KEGG   PATHWAY: tpai04060
Entry
tpai04060                   Pathway                                
Name
Cytokine-cytokine receptor interaction - Tympanuchus pallidicinctus (lesser prairie-chicken)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
tpai04060  Cytokine-cytokine receptor interaction
tpai04060

Organism
Tympanuchus pallidicinctus (lesser prairie-chicken) [GN:tpai]
Gene
128071584  TNFSF13B; tumor necrosis factor ligand superfamily member 13B [KO:K05476]
128071683  IL1RL1; interleukin-1 receptor-like 1 isoform X1 [KO:K05171]
128071687  IL18R1; interleukin-18 receptor 1 isoform X1 [KO:K05173]
128071732  IL18RAP; interleukin-18 receptor accessory protein isoform X1 [KO:K05174]
128071776  [KO:K05066]
128071785  CRLF2; cytokine receptor-like factor 2 isoform X1 [KO:K05078]
128071804  [KO:K05172]
128071805  [KO:K04386]
128071809  [KO:K04387]
128071948  IL23A; interleukin-23 subunit alpha [KO:K05426]
128072141  [KO:K05507]
128072298  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
128072360  MPL; thrombopoietin receptor isoform X1 [KO:K05082]
128072661  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
128072665  TNFSF4; tumor necrosis factor ligand superfamily member 4 [KO:K05469]
128072733  LEPR; leptin receptor isoform X1 [KO:K05062]
128072736  IL12RB2; interleukin-12 receptor subunit beta-2 isoform X1 [KO:K05064]
128072742  IL23R; interleukin-23 receptor isoform X1 [KO:K05065]
128072999  TNFRSF13C; tumor necrosis factor receptor superfamily member 13C [KO:K05151]
128073411  IL17RA; interleukin-17 receptor A isoform X1 [KO:K05164]
128073421  IFNG; interferon gamma [KO:K04687]
128073499  IL26; interleukin-26 [KO:K05446]
128073539  [KO:K05439]
128073632  [KO:K04738]
128073635  [KO:K04738]
128073638  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
128073812  IL22; interleukin-22 [KO:K05445]
128074113  TNFSF15; tumor necrosis factor ligand superfamily member 15 [KO:K05478]
128074114  TNFSF8; tumor necrosis factor ligand superfamily member 8 [KO:K05471]
128074464  LIFR; leukemia inhibitory factor receptor [KO:K05058]
128074467  OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057]
128074474  GHR; growth hormone receptor isoform X1 [KO:K05080]
128074490  CCL28; C-C motif chemokine 28 [KO:K05513]
128074507  IL6ST; interleukin-6 receptor subunit beta [KO:K05060]
128074512  IL31RA; interleukin-31 receptor subunit alpha [KO:K22630]
128074557  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
128074562  PRLR; prolactin receptor isoform X1 [KO:K05081]
128074606  IL11RA; interleukin-11 receptor subunit alpha isoform X1 [KO:K05056]
128074612  CNTFR; ciliary neurotrophic factor receptor subunit alpha [KO:K05059]
128074616  [KO:K05512]
128074617  CCL21; C-C motif chemokine 21 [KO:K16062]
128074649  [KO:K05415]
128074651  [KO:K05414]
128074653  [KO:K05414]
128074654  [KO:K05414]
128074655  [KO:K05414]
128074656  [KO:K05414]
128074657  [KO:K05414]
128074658  [KO:K05414]
128074659  [KO:K05414]
128074661  [KO:K05414]
128074875  IL17D; interleukin-17D [KO:K05492]
128074893  TNFRSF19; tumor necrosis factor receptor superfamily member 19 isoform X1 [KO:K05155]
128075158  IL16; pro-interleukin-16 isoform X1 [KO:K22628]
128075477  BMP2; bone morphogenetic protein 2 [KO:K21283]
128075793  IL13RA2; interleukin-13 receptor subunit alpha-2 [KO:K05077]
128075813  IL13RA1; interleukin-13 receptor subunit alpha-1 [KO:K05076]
128076070  CD40LG; CD40 ligand [KO:K03161]
128076082  EDA; ectodysplasin-A isoform X1 [KO:K05480]
128076089  IL2RG; cytokine receptor common subunit gamma isoform X1 [KO:K05070]
128076123  BMP15; bone morphogenetic protein 15 [KO:K05498]
128076156  EDA2R; tumor necrosis factor receptor superfamily member 27 [KO:K05163]
128076350  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
128076354  IL10RB; interleukin-10 receptor subunit beta [KO:K05135]
128076355  IFNGR2; interferon gamma receptor 2 [KO:K05133]
128076578  IFNAR2; LOW QUALITY PROTEIN: interferon alpha/beta receptor 2 [KO:K05131]
128076730  IL20RA; interleukin-20 receptor subunit alpha isoform X1 [KO:K05136]
128076749  IFNGR1; interferon gamma receptor 1 [KO:K05132]
128076754  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
128076824  [KO:K22669]
128076915  [KO:K04388] [EC:2.7.11.30]
128076923  ACVR1; activin receptor type-1 [KO:K04675] [EC:2.7.11.30]
128077003  ACVR1C; activin receptor type-1C [KO:K13568] [EC:2.7.11.30]
128077012  INHA; inhibin alpha chain [KO:K05500]
128077078  ACVR2A; activin receptor type-2A isoform X1 [KO:K04670] [EC:2.7.11.30]
128077149  ACKR3; atypical chemokine receptor 3 [KO:K04304]
128077165  CXCR1; C-X-C chemokine receptor type 1 [KO:K05050]
128077200  MSTN; growth/differentiation factor 8 [KO:K05497]
128077291  BMPR2; bone morphogenetic protein receptor type-2 isoform X1 [KO:K04671] [EC:2.7.11.30]
128077330  INHBB; inhibin beta B chain [KO:K22687]
128077468  BMPR1A; bone morphogenetic protein receptor type-1A [KO:K04673] [EC:2.7.11.30]
128077564  BMP5; bone morphogenetic protein 5 isoform X1 [KO:K04663]
128077695  [KO:K21283]
128077706  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
128077727  CXCL12; stromal cell-derived factor 1 [KO:K10031]
128077982  GDF10; growth/differentiation factor 10 [KO:K22674]
128077985  GDF2; growth/differentiation factor 2 [KO:K05503]
128078432  IL5RA; interleukin-5 receptor subunit alpha isoform X1 [KO:K05067]
128078659  IL17RC; interleukin-17 receptor C [KO:K05166]
128078660  IL17RE; LOW QUALITY PROTEIN: interleukin-17 receptor E [KO:K05168]
128078886  TNFRSF13B; tumor necrosis factor receptor superfamily member 13B [KO:K05150]
128078971  IL4R; interleukin-4 receptor subunit alpha [KO:K05071]
128078978  [KO:K05073]
128079217  IL21R; interleukin-21 receptor isoform X1 [KO:K05075]
128079317  IL20RB; interleukin-20 receptor subunit beta [KO:K05137]
128079603  IL15RA; interleukin-15 receptor subunit alpha [KO:K05068]
128079714  [KO:K05074]
128079879  [KO:K10032]
128079880  [KO:K10032]
128079881  [KO:K10032]
128080184  BMPR1B; bone morphogenetic protein receptor type-1B isoform X1 [KO:K13578] [EC:2.7.11.30]
128080268  RELL1; RELT-like protein 1 isoform X1 [KO:K26541]
128080384  BMP3; bone morphogenetic protein 3 [KO:K05496]
128080442  IL21; interleukin-21 [KO:K05434]
128080724  [KO:K10030]
128080725  [KO:K10030]
128080831  CD40; tumor necrosis factor receptor superfamily member 5 [KO:K03160]
128080849  TNFRSF6B; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 6B [KO:K05143]
128081025  BMP7; bone morphogenetic protein 7 [KO:K16621]
128081082  GDF5; growth/differentiation factor 5 [KO:K04664]
128081338  IL17B; LOW QUALITY PROTEIN: interleukin-17B [KO:K05490]
128081414  RELL2; RELT-like protein 2 isoform X1 [KO:K26541]
128081483  IL12B; interleukin-12 subunit beta isoform X1 [KO:K05425]
128081599  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
128081753  IL34; interleukin-34 isoform X1 [KO:K22633]
128081780  TGFB2; transforming growth factor beta-2 proprotein [KO:K13376]
128081855  THPO; thrombopoietin isoform X1 [KO:K06854]
128081922  TNFSF10; tumor necrosis factor ligand superfamily member 10 isoform X1 [KO:K04721]
128082082  CCL20; C-C motif chemokine 20 [KO:K14625]
128082091  IL17C; interleukin-17C [KO:K05491]
128082216  CX3CL1; fractalkine isoform X1 [KO:K05508]
128082226  CCL17; C-C motif chemokine 17 [KO:K21083]
128082460  IL12A; interleukin-12 subunit alpha [KO:K05406]
128082822  IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
128083454  [KO:K12964]
128083457  [KO:K12499]
128083474  [KO:K12964]
128083528  GDF7; growth/differentiation factor 7 [KO:K20013]
128083612  [KO:K05514]
128083770  CCR6; C-C chemokine receptor type 6 isoform X1 [KO:K04181]
128083782  CXCL14; C-X-C motif chemokine 14 [KO:K10033]
128084023  LIF; leukemia inhibitory factor [KO:K05419]
128084115  GDF9; growth/differentiation factor 9 [KO:K22673]
128084204  IL15; interleukin-15 [KO:K05433]
128084887  TNFRSF4; tumor necrosis factor receptor superfamily member 4 isoform X1 [KO:K05142]
128084889  TNFRSF18; tumor necrosis factor receptor superfamily member 18 [KO:K05154]
128084913  TNFRSF8; tumor necrosis factor receptor superfamily member 8 [KO:K05145]
128084943  TNFRSF9; tumor necrosis factor receptor superfamily member 9 isoform X1 [KO:K05146]
128084977  TNFRSF25; tumor necrosis factor receptor superfamily member 25 [KO:K05160]
128085130  TNFRSF1B; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 1B [KO:K05141]
128085147  TNFRSF21; tumor necrosis factor receptor superfamily member 21 [KO:K05157]
128085499  CNTF; ciliary neurotrophic factor [KO:K05420]
128085557  ACVR2B; activin receptor type-2B [KO:K13596] [EC:2.7.11.30]
128085831  IL6; interleukin-6 [KO:K05405]
128085847  [KO:K05494]
128085850  [KO:K05489]
128086037  ACKR4; LOW QUALITY PROTEIN: atypical chemokine receptor 4 [KO:K04186]
128086044  [KO:K04180]
128086045  [KO:K04180]
128086046  [KO:K04183]
128086047  XCR1; chemokine XC receptor 1 [KO:K04193]
128086049  CCR9; C-C chemokine receptor type 9 [KO:K04184]
128086084  [KO:K04183]
128086086  CX3CR1; CX3C chemokine receptor 1 [KO:K04192]
128086090  CCR4; C-C chemokine receptor type 4 [KO:K04179]
128086795  CLCF1; cardiotrophin-like cytokine factor 1 [KO:K05421]
128086877  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
128086966  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
128087220  BMP4; bone morphogenetic protein 4 [KO:K04662]
128087490  IL18; LOW QUALITY PROTEIN: interleukin-18 [KO:K05482]
128087622  CXCR5; C-X-C chemokine receptor type 5 [KO:K04190]
128087664  IL10RA; interleukin-10 receptor subunit alpha [KO:K05134]
128087782  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
128087818  PRL; prolactin [KO:K05439]
128087820  TNFRSF11A; tumor necrosis factor receptor superfamily member 11A isoform X1 [KO:K05147]
128087911  BMP6; bone morphogenetic protein 6 [KO:K16620]
128087993  NGF; beta-nerve growth factor [KO:K02582]
128088080  IL10; interleukin-10 isoform X1 [KO:K05443]
128088082  [KO:K22667]
128088187  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
128088336  IL22RA1; interleukin-22 receptor subunit alpha-1 [KO:K05138]
128088337  IFNLR1; LOW QUALITY PROTEIN: interferon lambda receptor 1 [KO:K05140]
128088338  [KO:K16622]
128088349  CSF3R; granulocyte colony-stimulating factor receptor [KO:K05061]
128088443  INHBA; inhibin beta A chain isoform X1 [KO:K04667]
128088626  RELT; tumor necrosis factor receptor superfamily member 19L [KO:K05156]
128088762  [KO:K05438]
128088851  GDF15; growth/differentiation factor 15 [KO:K05504]
128088868  GDF1; embryonic growth/differentiation factor 1 [KO:K05495]
128088969  IL12RB1; LOW QUALITY PROTEIN: interleukin-12 receptor subunit beta-1 [KO:K05063]
128089018  CSF3; granulocyte colony-stimulating factor [KO:K05423]
128089124  CCR10; C-C chemokine receptor type 10 [KO:K04185]
128089152  CCR7; C-C chemokine receptor type 7 [KO:K04182]
128089382  [KO:K05414]
128089886  [KO:K06454]
128089989  NODAL; nodal homolog [KO:K04666]
128090036  [KO:K04722]
128090040  BMP10; bone morphogenetic protein 10 [KO:K22670]
128090186  [KO:K04519]
128090376  AMH; muellerian-inhibiting factor [KO:K04665]
128090505  GDF11; LOW QUALITY PROTEIN: growth/differentiation factor 11 [KO:K22679]
128090506  [KO:K22689]
128090507  [KO:K22688]
128090747  GDF6; growth/differentiation factor 6 [KO:K20012]
128090884  TNFRSF11B; tumor necrosis factor receptor superfamily member 11B isoform X1 [KO:K05148]
128091763  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
128092110  TNFSF11; tumor necrosis factor ligand superfamily member 11 isoform X1 [KO:K05473]
128092152  EDAR; tumor necrosis factor receptor superfamily member EDAR isoform X1 [KO:K05162]
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Reference
PMID:21106488
  Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
  Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
  Journal
Hum Genomics 5:30-55 (2010)
DOI:10.1186/1479-7364-5-1-30
Reference
PMID:27577879
  Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
  Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
  Journal
J Allergy Clin Immunol 138:984-1010 (2016)
DOI:10.1016/j.jaci.2016.06.033
Reference
PMID:15500860
  Authors
Boulanger MJ, Garcia KC
  Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
  Journal
Adv Protein Chem 68:107-46 (2004)
DOI:10.1016/S0065-3233(04)68004-1
Reference
PMID:16034365
  Authors
Allan SM, Tyrrell PJ, Rothwell NJ
  Title
Interleukin-1 and neuronal injury.
  Journal
Nat Rev Immunol 5:629-40 (2005)
DOI:10.1038/nri1664
Reference
PMID:23847622
  Authors
Lopetuso LR, Chowdhry S, Pizarro TT
  Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
  Journal
Front Immunol 4:181 (2013)
DOI:10.3389/fimmu.2013.00181
Reference
PMID:21349428
  Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
  Title
Functional specialization of interleukin-17 family members.
  Journal
Immunity 34:149-62 (2011)
DOI:10.1016/j.immuni.2011.02.012
Reference
PMID:17530315
  Authors
Fischer P, Hilfiker-Kleiner D
  Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
  Journal
Basic Res Cardiol 102:279-97 (2007)
DOI:10.1007/s00395-007-0658-z
Reference
PMID:24381786
  Authors
Richards CD
  Title
The enigmatic cytokine oncostatin m and roles in disease.
  Journal
ISRN Inflamm 2013:512103 (2013)
DOI:10.1155/2013/512103
Reference
PMID:18926762
  Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
  Title
Structures and biological functions of IL-31 and IL-31 receptors.
  Journal
Cytokine Growth Factor Rev 19:347-56 (2008)
DOI:10.1016/j.cytogfr.2008.08.003
Reference
PMID:21155715
  Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
  Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
  Journal
Biochem J 434:343-51 (2011)
DOI:10.1042/BJ20101628
Reference
PMID:22410872
  Authors
de Weerd NA, Nguyen T
  Title
The interferons and their receptors--distribution and regulation.
  Journal
Immunol Cell Biol 90:483-91 (2012)
DOI:10.1038/icb.2012.9
Reference
PMID:12949498
  Authors
Aggarwal BB
  Title
Signalling pathways of the TNF superfamily: a double-edged sword.
  Journal
Nat Rev Immunol 3:745-56 (2003)
DOI:10.1038/nri1184
Reference
PMID:12189384
  Authors
Ashkenazi A
  Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
  Journal
Nat Rev Cancer 2:420-30 (2002)
DOI:10.1038/nrc821
Reference
PMID:26115564
  Authors
Seeger P, Musso T, Sozzani S
  Title
The TGF-beta superfamily in dendritic cell biology.
  Journal
Cytokine Growth Factor Rev 26:647-57 (2015)
DOI:10.1016/j.cytogfr.2015.06.002
Reference
PMID:23612460
  Authors
Wakefield LM, Hill CS
  Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
  Journal
Nat Rev Cancer 13:328-41 (2013)
DOI:10.1038/nrc3500
Reference
PMID:22710174
  Authors
Mueller TD, Nickel J
  Title
Promiscuity and specificity in BMP receptor activation.
  Journal
FEBS Lett 586:1846-59 (2012)
DOI:10.1016/j.febslet.2012.02.043
KO pathway
ko04060   

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