Entry
Name
Rheumatoid arthritis - Rousettus aegyptiacus (Egyptian rousette)
Description
Rheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune system elevates pro-inflammatory cytokines and chemokines levels, which can promote synovial angiogenesis and leukocyte infiltration. The synovium forms a hyperplastic pannus with infiltrated macrophage-like and fibroblast-like synoviocytes and invades joints by secreting proteinases and inducing osteoclast differentiation.
Class
Human Diseases; Immune disease
BRITE hierarchy
Pathway map
Ortholog table
Organism
Rousettus aegyptiacus (Egyptian rousette) [GN:
ray ]
Gene
107497773 CD86; T-lymphocyte activation antigen CD86 isoform X1 [KO:K05413 ]
107519371 CD28; T-cell-specific surface glycoprotein CD28 isoform X1 [KO:K06470 ]
107506765 DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752 ]
107506766 HLA class II histocompatibility antigen, DR alpha chain [KO:K06752 ]
107505772 HLA class II histocompatibility antigen, DQ alpha 2 chain-like [KO:K06752 ]
107505773 boLa class II histocompatibility antigen, DQB*0101 beta chain-like [KO:K06752 ]
107505774 HLA class II histocompatibility antigen, DQ alpha 2 chain-like [KO:K06752 ]
107511941 H-2 class II histocompatibility antigen, A-R alpha chain-like [KO:K06752 ]
107511990 HLA class II histocompatibility antigen, DO alpha chain [KO:K06752 ]
107511992 HLA class II histocompatibility antigen, DM beta chain [KO:K06752 ]
107511993 HLA class II histocompatibility antigen, DM alpha chain isoform X1 [KO:K06752 ]
107511999 HLA class II histocompatibility antigen, DO beta chain isoform X1 [KO:K06752 ]
107512001 HLA class II histocompatibility antigen, DQ beta 1 chain-like isoform X1 [KO:K06752 ]
107507331 HLA class II histocompatibility antigen, DQ alpha 2 chain-like [KO:K06752 ]
107507332 SLA class II histocompatibility antigen, DQ haplotype C beta chain-like isoform X1 [KO:K06752 ]
107506405 TNFSF13; tumor necrosis factor ligand superfamily member 13 isoform X1 [KO:K05475 ]
107511110 TNFSF13B; tumor necrosis factor ligand superfamily member 13B isoform X1 [KO:K05476 ]
107516132 CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453 ]
107517455 TNFSF11; LOW QUALITY PROTEIN: tumor necrosis factor ligand superfamily member 11 [KO:K05473 ]
107501393 TNFRSF11A; tumor necrosis factor receptor superfamily member 11A [KO:K05147 ]
107503746 ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147 ]
107516231 ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147 ]
107501201 ATP6V1C2; V-type proton ATPase subunit C 2 isoform X1 [KO:K02148 ]
107503259 ATP6V1D; LOW QUALITY PROTEIN: V-type proton ATPase subunit D [KO:K02149 ]
107503485 TCIRG1; V-type proton ATPase 116 kDa subunit a isoform 3 [KO:K02154 ]
107504599 V-type proton ATPase 116 kDa subunit a isoform 2 isoform X1 [KO:K02154 ]
107519336 ATP6V0A4; V-type proton ATPase 116 kDa subunit a isoform 4 isoform X1 [KO:K02154 ]
107513825 ATP6V0A1; V-type proton ATPase 116 kDa subunit a isoform 1 isoform X1 [KO:K02154 ]
107514921 ATP6V0D2; V-type proton ATPase subunit d 2 isoform X1 [KO:K02146 ]
107506034 ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit isoform X1 [KO:K02155 ]
107499515 ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit isoform X1 [KO:K03661 ]
107497048 CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427 ]
107502007 VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448 ]
Compound
Reference
Authors
Zwerina J, Redlich K, Schett G, Smolen JS
Title
Pathogenesis of rheumatoid arthritis: targeting cytokines.
Journal
Reference
Authors
Szekanecz Z, Vegvari A, Szabo Z, Koch AE
Title
Chemokines and chemokine receptors in arthritis.
Journal
Front Biosci (Schol Ed) 2:153-67 (2010)
DOI:
10.2741/53
Reference
Authors
Isaacs JD
Title
The changing face of rheumatoid arthritis: sustained remission for all?
Journal
Reference
Authors
Strand V, Kimberly R, Isaacs JD
Title
Biologic therapies in rheumatology: lessons learned, future directions.
Journal
Reference
Authors
Bartok B, Firestein GS
Title
Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis.
Journal
Reference
Authors
Dai SM, Shan ZZ, Xu H, Nishioka K
Title
Cellular targets of interleukin-18 in rheumatoid arthritis.
Journal
Reference
Authors
Koch AE
Title
Review: angiogenesis: implications for rheumatoid arthritis.
Journal
Reference
Authors
Szekanecz Z, Besenyei T, Szentpetery A, Koch AE
Title
Angiogenesis and vasculogenesis in rheumatoid arthritis.
Journal
Reference
Authors
Brunner-Weinzierl MC, Hoff H, Burmester GR
Title
Multiple functions for CD28 and cytotoxic T lymphocyte antigen-4 during different phases of T cell responses: implications for arthritis and autoimmune diseases.
Journal
Reference
Authors
Theill LE, Boyle WJ, Penninger JM
Title
RANK-L and RANK: T cells, bone loss, and mammalian evolution.
Journal
Reference
Authors
Mensah KA, Li J, Schwarz EM
Title
The emerging field of osteoimmunology.
Journal
Reference
Authors
Takayanagi H, Sato K, Takaoka A, Taniguchi T
Title
Interplay between interferon and other cytokine systems in bone metabolism.
Journal
Reference
Authors
Takayanagi H
Title
New immune connections in osteoclast formation.
Journal
Reference
Authors
Nakashima T, Takayanagi H
Title
Osteoimmunology: crosstalk between the immune and bone systems.
Journal
Reference
Authors
Nakashima T, Takayanagi H
Title
Osteoclasts and the immune system.
Journal
Reference
Authors
Takayanagi H
Title
Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems.
Journal
Reference
Authors
Fox DA, Gizinski A, Morgan R, Lundy SK
Title
Cell-cell interactions in rheumatoid arthritis synovium.
Journal
Reference
Authors
Rho J, Takami M, Choi Y
Title
Osteoimmunology: interactions of the immune and skeletal systems.
Journal
Mol Cells 17:1-9 (2004)
Related pathway
ray04620 Toll-like receptor signaling pathway
ray04660 T cell receptor signaling pathway
ray04670 Leukocyte transendothelial migration
KO pathway
LinkDB
All DBs