KEGG   PATHWAY: pyo03040
Entry
pyo03040                    Pathway                                
Name
Spliceosome - Plasmodium yoelii
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
Pathway map
pyo03040  Spliceosome
pyo03040

Other DBs
GO: 0005681
Organism
Plasmodium yoelii [GN:pyo]
Gene
PY17X_0913100  U2 spliceosomal RNA [KO:K14277]
PY17X_0409000  U4 spliceosomal RNA [KO:K14278]
PY17X_1313600  U5 spliceosomal RNA [KO:K14279]
PY17X_1109400  RNA helicase [KO:K12811] [EC:5.6.2.7]
PY17X_0307400  ATP-dependent RNA helicase UAP56, putative [KO:K12812] [EC:5.6.2.7]
PY17X_1141600  pre-mRNA splicing factor ATP-dependent RNA helicase [KO:K12815] [EC:5.6.2.6]
PY17X_1437700  uncharacterized protein [KO:K12816]
PY17X_0826900  pre-mRNA-splicing factor 18, putative [KO:K12817]
PY17X_0515200  pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22, putative [KO:K12818] [EC:5.6.2.6]
PY17X_0110200  pre-mRNA-splicing factor SLU7, putative [KO:K12819]
PY17X_0821900  ATP-dependent RNA helicase protein [KO:K12820] [EC:5.6.2.6]
PY17X_1030300  small nuclear ribonucleoprotein-associated protein B, putative [KO:K11086]
PY17X_0924800  small nuclear riboprotein Sm-D1 [KO:K11087]
PY17X_0315700  small nuclear ribonucleoprotein [KO:K11096]
PY17X_0814300  small nuclear ribonucleoprotein Sm D3, putative [KO:K11088]
PY17X_1368700  small nuclear ribonucleoprotein E, putative [KO:K11097]
PY17X_0923500  small nuclear ribonucleoprotein F, putative [KO:K11098]
PY17X_0708600  small nuclear ribonucleoprotein G, putative [KO:K11099]
PY17X_1144300  U1 small nuclear ribonucleoprotein 70 kDa [KO:K11093]
PY17X_1407100  U1 small nuclear ribonucleoprotein A, putative [KO:K11091]
PY17X_1426800  U1 small nuclear ribonucleoprotein C, putative [KO:K11095]
PY17X_1416700  uncharacterized protein [KO:K12821]
PY17X_0110300  uncharacterized protein [KO:K12822]
PY17X_1313500  ATP-dependent RNA helicase DDX5, putative [KO:K12823] [EC:5.6.2.7]
PY17X_1444400  DNA helicase 60, putative [KO:K12823] [EC:5.6.2.7]
PY17X_1147000  U2 small nuclear ribonucleoprotein A', putative [KO:K11092]
PY17X_0839200  U2 small nuclear ribonucleoprotein B'', putative [KO:K11094]
PY17X_1305300  splicing factor 3A subunit 1, putative [KO:K12825]
PY17X_1120200  splicing factor 3A subunit 2, putative [KO:K12826]
PY17X_0828900  splicing factor 3A subunit 3, putative [KO:K12827]
PY17X_0409500  splicing factor 3B subunit 1, putative [KO:K12828]
PY17X_1329100  splicing factor 3B subunit 2, putative [KO:K12829]
PY17X_1451900  splicing factor 3B subunit 3, putative [KO:K12830]
PY17X_1025100  splicing factor 3B subunit 4, putative [KO:K12831]
PY17X_1133600  splicing factor 3B subunit 5, putative [KO:K12832]
PY17X_1442300  splicing factor 3B subunit 6, putative [KO:K12833]
PY17X_0503800  pre-mRNA-splicing factor RDS3, putative [KO:K12834]
PY17X_1220100  ATP-dependent RNA helicase [KO:K12835] [EC:5.6.2.7]
PY17X_0930800  uncharacterized protein [KO:K12836]
PY17X_1336700  uncharacterized protein [KO:K12837]
PY17X_1346200  RNA-binding protein, putative [KO:K12837]
PY17X_1321500  uncharacterized protein [KO:K12840]
PY17X_1041700  U2 snRNP-associated SURP motif-containing protein, putative [KO:K12842]
PY17X_1238500  U6 snRNA-associated Sm-like protein LSm2, putative [KO:K12621]
PY17X_0711100  U6 snRNA-associated Sm-like protein LSm3, putative [KO:K12622]
PY17X_0942400  U6 snRNA-associated Sm-like protein LSm4, putative [KO:K12623]
PY17X_1311000  U6 snRNA-associated Sm-like protein LSm5, putative [KO:K12624]
PY17X_1344900  U6 snRNA-associated Sm-like protein LSm6, putative [KO:K12625]
PY17X_0610100  U6 snRNA-associated Sm-like protein LSm7, putative [KO:K12626]
PY17X_0701700  U6 snRNA-associated Sm-like protein LSm8, putative [KO:K12627]
PY17X_1409600  U4/U6-associated RNA splicing factor [KO:K12843]
PY17X_1362600  uncharacterized protein [KO:K12662]
PY17X_1229000  peptidyl-prolyl cis-trans isomerase, putative [KO:K09567] [EC:5.2.1.8]
PY17X_1008100  U4/U6 small nuclear ribonucleoprotein PRP31, putative [KO:K12844]
PY17X_0926400  13 kDa ribonucleoprotein-associated protein, putative [KO:K12845]
PY17X_1417200  uncharacterized protein [KO:K12847]
PY17X_1218000  U4/U6.U5 tri-snRNP-associated protein 1, putative [KO:K11984]
PY17X_0917300  pre-mRNA-splicing factor 38A, putative [KO:K12849]
PY17X_1037300  pre-mRNA-splicing factor 38B, putative [KO:K12850]
PY17X_1205300  uncharacterized protein [KO:K12852]
PY17X_0939400  pre-mRNA-processing factor 6, putative [KO:K12855]
PY17X_1004500  pre-mRNA-processing-splicing factor 8, putative [KO:K12856]
PY17X_0708100  U5 small nuclear ribonucleoprotein 40 kDa protein, putative [KO:K12857]
PY17X_1236700  ATP-dependent RNA helicase DDX23, putative [KO:K12858] [EC:5.6.2.7]
PY17X_1448700  uncharacterized protein [KO:K12859]
PY17X_0409200  pre-mRNA-processing factor 19, putative [KO:K10599] [EC:2.3.2.27]
PY17X_0518500  uncharacterized protein [KO:K12860]
PY17X_1232600  uncharacterized protein [KO:K12861]
PY17X_0403200  uncharacterized protein [KO:K12862]
PY17X_0622700  pre-mRNA-splicing factor CWC15, putative [KO:K12863]
PY17X_0911500  beta-catenin-like protein 1, putative [KO:K12864]
PY17X_0712100  heat shock protein 70, putative [KO:K03283]
PY17X_0315900  chromapatatin-binding protein [KO:K06063]
PY17X_1453000  uncharacterized protein [KO:K12867]
PY17X_1002800  pre-mRNA-splicing factor CLF1, putative [KO:K12869]
PY17X_1339900  pre-mRNA-splicing factor ISY1, putative [KO:K12870]
PY17X_1246700  cyclophilin protein [KO:K12733] [EC:5.2.1.8]
PY17X_1319000  pre-mRNA-splicing factor CWF18, putative [KO:K12871]
PY17X_1463700  uncharacterized protein [KO:K12872]
PY17X_1240800  uncharacterized protein [KO:K12873]
PY17X_1371100  intron-binding protein aquarius, putative [KO:K12874]
PY17X_0524500  eukaryotic initiation factor 4A-III, putative [KO:K13025] [EC:5.6.2.7]
PY17X_1038600  RNA-binding protein 8A, putative [KO:K12876]
PY17X_0625400  mago nashi protein homologue, putative [KO:K12877]
PY17X_1233900  RNA and export factor binding protein, putative [KO:K12881]
PY17X_0717700  nuclear cap-binding protein subunit 2, putative [KO:K12883]
PY17X_1235500  splicing factor 1 [KO:K12890]
PY17X_0507700  splicing factor [KO:K12893]
PY17X_1203900  transformer-2 protein homolog beta, putative [KO:K12897]
PY17X_1104100  serine/arginine-rich splicing factor 12, putative [KO:K12900]
Reference
PMID:19239890
  Authors
Wahl MC, Will CL, Luhrmann R
  Title
The spliceosome: design principles of a dynamic RNP machine.
  Journal
Cell 136:701-18 (2009)
DOI:10.1016/j.cell.2009.02.009
Reference
PMID:10978320
  Authors
Morris DP, Greenleaf AL
  Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
  Journal
J Biol Chem 275:39935-43 (2000)
DOI:10.1074/jbc.M004118200
Reference
PMID:17537823
  Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
  Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
  Journal
Nucleic Acids Res 35:3928-44 (2007)
DOI:10.1093/nar/gkm347
Reference
PMID:19733268
  Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
  Title
Spliceosome structure: piece by piece.
  Journal
Biochim Biophys Acta 1789:624-33 (2009)
DOI:10.1016/j.bbagrm.2009.08.010
KO pathway
ko03040   
LinkDB

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