KEGG   PATHWAY: sund04512
Entry
sund04512                   Pathway                                
Name
ECM-receptor interaction - Sceloporus undulatus (fence lizard)
Description
The extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell and tissue structure and function. Specific interactions between cells and the ECM are mediated by transmembrane molecules, mainly integrins and perhaps also proteoglycans, CD36, or other cell-surface-associated components. These interactions lead to a direct or indirect control of cellular activities such as adhesion, migration, differentiation, proliferation, and apoptosis. In addition, integrins function as mechanoreceptors and provide a force-transmitting physical link between the ECM and the cytoskeleton. Integrins are a family of glycosylated, heterodimeric transmembrane adhesion receptors that consist of noncovalently bound alpha- and beta-subunits.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
sund04512  ECM-receptor interaction
sund04512

Other DBs
GO: 0005201
Organism
Sceloporus undulatus (fence lizard) [GN:sund]
Gene
121933297  COL1A1; collagen alpha-1(I) chain [KO:K06236]
121935136  COL1A2; collagen alpha-2(I) chain [KO:K06236]
121922506  COL2A1; collagen alpha-1(II) chain [KO:K19719]
121927334  COL4A4; collagen alpha-4(IV) chain isoform X1 [KO:K06237]
121919299  COL4A2; LOW QUALITY PROTEIN: collagen alpha-2(IV) chain [KO:K06237]
121919300  COL4A1; LOW QUALITY PROTEIN: collagen alpha-1(IV) chain [KO:K06237]
121936332  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
121936775  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
121926784  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
121933001  collagen alpha-6(VI) chain-like [KO:K06238]
121933367  LOW QUALITY PROTEIN: collagen alpha-6(VI) chain-like [KO:K06238]
121922839  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
121919175  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
121925548  COL6A2; LOW QUALITY PROTEIN: collagen alpha-2(VI) chain [KO:K06238]
121935668  collagen alpha-6(VI) chain-like [KO:K06238]
121916330  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
121919496  COL9A1; collagen alpha-1(IX) chain isoform X1 [KO:K08131]
121929470  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
121917303  laminin subunit alpha-1-like isoform X1 [KO:K05637]
121917315  laminin subunit alpha-1-like isoform X1 [KO:K05637]
121925145  LAMA2; LOW QUALITY PROTEIN: laminin subunit alpha-2 [KO:K05637]
121928135  LAMA5; laminin subunit alpha-5 [KO:K06240]
121917420  laminin subunit alpha-3-like [KO:K06240]
121917435  laminin subunit alpha-3-like [KO:K06240]
121916533  LAMA4; laminin subunit alpha-4 [KO:K06241]
121931014  LAMB1; laminin subunit beta-1 isoform X1 [KO:K05636]
121923220  laminin subunit beta-4-like [KO:K06243]
121920310  LAMB2; LOW QUALITY PROTEIN: laminin subunit beta-2 [KO:K06243]
121929644  LAMB3; LOW QUALITY PROTEIN: laminin subunit beta-3 [KO:K06244]
121932229  LAMB4; laminin subunit beta-4 isoform X1 [KO:K06245]
121928192  LAMC1; laminin subunit gamma-1 [KO:K05635]
121923847  CHAD; chondroadherin [KO:K06248]
121930796  RELN; LOW QUALITY PROTEIN: reelin [KO:K06249] [EC:3.4.21.-]
121929146  THBS1; thrombospondin-1 isoform X1 [KO:K16857]
121916618  LOW QUALITY PROTEIN: cartilage oligomeric matrix protein [KO:K04659]
121919492  THBS2; thrombospondin-2 [KO:K04659]
121921688  THBS4; thrombospondin-4 isoform X1 [KO:K04659]
121916045  THBS3; thrombospondin-3 [KO:K04659]
121917568  FN1; fibronectin isoform X1 [KO:K05717]
121932142  SPP1; osteopontin [KO:K06250]
121916891  VTN; vitronectin [KO:K06251]
121929883  TNR; tenascin-R [KO:K06252]
121929950  TNN; tenascin-N [KO:K06252]
121936684  TNC; tenascin isoform X1 [KO:K06252]
121921797  TNXB; LOW QUALITY PROTEIN: tenascin-X [KO:K06252]
121931717  NPNT; nephronectin [KO:K06824]
121931386  FRAS1; extracellular matrix organizing protein FRAS1 [KO:K23379]
121927983  LOW QUALITY PROTEIN: FRAS1-related extracellular matrix protein 1-like [KO:K23380]
121923795  FREM1; FRAS1-related extracellular matrix protein 1 isoform X1 [KO:K23380]
121931398  VWF; von Willebrand factor isoform X1 [KO:K03900]
121931521  bone sialoprotein 2 [KO:K06253]
121931732  DMP1; dentin matrix acidic phosphoprotein 1 [KO:K23328]
121931553  MEPE; matrix extracellular phosphoglycoprotein [KO:K26442]
121936715  AGRN; agrin isoform X1 [KO:K06254]
121936072  HSPG2; LOW QUALITY PROTEIN: basement membrane-specific heparan sulfate proteoglycan core protein [KO:K06255]
121922179  ITGA1; integrin alpha-1 [KO:K06480]
121922385  ITGA2; integrin alpha-2 isoform X1 [KO:K06481]
121934327  ITGA2B; integrin alpha-IIb [KO:K06476]
121934643  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
121924170  ITGA4; integrin alpha-4 [KO:K06483]
121921545  ITGA5; LOW QUALITY PROTEIN: integrin alpha-5 [KO:K06484]
121927338  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
121921103  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
121935359  ITGA8; integrin alpha-8 [KO:K06584]
121934782  ITGA9; integrin alpha-9 [KO:K06585]
121915642  ITGA10; integrin alpha-10 [KO:K06586]
121933080  ITGA11; integrin alpha-11 [KO:K06587]
121929473  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
121933495  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
121934741  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
121923354  ITGB4; integrin beta-4 [KO:K06525]
121923162  ITGB5; integrin beta-5 isoform X1 [KO:K06588]
121919881  ITGB6; integrin beta-6 [KO:K06589]
121923851  ITGB7; integrin beta-7 [KO:K06590]
121934217  ITGB8; integrin beta-8 [KO:K06591]
121915924  SDC1; syndecan-1 [KO:K06257]
121928371  SDC4; syndecan-4 isoform X1 [KO:K16338]
121916209  SV2A; synaptic vesicle glycoprotein 2A [KO:K06258]
121923634  SV2C; synaptic vesicle glycoprotein 2C [KO:K06258]
121934960  SV2B; synaptic vesicle glycoprotein 2B [KO:K06258]
121930698  CD36; platelet glycoprotein 4 [KO:K06259]
121924729  GP5; platelet glycoprotein V [KO:K06260]
121933954  GP1BA; platelet glycoprotein Ib alpha chain [KO:K06261]
121916632  GP1BB; platelet glycoprotein Ib beta chain [KO:K06262]
121922827  platelet glycoprotein IX-like [KO:K06263]
121922882  platelet glycoprotein IX-like [KO:K06263]
121921252  DAG1; dystroglycan [KO:K06265]
121917205  leukocyte surface antigen CD47-like isoform X1 [KO:K06266]
121917250  leukocyte surface antigen CD47-like isoform X1 [KO:K06266]
121924367  HMMR; hyaluronan mediated motility receptor isoform X1 [KO:K06267]
Compound
G10505  Hyaluronic acid
Reference
PMID:11572082
  Authors
van der Flier A, Sonnenberg A.
  Title
Function and interactions of integrins.
  Journal
Cell Tissue Res 305:285-98 (2001)
DOI:10.1007/s004410100417
Reference
PMID:12921709
  Authors
Reddy KV, Mangale SS.
  Title
Integrin receptors: the dynamic modulators of endometrial function.
  Journal
Tissue Cell 35:260-73 (2003)
DOI:10.1016/S0040-8166(03)00039-9
Reference
PMID:12125070
  Authors
Milner R, Campbell IL.
  Title
The integrin family of cell adhesion molecules has multiple functions within the CNS.
  Journal
J Neurosci Res 69:286-91 (2002)
DOI:10.1002/jnr.10321
Reference
PMID:12796473
  Authors
Cichy J, Pure E.
  Title
The liberation of CD44.
  Journal
J Cell Biol 161:839-43 (2003)
DOI:10.1083/jcb.200302098
Reference
PMID:7698997
  Authors
Elenius K, Jalkanen M.
  Title
Function of the syndecans--a family of cell surface proteoglycans.
  Journal
J Cell Sci 107 ( Pt 11):2975-82 (1994)
Reference
PMID:10617638
  Authors
Son YJ, Scranton TW, Sunderland WJ, Baek SJ, Miner JH, Sanes JR, Carlson SS.
  Title
The synaptic vesicle protein SV2 is complexed with an alpha5-containing laminin on the nerve terminal surface.
  Journal
J Biol Chem 275:451-60 (2000)
DOI:10.1074/jbc.275.1.451
Reference
PMID:15036264
  Authors
Sid B, Sartelet H, Bellon G, El Btaouri H, Rath G, Delorme N, Haye B, Martiny L.
  Title
Thrombospondin 1: a multifunctional protein implicated in the regulation of tumor growth.
  Journal
Crit Rev Oncol Hematol 49:245-58 (2004)
DOI:10.1016/j.critrevonc.2003.09.009
Reference
PMID:15381249
  Authors
Canobbio I, Balduini C, Torti M.
  Title
Signalling through the platelet glycoprotein Ib-V-IX complex.
  Journal
Cell Signal 16:1329-44 (2004)
DOI:10.1016/j.cellsig.2004.05.008
Reference
PMID:11331578
  Authors
Nieswandt B, Brakebusch C, Bergmeier W, Schulte V, Bouvard D, Mokhtari-Nejad R, Lindhout T, Heemskerk JW, Zirngibl H, Fassler R.
  Title
Glycoprotein VI but not alpha2beta1 integrin is essential for platelet interaction with collagen.
  Journal
EMBO J 20:2120-30 (2001)
DOI:10.1093/emboj/20.9.2120
Reference
PMID:12736199
  Authors
Martin PT.
  Title
Dystroglycan glycosylation and its role in matrix binding in skeletal muscle.
  Journal
Glycobiology 13:55R-66R (2003)
DOI:10.1093/glycob/cwg076
Reference
PMID:15229478
  Authors
Toole BP.
  Title
Hyaluronan: from extracellular glue to pericellular cue.
  Journal
Nat Rev Cancer 4:528-39 (2004)
DOI:10.1038/nrc1391
Reference
PMID:12845610
  Authors
Bosman FT, Stamenkovic I.
  Title
Functional structure and composition of the extracellular matrix.
  Journal
J Pathol 200:423-8 (2003)
DOI:10.1002/path.1437
Reference
PMID:29079659
  Authors
van der Ven AT, Vivante A, Hildebrandt F
  Title
Novel Insights into the Pathogenesis of Monogenic Congenital Anomalies of the Kidney and Urinary Tract.
  Journal
J Am Soc Nephrol 29:36-50 (2018)
DOI:10.1681/ASN.2017050561
Related
pathway
sund04510  Focal adhesion
KO pathway
ko04512   
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