KEGG   PATHWAY: sbq05020
Entry
sbq05020                    Pathway                                
Name
Prion disease - Saimiri boliviensis boliviensis (Bolivian squirrel monkey)
Description
Prion diseases, also termed transmissible spongiform encephalopathies (TSEs), are a group of fatal neurodegenerative diseases that affect humans and a number of other animal species. The etiology of these diseases is thought to be associated with the conversion of a normal protein, PrPC, into an infectious, pathogenic form, PrPSc. The conversion is induced by prion infections (for example, variant Creutzfeldt-Jakob disease (vCJD), iatrogenic CJD, Kuru), mutations (familial CJD, Gerstmann-Straussler-Scheinker syndrome, fatal familial insomnia (FFI)) or unknown factors (sporadic CJD (sCJD)), and is thought to occur after PrPC has reached the plasma membrane or is re-internalized for degradation. The PrPSc form shows greater protease resistance than PrPC and accumulates in affected individuals, often in the form of extracellular plaques. Pathways that may lead to neuronal death comprise oxidative stress, regulated activation of complement, ubiquitin-proteasome and endosomal-lysosomal systems, synaptic alterations and dendritic atrophy, corticosteroid response, and endoplasmic reticulum stress. In addition, the conformational transition could lead to the lost of a beneficial activity of the natively folded protein, PrPC.
Class
Human Diseases; Neurodegenerative disease
Pathway map
sbq05020  Prion disease
sbq05020

Organism
Saimiri boliviensis boliviensis (Bolivian squirrel monkey) [GN:sbq]
Gene
101039770  PRNP; major prion protein [KO:K05634]
101050508  NCAM1; neural cell adhesion molecule 1 isoform X17 [KO:K06491]
101027580  NCAM2; neural cell adhesion molecule 2 isoform X2 [KO:K06491]
101037029  LAMC1; laminin subunit gamma-1 [KO:K05635]
101041105  SOD1; superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
101050084  superoxide dismutase [Cu-Zn]-like [KO:K04565] [EC:1.15.1.1]
101028449  STIP1; stress-induced-phosphoprotein 1 [KO:K09553]
101034152  cAMP-dependent protein kinase catalytic subunit gamma-like [KO:K04345] [EC:2.7.11.11]
101036705  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
101043989  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma isoform X1 [KO:K04345] [EC:2.7.11.11]
101047300  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
101050177  BAX; apoptosis regulator BAX [KO:K02159]
101051746  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
101054145  GRIN1; glutamate receptor ionotropic, NMDA 1 [KO:K05208]
101030380  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
101036659  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
101040894  GRIN2C; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
101036810  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
101039341  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
101032406  GRIN3B; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
101049976  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
101040048  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
101043152  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
101034685  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
101042219  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
101050180  HSPA5; 78 kDa glucose-regulated protein [KO:K09490] [EC:3.6.4.10]
101031964  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
101032811  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 isoform X2 [KO:K03237]
101034435  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
104651132  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
101040405  RYR1; ryanodine receptor 1 [KO:K04961]
101044099  RYR2; ryanodine receptor 2 [KO:K04962]
101038051  RYR3; ryanodine receptor 3 [KO:K04963]
101029556  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
101049881  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
101048916  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
101045514  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X4 [KO:K04348] [EC:3.1.3.16]
101035788  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101032266  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101039659  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
104650539  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
101049631  BAD; bcl2-associated agonist of cell death [KO:K02158]
101031406  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
104649961  LOW QUALITY PROTEIN: voltage-dependent anion-selective channel protein 1-like [KO:K05862]
101038914  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
101045138  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X2 [KO:K15041]
101034520  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
101037746  LOW QUALITY PROTEIN: ADP/ATP translocase 3-like [KO:K05863]
101030497  LOW QUALITY PROTEIN: ADP/ATP translocase 2-like [KO:K05863]
101048239  LOW QUALITY PROTEIN: ADP/ATP translocase 3-like [KO:K05863]
101039411  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
101043018  SLC25A4; LOW QUALITY PROTEIN: ADP/ATP translocase 1 [KO:K05863]
101036833  ADP/ATP translocase 3 [KO:K05863]
101032370  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
101048222  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
101033270  cytochrome c [KO:K08738]
101034412  cytochrome c-like [KO:K08738]
101051525  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
101029697  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
101031167  MCU; calcium uniporter protein, mitochondrial [KO:K20858]
13228911  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
13228912  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
13228918  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
13228910  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
13228919  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
13228907  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
13228908  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
101047545  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
101044354  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
101035145  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
101053450  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
101052501  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 isoform X2 [KO:K03946]
101030840  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
101035938  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
101031560  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
101039979  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like isoform X1 [KO:K03949]
101027595  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
101035220  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like isoform X1 [KO:K03949]
104653297  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like isoform X1 [KO:K03949]
104652594  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like [KO:K03949]
101051623  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
101038075  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
101035659  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
101028201  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
101028433  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
101035902  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
101030516  acyl carrier protein, mitochondrial-like [KO:K03955]
101047198  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
101044072  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
101047340  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
101051290  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial isoform X1 [KO:K03958]
101039525  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial-like [KO:K03958]
101029660  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
101048990  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
101034513  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
101044891  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 isoform X2 [KO:K03962]
101033565  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
104650487  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial isoform X1 [KO:K03964]
101028411  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
101034007  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
101039653  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
101035051  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
101037033  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
101049213  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
101031505  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
101039247  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
101044441  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
101047065  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
101027656  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X1 [KO:K03940] [EC:7.1.1.2]
101027721  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
101051211  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
101049489  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [KO:K00234] [EC:1.3.5.1]
101044303  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
101051329  succinate dehydrogenase cytochrome b560 subunit, mitochondrial-like isoform X2 [KO:K00236]
101052834  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1 [KO:K00236]
101028994  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
101051648  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
13228909  CYTB; cytochrome b [KO:K00412]
101028265  cytochrome c1, heme protein, mitochondrial [KO:K00413]
101044497  cytochrome b-c1 complex subunit 1, mitochondrial [KO:K00414]
101027563  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
101048570  cytochrome b-c1 complex subunit 6, mitochondrial isoform X1 [KO:K00416]
101033949  cytochrome b-c1 complex subunit 7 [KO:K00417]
101035084  cytochrome b-c1 complex subunit 8 [KO:K00418]
101049239  cytochrome b-c1 complex subunit 9 [KO:K00419]
101046568  cytochrome b-c1 complex subunit 9 [KO:K00419]
101029246  cytochrome b-c1 complex subunit 10 [KO:K00420]
13228917  COX3; cytochrome c oxidase subunit III [KO:K02262]
13228913  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
13228914  COX2; cytochrome c oxidase subunit II [KO:K02261]
101034432  cytochrome c oxidase subunit 4 isoform 2, mitochondrial [KO:K02263]
101039974  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
101040245  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
101035543  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
101035057  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
104652045  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
101046056  cytochrome c oxidase subunit 6B1-like [KO:K02267]
101053685  cytochrome c oxidase subunit 6B1 [KO:K02267]
101048324  cytochrome c oxidase subunit 6B2 [KO:K02267]
104651513  cytochrome c oxidase subunit 6C [KO:K02268]
104653005  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
101040014  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
101047978  LOW QUALITY PROTEIN: cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
101031292  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
101052499  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
101048999  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
104650017  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
101037219  cytochrome c oxidase subunit 8C, mitochondrial [KO:K02273]
101045622  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
101039546  ATP5A1; ATP synthase subunit alpha, mitochondrial [KO:K02132]
101030792  ATP5B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
101032905  ATP5C1; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
101033378  ATP5D; ATP synthase subunit delta, mitochondrial [KO:K02134]
101042605  ATP5E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
13228916  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
101046852  ATP5F1; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
101041657  ATP5G1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
101034795  ATP5G2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
101035317  ATP5G3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
101043332  ATP5H; ATP synthase subunit d, mitochondrial [KO:K02138]
101029644  ATP synthase subunit d, mitochondrial-like isoform X1 [KO:K02138]
101029354  ATP synthase subunit d, mitochondrial-like isoform X1 [KO:K02138]
101039563  LOW QUALITY PROTEIN: ATP synthase subunit d, mitochondrial-like [KO:K02138]
101032192  ATP5O; ATP synthase subunit O, mitochondrial [KO:K02137]
101044387  ATP synthase subunit O, mitochondrial-like [KO:K02137]
101046136  ATP synthase subunit O, mitochondrial-like [KO:K02137]
101030869  ATP5J; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
13228915  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
101049858  PSMA6; proteasome subunit alpha type-6 [KO:K02730] [EC:3.4.25.1]
101049293  PSMA2; proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
101049260  PSMA4; proteasome subunit alpha type-4 [KO:K02728] [EC:3.4.25.1]
101040963  PSMA8; proteasome subunit alpha type-7-like isoform X1 [KO:K02731] [EC:3.4.25.1]
101046957  PSMA7; proteasome subunit alpha type-7 [KO:K02731] [EC:3.4.25.1]
101029804  PSMA5; proteasome subunit alpha type-5 [KO:K02729] [EC:3.4.25.1]
101046817  LOW QUALITY PROTEIN: proteasome subunit alpha type-1-like [KO:K02725] [EC:3.4.25.1]
101046358  PSMA1; proteasome subunit alpha type-1 [KO:K02725] [EC:3.4.25.1]
101053223  PSMA3; proteasome subunit alpha type-3 [KO:K02727] [EC:3.4.25.1]
101036005  PSMB6; proteasome subunit beta type-6 isoform X1 [KO:K02738] [EC:3.4.25.1]
101028673  PSMB7; proteasome subunit beta type-7 [KO:K02739] [EC:3.4.25.1]
101052796  PSMB3; proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
101050480  PSMB2; proteasome subunit beta type-2 [KO:K02734] [EC:3.4.25.1]
101036697  PSMB5; proteasome subunit beta type-5 [KO:K02737] [EC:3.4.25.1]
101040985  PSMB1; proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
101037466  PSMB4; proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
101035203  PSMC2; 26S protease regulatory subunit 7 [KO:K03061]
104650040  26S protease regulatory subunit 7-like [KO:K03061]
101050505  PSMC1; 26S protease regulatory subunit 4 [KO:K03062]
101038431  PSMC4; 26S protease regulatory subunit 6B [KO:K03063]
101042596  PSMC6; 26S protease regulatory subunit 10B [KO:K03064]
101029070  PSMC3; 26S protease regulatory subunit 6A [KO:K03065]
101037999  PSMC5; 26S protease regulatory subunit 8 [KO:K03066]
101041527  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
101038549  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
101040762  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
101042285  PSMD9; 26S proteasome non-ATPase regulatory subunit 9 isoform X1 [KO:K06693]
101039816  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
101049689  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
101034589  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
101037220  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
101049458  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
101036826  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 isoform X1 [KO:K03029]
101043814  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
101047735  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
101048232  ADRM1; proteasomal ubiquitin receptor ADRM1 [KO:K06691]
101052283  SHFM1; 26S proteasome complex subunit DSS1 isoform X2 [KO:K10881]
101040214  C5; complement C5 [KO:K03994]
101028369  C6; complement component C6 [KO:K03995]
101029227  C7; complement component C7 [KO:K03996]
101046777  C8A; complement component C8 alpha chain [KO:K03997]
101047099  C8B; complement component C8 beta chain [KO:K03998]
101034811  C8G; complement component C8 gamma chain [KO:K03999]
101034195  C9; complement component C9 [KO:K04000]
101048882  C1QA; complement C1q subcomponent subunit A [KO:K03986]
101049399  C1QB; complement C1q subcomponent subunit B [KO:K03987]
101048354  C1QC; complement C1q subcomponent subunit C [KO:K03988]
101049152  HSPA1A; heat shock 70 kDa protein 1A/1B [KO:K03283]
101049467  HSPA1L; heat shock 70 kDa protein 1-like [KO:K03283]
101032912  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
101050736  HSPA6; heat shock 70 kDa protein 6 [KO:K03283]
101030819  NOTCH1; neurogenic locus notch homolog protein 1 [KO:K02599]
101039198  CAV1; caveolin-1 isoform X1 [KO:K06278]
101039961  CAV2; caveolin-2 [KO:K12958]
101051489  CAV3; caveolin-3 [KO:K12959]
101029768  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101052779  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101027982  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101032496  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
101033359  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101050592  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
101044546  PRKCD; protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
101052306  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
101045425  cytochrome b-245 light chain [KO:K08009]
101034334  NCF4; neutrophil cytosol factor 4 [KO:K08012]
101054407  NCF1; LOW QUALITY PROTEIN: neutrophil cytosol factor 1 [KO:K08011]
101034817  NCF2; neutrophil cytosol factor 2 isoform X1 [KO:K08010]
101042808  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
101029481  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
101037444  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
101044137  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
101040899  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
101052690  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
101039160  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101027742  MAPK9; mitogen-activated protein kinase 9 isoform X4 [KO:K04440] [EC:2.7.11.24]
101048066  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
101038546  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
101043202  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101034085  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
101035834  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
101042795  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
101044974  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
101036473  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
101052885  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
101041199  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X4 [KO:K09048]
101054090  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
101047355  ATF6B; LOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-6 beta [KO:K09049]
101040906  EGR1; early growth response protein 1 [KO:K09203]
101053219  CCL5; C-C motif chemokine 5 [KO:K12499]
101033360  IL1A; interleukin-1 alpha [KO:K04383]
101033664  IL1B; interleukin-1 beta [KO:K04519]
101034757  IL6; interleukin-6 [KO:K05405]
101031357  TNF; tumor necrosis factor isoform X2 [KO:K03156]
101051107  GSK3B; glycogen synthase kinase-3 beta isoform X2 [KO:K03083] [EC:2.7.11.26]
101039128  CSNK2A1; casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
101048418  CSNK2A2; casein kinase II subunit alpha' [KO:K03097] [EC:2.7.11.1]
101027852  CSNK2B; casein kinase II subunit beta [KO:K03115]
101042531  KIF5B; kinesin-1 heavy chain [KO:K10396]
101054225  KIF5C; kinesin heavy chain isoform 5C [KO:K10396]
101034824  KIF5A; kinesin heavy chain isoform 5A [KO:K10396]
101027613  KLC4; kinesin light chain 4 [KO:K10407]
101049946  KLC2; kinesin light chain 2 [KO:K10407]
101053806  KLC3; kinesin light chain 3 [KO:K10407]
101038361  KLC1; kinesin light chain 1 isoform X8 [KO:K10407]
101046265  tubulin alpha-1B chain [KO:K07374]
101047200  tubulin alpha-1A chain [KO:K07374]
101046886  tubulin alpha-1C chain [KO:K07374]
101039362  TUBA8; tubulin alpha-8 chain [KO:K07374]
101040729  TUBAL3; tubulin alpha chain-like 3 isoform X2 [KO:K07374]
101027836  TUBA4A; LOW QUALITY PROTEIN: tubulin alpha-4A chain [KO:K07374]
101045575  tubulin beta-2A chain [KO:K07375]
101051381  tubulin beta chain-like [KO:K07375]
101041752  TUBB1; tubulin beta-1 chain [KO:K07375]
101036523  tubulin beta-8 chain-like [KO:K07375]
101043702  TUBB4A; tubulin beta-4A chain [KO:K07375]
101052549  tubulin beta chain [KO:K07375]
101052315  TUBB6; tubulin beta-6 chain [KO:K07375]
101034943  TUBB; tubulin beta chain [KO:K07375]
101034100  TUBB3; tubulin beta-3 chain [KO:K07375]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00575  3',5'-Cyclic AMP
C00704  Superoxide
C02140  Corticosterone
Reference
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  Title
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Expert Rev Mol Med 18:e5 (2016)
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PMID:25584786
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Mol Cell Neurosci 66:12-20 (2015)
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Reference
PMID:20889378
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Trends Mol Med 17:14-24 (2011)
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PMID:32565065
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Reference
PMID:15695097
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Reference
PMID:17051207
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Nature 443:803-10 (2006)
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Reference
PMID:11592845
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Neurobiol Dis 8:743-63 (2001)
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Reference
PMID:17085779
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Prions: protein only or something more? Overview of potential prion cofactors.
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J Mol Neurosci 29:195-214 (2006)
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Reference
PMID:14705136
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J Neurosci Res 75:153-61 (2004)
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Reference
PMID:10398674
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Cellular biology of prion diseases.
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Reference
PMID:15890824
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Prion biology relevant to bovine spongiform encephalopathy.
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J Anim Sci 83:1455-76 (2005)
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PMID:27581199
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Almost a century of prion protein(s): From pathology to physiology, and back to pathology.
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Biochem Biophys Res Commun 483:1148-1155 (2017)
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PMID:31618844
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Int J Mol Sci 20:E5107 (2019)
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Reference
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Int J Mol Sci 20:E6004 (2019)
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Reference
PMID:30710214
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Mol Neurobiol 56:6035-6045 (2019)
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Molecular mechanisms of neurodegeneration mediated by dysfunctional subcellular organelles in transmissible spongiform encephalopathies.
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Acta Biochim Biophys Sin (Shanghai) 45:452-64 (2013)
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J Neurochem 142:812-826 (2017)
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Reference
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What Is Our Current Understanding of PrP(Sc)-Associated Neurotoxicity and Its Molecular Underpinnings?
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Pathogens 6:E63 (2017)
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Reference
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Nat Rev Neurosci 15:233-49 (2014)
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Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD.
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Front Cell Neurosci 13:350 (2019)
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PLoS One 12:e0188340 (2017)
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Reference
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Understanding the neurospecificity of Prion protein signaling.
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Front Biosci (Landmark Ed) 16:169-86 (2011)
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PMID:23479001
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Cell Mol Biol Lett 18:209-30 (2013)
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Reference
PMID:28507517
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Front Aging Neurosci 9:120 (2017)
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Reference
PMID:15528202
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Pathological prion protein exposure switches on neuronal mitogen-activated protein kinase pathway resulting in microglia recruitment.
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J Biol Chem 280:1529-34 (2005)
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Reference
PMID:15640354
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Notch-1 activation and dendritic atrophy in prion disease.
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Proc Natl Acad Sci U S A 102:886-91 (2005)
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Reference
PMID:20205843
  Authors
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  Title
PrPSc accumulation in neuronal plasma membranes links Notch-1 activation to dendritic degeneration in prion diseases.
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Mol Neurodegener 5:6 (2010)
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Reference
PMID:29998397
  Authors
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  Title
Epigenetic Control of the Notch and Eph Signaling Pathways by the Prion Protein: Implications for Prion Diseases.
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Mol Neurobiol 56:2159-2173 (2019)
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Reference
PMID:28714865
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Aguzzi A, Zhu C
  Title
Microglia in prion diseases.
  Journal
J Clin Invest 127:3230-3239 (2017)
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Reference
PMID:15342004
  Authors
Mabbott NA
  Title
The complement system in prion diseases.
  Journal
Curr Opin Immunol 16:587-93 (2004)
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Reference
PMID:15611724
  Authors
Mallucci G, Collinge J
  Title
Rational targeting for prion therapeutics.
  Journal
Nat Rev Neurosci 6:23-34 (2005)
DOI:10.1038/nrn1584
Related
pathway
sbq00190  Oxidative phosphorylation
sbq03050  Proteasome
sbq04020  Calcium signaling pathway
sbq04140  Autophagy - animal
sbq04141  Protein processing in endoplasmic reticulum
sbq04142  Lysosome
sbq04144  Endocytosis
sbq04210  Apoptosis
sbq04330  Notch signaling pathway
sbq04610  Complement and coagulation cascades
sbq04668  TNF signaling pathway
KO pathway
ko05020   
LinkDB

DBGET integrated database retrieval system