface antigen CD2 [KO:K06449]
100987506  CD5; T-cell surface glycoprotein CD5 [KO:K06455]
100985794  T-cell surface glycoprotein CD1e, membrane-associated [KO:K06448]
100986789  CD1B; T-cell surface glycoprotein CD1b [KO:K06448]
100987121  CD1A; T-cell surface glycoprotein CD1a isoform X1 [KO:K06448]
100987470  CD1C; T-cell surface glycoprotein CD1c [KO:K06448]
100988149  CD1D; antigen-presenting glycoprotein CD1d isoform X1 [KO:K06448]
100970574  CD4; T-cell surface glycoprotein CD4 [KO:K06454]
100968474  CD8A; T-cell surface glycoprotein CD8 alpha chain [KO:K06458]
100969045  CD8B; T-cell surface glycoprotein CD8 beta chain isoform X1 [KO:K06459]
100979946  T-cell surface glycoprotein CD3 delta chain isoform X1 [KO:K06450]
100978919  T-cell surface glycoprotein CD3 epsilon chain [KO:K06451]
100979261  T-cell surface glycoprotein CD3 gamma chain isoform X1 [KO:K06452]
100985469  MME; neprilysin [KO:K01389] [EC:3.4.24.11]
100984689  CD9; CD9 antigen isoform X2 [KO:K06460]
100992335  CD19; B-lymphocyte antigen CD19 isoform X2 [KO:K06465]
100980861  CD22; B-cell receptor CD22 isoform X1 [KO:K06467]
100982539  signal transducer CD24 [KO:K06469]
129393939  signal transducer CD24 [KO:K06469]
100993062  MS4A1; B-lymphocyte antigen CD20 [KO:K06466]
100983119  CR2; complement receptor type 2 isoform X1 [KO:K04012]
100969851  CD37; leukocyte antigen CD37 isoform X1 [KO:K06475]
100981027  FCER2; low affinity immunoglobulin epsilon Fc receptor isoform X1 [KO:K06468]
100982795  CR1; complement receptor type 1 [KO:K04011]
100983058  myeloid cell surface antigen CD33 [KO:K06473]
100969808  IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071]
100972031  IL6R; interleukin-6 receptor subunit alpha isoform X1 [KO:K05055]
100984157  FCGR1A; high affinity immunoglobulin gamma Fc receptor I isoform X2 [KO:K06498]
100974967  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
100977702  ANPEP; aminopeptidase N [KO:K11140] [EC:3.4.11.2]
100992002  ITGAM; integrin alpha-M isoform X1 [KO:K06461]
100972677  CD14; monocyte differentiation antigen CD14 [KO:K04391]
100991889  LOW QUALITY PROTEIN: interleukin-9 receptor [KO:K05073]
100972617  IL1R1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
100972054  IL1R2; interleukin-1 receptor type 2 isoform X2 [KO:K04387]
100974292  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
100988791  IL5RA; interleukin-5 receptor subunit alpha [KO:K05067]
100980274  EPOR; erythropoietin receptor isoform X2 [KO:K05079]
100984927  CD36; platelet glycoprotein 4 [KO:K06259]
100988344  GYPA; glycophorin-A isoform X1 [KO:K06575]
100983678  CD55; complement decay-accelerating factor isoform X8 [KO:K04006]
100976877  IL11RA; interleukin-11 receptor subunit alpha isoform X6 [KO:K05056]
100974497  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
100991197  ITGA2B; integrin alpha-IIb [KO:K06476]
100986083  GP9; platelet glycoprotein IX isoform X2 [KO:K06263]
100982933  GP1BA; platelet glycoprotein Ib alpha chain [KO:K06261]
117977508  GP1BB; platelet glycoprotein Ib beta chain [KO:K06262]
100987605  GP5; platelet glycoprotein V [KO:K06260]
100978092  ITGA1; integrin alpha-1 [KO:K06480]
100978441  ITGA2; integrin alpha-2 [KO:K06481]
100993709  ITGA3; integrin alpha-3 isoform X2 [KO:K06482]
100983460  ITGA4; integrin alpha-4 [KO:K06483]
100968295  ITGA5; integrin alpha-5 [KO:K06484]
100967602  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
Reference
  Authors
Janeway CA Jr, Travers P, Walport M, Shlomchik MJ
  Title
Immunobiology - International editon: The immune system in health and disease
  Journal
Harcourt Publishers Ltd, a subsidiary of Harcourt International Ltd (2001)
Reference
  Authors
Abe T
  Title
[Atlas of malignancies in hematopoietic organ - Morphology, immunology, chromosome and gene] (In Japanese)
  Journal
Nihonijishinhousya (2000)
Reference
PMID:15771582
  Authors
Rothenberg EV, Taghon T.
  Title
Molecular genetics of T cell development.
  Journal
Annu Rev Immunol 23:601-49 (2005)
DOI:10.1146/annurev.immunol.23.021704.115737
Reference
PMID:12415312
  Authors
Ceredig R, Rolink T.
  Title
A positive look at double-negative thymocytes.
  Journal
Nat Rev Immunol 2:888-97 (2002)
DOI:10.1038/nri937
Reference
PMID:15156179
  Authors
de Bruijn MF, Speck NA.
  Title
Core-binding factors in hematopoiesis and immune function.
  Journal
Oncogene 23:4238-48 (2004)
DOI:10.1038/sj.onc.1207763
Reference
PMID:14985712
  Authors
Radtke F, Wilson A, Mancini SJ, MacDonald HR.
  Title
Notch regulation of lymphocyte development and function.
  Journal
Nat Immunol 5:247-53 (2004)
DOI:10.1038/ni1045
Reference
PMID:12360214
  Authors
Spits H.
  Title
Development of alphabeta T cells in the human thymus.
  Journal
Nat Rev Immunol 2:760-72 (2002)
DOI:10.1038/nri913
Reference
PMID:9927518
  Authors
Di Santo JP, Aifantis I, Rosmaraki E, Garcia C, Feinberg J, Fehling HJ, Fischer A, von Boehmer H, Rocha B.
  Title
The common cytokine receptor gamma chain and the pre-T cell receptor provide independent but critically overlapping signals in early alpha/beta T cell development.
  Journal
J Exp Med 189:563-74 (1999)
DOI:10.1084/jem.189.3.563
Reference
PMID:11905810
  Authors
Mak TW, Penninger JM, Ohashi PS.
  Title
Knockout mice: a paradigm shift in modern immunology.
  Journal
Nat Rev Immunol 1:11-9 (2001)
DOI:10.1038/35095551
Reference
PMID:15738953
  Authors
Shapiro-Shelef M, Calame K.
  Title
Regulation of plasma-cell development.
  Journal
Nat Rev Immunol 5:230-42 (2005)
DOI:10.1038/nri1572
Reference
PMID:14670296
  Authors
Maillard I, Adler SH, Pear WS.
  Title
Notch and the immune system.
  Journal
Immunity 19:781-91 (2003)
DOI:10.1016/S1074-7613(03)00325-X
Reference
PMID:15629410
  Authors
Alpdogan O, van den Brink MR.
  Title
IL-7 and IL-15: therapeutic cytokines for immunodeficiency.
  Journal
Trends Immunol 26:56-64 (2005)
DOI:10.1016/j.it.2004.11.002
KO pathway
ko04640   
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