KEGG   PATHWAY: pflv04120
Entry
pflv04120                   Pathway                                
Name
Ubiquitin mediated proteolysis - Perca flavescens (yellow perch)
Description
Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
pflv04120  Ubiquitin mediated proteolysis
pflv04120

Other DBs
GO: 0016567
Organism
Perca flavescens (yellow perch) [GN:pflv]
Gene
114567297  ubb; polyubiquitin-B isoform X1 [KO:K04551]
114571049  LOW QUALITY PROTEIN: polyubiquitin-B-like [KO:K04551]
114561363  uba52; ubiquitin-60S ribosomal protein L40 [KO:K02927]
114572637  rps27a; ubiquitin-40S ribosomal protein S27a [KO:K02977]
114554538  LOW QUALITY PROTEIN: ubiquitin-like modifier-activating enzyme 1 [KO:K03178] [EC:6.2.1.45]
114558334  uba1; ubiquitin-like modifier-activating enzyme 1 [KO:K03178] [EC:6.2.1.45]
114552583  sae1; SUMO-activating enzyme subunit 1 [KO:K10684] [EC:6.2.1.45]
114560669  uba2; SUMO-activating enzyme subunit 2 [KO:K10685] [EC:6.2.1.45]
114554110  NEDD8-activating enzyme E1 catalytic subunit isoform X1 [KO:K10686] [EC:6.2.1.64]
114558205  NEDD8-activating enzyme E1 catalytic subunit-like isoform X1 [KO:K10686] [EC:6.2.1.64]
114571763  uba6; ubiquitin-like modifier-activating enzyme 6 isoform X1 [KO:K10699] [EC:6.2.1.45]
114563153  ube2a; ubiquitin-conjugating enzyme E2 A [KO:K10573] [EC:2.3.2.23]
114563963  ubiquitin-conjugating enzyme E2 A-like isoform X1 [KO:K10573] [EC:2.3.2.23]
114566977  ube2b; ubiquitin-conjugating enzyme E2 B [KO:K10574] [EC:2.3.2.23]
114554261  ube2c; ubiquitin-conjugating enzyme E2 C [KO:K06688] [EC:2.3.2.23]
114546614  ubiquitin-conjugating enzyme E2 D2-like isoform X1 [KO:K06689] [EC:2.3.2.23]
114548036  ubiquitin-conjugating enzyme E2 D4-like isoform X1 [KO:K06689] [EC:2.3.2.23]
114571849  ubiquitin-conjugating enzyme E2 D4-like [KO:K06689] [EC:2.3.2.23]
114555802  ubiquitin-conjugating enzyme E2 D4 [KO:K06689] [EC:2.3.2.23]
114562606  ubiquitin-conjugating enzyme E2 D2 [KO:K06689] [EC:2.3.2.23]
114562921  ubiquitin-conjugating enzyme E2-17 kDa-like isoform X1 [KO:K06689] [EC:2.3.2.23]
114567899  ubiquitin-conjugating enzyme E2 E2-like [KO:K20217] [EC:2.3.2.23]
114568262  ubiquitin-conjugating enzyme E2 E1 isoform X1 [KO:K20217] [EC:2.3.2.23]
114556868  ubiquitin-conjugating enzyme E2 E2 [KO:K20217] [EC:2.3.2.23]
114557084  ubiquitin-conjugating enzyme E2 E1-like [KO:K20217] [EC:2.3.2.23]
114564052  ube2f; NEDD8-conjugating enzyme UBE2F [KO:K10687] [EC:2.3.2.34]
114566545  ube2g1; ubiquitin-conjugating enzyme E2 G1 [KO:K10575] [EC:2.3.2.23]
114555084  ubiquitin-conjugating enzyme E2 G1-like [KO:K10575] [EC:2.3.2.23]
114571176  ubiquitin-conjugating enzyme E2 G1-like [KO:K10575] [EC:2.3.2.23]
114564682  ube2g2; ubiquitin-conjugating enzyme E2 G2 [KO:K04555] [EC:2.3.2.23]
114560829  ubiquitin-conjugating enzyme E2 H-like [KO:K10576] [EC:2.3.2.23]
114550389  ube2h; ubiquitin-conjugating enzyme E2 H [KO:K10576] [EC:2.3.2.23]
114569929  SUMO-conjugating enzyme UBC9-like [KO:K10577]
114547912  ube2i; SUMO-conjugating enzyme UBC9 [KO:K10577]
114573688  ube2j1; ubiquitin-conjugating enzyme E2 J1 [KO:K10578] [EC:2.3.2.23]
114554008  ube2j2; ubiquitin-conjugating enzyme E2 J2 [KO:K04554] [EC:2.3.2.23]
114562611  ubiquitin-conjugating enzyme E2 K isoform X1 [KO:K04649] [EC:2.3.2.23]
114564259  ube2k; ubiquitin-conjugating enzyme E2 K [KO:K04649] [EC:2.3.2.23]
114571380  ubiquitin-conjugating enzyme E2 L3-like [KO:K04552] [EC:2.3.2.23]
114555192  ubiquitin-conjugating enzyme E2 L3 [KO:K04552] [EC:2.3.2.23]
114569626  ube2m; NEDD8-conjugating enzyme Ubc12 [KO:K10579] [EC:2.3.2.34]
114559853  ube2n; ubiquitin-conjugating enzyme E2 N [KO:K10580] [EC:2.3.2.23]
114550333  ubiquitin-conjugating enzyme E2 N-like isoform X1 [KO:K10580] [EC:2.3.2.23]
114567858  ube2o; (E3-independent) E2 ubiquitin-conjugating enzyme isoform X1 [KO:K10581] [EC:2.3.2.24]
114568420  ube2ql1; ubiquitin-conjugating enzyme E2Q-like protein 1 [KO:K10582] [EC:2.3.2.23]
114560444  ubiquitin-conjugating enzyme E2 Q2-like isoform X1 [KO:K10582] [EC:2.3.2.23]
114557082  ubiquitin-conjugating enzyme E2 Q2-like isoform X1 [KO:K10582] [EC:2.3.2.23]
114564784  ubiquitin-conjugating enzyme E2 R1 [KO:K02207] [EC:2.3.2.23]
114553972  ube2r2; ubiquitin-conjugating enzyme E2 R2 [KO:K02207] [EC:2.3.2.23]
114561232  ubiquitin-conjugating enzyme E2 R2-like [KO:K02207] [EC:2.3.2.23]
114557267  ube2s; ubiquitin-conjugating enzyme E2 S [KO:K10583] [EC:2.3.2.23]
114549410  ube2w; ubiquitin-conjugating enzyme E2 W [KO:K10688] [EC:2.3.2.23 2.3.2.25]
114569703  ube2z; ubiquitin-conjugating enzyme E2 Z [KO:K10585] [EC:2.3.2.23]
114572320  birc6; baculoviral IAP repeat-containing protein 6 isoform X1 [KO:K10586] [EC:2.3.2.23]
114550838  ubiquitin-protein ligase E3A-like [KO:K10587] [EC:2.3.2.26]
114561817  ubiquitin-protein ligase E3A-like isoform X1 [KO:K10587] [EC:2.3.2.26]
114555089  ube3b; ubiquitin-protein ligase E3B [KO:K10588] [EC:2.3.2.26]
114549209  ube3c; ubiquitin-protein ligase E3C [KO:K10589] [EC:2.3.2.26]
114569505  E3 ubiquitin-protein ligase SMURF2 isoform X1 [KO:K04678] [EC:2.3.2.26]
114569633  smurf1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
114571256  E3 ubiquitin-protein ligase SMURF2-like [KO:K04678] [EC:2.3.2.26]
114558669  E3 ubiquitin-protein ligase Itchy-like isoform X1 [KO:K05632] [EC:2.3.2.26]
114554326  E3 ubiquitin-protein ligase Itchy-like [KO:K05632] [EC:2.3.2.26]
114549454  wwp1; NEDD4-like E3 ubiquitin-protein ligase WWP1 [KO:K05633] [EC:2.3.2.26]
114560567  NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform X1 [KO:K05630] [EC:2.3.2.26]
114552344  trip12; E3 ubiquitin-protein ligase TRIP12 isoform X1 [KO:K10590] [EC:2.3.2.26]
114552458  nedd4; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase NEDD4 [KO:K10591] [EC:2.3.2.26]
114570535  nedd4l; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
114559188  huwe1; E3 ubiquitin-protein ligase HUWE1 isoform X1 [KO:K10592] [EC:2.3.2.26]
114556630  ubr5; E3 ubiquitin-protein ligase UBR5 isoform X1 [KO:K10593] [EC:2.3.2.26]
114560594  herc1; probable E3 ubiquitin-protein ligase HERC1 isoform X1 [KO:K10594] [EC:2.3.2.26]
114571382  probable E3 ubiquitin-protein ligase HERC1 isoform X1 [KO:K10594] [EC:2.3.2.26]
114562040  herc2; E3 ubiquitin-protein ligase HERC2 isoform X1 [KO:K10595] [EC:2.3.2.26]
114560200  probable E3 ubiquitin-protein ligase HERC3 isoform X1 [KO:K10614] [EC:2.3.2.26]
114560199  probable E3 ubiquitin-protein ligase HERC3 isoform X1 [KO:K10614] [EC:2.3.2.26]
114565826  herc3; probable E3 ubiquitin-protein ligase HERC3 isoform X1 [KO:K10614] [EC:2.3.2.26]
114572066  herc4; probable E3 ubiquitin-protein ligase HERC4 isoform X1 [KO:K10615] [EC:2.3.2.26]
114552784  ube4a; ubiquitin conjugation factor E4 A [KO:K10596] [EC:2.3.2.27]
114558482  ube4b; ubiquitin conjugation factor E4 B isoform X1 [KO:K10597] [EC:2.3.2.27]
114569624  E3 ubiquitin-protein ligase CHIP-like [KO:K09561] [EC:2.3.2.27]
114548380  stub1; E3 ubiquitin-protein ligase CHIP [KO:K09561] [EC:2.3.2.27]
114555567  ppil2; RING-type E3 ubiquitin-protein ligase PPIL2 [KO:K10598] [EC:5.2.1.8]
114562753  prpf19; pre-mRNA-processing factor 19 [KO:K10599] [EC:2.3.2.27]
114555491  ubox5; RING finger protein 37 [KO:K10600]
114550246  mdm2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
114552357  cbl; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
114566816  E3 ubiquitin-protein ligase CBL-like isoform X1 [KO:K04707] [EC:2.3.2.27]
114566515  cblb; E3 ubiquitin-protein ligase CBL-B [KO:K22517] [EC:2.3.2.27]
114557176  cblc; E3 ubiquitin-protein ligase CBL-C isoform X1 [KO:K22518] [EC:2.3.2.27]
114572102  prkn; E3 ubiquitin-protein ligase parkin [KO:K04556] [EC:2.3.2.31]
114560246  E3 ubiquitin-protein ligase Siah1 isoform X1 [KO:K04506] [EC:2.3.2.27]
114552813  traf6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
114565737  cop1; E3 ubiquitin-protein ligase COP1 [KO:K10143] [EC:2.3.2.27]
114555332  rchy1; RING finger and CHY zinc finger domain-containing protein 1 [KO:K10144] [EC:2.3.2.27]
114566357  inhibitor of apoptosis protein-like [KO:K16060]
114563007  xiap; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
114558661  baculoviral IAP repeat-containing protein 7-like isoform X1 [KO:K16061]
114559849  E3 SUMO-protein ligase PIAS1-like isoform X1 [KO:K04706] [EC:2.3.2.-]
114555191  E3 SUMO-protein ligase PIAS2-like isoform X1 [KO:K16063] [EC:2.3.2.-]
114561812  pias4; E3 SUMO-protein ligase PIAS4 [KO:K16065] [EC:2.3.2.27]
114562737  syvn1; E3 ubiquitin-protein ligase synoviolin [KO:K10601] [EC:2.3.2.27]
114557711  nhlrc1; E3 ubiquitin-protein ligase NHLRC1 [KO:K10602] [EC:2.3.2.27]
114570158  mgrn1; E3 ubiquitin-protein ligase MGRN1 isoform X1 [KO:K10604] [EC:2.3.2.27]
114548467  brca1; breast cancer type 1 susceptibility protein isoform X1 [KO:K10605] [EC:2.3.2.27]
114571876  fancl; E3 ubiquitin-protein ligase FANCL [KO:K10606] [EC:2.3.2.27]
114550884  E3 ubiquitin-protein ligase Midline-1-like [KO:K08285] [EC:2.3.2.27]
114564059  E3 ubiquitin-protein ligase Midline-1-like isoform X1 [KO:K08285] [EC:2.3.2.27]
114571393  trim32; E3 ubiquitin-protein ligase TRIM32 [KO:K10607] [EC:2.3.2.27]
114566831  trim37; E3 ubiquitin-protein ligase TRIM37 isoform X1 [KO:K10608] [EC:2.3.2.27]
114569772  rbx1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
114549315  cul1; cullin-1 [KO:K03347]
114567245  skp1; S-phase kinase-associated protein 1 [KO:K03094]
114562291  F-box/WD repeat-containing protein 11 isoform X1 [KO:K03362]
114571071  skp2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
114566078  fbxw7; F-box/WD repeat-containing protein 7 isoform X1 [KO:K10260]
114546210  ABC transporter F family member 4-like [KO:K10260]
114554370  F-box only protein 2-like [KO:K10099]
114555790  fbxo4; F-box only protein 4 [KO:K10291]
114549501  cul2; cullin-2 [KO:K03870]
114549200  eloc; elongin-C [KO:K03872]
114570415  elongin-B isoform X1 [KO:K03873]
114548231  elongin-B-like [KO:K03873]
114553605  vhl; von Hippel-Lindau disease tumor suppressor [KO:K03871]
114564929  cullin-3-like [KO:K03869]
114552757  cullin-3 isoform X1 [KO:K03869]
114567260  keap1; kelch-like ECH-associated protein 1 [KO:K10456]
114546874  kelch-like ECH-associated protein 1 [KO:K10456]
114566493  kelch-like protein 13 isoform X1 [KO:K10447]
114564339  kelch-like protein 9 [KO:K10447]
114555262  rho-related BTB domain-containing protein 2-like isoform X1 [KO:K07868]
114556125  rhobtb2; rho-related BTB domain-containing protein 2 isoform X1 [KO:K07868]
114554153  cul4a; cullin-4A [KO:K10609]
114563043  cul4b; cullin-4B [KO:K10609]
114553273  ddb1; DNA damage-binding protein 1 [KO:K10610]
114560042  ddb2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
114555956  ercc8; DNA excision repair protein ERCC-8 isoform X1 [KO:K10570]
114560841  det1; DET1 homolog [KO:K10571]
114552504  rnf7; RING-box protein 2 [KO:K10611]
114552403  cullin-5-like isoform X1 [KO:K10612]
114567163  cullin-5 isoform X1 [KO:K10612]
114569781  socs1; suppressor of cytokine signaling 1 [KO:K04694]
114573238  suppressor of cytokine signaling 1-like [KO:K04694]
114569548  socs3; suppressor of cytokine signaling 3 [KO:K04696]
114547891  suppressor of cytokine signaling 3-like [KO:K04696]
114556206  fbxw8; F-box/WD repeat-containing protein 8 isoform X1 [KO:K10264]
114571575  anapc11; anaphase-promoting complex subunit 11 [KO:K03358]
114569799  anapc2; anaphase-promoting complex subunit 2 isoform X1 [KO:K03349]
114564749  cell division cycle protein 20 homolog isoform X1 [KO:K03363]
114564750  cdc20; cell division cycle protein 20 homolog [KO:K03363]
114555565  cdc20b; cell division cycle protein 20 homolog B [KO:K03363]
114565744  fizzy-related protein homolog [KO:K03364]
114560924  fizzy-related protein homolog isoform X1 [KO:K03364]
114565087  fizzy-related protein homolog [KO:K03364]
114572060  anapc1; anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
114569859  cdc27; cell division cycle protein 27 homolog [KO:K03350]
114562077  anapc4; anaphase-promoting complex subunit 4 isoform X1 [KO:K03351]
114556203  anapc5; anaphase-promoting complex subunit 5 [KO:K03352]
114564533  cdc16; cell division cycle protein 16 homolog [KO:K03353]
114555079  anapc7; anaphase-promoting complex subunit 7 [KO:K03354]
114566613  cdc23; LOW QUALITY PROTEIN: cell division cycle protein 23 homolog [KO:K03355]
114545586  anapc10; anaphase-promoting complex subunit 10 [KO:K03357]
114571526  cdc26; anaphase-promoting complex subunit CDC26 [KO:K03359]
114560832  anapc13; anaphase-promoting complex subunit 13 [KO:K12456]
114552613  anapc15; anaphase-promoting complex subunit 15 isoform X1 [KO:K25228]
114547879  anapc16; anaphase-promoting complex subunit 16 isoform X1 [KO:K25229]
Reference
PMID:16922370
  Authors
Kamura T.
  Title
[Cullin-based E3 family]
  Journal
Tanpakushitsu Kakusan Koso 51:1167-72 (2006)
Reference
PMID:16922408
  Authors
Matsuda N.
  Title
[Overview: hereditary disorders caused by dysfunction of ubiquitylation]
  Journal
Tanpakushitsu Kakusan Koso 51:1402-7 (2006)
Reference
PMID:16922367
  Authors
Tokunaga F.
  Title
[E2 ubiquitin-conjugating enzymes: structures and functions]
  Journal
Tanpakushitsu Kakusan Koso 51:1150-6 (2006)
Reference
PMID:16816840
  Authors
Nalepa G, Rolfe M, Harper JW.
  Title
Drug discovery in the ubiquitin-proteasome system.
  Journal
Nat Rev Drug Discov 5:596-613 (2006)
DOI:10.1038/nrd2056
Reference
PMID:16405856
  Authors
Hsu YJ, Goodman SR.
  Title
Spectrin and ubiquitination: a review.
  Journal
Cell Mol Biol (Noisy-le-grand) Suppl 51:OL801-7 (2005)
Reference
PMID:12944364
  Authors
Hatakeyama S, Nakayama KI.
  Title
Ubiquitylation as a quality control system for intracellular proteins.
  Journal
J Biochem 134:1-8 (2003)
DOI:10.1093/jb/mvg106
Reference
PMID:17588513
  Authors
Lee J, Zhou P.
  Title
DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase.
  Journal
Mol Cell 26:775-80 (2007)
DOI:10.1016/j.molcel.2007.06.001
Related
pathway
pflv03050  Proteasome
KO pathway
ko04120   
LinkDB

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