KEGG   PATHWAY: scan03015
Entry
scan03015                   Pathway                                
Name
mRNA surveillance pathway - Serinus canaria (common canary)
Description
The mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go decay (NGD). NMD is a mechanism that eliminates mRNAs containing premature translation-termination codons (PTCs). In vertebrates, PTCs trigger efficient NMD when located upstream of an exon junction complex (EJC). Upf3, together with Upf1 and Upf2, may signal the presence of the PTC to the 5'end of the transcript, resulting in decapping and rapid exonucleolytic digestion of the mRNA. In the NSD pathway, which targets mRNAs lacking termination codons, the ribosome is believed to translate through the 3' untranslated region and stall at the end of the poly(A) tail. NSD involves an eRF3-like protein, Ski7p, which is hypothesized to bind the empty A site of the ribosome and recruit the exosome to degrade the mRNA from the 3' end. NGD targets mRNAs with stalls in translation elongation for endonucleolytic cleavage in a process involving the Dom34 and Hbs1 proteins.
Class
Genetic Information Processing; Translation
Pathway map
scan03015  mRNA surveillance pathway
scan03015

Other DBs
GO: 0071028
Organism
Serinus canaria (common canary) [GN:scan]
Gene
103821859  NCBP1; nuclear cap-binding protein subunit 1 [KO:K12882]
103815404  NCBP2; nuclear cap-binding protein subunit 2 isoform X2 [KO:K12883]
103824214  nuclear cap-binding protein subunit 2 [KO:K12883]
103816397  UPF3B; regulator of nonsense transcripts 3B [KO:K14328]
103812387  UPF3A; regulator of nonsense transcripts 3A [KO:K14328]
103825232  RBM8A; RNA-binding protein 8A [KO:K12876]
103815035  MAGOH; protein mago nashi homolog [KO:K12877]
103821751  CASC3; protein CASC3 [KO:K14323]
103821332  EIF4A3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
103827315  SAP18; histone deacetylase complex subunit SAP18 [KO:K14324]
103826539  PNN; pinin [KO:K13114]
103824362  RNPS1; RNA-binding protein with serine-rich domain 1 [KO:K14325]
103819915  LOW QUALITY PROTEIN: THO complex subunit 4 [KO:K12881]
115484521  LOW QUALITY PROTEIN: THO complex subunit 4-like [KO:K12881]
103824337  ATP-dependent RNA helicase DDX19B [KO:K18655] [EC:5.6.2.7]
103819029  GLE1; nucleoporin GLE1 [KO:K18723]
103816374  NXT2; NTF2-related export protein 2 isoform X1 [KO:K14285]
103823569  SRRM1; LOW QUALITY PROTEIN: serine/arginine repetitive matrix protein 1 [KO:K13171]
103819287  RNGTT; mRNA-capping enzyme isoform X1 [KO:K13917] [EC:2.7.7.50 3.6.1.74]
103826451  mRNA cap guanine-N7 methyltransferase [KO:K00565] [EC:2.1.1.56]
103820769  TARDBP; TAR DNA-binding protein 43 [KO:K23600]
103816889  PABPN1L; embryonic polyadenylate-binding protein 2 [KO:K14396]
115484225  PABPN1; polyadenylate-binding protein 2 [KO:K14396]
103813677  CPSF6; cleavage and polyadenylation specificity factor subunit 6 isoform X1 [KO:K14398]
103822270  CPSF7; cleavage and polyadenylation specificity factor subunit 7 [KO:K14398]
103819322  PAPOLG; poly(A) polymerase gamma isoform X1 [KO:K14376] [EC:2.7.7.19]
103826440  PAPOLA; poly(A) polymerase alpha isoform X1 [KO:K14376] [EC:2.7.7.19]
103822156  polyribonucleotide 5'-hydroxyl-kinase Clp1 [KO:K14399] [EC:2.7.1.78]
103812500  PCF11; pre-mRNA cleavage complex 2 protein Pcf11 [KO:K14400]
103826468  CPSF2; cleavage and polyadenylation specificity factor subunit 2 [KO:K14402]
103820423  CPSF3; cleavage and polyadenylation specificity factor subunit 3 isoform X1 [KO:K14403] [EC:3.1.27.-]
103817613  CPSF4; cleavage and polyadenylation specificity factor subunit 4 [KO:K14404]
103819959  CPSF4L; putative cleavage and polyadenylation specificity factor subunit 4-like protein isoform X1 [KO:K14404]
103826187  FIP1L1; pre-mRNA 3'-end-processing factor FIP1 [KO:K14405]
103816502  pre-mRNA 3'-end-processing factor FIP1-like [KO:K14405]
103815523  WDR33; pre-mRNA 3' end processing protein WDR33 isoform X1 [KO:K15542]
103824293  WDR82; WD repeat-containing protein 82 [KO:K14962]
103817249  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
103818147  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
103822255  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
103820799  SSU72; RNA polymerase II subunit A C-terminal domain phosphatase SSU72 [KO:K15544] [EC:3.1.3.16]
103818757  CSTF1; cleavage stimulation factor subunit 1 isoform X1 [KO:K14406]
103816457  CSTF2; cleavage stimulation factor subunit 2 isoform X1 [KO:K14407]
103822101  CSTF3; cleavage stimulation factor subunit 3 [KO:K14408]
103818041  MSI1; RNA-binding protein Musashi homolog 1 [KO:K14411]
103820347  MSI2; RNA-binding protein Musashi homolog 2 isoform X1 [KO:K14411]
108963055  DAZ-associated protein 1 isoform X1 [KO:K14411]
103813885  PABPC1; polyadenylate-binding protein 1 [KO:K13126]
103818799  PABPC1L; polyadenylate-binding protein 1-like [KO:K13126]
103823496  PABPC4; polyadenylate-binding protein 4 [KO:K13126]
103823779  ETF1; LOW QUALITY PROTEIN: eukaryotic peptide chain release factor subunit 1 [KO:K03265]
103817712  GSPT1; eukaryotic peptide chain release factor GTP-binding subunit ERF3A isoform X1 [KO:K03267]
103824543  UPF1; regulator of nonsense transcripts 1 isoform X1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
103813572  UPF2; regulator of nonsense transcripts 2 [KO:K14327]
103817897  SMG1; serine/threonine-protein kinase SMG1 [KO:K08873] [EC:2.7.11.1]
103814818  SMG7; protein SMG7 isoform X1 [KO:K14409]
103824055  SMG5; protein SMG5 [KO:K11125]
103820119  SMG6; telomerase-binding protein EST1A isoform X1 [KO:K11124] [EC:3.1.-.-]
103817471  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
103823422  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
103817406  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform [KO:K04354]
103824110  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X2 [KO:K04354]
103822705  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
103814089  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354]
103812324  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
103815474  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha [KO:K11583]
103826933  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma [KO:K11583]
103821519  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
103826366  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X2 [KO:K11584]
103826422  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
103821293  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X1 [KO:K11584]
115484937  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform-like [KO:K11584]
103820553  HBS1L; HBS1-like protein isoform X1 [KO:K14416]
103821088  PELO; protein pelota homolog [KO:K06965]
Reference
PMID:15040442
  Authors
Maquat LE
  Title
Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics.
  Journal
Nat Rev Mol Cell Biol 5:89-99 (2004)
DOI:10.1038/nrm1310
Reference
PMID:16723977
  Authors
Amrani N, Sachs MS, Jacobson A
  Title
Early nonsense: mRNA decay solves a translational problem.
  Journal
Nat Rev Mol Cell Biol 7:415-25 (2006)
DOI:10.1038/nrm1942
Reference
PMID:17183357
  Authors
Eulalio A, Behm-Ansmant I, Izaurralde E
  Title
P bodies: at the crossroads of post-transcriptional pathways.
  Journal
Nat Rev Mol Cell Biol 8:9-22 (2007)
DOI:10.1038/nrm2080
Reference
PMID:18158581
  Authors
Mandel CR, Bai Y, Tong L
  Title
Protein factors in pre-mRNA 3'-end processing.
  Journal
Cell Mol Life Sci 65:1099-122 (2008)
DOI:10.1007/s00018-007-7474-3
Reference
PMID:16715045
  Authors
Clement SL, Lykke-Andersen J
  Title
No mercy for messages that mess with the ribosome.
  Journal
Nat Struct Mol Biol 13:299-301 (2006)
DOI:10.1038/nsmb0406-299
Related
pathway
scan03013  Nucleocytoplasmic transport
scan03018  RNA degradation
scan03040  Spliceosome
KO pathway
ko03015   
LinkDB

DBGET integrated database retrieval system