KEGG   PATHWAY: tvc03083
Entry
tvc03083                    Pathway                                
Name
Polycomb repressive complex - Tachysurus vachellii
Class
Genetic Information Processing; Chromosome
Pathway map
tvc03083  Polycomb repressive complex
tvc03083

Organism
Tachysurus vachellii [GN:tvc]
Gene
132861544  ezh1; histone-lysine N-methyltransferase EZH1 isoform X1 [KO:K17451] [EC:2.1.1.356]
132840289  ezh2; histone-lysine N-methyltransferase EZH2 [KO:K11430] [EC:2.1.1.356]
132839584  eed; polycomb protein eed isoform X1 [KO:K11462]
132861430  suz12a; polycomb protein suz12-A isoform X1 [KO:K11463]
132845049  suz12b; polycomb protein suz12-B isoform X1 [KO:K11463]
132851539  rbb4l; histone-binding protein RBBP7 [KO:K10752]
132863922  rbbp4; histone-binding protein RBBP4 [KO:K10752]
132840445  phf1; PHD finger protein 1 isoform X1 [KO:K11467]
132844133  mtf2; metal-response element-binding transcription factor 2 [KO:K11485]
132853852  phf19; PHD finger protein 19 [KO:K11486]
132838904  lcor; ligand-dependent corepressor [KO:K26260]
132858875  aebp2; zinc finger protein AEBP2 isoform X1 [KO:K17452]
132842730  jarid2b; protein Jumonji [KO:K11478]
132846265  jarid2a; protein Jumonji isoform X1 [KO:K11478]
132837794  bap1; ubiquitin carboxyl-terminal hydrolase BAP1 isoform X1 [KO:K08588] [EC:3.4.19.12]
132862693  asxl1; putative Polycomb group protein ASXL1 isoform X1 [KO:K11471]
132852659  asxl2; putative Polycomb group protein ASXL2 isoform X1 [KO:K11471]
132856337  UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform X1 [KO:K09667] [EC:2.4.1.255]
132856338  UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit-like isoform X1 [KO:K09667] [EC:2.4.1.255]
132853167  hcfc1b; host cell factor 1b isoform X1 [KO:K14966]
132843276  yy1b; transcriptional repressor protein YY1b isoform X1 [KO:K09201]
132852721  yy1a; transcriptional repressor protein YY1a [KO:K09201]
132844920  methyl-CpG-binding domain protein 5-like isoform X1 [KO:K23219]
132844590  mbd6; mucin-2 [KO:K26585]
132842592  forkhead box protein K2-like [KO:K09404]
132863969  foxk1; forkhead box protein K1 [KO:K09404]
132839985  foxk2a; forkhead box protein K2 isoform X1 [KO:K09404]
132857967  rnf2; E3 ubiquitin-protein ligase RING2 [KO:K10695] [EC:2.3.2.27]
132848350  bmi1b; polycomb complex protein BMI-1-B [KO:K11459]
132839926  LOW QUALITY PROTEIN: polycomb complex protein BMI-1-A-like [KO:K11459]
132842159  cbx2; chromobox protein homolog 2 [KO:K11451]
132861220  cbx4; E3 SUMO-protein ligase CBX4 isoform X1 [KO:K11452] [EC:2.3.2.-]
132845044  E3 SUMO-protein ligase CBX4-like [KO:K11452] [EC:2.3.2.-]
132842541  cbx7a; chromobox homolog 7a [KO:K11454]
132838888  cbx7b; chromobox protein homolog 7 isoform X1 [KO:K11454]
132861288  cbx8a; chromobox protein homolog 8a [KO:K11455]
132845045  cbx8b; chromobox protein homolog 8b [KO:K11455]
132846291  phc1; polyhomeotic-like protein 1 isoform X1 [KO:K11456]
132861930  phc2a; polyhomeotic-like protein 2 isoform X1 [KO:K11457]
132844552  phc2b; polyhomeotic-like protein 2b isoform X1 [KO:K11457]
132861815  sex comb on midleg-like protein 2 [KO:K11465]
132838847  scml2; sex comb on midleg-like protein 2 [KO:K11465]
132845742  polycomb protein SCMH1-like [KO:K11461]
132838016  sfmbt1; scm-like with four MBT domains protein 1 [KO:K26269]
132858659  sfmbt2; scm-like with four MBT domains protein 2 isoform X1 [KO:K26269]
132860933  aurkb; aurora kinase B [KO:K11479] [EC:2.7.11.1]
132841600  ube2d1b; ubiquitin-conjugating enzyme E2 D1b [KO:K06689] [EC:2.3.2.23]
132861687  ube2d2l; ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast), like [KO:K06689] [EC:2.3.2.23]
132856687  ube2d2; ubiquitin-conjugating enzyme E2 D2 [KO:K06689] [EC:2.3.2.23]
132853386  ube2d4; ubiquitin-conjugating enzyme E2 D4 [KO:K06689] [EC:2.3.2.23]
132847160  ube2d3; ubiquitin-conjugating enzyme E2 D3 isoform X1 [KO:K06689] [EC:2.3.2.23]
132858182  usp16; ubiquitin carboxyl-terminal hydrolase 16 isoform X1 [KO:K11844] [EC:3.4.19.12]
132847603  usp45; ubiquitin carboxyl-terminal hydrolase 45 isoform X1 [KO:K11844] [EC:3.4.19.12]
132844677  rybpb; RING1 and YY1-binding protein B isoform X1 [KO:K11469]
132862676  rybpa; RING1 and YY1-binding protein A isoform X1 [KO:K11469]
132856566  yaf2; YY1-associated factor 2 [KO:K11468]
132856291  pcgf1; polycomb group RING finger protein 1 isoform X1 [KO:K11487]
132855535  kdm2ab; lysine-specific demethylase 2A isoform X1 [KO:K10276] [EC:1.14.11.27]
132853899  kdm2ba; lysine (K)-specific demethylase 2Ba isoform X1 [KO:K10276] [EC:1.14.11.27]
132847541  kdm2aa; lysine (K)-specific demethylase 2Aa isoform X1 [KO:K10276] [EC:1.14.11.27]
132838832  bcor; BCL-6 corepressor isoform X1 [KO:K23215]
132856046  bcorl1; BCL-6 corepressor-like protein 1 [KO:K26199]
132859931  skp1; S-phase kinase-associated protein 1 [KO:K03094]
132861750  usp7; ubiquitin carboxyl-terminal hydrolase 7 isoform X1 [KO:K11838] [EC:3.4.19.12]
132856764  polycomb group RING finger protein 3 [KO:K11488]
132839734  pcgf5b; polycomb group RING finger protein 5-B isoform X1 [KO:K11489]
132852756  pcgf5a; polycomb group RING finger protein 5-A isoform X1 [KO:K11489]
132842745  csnk2b; casein kinase II subunit beta [KO:K03115]
132857750  auts2b; autism susceptibility gene 2 protein isoform X1 [KO:K23214]
132838668  fbrs; autism susceptibility gene 2 protein isoform X1 [KO:K26253]
132854632  fbrsl1; autism susceptibility gene 2 protein homolog isoform X1 [KO:K26254]
132861562  dcaf7; DDB1- and CUL4-associated factor 7 isoform X1 [KO:K11805]
132840001  tex10; testis-expressed protein 10 homolog [KO:K14827]
132842528  ep300b; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
132860854  crebbpb; CREB binding protein b isoform X1 [KO:K04498] [EC:2.3.1.48]
132838641  ep300a; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
132838823  crebbpa; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
132847360  pcgf6; polycomb group RING finger protein 6 isoform X1 [KO:K11470]
132843228  e2f6; transcription factor E2F6 [KO:K09390]
132850132  tfdp1a; transcription factor Dp-1a [KO:K04683]
132839270  tfdp1b; transcription factor Dp-1b isoform X1 [KO:K04683]
132843049  max; protein max isoform X1 [KO:K04453]
132852755  protein max isoform X1 [KO:K04453]
132852422  mgaa; MAX dimerization protein MGA a isoform X1 [KO:K23399]
132854398  l3mbtl3; lethal(3)malignant brain tumor-like protein 3 [KO:K24387]
132862017  l3mbtl1; lethal(3)malignant brain tumor-like protein 1 isoform X1 [KO:K24387]
132838935  l3mbtl2; lethal(3)malignant brain tumor-like protein 2 isoform X1 [KO:K24387]
132845613  lethal(3)malignant brain tumor-like protein 4 isoform X1 [KO:K24387]
132840195  l3mbtl1b; lethal(3)malignant brain tumor-like protein 4 isoform X1 [KO:K24387]
132837507  cbx3a; chromobox protein homolog 3a [KO:K11586]
132846018  cbx3b; chromobox protein homolog 3b isoform X1 [KO:K11586]
132860037  wdr5; WD repeat-containing protein 5 [KO:K14963]
132842781  hdac1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
Reference
PMID:21881606
  Authors
Richly H, Aloia L, Di Croce L
  Title
Roles of the Polycomb group proteins in stem cells and cancer.
  Journal
Cell Death Dis 2:e204 (2011)
DOI:10.1038/cddis.2011.84
Reference
PMID:28202673
  Authors
Chittock EC, Latwiel S, Miller TC, Muller CW
  Title
Molecular architecture of polycomb repressive complexes.
  Journal
Biochem Soc Trans 45:193-205 (2017)
DOI:10.1042/BST20160173
Reference
PMID:33202645
  Authors
Geng Z, Gao Z
  Title
Mammalian PRC1 Complexes: Compositional Complexity and Diverse Molecular Mechanisms.
  Journal
Int J Mol Sci 21:ijms21228594 (2020)
DOI:10.3390/ijms21228594
Reference
PMID:35681061
  Authors
Kim JJ, Kingston RE
  Title
Context-specific Polycomb mechanisms in development.
  Journal
Nat Rev Genet 23:680-695 (2022)
DOI:10.1038/s41576-022-00499-0
Reference
PMID:36076977
  Authors
Dong GJ, Xu JL, Qi YR, Yuan ZQ, Zhao W
  Title
Critical Roles of Polycomb Repressive Complexes in Transcription and Cancer.
  Journal
Int J Mol Sci 23:ijms23179574 (2022)
DOI:10.3390/ijms23179574
Reference
PMID:37086328
  Authors
Ryan CW, Peirent ER, Regan SL, Guxholli A, Bielas SL
  Title
H2A monoubiquitination: insights from human genetics and animal models.
  Journal
Hum Genet 10.1007/s00439-023-02557-x (2023)
DOI:10.1007/s00439-023-02557-x
KO pathway
ko03083   
LinkDB

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