KEGG   PATHWAY: pflv04350
Entry
pflv04350                   Pathway                                
Name
TGF-beta signaling pathway - Perca flavescens (yellow perch)
Description
The transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species ranging from worms and insects to mammals. A wide spectrum of cellular functions such as proliferation, apoptosis, differentiation and migration are regulated by TGF-beta family members. TGF-beta family member binds to the Type II receptor and recruits Type I, whereby Type II receptor phosphorylates and activates Type I. The Type I receptor, in turn, phosphorylates receptor-activated Smads ( R-Smads: Smad1, Smad2, Smad3, Smad5, and Smad8). Once phosphorylated, R-Smads associate with the co-mediator Smad, Smad4, and the heteromeric complex then translocates into the nucleus. In the nucleus, Smad complexes activate specific genes through cooperative interactions with other DNA-binding and coactivator (or co-repressor) proteins.
Class
Environmental Information Processing; Signal transduction
Pathway map
pflv04350  TGF-beta signaling pathway
pflv04350

Other DBs
GO: 0007179
Organism
Perca flavescens (yellow perch) [GN:pflv]
Gene
114552503  chrd; chordin isoform X1 [KO:K04657]
114569524  noggin-like [KO:K04658]
114547966  noggin-2-like [KO:K04658]
114548430  nog; noggin [KO:K04658]
114553878  neuroblastoma suppressor of tumorigenicity 1 [KO:K19558]
114547219  gremlin-1-like [KO:K23318]
114572496  grem2; gremlin-2 [KO:K23318]
114573651  grem1; gremlin-1 [KO:K23318]
114546727  thrombospondin-1-like [KO:K16857]
114573037  thbs1; thrombospondin-1 [KO:K16857]
114549919  dcn; decorin [KO:K04660]
114559420  fibromodulin-like [KO:K08121]
114554599  fibromodulin-like [KO:K08121]
114573736  left-right determination factor 2-like [KO:K04668]
114556105  fst; LOW QUALITY PROTEIN: follistatin [KO:K04661]
114552582  bone morphogenetic protein 4-like [KO:K21283]
114565836  bone morphogenetic protein 2-like [KO:K21283]
114547607  bone morphogenetic protein 2-like isoform X1 [KO:K21283]
114572770  bmp2; bone morphogenetic protein 2 [KO:K21283]
114546704  bmp4; bone morphogenetic protein 4 [KO:K04662]
114548846  bmp6; bone morphogenetic protein 6 [KO:K16620]
114554436  inhibin beta B chain-like [KO:K22687]
114551010  inhibin beta B chain-like [KO:K22687]
114564309  inhibin beta B chain-like [KO:K22687]
114565214  serotransferrin-like isoform X1 [KO:K14736]
114572005  bmp5; bone morphogenetic protein 5 [KO:K04663]
114559034  bone morphogenetic protein 7-like [KO:K16621]
114554141  bone morphogenetic protein 7-like isoform X1 [KO:K16621]
114568041  bmp8a; bone morphogenetic protein 8A [KO:K16622]
114554684  gdf5; growth/differentiation factor 5 [KO:K04664]
114567738  gdf6; growth/differentiation factor 6 [KO:K20012]
114557390  growth/differentiation factor 6-A-like [KO:K20012]
114561697  amh; muellerian-inhibiting factor [KO:K04665]
114568210  tumor necrosis factor-like [KO:K03156]
114573216  thrombospondin type-1 domain-containing protein 4-like [KO:K23377]
114558167  thsd4; thrombospondin type-1 domain-containing protein 4 isoform X1 [KO:K23377]
114556576  fbn1; fibrillin-1 [KO:K06825]
114571722  ltbp1; latent-transforming growth factor beta-binding protein 1 isoform X1 [KO:K19559]
114552362  transforming growth factor beta-1 proprotein-like [KO:K13375]
114562717  transforming growth factor beta-2 proprotein-like [KO:K13376]
114557393  tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
114546436  tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
114573007  transforming growth factor beta-3 proprotein-like [KO:K13377]
114565658  inhibin beta A chain-like [KO:K04667]
114548903  inhibin beta A chain-like [KO:K04667]
114571320  nodal homolog 2-A-like [KO:K04666]
114548143  nodal; nodal homolog [KO:K04666]
114556159  nodal homolog [KO:K04666]
114572242  bmpr1a; bone morphogenetic protein receptor type-1A isoform X1 [KO:K04673] [EC:2.7.11.30]
114570926  bone morphogenetic protein receptor type-1B-like [KO:K13578] [EC:2.7.11.30]
114555306  bmpr1b; bone morphogenetic protein receptor type-1B [KO:K13578] [EC:2.7.11.30]
114546643  activin receptor type-1-like [KO:K04675] [EC:2.7.11.30]
114563841  acvr1; activin receptor type-1 [KO:K04675] [EC:2.7.11.30]
114550971  bmpr2; bone morphogenetic protein receptor type-2 [KO:K04671] [EC:2.7.11.30]
114550865  acvr2a; activin receptor type-2A [KO:K04670] [EC:2.7.11.30]
114563875  activin receptor type-2A-like isoform X1 [KO:K04670] [EC:2.7.11.30]
114557649  LOW QUALITY PROTEIN: hemojuvelin-like [KO:K23100]
114561026  neo1; neogenin isoform X1 [KO:K06766]
114551755  tfr2; transferrin receptor protein 2 [KO:K23910]
114565829  tfrc; transferrin receptor protein 1 [KO:K06503]
114549294  transferrin receptor protein 1-like [KO:K06503]
114560469  rgma; repulsive guidance molecule A isoform X1 [KO:K23096]
114561357  repulsive guidance molecule A-like [KO:K23096]
114555602  rgmb; RGM domain family member B [KO:K06847]
114549045  tgfbr1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
114568194  tgfbr2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
114556613  TGF-beta receptor type-2-like isoform X1 [KO:K04388] [EC:2.7.11.30]
114563526  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
114554891  epithelial membrane protein 3-like [KO:K26257]
114558675  epithelial membrane protein 3-like [KO:K26257]
114567177  lrrc32; transforming growth factor beta activator LRRC32 isoform X1 [KO:K26316]
114562354  transforming growth factor beta activator LRRC32-like isoform X1 [KO:K26316]
114548821  nrros; transforming growth factor beta activator LRRC33 [KO:K26317]
114558805  activin receptor type-1B-like isoform X1 [KO:K13567] [EC:2.7.11.30]
114553596  activin receptor type-1B-like isoform X1 [KO:K13567] [EC:2.7.11.30]
114565748  acvr2b; activin receptor type-2B [KO:K13596] [EC:2.7.11.30]
114548898  activin receptor type-2B-like [KO:K13596] [EC:2.7.11.30]
114563656  acvr1c; activin receptor type-1C [KO:K13568] [EC:2.7.11.30]
114549259  bambi; BMP and activin membrane-bound inhibitor homolog [KO:K10162]
114574083  smad1; mothers against decapentaplegic homolog 1 [KO:K04676]
114562894  mothers against decapentaplegic homolog 5 [KO:K16790]
114567181  smad9; mothers against decapentaplegic homolog 9 [KO:K16791]
114556042  mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
114557607  mothers against decapentaplegic homolog 3 [KO:K23605]
114559543  mothers against decapentaplegic homolog 3-like isoform X1 [KO:K23605]
114568081  mothers against decapentaplegic homolog 4-like isoform X1 [KO:K04501]
114570708  mothers against decapentaplegic homolog 4-like [KO:K04501]
114555571  mothers against decapentaplegic homolog 4-like [KO:K04501]
114559730  smad6; mothers against decapentaplegic homolog 6 [KO:K04677]
114557448  mothers against decapentaplegic homolog 6-like [KO:K04677]
114571108  smad7; mothers against decapentaplegic homolog 7 [KO:K19631]
114569505  E3 ubiquitin-protein ligase SMURF2 isoform X1 [KO:K04678] [EC:2.3.2.26]
114569633  smurf1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
114571256  E3 ubiquitin-protein ligase SMURF2-like [KO:K04678] [EC:2.3.2.26]
114564761  zfyve9; zinc finger FYVE domain-containing protein 9 [KO:K04679]
114571217  zinc finger FYVE domain-containing protein 16-like [KO:K04679]
114561631  zinc finger FYVE domain-containing protein 9-like [KO:K04679]
114569772  rbx1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
114549315  cul1; cullin-1 [KO:K03347]
114567245  skp1; S-phase kinase-associated protein 1 [KO:K03094]
114569468  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
114555749  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
114558364  rho-related GTP-binding protein RhoA-D [KO:K04513]
114558365  rho-related GTP-binding protein RhoA-C-like [KO:K04513]
114558700  rho-related GTP-binding protein RhoA-C [KO:K04513]
114558914  rho-related GTP-binding protein RhoA-B-like [KO:K04513]
114553635  rho-related GTP-binding protein RhoA-D-like [KO:K04513]
114553877  rho-related GTP-binding protein RhoA-B [KO:K04513]
114565008  rock1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
114553318  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
114566770  ppp2ca; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
114555270  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
114562339  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform X1 [KO:K04382] [EC:3.1.3.16]
114552495  ribosomal protein S6 kinase beta-1-like [KO:K04688] [EC:2.7.11.1]
114566849  rps6kb1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
114571970  ribosomal protein S6 kinase beta-2-like isoform X1 [KO:K04688] [EC:2.7.11.1]
114556939  hamp; hepcidin [KO:K23106]
114556991  hepcidin-like [KO:K23106]
114557338  hepcidin-like [KO:K23106]
114554346  DNA-binding protein inhibitor ID-1-like [KO:K04680]
114556322  uncharacterized protein LOC114556322 [KO:K04680]
114546878  id2; DNA-binding protein inhibitor ID-2 [KO:K17693]
114546850  id3; DNA-binding protein inhibitor ID-3 [KO:K17694]
114557260  DNA-binding protein inhibitor ID-4-like [KO:K17695]
114554690  rbl1; retinoblastoma-like protein 1 [KO:K04681]
114561085  rbl2; retinoblastoma-like protein 2 [KO:K04681]
114566169  transcription factor E2F4-like [KO:K04682]
114560148  e2f4; transcription factor E2F4 [KO:K04682]
114564958  transcription factor E2F5-like isoform X1 [KO:K04682]
114563871  tfdp1; transcription factor Dp-1 [KO:K04683]
114565696  CREB-binding protein-like isoform X1 [KO:K04498] [EC:2.3.1.48]
114568976  crebbp; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
114569286  histone acetyltransferase p300-like [KO:K04498] [EC:2.3.1.48]
114547784  LOW QUALITY PROTEIN: histone acetyltransferase p300-like [KO:K04498] [EC:2.3.1.48]
114554650  sp1; transcription factor Sp1 isoform X1 [KO:K04684]
114565159  skil; ski-like protein isoform X1 [KO:K18499]
114558701  ski; ski oncogene [KO:K26503]
114554177  ski oncogene-like [KO:K26503]
114560820  sin3a; paired amphipathic helix protein Sin3a isoform X1 [KO:K11644]
114556728  paired amphipathic helix protein Sin3a-like [KO:K11644]
114546671  histone deacetylase 1 isoform X1 [KO:K06067] [EC:3.5.1.98]
114568387  probable histone deacetylase 1-B [KO:K06067] [EC:3.5.1.98]
114567299  ncor1; nuclear receptor corepressor 1 [KO:K04650]
114549277  homeobox protein TGIF1-like isoform X1 [KO:K19383]
114565462  transcriptional regulator Myc-like isoform X1 [KO:K04377]
114549120  myc; myc proto-oncogene protein isoform X1 [KO:K04377]
114567514  cyclin-dependent kinase 4 inhibitor B-like [KO:K04685]
114563155  pitx2; pituitary homeobox 2 isoform X1 [KO:K04686]
Compound
C14819  Fe3+
Reference
PMID:12809600
  Authors
Shi Y, Massague J.
  Title
Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
  Journal
Cell 113:685-700 (2003)
DOI:10.1016/S0092-8674(03)00432-X
Reference
PMID:14534577
  Authors
Derynck R, Zhang YE.
  Title
Smad-dependent and Smad-independent pathways in TGF-beta family signalling.
  Journal
Nature 425:577-84 (2003)
DOI:10.1038/nature02006
Reference
PMID:11252892
  Authors
Massague J.
  Title
How cells read TGF-beta signals.
  Journal
Nat Rev Mol Cell Biol 1:169-78 (2000)
DOI:10.1038/35043051
Reference
PMID:14557817
  Authors
Siegel PM, Massague J.
  Title
Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer.
  Journal
Nat Rev Cancer 3:807-21 (2003)
DOI:10.1038/nrc1208
Reference
PMID:14769828
  Authors
Shimasaki S, Moore RK, Otsuka F, Erickson GF.
  Title
The bone morphogenetic protein system in mammalian reproduction.
  Journal
Endocr Rev 25:72-101 (2004)
DOI:10.1210/er.2003-0007
Reference
PMID:11252746
  Authors
De Robertis EM, Larrain J, Oelgeschlager M, Wessely O.
  Title
The establishment of Spemann's organizer and patterning of the vertebrate embryo.
  Journal
Nat Rev Genet 1:171-81 (2000)
DOI:10.1038/35042039
Reference
PMID:12163231
  Authors
Gumienny TL, Padgett RW.
  Title
The other side of TGF-beta superfamily signal regulation: thinking outside the cell.
  Journal
Trends Endocrinol Metab 13:295-9 (2002)
DOI:10.1016/S1043-2760(02)00615-X
Reference
PMID:11836504
  Authors
Hamada H, Meno C, Watanabe D, Saijoh Y.
  Title
Establishment of vertebrate left-right asymmetry.
  Journal
Nat Rev Genet 3:103-13 (2002)
DOI:10.1038/nrg732
Reference
PMID:12466190
  Authors
Chang H, Brown CW, Matzuk MM.
  Title
Genetic analysis of the mammalian transforming growth factor-beta superfamily.
  Journal
Endocr Rev 23:787-823 (2002)
DOI:10.1210/er.2002-0003
Reference
PMID:10021351
  Authors
Morita K, Chow KL, Ueno N.
  Title
Regulation of body length and male tail ray pattern formation of Caenorhabditis elegans by a member of TGF-beta family.
  Journal
Development 126:1337-47 (1999)
Reference
PMID:9847239
  Authors
Krishna S, Maduzia LL, Padgett RW.
  Title
Specificity of TGFbeta signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans.
  Journal
Development 126:251-60 (1999)
Reference
PMID:15063168
  Authors
Chen Y, Mironova E, Whitaker LL, Edwards L, Yost HJ, Ramsdell AF.
  Title
ALK4 functions as a receptor for multiple TGF beta-related ligands to regulate left-right axis determination and mesoderm induction in Xenopus.
  Journal
Dev Biol 268:280-94 (2004)
DOI:10.1016/j.ydbio.2003.12.035
Reference
PMID:10519551
  Authors
Onichtchouk D, Chen YG, Dosch R, Gawantka V, Delius H, Massague J, Niehrs C
  Title
Silencing of TGF-beta signalling by the pseudoreceptor BAMBI.
  Journal
Nature 401:480-5 (1999)
DOI:10.1038/46794
Reference
PMID:19758997
  Authors
Yan X, Lin Z, Chen F, Zhao X, Chen H, Ning Y, Chen YG
  Title
Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-beta signaling.
  Journal
J Biol Chem 284:30097-104 (2009)
DOI:10.1074/jbc.M109.049304
Reference
PMID:8093006
  Authors
Hildebrand A, Romaris M, Rasmussen LM, Heinegard D, Twardzik DR, Border WA, Ruoslahti E
  Title
Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta.
  Journal
Biochem J 302 ( Pt 2):527-34 (1994)
DOI:10.1042/bj3020527
Reference
PMID:10934147
  Authors
Soo C, Hu FY, Zhang X, Wang Y, Beanes SR, Lorenz HP, Hedrick MH, Mackool RJ, Plaas A, Kim SJ, Longaker MT, Freymiller E, Ting K
  Title
Differential expression of fibromodulin, a transforming growth factor-beta modulator, in fetal skin development and scarless repair.
  Journal
Am J Pathol 157:423-33 (2000)
DOI:10.1016/s0002-9440(10)64555-5
Reference
PMID:16642010
  Authors
Anderson GJ, Frazer DM
  Title
Iron metabolism meets signal transduction.
  Journal
Nat Genet 38:503-4 (2006)
DOI:10.1038/ng0506-503
Reference
PMID:26735394
  Authors
Canali S, Core AB, Zumbrennen-Bullough KB, Merkulova M, Wang CY, Schneyer AL, Pietrangelo A, Babitt JL
  Title
Activin B Induces Noncanonical SMAD1/5/8 Signaling via BMP Type I Receptors in Hepatocytes: Evidence for a Role in Hepcidin Induction by Inflammation in Male Mice.
  Journal
Endocrinology 157:1146-62 (2016)
DOI:10.1210/en.2015-1747
Reference
PMID:26160612
  Authors
Ganz T, Nemeth E
  Title
Iron homeostasis in host defence and inflammation.
  Journal
Nat Rev Immunol 15:500-10 (2015)
DOI:10.1038/nri3863
Reference
PMID:15975920
  Authors
Babitt JL, Zhang Y, Samad TA, Xia Y, Tang J, Campagna JA, Schneyer AL, Woolf CJ, Lin HY
  Title
Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor.
  Journal
J Biol Chem 280:29820-7 (2005)
DOI:10.1074/jbc.M503511200
Reference
PMID:15671031
  Authors
Samad TA, Rebbapragada A, Bell E, Zhang Y, Sidis Y, Jeong SJ, Campagna JA, Perusini S, Fabrizio DA, Schneyer AL, Lin HY, Brivanlou AH, Attisano L, Woolf CJ
  Title
DRAGON, a bone morphogenetic protein co-receptor.
  Journal
J Biol Chem 280:14122-9 (2005)
DOI:10.1074/jbc.M410034200
Reference
PMID:33925597
  Authors
Vogt AS, Arsiwala T, Mohsen M, Vogel M, Manolova V, Bachmann MF
  Title
On Iron Metabolism and Its Regulation.
  Journal
Int J Mol Sci 22:ijms22094591 (2021)
DOI:10.3390/ijms22094591
Reference
PMID:20495575
  Authors
Ikushima H, Miyazono K
  Title
TGFbeta signalling: a complex web in cancer progression.
  Journal
Nat Rev Cancer 10:415-24 (2010)
DOI:10.1038/nrc2853
Related
pathway
pflv04010  MAPK signaling pathway
pflv04110  Cell cycle
pflv04120  Ubiquitin mediated proteolysis
pflv04210  Apoptosis
KO pathway
ko04350   
LinkDB

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