KEGG   PATHWAY: sgh04141
Entry
sgh04141                    Pathway                                
Name
Protein processing in endoplasmic reticulum - Sinocyclocheilus grahami (golden-line barbel)
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
sgh04141  Protein processing in endoplasmic reticulum
sgh04141

Other DBs
GO: 0030433 0034976
Organism
Sinocyclocheilus grahami (golden-line barbel) [GN:sgh]
Gene
107585114  protein transport protein Sec61 subunit alpha-like 1 isoform X1 [KO:K10956]
107573737  protein transport protein Sec61 subunit alpha-like 1 [KO:K10956]
107584460  protein transport protein Sec61 subunit alpha-like 1 [KO:K10956]
107593687  protein transport protein Sec61 subunit beta-like isoform X1 [KO:K09481]
107595994  protein transport protein Sec61 subunit beta-like [KO:K09481]
107595136  protein transport protein Sec61 subunit gamma [KO:K07342]
107566778  protein transport protein Sec61 subunit gamma [KO:K07342]
107591342  sec62; translocation protein SEC62 isoform X1 [KO:K12275]
107558802  translocation protein SEC62-like [KO:K12275]
107602504  sec63; translocation protein SEC63 homolog [KO:K09540]
107601196  translocation protein SEC63 homolog isoform X1 [KO:K09540]
107573146  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1-like [KO:K12666]
107566443  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1-like [KO:K12666]
107560427  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2-like [KO:K12667]
107557908  rpn2; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform X1 [KO:K12667]
107600203  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit dad1-like [KO:K12668]
107558269  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit dad1 [KO:K12668]
107593933  ddost; dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit [KO:K12670]
107591123  dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit-like [KO:K12670]
107551195  stt3b; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B [KO:K07151] [EC:2.4.99.18]
107583387  stt3a; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A [KO:K07151] [EC:2.4.99.18]
107565263  LOW QUALITY PROTEIN: dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A-like [KO:K07151] [EC:2.4.99.18]
107566619  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B-like [KO:K07151] [EC:2.4.99.18]
107600616  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B [KO:K07151] [EC:2.4.99.18]
107562930  tumor suppressor candidate 3 [KO:K19478]
107566011  magnesium transporter protein 1 [KO:K19478]
107568992  magnesium transporter protein 1-like [KO:K19478]
107554394  tumor suppressor candidate 3-like [KO:K19478]
107568856  oligosaccharyltransferase complex subunit ostc [KO:K26501]
107551429  transmembrane protein 258 [KO:K26502]
107561170  transmembrane protein 258 [KO:K26502]
107551727  mannosyl-oligosaccharide glucosidase-like isoform X1 [KO:K01228] [EC:3.2.1.106]
107567052  mannosyl-oligosaccharide glucosidase-like isoform X1 [KO:K01228] [EC:3.2.1.106]
107569106  myosin-7B-like [KO:K13999]
107600559  ribosome-binding protein 1-like [KO:K14000]
107585504  ribosome-binding protein 1-like isoform X1 [KO:K14000]
107575072  ribosome-binding protein 1-like isoform X1 [KO:K14000]
107554832  nucleotide exchange factor SIL1-like [KO:K14001]
107580120  nucleotide exchange factor SIL1-like [KO:K14001]
107577052  hypoxia up-regulated protein 1-like [KO:K09486]
107588517  hypoxia up-regulated protein 1 [KO:K09486]
107574517  78 kDa glucose-regulated protein-like [KO:K09490] [EC:3.6.4.10]
107567952  78 kDa glucose-regulated protein [KO:K09490] [EC:3.6.4.10]
107572499  78 kDa glucose-regulated protein-like isoform X1 [KO:K09490] [EC:3.6.4.10]
107572500  78 kDa glucose-regulated protein-like [KO:K09490] [EC:3.6.4.10]
107569729  dnaJ homolog subfamily B member 11-like [KO:K09517]
107595843  dnaJ homolog subfamily B member 11 [KO:K09517]
107585399  dnaJ homolog subfamily C member 1-like [KO:K09521]
107589882  dnaJ homolog subfamily C member 1-like [KO:K09521]
107555214  dnajc3; dnaJ homolog subfamily C member 3 [KO:K09523]
107595288  dnaJ homolog subfamily C member 3-like [KO:K09523]
107601384  dnajc10; dnaJ homolog subfamily C member 10 [KO:K09530] [EC:1.8.4.-]
107601604  dnaJ homolog subfamily C member 10-like [KO:K09530] [EC:1.8.4.-]
107576609  endoplasmin [KO:K09487]
107581282  endoplasmin-like [KO:K09487]
107592208  endoplasmin-like [KO:K09487]
107548499  neutral alpha-glucosidase AB-like [KO:K05546] [EC:3.2.1.207]
107556017  neutral alpha-glucosidase AB-like [KO:K05546] [EC:3.2.1.207]
107601512  neutral alpha-glucosidase AB-like isoform X1 [KO:K05546] [EC:3.2.1.207]
107550893  ganab; neutral alpha-glucosidase AB isoform X1 [KO:K05546] [EC:3.2.1.207]
107596813  prkcsh; glucosidase 2 subunit beta [KO:K08288]
107587972  glucosidase 2 subunit beta-like [KO:K08288]
107554653  calnexin-like [KO:K08054]
107550987  calnexin-like [KO:K08054]
107579451  calnexin-like [KO:K08054]
107564199  calmegin-like [KO:K08054]
107597998  protein disulfide-isomerase A3-like [KO:K08056] [EC:5.3.4.1]
107554937  protein disulfide-isomerase A3-like [KO:K08056] [EC:5.3.4.1]
107584312  protein disulfide-isomerase A3-like [KO:K08056] [EC:5.3.4.1]
107573964  protein disulfide-isomerase A3-like [KO:K08056] [EC:5.3.4.1]
107587817  protein disulfide-isomerase A3-like [KO:K08056] [EC:5.3.4.1]
107580239  calreticulin-like [KO:K08057]
107548191  calreticulin-like [KO:K08057]
107549384  calreticulin-like [KO:K08057]
107552714  calreticulin-like [KO:K08057]
107561598  calreticulin-like isoform X1 [KO:K08057]
107599818  calreticulin-like [KO:K08057]
107596243  calreticulin-like [KO:K08057]
107549685  mannosyl-oligosaccharide 1,2-alpha-mannosidase IA-like [KO:K01230] [EC:3.2.1.113]
107567287  mannosyl-oligosaccharide 1,2-alpha-mannosidase IA-like [KO:K01230] [EC:3.2.1.113]
107597367  mannosyl-oligosaccharide 1,2-alpha-mannosidase IB-like [KO:K01230] [EC:3.2.1.113]
107569377  mannosyl-oligosaccharide 1,2-alpha-mannosidase IB [KO:K01230] [EC:3.2.1.113]
107601975  mannosyl-oligosaccharide 1,2-alpha-mannosidase IA-like [KO:K01230] [EC:3.2.1.113]
107564091  mannosyl-oligosaccharide 1,2-alpha-mannosidase IA-like isoform X1 [KO:K01230] [EC:3.2.1.113]
107571284  mannosyl-oligosaccharide 1,2-alpha-mannosidase IA-like [KO:K01230] [EC:3.2.1.113]
107587425  endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase-like [KO:K23741] [EC:3.2.1.209]
107560236  endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase-like [KO:K23741] [EC:3.2.1.209]
107595674  endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase-like [KO:K23741] [EC:3.2.1.209]
107548773  endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase-like [KO:K23741] [EC:3.2.1.209]
107598312  lman2; vesicular integral-membrane protein VIP36 isoform X1 [KO:K10082]
107563601  vesicular integral-membrane protein VIP36-like [KO:K10082]
107584635  protein ERGIC-53-like [KO:K10080]
107600893  protein ERGIC-53-like [KO:K10080]
107598936  prolactin regulatory element-binding protein-like [KO:K14003]
107562421  preb; prolactin regulatory element-binding protein [KO:K14003]
107575763  GTP-binding protein SAR1b-like [KO:K07953] [EC:3.6.5.-]
107603246  GTP-binding protein SAR1b isoform X1 [KO:K07953] [EC:3.6.5.-]
107588735  GTP-binding protein SAR1b-like [KO:K07953] [EC:3.6.5.-]
107570432  GTP-binding protein SAR1b-like [KO:K07953] [EC:3.6.5.-]
107564344  GTP-binding protein SAR1b-like [KO:K07953] [EC:3.6.5.-]
107595199  GTP-binding protein SAR1b-like [KO:K07953] [EC:3.6.5.-]
107562731  protein SEC13 homolog [KO:K14004]
107557974  protein SEC13 homolog [KO:K14004]
107560399  sec31a; protein transport protein Sec31A [KO:K14005]
107597776  protein transport protein Sec31A-like [KO:K14005]
107558245  protein transport protein Sec31A-like [KO:K14005]
107576311  protein transport protein Sec31A-like [KO:K14005]
107595197  protein transport protein Sec31A-like [KO:K14005]
107578631  protein transport protein Sec23A-like [KO:K14006]
107551934  protein transport protein Sec23A [KO:K14006]
107589610  protein transport protein Sec23A [KO:K14006]
107586586  protein transport protein Sec23A-like [KO:K14006]
107575942  protein transport protein Sec24C-like [KO:K14007]
107595973  protein transport protein Sec24C-like [KO:K14007]
107561511  protein transport protein Sec24D-like [KO:K14007]
107561851  sec24c; protein transport protein Sec24C isoform X1 [KO:K14007]
107603243  sec24a; protein transport protein Sec24A isoform X1 [KO:K14007]
107601422  protein transport protein Sec24C-like isoform X1 [KO:K14007]
107552989  sec24d; protein transport protein Sec24D isoform X1 [KO:K14007]
107596339  protein transport protein Sec24B-like isoform X1 [KO:K14007]
107571604  protein transport protein Sec24A-like [KO:K14007]
107552327  protein transport protein Sec24B-like [KO:K14007]
107555197  UDP-glucose:glycoprotein glucosyltransferase 2-like [KO:K11718] [EC:2.4.1.-]
107602600  UDP-glucose:glycoprotein glucosyltransferase 1-like [KO:K11718] [EC:2.4.1.-]
107600415  UDP-glucose:glycoprotein glucosyltransferase 2-like [KO:K11718] [EC:2.4.1.-]
107588898  UDP-glucose:glycoprotein glucosyltransferase 1-like [KO:K11718] [EC:2.4.1.-]
107552651  ER degradation-enhancing alpha-mannosidase-like protein 1 [KO:K10084]
107584463  ER degradation-enhancing alpha-mannosidase-like protein 1 isoform X1 [KO:K10084]
107601347  edem2; ER degradation-enhancing alpha-mannosidase-like protein 2 isoform X1 [KO:K10085]
107585860  ER degradation-enhancing alpha-mannosidase-like protein 3 isoform X1 [KO:K10086]
107595666  ER degradation-enhancing alpha-mannosidase-like protein 3 isoform X1 [KO:K10086]
107584610  ER degradation-enhancing alpha-mannosidase-like protein 3 [KO:K10086]
107548759  ER degradation-enhancing alpha-mannosidase-like protein 3 isoform X1 [KO:K10086]
107553316  protein disulfide-isomerase-like [KO:K09580] [EC:5.3.4.1]
107591928  protein disulfide-isomerase-like [KO:K09580] [EC:5.3.4.1]
107595128  pdia4; protein disulfide-isomerase A4 [KO:K09582] [EC:5.3.4.1]
107549125  protein disulfide-isomerase A6-like [KO:K09584] [EC:5.3.4.1]
107601540  protein disulfide-isomerase A6-like [KO:K09584] [EC:5.3.4.1]
107557239  thioredoxin domain-containing protein 5-like [KO:K13984] [EC:5.3.4.1]
107550028  txndc5; thioredoxin domain-containing protein 5 [KO:K13984] [EC:5.3.4.1]
107564954  ERO1-like protein alpha [KO:K10950] [EC:1.8.4.-]
107583613  ERO1-like protein alpha [KO:K10950] [EC:1.8.4.-]
107564746  ero1b; LOW QUALITY PROTEIN: ERO1-like protein beta [KO:K10976] [EC:1.8.4.-]
107582707  protein OS-9-like isoform X1 [KO:K10088]
107585136  protein OS-9-like [KO:K10088]
107602915  endoplasmic reticulum lectin 1-like [KO:K14008]
107553195  erlec1; endoplasmic reticulum lectin 1 isoform X1 [KO:K14008]
107574251  translocon-associated protein subunit alpha-like [KO:K13249]
107572627  ssr1; translocon-associated protein subunit alpha [KO:K13249]
107580381  translocon-associated protein subunit beta-like [KO:K13250]
107565562  translocon-associated protein subunit beta-like [KO:K13250]
107599560  ssr2; translocon-associated protein subunit beta [KO:K13250]
107571207  translocon-associated protein subunit gamma [KO:K13251]
107566582  translocon-associated protein subunit gamma-like [KO:K13251]
107560913  translocon-associated protein subunit delta-like [KO:K04571]
107562474  translocon-associated protein subunit delta-like [KO:K04571]
107584922  B-cell receptor-associated protein 31-like [KO:K14009]
107601763  B-cell receptor-associated protein 31-like [KO:K14009]
107564801  translocating chain-associated membrane protein 1-like [KO:K14010]
107596048  translocating chain-associated membrane protein 1-like 1 [KO:K14010]
107589926  tram1; translocating chain-associated membrane protein 1 isoform X1 [KO:K14010]
107555798  translocating chain-associated membrane protein 1-like [KO:K14010]
107595682  derlin-1-like [KO:K11519]
107593655  derlin-1 [KO:K11519]
107600006  derlin-2-like [KO:K13989]
107602852  derlin-2-like [KO:K13989]
107561584  derl2; derlin-2 [KO:K13989]
107580170  derlin-2-like [KO:K13989]
107600784  derlin-2 [KO:K13989]
107569017  UBX domain-containing protein 4-like [KO:K24348]
107550866  ubxn1; UBX domain-containing protein 1 [KO:K24348]
107601482  UBX domain-containing protein 1-like [KO:K24348]
107600119  UBX domain-containing protein 2A-like isoform X1 [KO:K24349]
107593331  UBX domain-containing protein 6-like [KO:K14011]
107586413  UBX domain-containing protein 6-like isoform X1 [KO:K14011]
107573258  ubxn8; UBX domain-containing protein 8 [KO:K24351]
107560918  NSFL1 cofactor p47-like [KO:K14012]
107562467  NSFL1 cofactor p47-like [KO:K14012]
107570089  svip; small VCP/p97-interacting protein [KO:K14014]
107594236  transitional endoplasmic reticulum ATPase-like [KO:K13525]
107552546  transitional endoplasmic reticulum ATPase [KO:K13525]
107601397  nuclear protein localization protein 4 homolog [KO:K14015]
107561846  nuclear protein localization protein 4 homolog [KO:K14015]
107552148  ubiquitin fusion degradation protein 1 homolog [KO:K14016]
107553030  ubiquitin fusion degradation protein 1 homolog [KO:K14016]
107582617  heat shock cognate 70 kDa protein [KO:K03283]
107577128  heat shock cognate 71 kDa protein-like [KO:K03283]
107585770  heat shock cognate 71 kDa protein-like [KO:K03283]
107588586  heat shock cognate 71 kDa protein [KO:K03283]
107597532  heat shock cognate 71 kDa protein-like isoform X1 [KO:K03283]
107603013  dnaJ homolog subfamily A member 1-like [KO:K09502]
107551804  dnaJ homolog subfamily A member 1-like [KO:K09502]
107564913  dnaja2; dnaJ homolog subfamily A member 2 [KO:K09503]
107598689  dnaJ homolog subfamily A member 2-like [KO:K09503]
107600593  dnaJ homolog subfamily A member 2-like [KO:K09503]
107591030  dnaJ homolog subfamily A member 2-like [KO:K09503]
107602716  dnaJ homolog subfamily B member 1-like [KO:K09507]
107599305  dnaJ homolog subfamily B member 1-like [KO:K09507]
107573606  dnaJ homolog subfamily B member 1-like [KO:K09507]
107594241  dnaJ homolog subfamily B member 1-like [KO:K09507]
107602899  dnaJ homolog subfamily B member 2-like isoform X1 [KO:K09508]
107551057  dnaJ homolog subfamily B member 2-like [KO:K09508]
107597775  dnajb12; dnaJ homolog subfamily B member 12 [KO:K09518]
107588700  dnaJ homolog subfamily B member 12-like [KO:K09518]
107585300  dnaJ homolog subfamily B member 12-like [KO:K09518]
107580613  dnaJ homolog subfamily C member 5-like [KO:K09525]
107598061  dnaJ homolog subfamily C member 5-like isoform X1 [KO:K09525]
107549528  dnaJ homolog subfamily C member 5-like [KO:K09525]
107563663  dnaJ homolog subfamily C member 5-like isoform X1 [KO:K09525]
107560895  dnaJ homolog subfamily C member 5-like isoform X1 [KO:K09525]
107549988  dnaJ homolog subfamily C member 5-like [KO:K09525]
107586796  dnaJ homolog subfamily C member 5-like [KO:K09525]
107552025  dnaJ homolog subfamily C member 5-like [KO:K09525]
107557012  heat shock protein HSP 90-alpha 1 isoform X1 [KO:K04079]
107559118  heat shock protein HSP 90-beta-like isoform X1 [KO:K04079]
107564585  heat shock protein HSP 90-alpha 1 isoform X1 [KO:K04079]
107564592  heat shock protein HSP 90-alpha [KO:K04079]
107568216  heat shock protein HSP 90-beta [KO:K04079]
107561683  heat shock 70 kDa protein 4L-like isoform X1 [KO:K09485]
107586823  heat shock 70 kDa protein 4L-like isoform X1 [KO:K09485]
107580615  BAG family molecular chaperone regulator 1-like [KO:K09555]
107556611  BAG family molecular chaperone regulator 1-like [KO:K09555]
107579699  bag2; BAG family molecular chaperone regulator 2 isoform X1 [KO:K09556]
107563236  hspbp1; hsp70-binding protein 1 [KO:K09562]
107579512  hsp70-binding protein 1-like [KO:K09562]
107588844  alpha-crystallin A chain [KO:K09541]
107552378  alpha-crystallin A chain-like [KO:K09541]
107582578  alpha-crystallin B chain-like [KO:K09542]
107603201  alpha-crystallin B chain-like [KO:K09542]
107574702  alpha-crystallin B chain-like [KO:K09542]
107571389  alpha-crystallin A chain-like [KO:K09542]
107580473  ubiquitin thioesterase OTU1 [KO:K13719] [EC:3.1.2.-]
107582461  ubiquitin thioesterase OTU1-like [KO:K13719] [EC:3.1.2.-]
107597871  LOW QUALITY PROTEIN: phospholipase A-2-activating protein-like [KO:K14018]
107549730  phospholipase A-2-activating protein-like [KO:K14018]
107569527  UV excision repair protein RAD23 homolog A-like [KO:K10839]
107570951  UV excision repair protein RAD23 homolog B-like [KO:K10839]
107549361  UV excision repair protein RAD23 homolog A-like [KO:K10839]
107567907  UV excision repair protein RAD23 homolog B-like isoform X1 [KO:K10839]
107583207  UV excision repair protein RAD23 homolog A-like [KO:K10839]
107575888  ubiquilin-4-like [KO:K04523]
107592473  ubqln4; ubiquilin-4 [KO:K04523]
107592173  ubiquilin-4-like [KO:K04523]
107593604  ngly1; peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase [KO:K01456] [EC:3.5.1.52]
107579448  peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase-like [KO:K01456] [EC:3.5.1.52]
107575702  ataxin-3-like [KO:K11863] [EC:3.4.22.-]
107570768  ubiquitin conjugation factor E4 B-like isoform X1 [KO:K10597] [EC:2.3.2.27]
107586519  LOW QUALITY PROTEIN: ubiquitin conjugation factor E4 B-like [KO:K10597] [EC:2.3.2.27]
107556913  eukaryotic translation initiation factor 2-alpha kinase 3-like [KO:K08860] [EC:2.7.11.1]
107568644  eukaryotic translation initiation factor 2-alpha kinase 3-like [KO:K08860] [EC:2.7.11.1]
107563904  eukaryotic translation initiation factor 2 subunit 1-like [KO:K03237]
107559120  eukaryotic translation initiation factor 2 subunit 1-like [KO:K03237]
107553277  eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
107568209  eukaryotic translation initiation factor 2 subunit 1-like [KO:K03237]
107600731  nuclear factor erythroid 2-related factor 2-like [KO:K05638]
107568392  atf4; cyclic AMP-dependent transcription factor ATF-4 isoform X1 [KO:K04374]
107582897  cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
107585034  cyclic AMP-dependent transcription factor ATF-4-like isoform X1 [KO:K04374]
107572342  cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
107566410  ddit3; DNA damage-inducible transcript 3 protein isoform X1 [KO:K04452]
107590259  apoptosis regulator Bcl-2-like [KO:K02161]
107593762  apoptosis regulator Bcl-2-like [KO:K02161]
107559382  apoptosis regulator Bcl-2-like [KO:K02161]
107558547  apoptosis regulator Bcl-2-like [KO:K02161]
107601246  cyclic AMP-dependent transcription factor ATF-6 alpha-like isoform X1 [KO:K09054]
107555632  cyclic AMP-dependent transcription factor ATF-6 alpha-like [KO:K09054]
107567815  cyclic AMP-dependent transcription factor ATF-6 beta-like isoform X1 [KO:K09049]
107566938  cyclic AMP-dependent transcription factor ATF-6 beta-like [KO:K09049]
107562941  wolframin-like isoform X1 [KO:K14020]
107565338  wolframin-like [KO:K14020]
107591887  wolframin-like [KO:K14020]
107583850  membrane-bound transcription factor site-1 protease [KO:K08653] [EC:3.4.21.112]
107596929  membrane-bound transcription factor site-1 protease-like isoform X1 [KO:K08653] [EC:3.4.21.112]
107590223  membrane-bound transcription factor site-2 protease-like [KO:K07765] [EC:3.4.24.85]
107586733  membrane-bound transcription factor site-2 protease-like [KO:K07765] [EC:3.4.24.85]
107555087  serine/threonine-protein kinase/endoribonuclease IRE1-like [KO:K08852] [EC:2.7.11.1 3.1.26.-]
107565200  ern2; serine/threonine-protein kinase/endoribonuclease IRE2 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
107590742  serine/threonine-protein kinase/endoribonuclease IRE1-like [KO:K08852] [EC:2.7.11.1 3.1.26.-]
107556589  serine/threonine-protein kinase/endoribonuclease IRE1-like [KO:K08852] [EC:2.7.11.1 3.1.26.-]
107563253  serine/threonine-protein kinase/endoribonuclease ire-1-like isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
107550260  serine/threonine-protein kinase ppk4-like isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
107591521  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
107595988  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
107557572  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
107567702  TNF receptor-associated factor 2-like isoform X1 [KO:K03173] [EC:2.3.2.27]
107587320  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
107560229  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
107556089  mitogen-activated protein kinase kinase kinase 5-like isoform X1 [KO:K04426] [EC:2.7.11.25]
107588497  mitogen-activated protein kinase kinase kinase 5-like isoform X1 [KO:K04426] [EC:2.7.11.25]
107570516  mitogen-activated protein kinase kinase kinase 5-like [KO:K04426] [EC:2.7.11.25]
107554152  mitogen-activated protein kinase kinase kinase 5-like [KO:K04426] [EC:2.7.11.25]
107602992  dual specificity mitogen-activated protein kinase kinase 7-like [KO:K04431] [EC:2.7.12.2]
107567797  map2k7; dual specificity mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
107566214  mitogen-activated protein kinase 9-like isoform X1 [KO:K04440] [EC:2.7.11.24]
107565387  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
107584639  mitogen-activated protein kinase 10-like [KO:K04440] [EC:2.7.11.24]
107588610  mitogen-activated protein kinase 8B isoform X1 [KO:K04440] [EC:2.7.11.24]
107548633  mitogen-activated protein kinase 8B isoform X1 [KO:K04440] [EC:2.7.11.24]
107590058  mitogen-activated protein kinase 9-like [KO:K04440] [EC:2.7.11.24]
107571265  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
107590365  apoptosis regulator BAX-like [KO:K02159]
107548334  apoptosis regulator BAX-like [KO:K02159]
107601305  apoptosis regulator BAX-like [KO:K02159]
107548291  apoptosis regulator BAX-like [KO:K02159]
107594474  apoptosis regulator BAX-like [KO:K02159]
107583031  apoptosis regulator BAX-like [KO:K02159]
107559906  calpain-1 catalytic subunit-like isoform X1 [KO:K01367] [EC:3.4.22.52]
107570763  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
107586085  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
107560673  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
107565170  calpain-1 catalytic subunit-like isoform X1 [KO:K01367] [EC:3.4.22.52]
107569123  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
107554500  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
107560139  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
107549131  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
107566058  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
107586086  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
107571859  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
107565171  calpain-2 catalytic subunit-like isoform X1 [KO:K03853] [EC:3.4.22.53]
107565172  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
107565180  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
107569122  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
107577564  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
107549147  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
107550690  E3 ubiquitin-protein ligase MARCH6-like [KO:K10661] [EC:2.3.2.27]
107584311  march6; E3 ubiquitin-protein ligase MARCH6 [KO:K10661] [EC:2.3.2.27]
107562346  ube2j1; ubiquitin-conjugating enzyme E2 J1 [KO:K10578] [EC:2.3.2.23]
107599097  ubiquitin-conjugating enzyme E2 J2 [KO:K04554] [EC:2.3.2.23]
107555999  ubiquitin-conjugating enzyme E2 J2-like [KO:K04554] [EC:2.3.2.23]
107593951  ubiquitin-conjugating enzyme E2 J2-like [KO:K04554] [EC:2.3.2.23]
107595690  ubiquitin-conjugating enzyme E2 G1-like [KO:K10575] [EC:2.3.2.23]
107587356  ubiquitin-conjugating enzyme E2 G1 [KO:K10575] [EC:2.3.2.23]
107597432  ubiquitin-conjugating enzyme E2 G1-like isoform X1 [KO:K10575] [EC:2.3.2.23]
107556945  ubiquitin-conjugating enzyme E2 G1-like [KO:K10575] [EC:2.3.2.23]
107551904  ubiquitin-conjugating enzyme E2 G2-like [KO:K04555] [EC:2.3.2.23]
107551905  ubiquitin-conjugating enzyme E2 G2-like [KO:K04555] [EC:2.3.2.23]
107581339  ubiquitin-conjugating enzyme E2 G2 isoform X1 [KO:K04555] [EC:2.3.2.23]
107598309  E3 ubiquitin-protein ligase synoviolin isoform X1 [KO:K10601] [EC:2.3.2.27]
107563593  E3 ubiquitin-protein ligase synoviolin-like isoform X1 [KO:K10601] [EC:2.3.2.27]
107557472  rnf5; E3 ubiquitin-protein ligase RNF5 [KO:K10666] [EC:2.3.2.27]
107566615  E3 ubiquitin-protein ligase RNF5-like [KO:K10666] [EC:2.3.2.27]
107565142  E3 ubiquitin-protein ligase RNF185-like isoform X1 [KO:K10666] [EC:2.3.2.27]
107562859  vimp; selenoprotein S isoform X1 [KO:K14025]
107570773  protein sel-1 homolog 3-like [KO:K14026]
107602349  protein sel-1 homolog 1-like [KO:K14026]
107585782  protein sel-1 homolog 1-like [KO:K14026]
107583788  homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein [KO:K14027]
107549637  homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein [KO:K14027]
107566269  E3 ubiquitin-protein ligase AMFR-like [KO:K10636] [EC:2.3.2.36]
107555700  E3 ubiquitin-protein ligase AMFR-like [KO:K10636] [EC:2.3.2.36]
107556653  stub1; E3 ubiquitin-protein ligase CHIP [KO:K09561] [EC:2.3.2.27]
107561107  STIP1 homology and U box-containing protein 1-like [KO:K09561] [EC:2.3.2.27]
107569418  ubiquitin-conjugating enzyme E2 D2-like [KO:K06689] [EC:2.3.2.23]
107589096  ubiquitin-conjugating enzyme E2 D2 isoform X1 [KO:K06689] [EC:2.3.2.23]
107593498  ubiquitin-conjugating enzyme E2 D4-like [KO:K06689] [EC:2.3.2.23]
107587054  ubiquitin-conjugating enzyme E2 D2-like [KO:K06689] [EC:2.3.2.23]
107559289  ubiquitin-conjugating enzyme E2 D2 [KO:K06689] [EC:2.3.2.23]
107556230  ubiquitin-conjugating enzyme E2 D4 [KO:K06689] [EC:2.3.2.23]
107583697  ubiquitin-conjugating enzyme E2 D4-like [KO:K06689] [EC:2.3.2.23]
107595736  ubiquitin-conjugating enzyme E2 D2-like [KO:K06689] [EC:2.3.2.23]
107553913  ubiquitin-conjugating enzyme E2 D4-like [KO:K06689] [EC:2.3.2.23]
107596568  ubiquitin-conjugating enzyme E2 D4-like isoform X1 [KO:K06689] [EC:2.3.2.23]
107585246  ubiquitin-conjugating enzyme E2 D2-like isoform X1 [KO:K06689] [EC:2.3.2.23]
107563169  ubiquitin-conjugating enzyme E2 D4 [KO:K06689] [EC:2.3.2.23]
107586494  park2; E3 ubiquitin-protein ligase parkin [KO:K04556] [EC:2.3.2.31]
107602336  rbx1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
107580054  RING-box protein 1 [KO:K03868] [EC:2.3.2.32]
107549182  cullin-1-like [KO:K03347]
107595130  cullin-1-like [KO:K03347]
107599244  cullin-1 [KO:K03347]
107600214  cullin-1-like [KO:K03347]
107603266  skp1; S-phase kinase-associated protein 1 isoform X1 [KO:K03094]
107578216  F-box only protein 2-like [KO:K10099]
107582401  F-box only protein 2-like [KO:K10099]
107561437  uncharacterized protein LOC107561437 [KO:K10099]
107559475  F-box only protein 6-like [KO:K10100]
107603135  F-box only protein 6-like isoform X1 [KO:K10100]
107559474  F-box only protein 44-like isoform X1 [KO:K10100]
Compound
C00076  Calcium cation
G00009   
G00010   
G00011   
G00012   
G10694   
Reference
PMID:19491040
  Authors
Naidoo N
  Title
ER and aging-Protein folding and the ER stress response.
  Journal
Ageing Res Rev 8:150-9 (2009)
DOI:10.1016/j.arr.2009.03.001
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:20347046
  Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  Title
Protein quality control in the ER: the recognition of misfolded proteins.
  Journal
Semin Cell Dev Biol 21:500-11 (2010)
DOI:10.1016/j.semcdb.2010.03.006
Reference
PMID:20219571
  Authors
Stolz A, Wolf DH
  Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  Journal
Biochim Biophys Acta 1803:694-705 (2010)
DOI:10.1016/j.bbamcr.2010.02.005
Reference
PMID:20112977
  Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  Journal
J Proteome Res 9:1763-71 (2010)
DOI:10.1021/pr900900x
Related
pathway
sgh00510  N-Glycan biosynthesis
sgh03050  Proteasome
sgh03060  Protein export
sgh04210  Apoptosis
KO pathway
ko04141   
LinkDB

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