KEGG   PATHWAY: ptr04640
Entry
ptr04640                    Pathway                                
Name
Hematopoietic cell lineage - Pan troglodytes (chimpanzee)
Description
Blood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid progenitor (CLP) or a common myeloid progenitor (CMP). A CLP gives rise to the lymphoid lineage of white blood cells or leukocytes-the natural killer (NK) cells and the T and B lymphocytes. A CMP gives rise to the myeloid lineage, which comprises the rest of the leukocytes, the erythrocytes (red blood cells), and the megakaryocytes that produce platelets important in blood clotting. Cells undergoing these differentiation process express a stage- and lineage-specific set of surface markers. Therefore cellular stages are identified by the specific expression patterns of these genes.
Class
Organismal Systems; Immune system
Pathway map
ptr04640  Hematopoietic cell lineage
ptr04640

Organism
Pan troglodytes (chimpanzee) [GN:ptr]
Gene
452114  KITLG; kit ligand isoform X4 [KO:K05461]
464245  IL7; interleukin-7 isoform X2 [KO:K05431]
449565  IL4; interleukin-4 isoform 1 precursor [KO:K05430]
471627  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
100610021  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
743963  IL5; interleukin-5 [KO:K05428]
454641  CSF3; granulocyte colony-stimulating factor isoform X1 [KO:K05423]
471626  IL3; interleukin-3 precursor [KO:K04736]
463288  IL6; interleukin-6 isoform X1 [KO:K05405]
736204  IL11; interleukin-11 [KO:K05417]
470485  IL1A; interleukin-1 alpha [KO:K04383]
450200  IL1B; interleukin-1 beta [KO:K04519]
494186  TNF; tumor necrosis factor [KO:K03156]
457127  CSF1; macrophage colony-stimulating factor 1 isoform X5 [KO:K05453]
463609  EPO; erythropoietin [KO:K05437]
736549  THPO; thrombopoietin isoform X1 [KO:K06854]
457692  CD34; hematopoietic progenitor cell antigen CD34 isoform X2 [KO:K06474]
452508  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
466167  DNTT; DNA nucleotidylexotransferase isoform X2 [KO:K00977] [EC:2.7.7.31]
449592  PATR-DMB; major histocompatibility complex, class II, DM beta precursor [KO:K06752]
471974  PATR-DQA1; HLA class II histocompatibility antigen, DQ alpha 1 chain [KO:K06752]
471976  PATR-DQA2; HLA class II histocompatibility antigen, DQ alpha 2 chain [KO:K06752]
471977  PATR-DOB; patr class II histocompatibility antigen, DO beta chain precursor [KO:K06752]
471979  HLA class II histocompatibility antigen, DO alpha chain isoform X1 [KO:K06752]
462591  PATR-DRA; major histocompatibility complex, class II, DR alpha precursor [KO:K06752]
462594  PATR-DQB1; major histocompatibility complex, class II, DQ beta 1 precursor [KO:K06752]
462598  PATR-DPA1; HLA class II histocompatibility antigen, DP alpha 1 chain isoform X1 [KO:K06752]
462599  PATR-DPB1; HLA class II histocompatibility antigen, DP beta 1 chain [KO:K06752]
462592  PATR-DRB5; major histocompatibility complex, class II, DR beta 5 precursor [KO:K06752]
104006793  HLA class II histocompatibility antigen, DR beta 3 chain precursor [KO:K06752]
100616520  HLA class II histocompatibility antigen, DQ beta 1 chain isoform X3 [KO:K06752]
100608816  MAMU-DMA; HLA class II histocompatibility antigen, DM alpha chain isoform X1 [KO:K06752]
100610904  HLA class II histocompatibility antigen, DP beta 1 chain-like isoform X3 [KO:K06752]
451122  CD44; CD44 antigen isoform X8 [KO:K06256]
461316  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
450884  IL2RA; interleukin-2 receptor subunit alpha precursor [KO:K05068]
461922  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
460956  TFRC; transferrin receptor protein 1 [KO:K06503]
745433  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
745293  CD7; T-cell antigen CD7 [KO:K06457]
449512  CD2; T-cell surface antigen CD2 precursor [KO:K06449]
737721  CD5; T-cell surface glycoprotein CD5 isoform X1 [KO:K06455]
457418  CD1A; T-cell surface glycoprotein CD1a isoform X1 [KO:K06448]
457419  CD1C; T-cell surface glycoprotein CD1c isoform X1 [KO:K06448]
457421  CD1E; T-cell surface glycoprotein CD1e, membrane-associated isoform X8 [KO:K06448]
457420  CD1B; T-cell surface glycoprotein CD1b isoform X2 [KO:K06448]
469524  CD1D; antigen-presenting glycoprotein CD1d precursor [KO:K06448]
450124  CD4; T-cell surface glycoprotein CD4 precursor [KO:K06454]
735755  CD8A; T-cell surface glycoprotein CD8 alpha chain isoform X2 [KO:K06458]
470426  CD8B; T-cell surface glycoprotein CD8 beta chain isoform X4 [KO:K06459]
451584  CD3D; T-cell surface glycoprotein CD3 delta chain isoform X2 [KO:K06450]
742330  CD3E; T-cell surface glycoprotein CD3 epsilon chain [KO:K06451]
451585  CD3G; T-cell surface glycoprotein CD3 gamma chain [KO:K06452]
460792  MME; neprilysin [KO:K01389] [EC:3.4.24.11]
451775  CD9; CD9 antigen isoform X1 [KO:K06460]
454020  CD19; B-lymphocyte antigen CD19 isoform X1 [KO:K06465]
450167  CD22; B-cell receptor CD22 isoform X9 [KO:K06467]
104007026  CD24; signal transducer CD24 isoform X2 [KO:K06469]
107968591  signal transducer CD24 [KO:K06469]
451223  MS4A1; LOW QUALITY PROTEIN: B-lymphocyte antigen CD20 [KO:K06466]
112204125  MS4A1; LOW QUALITY PROTEIN: B-lymphocyte antigen CD20 [KO:K06466]
456200  CD37; leukocyte antigen CD37 isoform X1 [KO:K06475]
100608894  immunoglobulin heavy variable 3-23 [KO:K06856]
104002202  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
104002200  immunoglobulin heavy variable 6-1 [KO:K06856]
456434  FCER2; low affinity immunoglobulin epsilon Fc receptor isoform X1 [KO:K06468]
449643  CR1; complement receptor type 1 precursor [KO:K04011]
450119  CR1L; complement component receptor 1-like protein [KO:K04011]
746936  CSF2RA; granulocyte-macrophage colony-stimulating factor receptor subunit alpha [KO:K05066]
456242  CD33; myeloid cell surface antigen CD33 isoform X2 [KO:K06473]
454005  IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071]
469506  IL6R; interleukin-6 receptor subunit alpha isoform X2 [KO:K05055]
457259  high affinity immunoglobulin gamma Fc receptor I isoform X2 [KO:K06498]
462187  CSF1R; macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
107968418  ANPEP; aminopeptidase N [KO:K11140] [EC:3.4.11.2]
454069  ITGAM; integrin alpha-M precursor [KO:K06461]
462118  CD14; monocyte differentiation antigen CD14 precursor [KO:K04391]
459460  IL1R1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
470455  IL1R2; interleukin-1 receptor type 2 isoform X5 [KO:K04387]
456756  CSF3R; granulocyte colony-stimulating factor receptor isoform X3 [KO:K05061]
737582  IL5RA; interleukin-5 receptor subunit alpha isoform X2 [KO:K05067]
455728  EPOR; erythropoietin receptor isoform X1 [KO:K05079]
463949  CD36; platelet glycoprotein 4 isoform X1 [KO:K06259]
461520  glycophorin-A isoform X1 [KO:K06575]
739271  GYPE1; glycophorin-E [KO:K06575]
100609966  GYPB; glycophorin-B isoform X2 [KO:K06575]
744672  CD55; complement decay-accelerating factor isoform X6 [KO:K04006]
739046  CD59; CD59 glycoprotein precursor [KO:K04008]
100616505  IL11RA; interleukin-11 receptor subunit alpha precursor [KO:K05056]
468295  ITGB3; integrin beta-3 isoform X2 [KO:K06493]
454730  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
737968  GP9; platelet glycoprotein IX isoform X2 [KO:K06263]
468166  GP1BA; platelet glycoprotein Ib alpha chain [KO:K06261]
104003674  GP1BB; platelet glycoprotein Ib beta chain [KO:K06262]
741837  GP5; platelet glycoprotein V [KO:K06260]
461880  ITGA1; integrin alpha-1 [KO:K06480]
471550  ITGA2; integrin alpha-2 isoform X3 [KO:K06481]
455111  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
470596  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
451958  ITGA5; integrin alpha-5 isoform X1 [KO:K06484]
459742  ITGA6; integrin alpha-6 isoform X6 [KO:K06485]
Reference
  Authors
Janeway CA Jr, Travers P, Walport M, Shlomchik MJ
  Title
Immunobiology - International editon: The immune system in health and disease
  Journal
Harcourt Publishers Ltd, a subsidiary of Harcourt International Ltd (2001)
Reference
  Authors
Abe T
  Title
[Atlas of malignancies in hematopoietic organ - Morphology, immunology, chromosome and gene] (In Japanese)
  Journal
Nihonijishinhousya (2000)
Reference
PMID:15771582
  Authors
Rothenberg EV, Taghon T.
  Title
Molecular genetics of T cell development.
  Journal
Annu Rev Immunol 23:601-49 (2005)
DOI:10.1146/annurev.immunol.23.021704.115737
Reference
PMID:12415312
  Authors
Ceredig R, Rolink T.
  Title
A positive look at double-negative thymocytes.
  Journal
Nat Rev Immunol 2:888-97 (2002)
DOI:10.1038/nri937
Reference
PMID:15156179
  Authors
de Bruijn MF, Speck NA.
  Title
Core-binding factors in hematopoiesis and immune function.
  Journal
Oncogene 23:4238-48 (2004)
DOI:10.1038/sj.onc.1207763
Reference
PMID:14985712
  Authors
Radtke F, Wilson A, Mancini SJ, MacDonald HR.
  Title
Notch regulation of lymphocyte development and function.
  Journal
Nat Immunol 5:247-53 (2004)
DOI:10.1038/ni1045
Reference
PMID:12360214
  Authors
Spits H.
  Title
Development of alphabeta T cells in the human thymus.
  Journal
Nat Rev Immunol 2:760-72 (2002)
DOI:10.1038/nri913
Reference
PMID:9927518
  Authors
Di Santo JP, Aifantis I, Rosmaraki E, Garcia C, Feinberg J, Fehling HJ, Fischer A, von Boehmer H, Rocha B.
  Title
The common cytokine receptor gamma chain and the pre-T cell receptor provide independent but critically overlapping signals in early alpha/beta T cell development.
  Journal
J Exp Med 189:563-74 (1999)
DOI:10.1084/jem.189.3.563
Reference
PMID:11905810
  Authors
Mak TW, Penninger JM, Ohashi PS.
  Title
Knockout mice: a paradigm shift in modern immunology.
  Journal
Nat Rev Immunol 1:11-9 (2001)
DOI:10.1038/35095551
Reference
PMID:15738953
  Authors
Shapiro-Shelef M, Calame K.
  Title
Regulation of plasma-cell development.
  Journal
Nat Rev Immunol 5:230-42 (2005)
DOI:10.1038/nri1572
Reference
PMID:14670296
  Authors
Maillard I, Adler SH, Pear WS.
  Title
Notch and the immune system.
  Journal
Immunity 19:781-91 (2003)
DOI:10.1016/S1074-7613(03)00325-X
Reference
PMID:15629410
  Authors
Alpdogan O, van den Brink MR.
  Title
IL-7 and IL-15: therapeutic cytokines for immunodeficiency.
  Journal
Trends Immunol 26:56-64 (2005)
DOI:10.1016/j.it.2004.11.002
KO pathway
ko04640   
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