KEGG   PATHWAY: tpai04540
Entry
tpai04540                   Pathway                                
Name
Gap junction - Tympanuchus pallidicinctus (lesser prairie-chicken)
Description
Gap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels', each containing six connexins, contributed by each neighboring cell. These channels permit the direct transfer of small molecules including ions, amino acids, nucleotides, second messengers and other metabolites between adjacent cells. Gap junctional communication is essential for many physiological events, including embryonic development, electrical coupling, metabolic transport, apoptosis, and tissue homeostasis. Communication through Gap Junction is sensitive to a variety of stimuli, including changes in the level of intracellular Ca2+, pH, transjunctional applied voltage and phosphorylation/dephosphorylation processes. This figure represents the possible activation routes of different protein kinases involved in Cx43 and Cx36 phosphorylation.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
tpai04540  Gap junction
tpai04540

Other DBs
GO: 0005921
Organism
Tympanuchus pallidicinctus (lesser prairie-chicken) [GN:tpai]
Gene
128081298  GJA1; gap junction alpha-1 protein [KO:K07372]
128085908  GJD2; gap junction delta-2 protein [KO:K07373]
128089422  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
128083751  lysophosphatidic acid receptor 1-B-like isoform X1 [KO:K04289]
128088092  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
128078494  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
128079575  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
128079041  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
128073591  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
128074814  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
128084384  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
128080350  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
128080542  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
128081597  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
128088438  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
128083026  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
128086826  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
128087173  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
128086364  HRAS; GTPase HRas [KO:K02833]
128084496  KRAS; GTPase KRas isoform X1 [KO:K07827]
128088218  NRAS; GTPase NRas [KO:K07828]
128078363  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
128075267  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
128090447  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
128084585  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
128081145  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
128076663  MAP3K2; mitogen-activated protein kinase kinase kinase 2 isoform X1 [KO:K04420] [EC:2.7.11.25]
128075282  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
128073364  tubulin alpha-4 chain [KO:K07374]
128073373  tubulin alpha-2 chain [KO:K07374]
128074167  tubulin alpha-1B chain [KO:K07374]
128074168  TUBA1A; tubulin alpha-1A chain [KO:K07374]
128074169  tubulin alpha-1C chain [KO:K07374]
128082400  tubulin alpha-3 chain [KO:K07374]
128076767  tubulin alpha-5 chain isoform X1 [KO:K07374]
128090309  tubulin alpha-8 chain [KO:K07374]
128079690  tubulin alpha-3 chain [KO:K07374]
128081242  TUBB1; tubulin beta-1 chain isoform X1 [KO:K07375]
128087722  tubulin beta-2 chain [KO:K07375]
128087723  tubulin beta-1 chain [KO:K07375]
128082089  TUBB3; tubulin beta-3 chain [KO:K07375]
128090930  TUBB6; tubulin beta-6 chain isoform X1 [KO:K07375]
128073157  TUBB4B; tubulin beta-4B chain [KO:K07375]
128083218  CSNK1D; casein kinase I isoform X1 [KO:K08959] [EC:2.7.11.1]
128077997  CDK1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
128075481  TJP1; tight junction protein ZO-1 isoform X1 [KO:K05701]
128077971  ADRB1; beta-1 adrenergic receptor isoform X1 [KO:K04141]
128081634  DRD1; D(1A) dopamine receptor [KO:K04144]
128081238  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
128087621  DRD2; D(2) dopamine receptor isoform X1 [KO:K04145]
128087769  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
128091036  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
128084684  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
128077242  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
128082547  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
128091225  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
128078941  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
128072854  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
128082612  HTR2B; 5-hydroxytryptamine receptor 2B [KO:K04157]
128075792  HTR2C; 5-hydroxytryptamine receptor 2C isoform X1 [KO:K04157]
128071647  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
128074784  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
128073999  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
128090368  GNA11; guanine nucleotide-binding protein subunit alpha-11 isoform X1 [KO:K04635]
128089400  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
128086570  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
128087418  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
128075392  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
128078344  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
128084490  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
128088141  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
128083108  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
128078963  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
128074912  GUCY1A2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
128084367  GUCY1A1; guanylate cyclase soluble subunit alpha-1 isoform X1 [KO:K12318] [EC:4.6.1.2]
128082334  guanylate cyclase soluble subunit beta-2-like isoform X1 [KO:K12319] [EC:4.6.1.2]
128084370  GUCY1B1; guanylate cyclase soluble subunit beta-1 [KO:K12319] [EC:4.6.1.2]
128077911  PRKG1; cGMP-dependent protein kinase 1 isoform X1 [KO:K07376] [EC:2.7.11.12]
128080203  PRKG2; cGMP-dependent protein kinase 2 [KO:K19477] [EC:2.7.11.12]
128080602  LOW QUALITY PROTEIN: cGMP-dependent protein kinase, isozyme 1-like [KO:K19477] [EC:2.7.11.12]
Compound
C00025  L-Glutamate
C00076  Calcium cation
C00165  Diacylglycerol
C00533  Nitric oxide
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00681  1-Acyl-sn-glycerol 3-phosphate
C00780  Serotonin
C00942  3',5'-Cyclic GMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C03758  Dopamine
Reference
PMID:14506308
  Authors
Saez JC, Berthoud VM, Branes MC, Martinez AD, Beyer EC.
  Title
Plasma membrane channels formed by connexins: their regulation and functions.
  Journal
Physiol Rev 83:1359-400 (2003)
DOI:10.1152/physrev.00007.2003
Reference
PMID:15033580
  Authors
Warn-Cramer BJ, Lau AF.
  Title
Regulation of gap junctions by tyrosine protein kinases.
  Journal
Biochim Biophys Acta 1662:81-95 (2004)
DOI:10.1016/j.bbamem.2003.10.018
Reference
PMID:9535909
  Authors
Warn-Cramer BJ, Cottrell GT, Burt JM, Lau AF.
  Title
Regulation of connexin-43 gap junctional intercellular communication by mitogen-activated protein kinase.
  Journal
J Biol Chem 273:9188-96 (1998)
DOI:10.1074/jbc.273.15.9188
Reference
PMID:10751659
  Authors
Roerig B, Feller MB.
  Title
Neurotransmitters and gap junctions in developing neural circuits.
  Journal
Brain Res Brain Res Rev 32:86-114 (2000)
DOI:10.1016/S0165-0173(99)00069-7
Reference
PMID:10873290
  Authors
Hatton GI.
  Title
Synaptic modulation of neuronal coupling.
  Journal
Cell Biol Int 22:765-80 (1998)
DOI:10.1006/cbir.1998.0386
Reference
PMID:12566218
  Authors
Cruciani V, Mikalsen SO.
  Title
Connexins, gap junctional intercellular communication and kinases.
  Journal
Biol Cell 94:433-43 (2002)
DOI:10.1016/S0248-4900(02)00014-X
Reference
PMID:15094344
  Authors
Giepmans BN.
  Title
Gap junctions and connexin-interacting proteins.
  Journal
Cardiovasc Res 62:233-45 (2004)
DOI:10.1016/j.cardiores.2003.12.009
Reference
PMID:15955302
  Authors
Laird DW.
  Title
Connexin phosphorylation as a regulatory event linked to gap junction internalization and degradation.
  Journal
Biochim Biophys Acta 1711:172-82 (2005)
DOI:10.1016/j.bbamem.2004.09.009
Reference
PMID:15033579
  Authors
Peracchia C.
  Title
Chemical gating of gap junction channels; roles of calcium, pH and calmodulin.
  Journal
Biochim Biophys Acta 1662:61-80 (2004)
DOI:10.1016/j.bbamem.2003.10.020
Reference
PMID:15033578
  Authors
Bukauskas FF, Verselis VK.
  Title
Gap junction channel gating.
  Journal
Biochim Biophys Acta 1662:42-60 (2004)
DOI:10.1016/j.bbamem.2004.01.008
Related
pathway
tpai04010  MAPK signaling pathway
tpai04020  Calcium signaling pathway
tpai04060  Cytokine-cytokine receptor interaction
tpai04070  Phosphatidylinositol signaling system
tpai04080  Neuroactive ligand-receptor interaction
KO pathway
ko04540   
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