KEGG   PATHWAY: zne03040
Entry
zne03040                    Pathway                                
Name
Spliceosome - Zootermopsis nevadensis (dampwood termite)
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
Pathway map
zne03040  Spliceosome
zne03040

Other DBs
GO: 0005681
Organism
Zootermopsis nevadensis (dampwood termite) [GN:zne]
Gene
110836188  probable ATP-dependent RNA helicase DDX46 [KO:K12811] [EC:5.6.2.7]
110834555  ATP-dependent RNA helicase WM6 [KO:K12812] [EC:5.6.2.7]
110833815  putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 [KO:K12813] [EC:5.6.2.6]
110840179  putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 isoform X1 [KO:K12813] [EC:5.6.2.6]
110830010  pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 [KO:K12815] [EC:5.6.2.6]
110840053  LOW QUALITY PROTEIN: pre-mRNA-processing factor 17-like [KO:K12816]
110832015  pre-mRNA-processing factor 17 [KO:K12816]
110830766  LOW QUALITY PROTEIN: pre-mRNA-processing factor 17-like [KO:K12816]
110828797  pre-mRNA-splicing factor 18 isoform X1 [KO:K12817]
110836772  ATP-dependent RNA helicase DHX8 isoform X1 [KO:K12818] [EC:5.6.2.6]
110833152  pre-mRNA-splicing factor Slu7 [KO:K12819]
110828211  putative pre-mRNA-splicing factor ATP-dependent RNA helicase PRP1 [KO:K12820] [EC:5.6.2.6]
110837488  small nuclear ribonucleoprotein-associated protein B [KO:K11086]
110834696  small nuclear ribonucleoprotein Sm D1 [KO:K11087]
110834337  probable small nuclear ribonucleoprotein Sm D2 [KO:K11096]
110830820  small nuclear ribonucleoprotein Sm D3 [KO:K11088]
110832421  small nuclear ribonucleoprotein G [KO:K11099]
110828913  U1 small nuclear ribonucleoprotein 70 kDa-like [KO:K11093]
110834757  U1 small nuclear ribonucleoprotein C [KO:K11095]
110837389  pre-mRNA-processing factor 40 homolog B isoform X1 [KO:K12821]
110835534  LOW QUALITY PROTEIN: RNA-binding protein 25-like [KO:K12822]
110831617  LOW QUALITY PROTEIN: ATP-dependent RNA helicase dbp2-like [KO:K12823] [EC:5.6.2.7]
110836424  probable ATP-dependent RNA helicase DDX5 [KO:K12823] [EC:5.6.2.7]
110831646  ATP-dependent RNA helicase p62-like isoform X1 [KO:K12823] [EC:5.6.2.7]
110829812  transcription elongation regulator 1-like isoform X1 [KO:K12824]
110829399  RNA-binding protein cabeza-like isoform X1 [KO:K13098]
110829961  U2 small nuclear ribonucleoprotein A' [KO:K11092]
110836006  U1 small nuclear ribonucleoprotein A [KO:K11094]
110839705  splicing factor 3A subunit 1 [KO:K12825]
110832098  splicing factor 3A subunit 2-like [KO:K12826]
110830391  splicing factor 3A subunit 3 [KO:K12827]
110840729  LOW QUALITY PROTEIN: splicing factor 3B subunit 1 [KO:K12828]
110835098  LOW QUALITY PROTEIN: splicing factor 3B subunit 2-like [KO:K12829]
110829101  splicing factor 3B subunit 3 [KO:K12830]
110829320  splicing factor 3B subunit 4 [KO:K12831]
110835391  splicing factor 3B subunit 6-like protein [KO:K12833]
110833564  PHD finger-like domain-containing protein 5A [KO:K12834]
110839545  ATP-dependent RNA helicase DDX42 [KO:K12835] [EC:5.6.2.7]
110840956  splicing factor U2AF 35 kDa subunit isoform X1 [KO:K12836]
110837623  splicing factor U2AF 50 kDa subunit isoform X1 [KO:K12837]
110837676  poly(U)-binding-splicing factor half pint isoform X1 [KO:K12838]
110827224  survival of motor neuron-related-splicing factor 30 [KO:K12839]
110826847  splicing factor 45 [KO:K12840]
110832706  calcium homeostasis endoplasmic reticulum protein-like isoform X1 [KO:K12841]
110832710  calcium homeostasis endoplasmic reticulum protein isoform X1 [KO:K12841]
110840940  U2 snRNP-associated SURP motif-containing protein [KO:K12842]
110840462  U6 snRNA-associated Sm-like protein LSm2 [KO:K12621]
110831066  U6 snRNA-associated Sm-like protein LSm3 [KO:K12622]
110839722  U6 snRNA-associated Sm-like protein LSm4 [KO:K12623]
110832152  U6 snRNA-associated Sm-like protein LSm5 [KO:K12624]
110834883  U6 snRNA-associated Sm-like protein LSm7 [KO:K12626]
110828956  U6 snRNA-associated Sm-like protein LSm8 [KO:K12627]
110834154  U4/U6 small nuclear ribonucleoprotein Prp3 [KO:K12843]
110832929  U4/U6 small nuclear ribonucleoprotein Prp4 [KO:K12662]
110840717  peptidyl-prolyl cis-trans isomerase H [KO:K09567] [EC:5.2.1.8]
110830330  U4/U6 small nuclear ribonucleoprotein Prp31 [KO:K12844]
110837339  NHP2-like protein 1 homolog [KO:K12845]
110830560  U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein-like [KO:K12846]
110830561  U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein-like [KO:K12846]
110841545  U4/U6.U5 tri-snRNP-associated protein 2 [KO:K12847]
110828227  U4/U6.U5 tri-snRNP-associated protein 1 isoform X1 [KO:K11984]
110833143  zinc finger matrin-type protein 2 [KO:K12848]
110840852  pre-mRNA-splicing factor 38A [KO:K12849]
110831874  pre-mRNA-splicing factor 38B [KO:K12850]
110839219  116 kDa U5 small nuclear ribonucleoprotein component [KO:K12852]
110829636  putative U5 small nuclear ribonucleoprotein 200 kDa helicase [KO:K12854] [EC:5.6.2.6]
110830302  pre-mRNA-processing factor 6 [KO:K12855]
110836122  pre-mRNA-processing-splicing factor 8 [KO:K12856]
110830506  U5 small nuclear ribonucleoprotein 40 kDa protein [KO:K12857]
110832128  probable ATP-dependent RNA helicase DDX23 [KO:K12858] [EC:5.6.2.7]
110841407  uncharacterized protein LOC110841407 isoform X1 [KO:K12859]
110829376  pre-mRNA-processing factor 19 [KO:K10599] [EC:2.3.2.27]
110830396  cell division cycle 5-like protein [KO:K12860]
110841385  pre-mRNA-splicing factor SPF27 [KO:K12861]
110831886  pleiotropic regulator 1 isoform X1 [KO:K12862]
110837783  protein CWC15 homolog isoform X1 [KO:K12863]
110836881  beta-catenin-like protein 1 [KO:K12864]
110839640  heat shock 70 kDa protein cognate 2-like [KO:K03283]
110839156  heat shock protein 70 A1-like [KO:K03283]
110840352  heat shock 70 kDa protein cognate 4 isoform X1 [KO:K03283]
110838504  polyglutamine-binding protein 1 isoform X1 [KO:K12865]
110834077  WW domain-binding protein 11 isoform X1 [KO:K12866]
110832552  puff-specific protein Bx42-like [KO:K06063]
110833892  puff-specific protein Bx42-like isoform X1 [KO:K06063]
110833829  pre-mRNA-splicing factor SYF1 [KO:K12867]
110838170  pre-mRNA-splicing factor SYF2 [KO:K12868]
110828111  LOW QUALITY PROTEIN: protein crooked neck [KO:K12869]
110829258  pre-mRNA-splicing factor ISY1 homolog [KO:K12870]
110838193  peptidyl-prolyl cis-trans isomerase-like 1 isoform X1 [KO:K12733] [EC:5.2.1.8]
110837348  peptidyl-prolyl cis-trans isomerase E [KO:K09564] [EC:5.2.1.8]
110829559  coiled-coil domain-containing protein 12 [KO:K12871]
110827197  pre-mRNA-splicing factor RBM22 isoform X1 [KO:K12872]
110835742  protein BUD31 homolog [KO:K12873]
110829988  intron-binding protein aquarius [KO:K12874]
110830054  apoptotic chromatin condensation inducer in the nucleus [KO:K12875]
110829028  eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
110834741  RNA-binding protein 8A [KO:K12876]
110829409  THO complex subunit 1 [KO:K12878]
110834237  THO complex subunit 2 [KO:K12879]
110832129  THO complex subunit 3 [KO:K12880]
110839222  THO complex subunit 4 [KO:K12881]
110830956  nuclear cap-binding protein subunit 1 [KO:K12882]
110831965  nuclear cap-binding protein subunit 2 isoform X1 [KO:K12883]
110836598  heterogeneous nuclear ribonucleoprotein A1, A2/B1 homolog isoform X1 [KO:K12741]
110830353  heterogeneous nuclear ribonucleoprotein A1, A2/B1 homolog [KO:K12741]
110829266  heterogeneous nuclear ribonucleoprotein A1, A2/B1 homolog [KO:K12741]
110830672  heterogeneous nuclear ribonucleoprotein K isoform X1 [KO:K12886]
110830815  serine/arginine-rich splicing factor 1A [KO:K12890]
110835740  serine/arginine-rich splicing factor 2 isoform X1 [KO:K12891]
110827442  RNA-binding protein 1 [KO:K12892]
110837167  serine-arginine protein 55 isoform X1 [KO:K12893]
110838705  serine/arginine-rich splicing factor 7-like [KO:K12896]
110827767  serine/arginine-rich splicing factor 7-like [KO:K12896]
110836267  transformer-2 protein homolog alpha-like isoform X1 [KO:K12897]
Reference
PMID:19239890
  Authors
Wahl MC, Will CL, Luhrmann R
  Title
The spliceosome: design principles of a dynamic RNP machine.
  Journal
Cell 136:701-18 (2009)
DOI:10.1016/j.cell.2009.02.009
Reference
PMID:10978320
  Authors
Morris DP, Greenleaf AL
  Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
  Journal
J Biol Chem 275:39935-43 (2000)
DOI:10.1074/jbc.M004118200
Reference
PMID:17537823
  Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
  Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
  Journal
Nucleic Acids Res 35:3928-44 (2007)
DOI:10.1093/nar/gkm347
Reference
PMID:19733268
  Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
  Title
Spliceosome structure: piece by piece.
  Journal
Biochim Biophys Acta 1789:624-33 (2009)
DOI:10.1016/j.bbagrm.2009.08.010
KO pathway
ko03040   
LinkDB

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