KEGG ORTHOLOGY: K05505

ORTHOLOGY: K05505

Entry

K05505                      KO

Symbol

CXCL1_2_3, GRO

Name

C-X-C motif chemokine 1/2/3

Pathway

map04060

Cytokine-cytokine receptor interaction

map04061

Viral protein interaction with cytokine and cytokine receptor

map04062

Chemokine signaling pathway

map04064

NF-kappa B signaling pathway

map04621

NOD-like receptor signaling pathway

map04657

IL-17 signaling pathway

map04668

TNF signaling pathway

map04936

Alcoholic liver disease

map05120

Epithelial cell signaling in Helicobacter pylori infection

map05134

Legionellosis

map05146

Amoebiasis

map05167

Kaposi sarcoma-associated herpesvirus infection

map05323

Rheumatoid arthritis

map05417

Lipid and atherosclerosis

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    K05505  CXCL1_2_3, GRO; C-X-C motif chemokine 1/2/3
   04668 TNF signaling pathway
    K05505  CXCL1_2_3, GRO; C-X-C motif chemokine 1/2/3
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05505  CXCL1_2_3, GRO; C-X-C motif chemokine 1/2/3
   04061 Viral protein interaction with cytokine and cytokine receptor
    K05505  CXCL1_2_3, GRO; C-X-C motif chemokine 1/2/3
09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    K05505  CXCL1_2_3, GRO; C-X-C motif chemokine 1/2/3
   04657 IL-17 signaling pathway
    K05505  CXCL1_2_3, GRO; C-X-C motif chemokine 1/2/3
   04062 Chemokine signaling pathway
    K05505  CXCL1_2_3, GRO; C-X-C motif chemokine 1/2/3
09160 Human Diseases
  09172 Infectious disease: viral
   05167 Kaposi sarcoma-associated herpesvirus infection
    K05505  CXCL1_2_3, GRO; C-X-C motif chemokine 1/2/3
  09171 Infectious disease: bacterial
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K05505  CXCL1_2_3, GRO; C-X-C motif chemokine 1/2/3
   05134 Legionellosis
    K05505  CXCL1_2_3, GRO; C-X-C motif chemokine 1/2/3
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    K05505  CXCL1_2_3, GRO; C-X-C motif chemokine 1/2/3
  09163 Immune disease
   05323 Rheumatoid arthritis
    K05505  CXCL1_2_3, GRO; C-X-C motif chemokine 1/2/3
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K05505  CXCL1_2_3, GRO; C-X-C motif chemokine 1/2/3
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K05505  CXCL1_2_3, GRO; C-X-C motif chemokine 1/2/3
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides
    K05505  CXCL1_2_3, GRO; C-X-C motif chemokine 1/2/3
Cytokines and neuropeptides [BR:ko04052]
Cytokines
  Chemokines
   K05505  CXCL1_2_3, GRO; C-X-C motif chemokine 1/2/3

Genes

HSA:	2919(CXCL1) 2920(CXCL2) 2921(CXCL3)

PTR:	461255(CXCL3) 740176(CXCL2) 740567(CXCL1)

PPS:	100974886(CXCL2) 100975544 100976904(CXCL1)

GGO:	101131798(CXCL1) 101133388(CXCL3) 101134092

PON:	100438959(CXCL1) 100440799(CXCL3) 100441532(CXCL2)

NLE:	100588392(CXCL3) 100591876(CXCL1) 100592551(CXCL2)

HMH:	116466971 116475080 116475085(CXCL1)

MCC:	100424064 574222(CXCL1) 574223(CXCL3) 702067 703390

MCF:	102123272(CXCL2) 102123657 102126138(CXCL1)

MTHB:

126954905 126954911 126954917 126955314

MNI:	105471157 105477288(CXCL2) 105477292 105477297(CXCL1) 105477387

CSAB:

103235789(CXCL1) 103235792 103235798(CXCL3) 103236682

CATY:

105576876(CXCL2) 105576880 105596235(CXCL1) 105596237 105596241

PANU:

101022800 101024554 101026663(CXCL1) 103884403

TGE:	112616891 112624653 112624697 112625022 112625248

MLEU:

105531125 105531126 105531130 105531132(CXCL1)

RRO:	104654807 104658876(CXCL1) 104658882 104658884

RBB:	108513563 108515821 108523516 108539234 108539235

TFN:	117085487 117085490 117085495

PTEH:

111524574 111528185 111531279 111531286(CXCL1)

CANG:

105501289(CXCL1) 105501293 105501298

CJC:	100389870(CXCL2) 100400489 100401955(CXCL1)

SBQ:

101048540

CIMI:

108292194 108292198

CSYR:

103261912(CXCL1)

MMUR:

105860455

LCAT:

123624110 123624714 123624715

OGA:	100950823 100952509 100952827

MMU:	14825(Cxcl1) 20310(Cxcl2) 330122(Cxcl3)

MCAL:

110294442 110294443 110295209

MPAH:

110330904 110330924 110330950

RNO:	114105(Cxcl2) 171551(Cxcl3) 81503(Cxcl1)

MCOC:

116070642 116070643 116070644

ANU:	117712876 117712987 117713027

MUN:	110560483 110560489 110560490

CGE:	100689059(Cxcl1) 100689100(Cxcl3)

MAUA:

101827575 101834882 121140874

PROB:

127232100 127232102 127232104

PLEU:

114701719 114701735 114701736

MORG:

121460847 121460848(Cxcl3) 121460941

MFOT:

126506338 126506591 126506592

AAMP:

119816212 119816216

NGI:	103742468 103742470

HGL:	101705558(Cxcl1)

CPOC:

100135510(Cxcl1)

CCAN:

109691926 109700067

DORD:

105988528 105988529

DSP:	122106718 122106721

PLOP:

125364454 125365000

NCAR:

124994036 124994608

MMMA:

107158780 107158783

OCU:	100009245(GRO-A) 100328583(GRO-B)

OPI:	101521831 101534748 101534993

TUP:	102467686 102472622

GVR:	103590267 103591375 103600597 103600599 103600600

CFA:	119874472 119876918

CLUD:

112652148 112652150

VLG:	121472712 121473468 121473470

NPO:	129519109 129520159 129520255

AML:	100463732 100466241 100471490

UMR:	103665312 103665390

UAH:	113249941 113249943 113263276 113263277

UAR:	123787104 123789130 123789142

ELK:	111148819 111149266

LLV:	125093820 125093821 125093822

MPUF:

101672378 101672663

MNP:	132015959 132015978

MLK:	131823163 131823170 131823183

NVS:	122919245 122919267 122919268

ORO:	101365347 101377249

EJU:	114203885 114206733 114206753

ZCA:	113924854 113924855 118356741

NSU:	110591461 110591463 110591473

LWW:	102742158 102742576

FCA:	102901432 111560177 111560178

PYU:	121034414 121034424 121034449

PCOO:

112858315

PBG:	122478797 122478798 122478800

PVIV:

125163274 125164606 125164607

LRUF:

124520379 124520698 124520932

PPAD:

109277737

PUC:	125922824 125922825

AJU:	106981761 113599163 113599166

HHV:	120231058 120231111 120231112

BTA:	281212(GRO1) 281214(CXCL2) 613667(CXCL3)

BOM:

102269246

BIU:	109560573 109560578 109560579

BBUB:

102415247 102415899 102416225

BBIS:

104987311 104987339

CHX:	102182115 102182395 102182683

OAS:	101104661 114108665 443380(CXCL1)

BTAX:

128049546 128049610 128049611

ODA:	120861435 120861436 120861437

CCAD:

122428192 122428375 122428376

MBEZ:

129561737 129562028 129562061

SSC:	100525396 414904(CXCL2)

CFR:	102511405 116657068 116657069

CBAI:

105080430 105080431

CDK:	105091368 116158243 116158247

VPC:	102538005 107034385 116285036

BACU:

103005635 103005920 103006206

BMUS:

118895157 118895677 118895684

LVE:	103071404 103071675 103071959

OOR:	101277391 101285237 101285495

DLE:	111187576 111187591 111187662

PCAD:

102981375 102982314 112062060

PSIU:

116753842 116754232 116754241

NASI:

112392000 112405603 112405635 112405641

ECB:	100034121(CXCL1) 100056258(MIP-2BETA) 100233237(CXCL2)

EPZ:	103565789 103565792

EAI:	106829714 106829728 106829729

MYB:	102241767 102242280 102242586

MYD:

102760182

MMYO:

118669814 118669825 118669830

MLF:	102427247 102427544 102427867

PKL:

118705328

EFUS:

103288017 103288018 129151883

MNA:

107534487

DRO:	112319915(CXCL1) 112320502

SHON:

118999084(CXCL1) 118999119

AJM:	119052818 119059310

PDIC:

114491878 114491880 114492883

PHAS:

123831057 123831207 123831238 123831243

MMF:	118626364 118643206 118643274

PPAM:

129083870 129083875 129083885

HAI:	109371834 109371836 109394813

RFQ:	117022318 117022320 117022321

PALE:

102886142 102886385 102893266

PGIG:

120588200 120588202 120588203

PVP:

105292342

RAY:	107515315 107515316

MJV:	108397673 118969284

TOD:	119260635 119260855 119260938

SARA:

101544994 101545791

SETR:

126032263 126032541

LAV:	100665129 104846264(CXCL1)

TMU:	101346678 101357988

ETF:	101647727 101648039

DNM:	101442965 101443410

MDO:	100023783(CXCL1)

GAS:

123251660

SHR:

100915440

AFZ:	127540718 127540719

PCW:	110209790 110209791

OAA:

TGU:

LSR:

SCAN:

PHI:

CCAE:

CLV:

ASN:	112549131 112549464

PSS:

PBI:

NSS:

PMUA:

ZVI:

XTR:

TRU:

TFS:

ELY:

ECRA:

ONL:

OML:	112141026 112156372 118597875

XCO:	114139301 114157834

XHE:	116732162 116732171 116732208

PRET:

103475946

PMEI:

106917624

GAF:

122820361

CVG:	107085231 107085241

CTUL:

119773350 119773413 119773414 119773427

GMU:	124881141 124881203

XGL:

SASA:

ONE:

SNH:

ELS:

PKI:

PSPA:

CMK:

Reference

PMID:10028286

Authors

Modi WS, Yoshimura T

Title

Isolation of novel GRO genes and a phylogenetic analysis of the CXC chemokine subfamily in mammals.

Journal

Mol Biol Evol 16:180-93 (1999)
DOI:10.1093/oxfordjournals.molbev.a026101

Reference

PMID:2970963

Authors

Richmond A, Balentien E, Thomas HG, Flaggs G, Barton DE, Spiess J, Bordoni R, Francke U, Derynck R

Title

Molecular characterization and chromosomal mapping of melanoma growth stimulatory activity, a growth factor structurally related to beta-thromboglobulin.

Journal

EMBO J 7:2025-33 (1988)
DOI:10.1002/j.1460-2075.1988.tb03042.x

Sequence

[hsa:2919]

Reference

PMID:2078213

Authors

Iida N, Grotendorst GR

Title

Cloning and sequencing of a new gro transcript from activated human monocytes: expression in leukocytes and wound tissue.

Journal

Mol Cell Biol 10:5596-9 (1990)
DOI:10.1128/MCB.10.10.5596

Sequence

[hsa:2920]

Reference

PMID:2217207

Authors

Haskill S, Peace A, Morris J, Sporn SA, Anisowicz A, Lee SW, Smith T, Martin G, Ralph P, Sager R

Title

Identification of three related human GRO genes encoding cytokine functions.

Journal

Proc Natl Acad Sci U S A 87:7732-6 (1990)
DOI:10.1073/pnas.87.19.7732

Sequence

[hsa:2921]

LinkDB

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