KEGG   PATHWAY: pflv04010
Entry
pflv04010                   Pathway                                
Name
MAPK signaling pathway - Perca flavescens (yellow perch)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
pflv04010  MAPK signaling pathway
pflv04010

Other DBs
GO: 0000165
Organism
Perca flavescens (yellow perch) [GN:pflv]
Gene
114569401  voltage-dependent P/Q-type calcium channel subunit alpha-1A-like [KO:K04344]
114546705  cacna1a; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
114571315  voltage-dependent N-type calcium channel subunit alpha-1B-like isoform X1 [KO:K04849]
114555208  probable voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
114549894  voltage-dependent L-type calcium channel subunit alpha-1C-like isoform X1 [KO:K04850]
114558551  cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
114553636  LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04851]
114564839  voltage-dependent R-type calcium channel subunit alpha-1E-like isoform X1 [KO:K04852]
114561638  cacna1e; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
114558250  voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04853]
114547945  cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G [KO:K04854]
114569309  voltage-dependent T-type calcium channel subunit alpha-1I-like [KO:K04855]
114561173  voltage-dependent T-type calcium channel subunit alpha-1H-like isoform X1 [KO:K04855]
114569403  voltage-dependent T-type calcium channel subunit alpha-1I-like [KO:K04856]
114546896  voltage-dependent T-type calcium channel subunit alpha-1I-like [KO:K04856]
114553640  dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1-like isoform X1 [KO:K04857]
114558278  dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1-like [KO:K04857]
114559808  voltage-dependent calcium channel subunit alpha-2/delta-1-like isoform X1 [KO:K04858]
114549821  voltage-dependent calcium channel subunit alpha-2/delta-1-like isoform X1 [KO:K04858]
114553552  cacna2d2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
114554347  voltage-dependent calcium channel subunit alpha-2/delta-2-like isoform X1 [KO:K04859]
114554801  voltage-dependent calcium channel subunit alpha-2/delta-3-like isoform X1 [KO:K04860]
114558168  cacna2d3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
114559609  voltage-dependent calcium channel subunit alpha-2/delta-4-like isoform X1 [KO:K04861]
114550312  cacna2d4; voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X1 [KO:K04861]
114569057  cacnb1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
114548817  cacnb2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
114558749  voltage-dependent L-type calcium channel subunit beta-4-like [KO:K04864]
114550852  voltage-dependent L-type calcium channel subunit beta-4-like isoform X1 [KO:K04865]
114564014  cacnb4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
114569410  voltage-dependent calcium channel gamma-1 subunit-like [KO:K04866]
114561952  cacng1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
114569335  cacng2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
114546591  LOW QUALITY PROTEIN: voltage-dependent calcium channel gamma-2 subunit-like [KO:K04867]
114566220  voltage-dependent calcium channel gamma-3 subunit-like [KO:K04868]
114570161  cacng3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
114569718  voltage-dependent calcium channel gamma-4 subunit-like isoform X1 [KO:K04869]
114570934  cacng4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
114570099  voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
114573851  cacng5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
114568302  voltage-dependent calcium channel gamma-6 subunit-like isoform X1 [KO:K04871]
114557413  cacng6; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
114568777  voltage-dependent calcium channel gamma-7 subunit-like isoform X1 [KO:K04872]
114557951  voltage-dependent calcium channel gamma-7 subunit-like [KO:K04872]
114568424  voltage-dependent calcium channel gamma-4 subunit-like [KO:K04873]
114557666  voltage-dependent calcium channel gamma-4 subunit-like [KO:K04873]
114565306  prkaca; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
114565471  cAMP-dependent protein kinase catalytic subunit beta-like [KO:K04345] [EC:2.7.11.11]
114568922  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
114561605  prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
114565339  prkca; LOW QUALITY PROTEIN: protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
114570388  protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
114566211  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
114569627  prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
114557331  LOW QUALITY PROTEIN: protein kinase C gamma type-like [KO:K19663] [EC:2.7.11.13]
114568096  gna12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
114570321  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like [KO:K04347]
114561802  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7-like isoform X1 [KO:K04347]
114565227  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
114545488  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
114566730  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
114570715  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
114555314  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
114562882  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
114568444  calcineurin subunit B type 1-like [KO:K06268]
114572606  ppp3r1; calcineurin subunit B type 1 [KO:K06268]
114560574  ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
114573460  LOW QUALITY PROTEIN: ras-specific guanine nucleotide-releasing factor 1-like [KO:K04349]
114571098  ras-specific guanine nucleotide-releasing factor 2-like isoform X1 [KO:K12326]
114555854  rasgrf2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
114546691  rasgrp1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
114550240  RAS guanyl-releasing protein 1-like isoform X1 [KO:K04350]
114545322  rasgrp2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
114572113  rasgrp3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
114562530  rapgef2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
114549580  nf1; neurofibromin isoform X1 [KO:K08052]
114555174  rasa1; ras GTPase-activating protein 1 [KO:K04352]
114552347  rasa2; ras GTPase-activating protein 2 [KO:K08053]
114558435  ras-related protein Rap-1A [KO:K04353]
114553888  ras-related protein Rap-1A-like [KO:K04353]
114549955  ras-related protein Rap-1b [KO:K07836]
114563345  egf; pro-epidermal growth factor [KO:K04357]
114554686  tgfa; protransforming growth factor alpha [KO:K08774]
114556219  ereg; proepiregulin [KO:K09784]
114566759  fgf1; fibroblast growth factor 1 isoform X1 [KO:K18496]
114562676  fibroblast growth factor 1-like [KO:K18496]
114563146  fgf2; fibroblast growth factor 2 [KO:K18497]
114564643  fibroblast growth factor 4A-like [KO:K04358]
114552746  fgf7; fibroblast growth factor 7 isoform X1 [KO:K04358]
114545548  fibroblast growth factor 20-like [KO:K04358]
114567703  fgf8; fibroblast growth factor 8 [KO:K04358]
114559523  fgf6; fibroblast growth factor 6 [KO:K04358]
114559560  fgf4; fibroblast growth factor 4 [KO:K04358]
114572247  fibroblast growth factor 8 [KO:K04358]
114555299  fgf3; fibroblast growth factor 3 [KO:K04358]
114561623  fgf22; fibroblast growth factor 22 [KO:K04358]
114555705  fgf5; fibroblast growth factor 5 [KO:K04358]
114555947  fgf17; fibroblast growth factor 17 [KO:K04358]
114562447  fibroblast growth factor 4-like [KO:K04358]
114556244  fgf10; fibroblast growth factor 10 [KO:K04358]
114562726  fibroblast growth factor 18-like isoform X1 [KO:K04358]
114563073  fibroblast growth factor 20-like [KO:K04358]
114563092  fgf16; fibroblast growth factor 16 [KO:K04358]
114550268  fibroblast growth factor 6-like [KO:K04358]
114563270  fibroblast growth factor 18-like isoform X1 [KO:K04358]
114561481  fgf19; fibroblast growth factor 19 [KO:K22603]
114548450  fibroblast growth factor 21-like [KO:K22429]
114559522  fibroblast growth factor 23-like [KO:K22428]
114550439  fgf23; fibroblast growth factor 23 [KO:K22428]
114558351  nerve growth factor-like [KO:K02582]
114554921  ngf; beta-nerve growth factor [KO:K02582]
114558058  bdnf; brain-derived neurotrophic factor isoform X1 [KO:K04355]
114550458  ntf3; neurotrophin-3 [KO:K04356]
114567209  insulin [KO:K04526]
114562468  insulin-like [KO:K04526]
114559177  insulin-like growth factor I [KO:K05459]
114549943  igf1; insulin-like growth factor I isoform X1 [KO:K05459]
114559835  igf2; insulin-like growth factor II [KO:K13769]
114564713  platelet-derived growth factor subunit A-like [KO:K04359]
114570050  pdgfa; platelet-derived growth factor subunit A [KO:K04359]
114548096  uncharacterized protein LOC114548096 isoform X1 [KO:K17386]
114549755  pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
114562955  pdgfc; platelet-derived growth factor C isoform X1 [KO:K05450]
114560522  kitlg; kit ligand [KO:K05461]
114549968  uncharacterized protein LOC114549968 [KO:K05461]
114572978  vegfa; vascular endothelial growth factor A isoform X1 [KO:K05448]
114562277  vegfb; vascular endothelial growth factor B [KO:K05448]
114557256  vascular endothelial growth factor A-A-like isoform X1 [KO:K05448]
114547115  placenta growth factor-like [KO:K16859]
114573284  vascular endothelial growth factor A-like isoform X1 [KO:K16859]
114558708  vegfd; vascular endothelial growth factor D isoform X1 [KO:K05449]
114550825  vascular endothelial growth factor C-like [KO:K05449]
114564168  vegfc; vascular endothelial growth factor C [KO:K05449]
114560350  hepatocyte growth factor-like [KO:K05460]
114550128  hepatocyte growth factor-like [KO:K05460]
114568038  angpt1; angiopoietin-1 isoform X1 [KO:K05465]
114554663  angiopoietin-1-like [KO:K05465]
114567634  angiopoietin-2-like [KO:K05466]
114572004  angpt2; angiopoietin-2 [KO:K05466]
114568162  ephrin-A3-like isoform X1 [KO:K05462]
114568243  ephrin-A1-like isoform X1 [KO:K05462]
114547147  ephrin-A2-like [KO:K05462]
114571017  ephrin-A5b-like [KO:K05462]
114561491  ephrin-A2-like [KO:K05462]
114556391  ephrin-A5b-like isoform X1 [KO:K05462]
114557154  ephrin-A4-like [KO:K05462]
114557240  efna1; ephrin-A1 [KO:K05462]
114557654  efna3; ephrin-A3 isoform X1 [KO:K05462]
114571162  gdnf; glial cell line-derived neurotrophic factor [KO:K05452]
114555879  glial cell line-derived neurotrophic factor-like [KO:K05452]
114546697  persephin-like [KO:K25416]
114548913  melanoma receptor tyrosine-protein kinase-like [KO:K04361] [EC:2.7.10.1]
114564973  egfr; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
114547884  erbb2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
114559209  receptor tyrosine-protein kinase erbB-3-like [KO:K05084] [EC:2.7.10.1]
114554019  erbb3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
114550836  receptor tyrosine-protein kinase erbB-4-like isoform X1 [KO:K05085] [EC:2.7.10.1]
114563973  erbb4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
114555046  fgfr1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
114571184  fibroblast growth factor receptor 1-A-like isoform X1 [KO:K04362] [EC:2.7.10.1]
114552491  tyrosine kinase receptor Cad96Ca-like [KO:K05093] [EC:2.7.10.1]
114571757  fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
114546647  fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
114566310  fibroblast growth factor receptor 4-like [KO:K05095] [EC:2.7.10.1]
114569083  tumor necrosis factor receptor superfamily member 16-like isoform X1 [KO:K02583]
114548080  tumor necrosis factor receptor superfamily member 16-like [KO:K02583]
114557182  death domain-containing membrane protein NRADD-like [KO:K02583]
114557434  ntrk1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
114571365  BDNF/NT-3 growth factors receptor-like [KO:K04360] [EC:2.7.10.1]
114556221  ntrk2; BDNF/NT-3 growth factors receptor [KO:K04360] [EC:2.7.10.1]
114564739  insulin receptor-like [KO:K04527] [EC:2.7.10.1]
114562075  insulin receptor-like isoform X1 [KO:K04527] [EC:2.7.10.1]
114560454  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
114560702  insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
114561192  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
114566403  platelet-derived growth factor receptor beta-like [KO:K05089] [EC:2.7.10.1]
114562615  pdgfrb; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
114566378  macrophage colony-stimulating factor 1 receptor 2-like [KO:K05090] [EC:2.7.10.1]
114562755  csf1r; macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
114570046  mast/stem cell growth factor receptor kita-like isoform X1 [KO:K05091] [EC:2.7.10.1]
114561268  kit; LOW QUALITY PROTEIN: mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
114549361  flt3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
114562330  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
114549359  flt1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
114562616  flt4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
114561463  kdr; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
114560667  met; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
114558736  ephrin type-A receptor 2-like isoform X1 [KO:K05103] [EC:2.7.10.1]
114554290  ephrin type-A receptor 2-like isoform X1 [KO:K05103] [EC:2.7.10.1]
114572052  ret; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
114570079  grb2; growth factor receptor-bound protein 2 [KO:K04364]
114546491  sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
114568696  LOW QUALITY PROTEIN: son of sevenless homolog 1-like [KO:K03099]
114559784  hras; GTPase HRas [KO:K02833]
114559939  kras; GTPase KRas [KO:K07827]
114569569  GTPase HRas-like [KO:K07827]
114553173  rras2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
114570129  rras; ras-related protein R-Ras isoform X1 [KO:K07830]
114563940  mras; ras-related protein M-Ras [KO:K07831]
114555276  araf; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
114550105  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
114559447  raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
114559598  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
114565370  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
114561797  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
114546380  lamtor3; ragulator complex protein LAMTOR3 [KO:K04370]
114569468  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
114555749  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
114561364  mknk1; MAP kinase-interacting serine/threonine-protein kinase 1 [KO:K04372] [EC:2.7.11.1]
114561684  MAP kinase-interacting serine/threonine-protein kinase 2-like [KO:K04372] [EC:2.7.11.1]
114552672  ribosomal protein S6 kinase alpha-2-like isoform X1 [KO:K04373] [EC:2.7.11.1]
114546828  ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
114549180  ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
114562759  ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
114570148  cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
114573247  cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
114558838  ETS domain-containing protein Elk-3-like [KO:K04375]
114554138  ETS domain-containing protein Elk-4-like isoform X1 [KO:K04376]
114565462  transcriptional regulator Myc-like isoform X1 [KO:K04377]
114549120  myc; myc proto-oncogene protein isoform X1 [KO:K04377]
114565975  serum response factor-like [KO:K04378]
114571874  srf; serum response factor isoform X1 [KO:K04378]
114546536  proto-oncogene c-Fos-like [KO:K04379]
114573364  proto-oncogene c-Fos-like [KO:K04379]
114573365  proto-oncogene c-Fos-like [KO:K04379]
114570265  microtubule-associated protein tau-like [KO:K04380]
114548251  microtubule-associated protein tau-like isoform X1 [KO:K04380]
114568341  stathmin-like [KO:K04381]
114557246  stathmin-like [KO:K04381]
114569983  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
114569540  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
114570149  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
114562013  pla2g4a; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
114572512  cytosolic phospholipase A2 zeta-like [KO:K16342] [EC:3.1.1.4]
114568210  tumor necrosis factor-like [KO:K03156]
114555628  il1b; interleukin-1 beta [KO:K04519]
114552362  transforming growth factor beta-1 proprotein-like [KO:K13375]
114562717  transforming growth factor beta-2 proprotein-like [KO:K13376]
114557393  tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
114546436  tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
114573007  transforming growth factor beta-3 proprotein-like [KO:K13377]
114557503  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
114563795  interleukin-1 receptor type 1-like isoform X1 [KO:K04386]
114553249  il1rap; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
114549045  tgfbr1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
114568194  tgfbr2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
114556613  TGF-beta receptor type-2-like isoform X1 [KO:K04388] [EC:2.7.11.30]
114563526  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
114563150  tumor necrosis factor ligand superfamily member 6-like [KO:K04389]
114572155  tumor necrosis factor receptor superfamily member 6-like isoform X1 [KO:K04390]
114569702  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
114547620  rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
114565746  ras-related C3 botulinum toxin substrate 2 [KO:K07860]
114547780  rac3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
114559266  cell division control protein 42 homolog isoform X1 [KO:K04393]
114567735  cell division control protein 42 homolog [KO:K04393]
114554917  cell division control protein 42 homolog [KO:K04393]
114557534  cell division control protein 42 homolog [KO:K04393]
114558090  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
114570899  caspase-3-like [KO:K02187] [EC:3.4.22.56]
114563090  caspase-3-like isoform X1 [KO:K02187] [EC:3.4.22.56]
114563091  caspase-3-like [KO:K02187] [EC:3.4.22.56]
114571020  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
114571300  TNF receptor-associated factor 2-like isoform X1 [KO:K03173] [EC:2.3.2.27]
114555721  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
114568372  death domain-associated protein 6-like [KO:K02308]
114549018  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
114559390  LOW QUALITY PROTEIN: interleukin-1 receptor-associated kinase 1-like [KO:K04730] [EC:2.7.11.1]
114559818  irak4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
114552813  traf6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
114570772  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
114571295  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
114561373  growth arrest and DNA damage-inducible protein GADD45 alpha-like isoform X1 [KO:K04402]
114561492  gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
114555572  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
114565084  growth arrest and DNA damage-inducible protein GADD45 alpha-like isoform X1 [KO:K04402]
114568112  tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
114573158  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
114573942  ecsit; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
114571755  map4k3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
114563113  mitogen-activated protein kinase kinase kinase kinase 4-like [KO:K04407] [EC:2.7.11.1]
114550835  map4k4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
114563793  mitogen-activated protein kinase kinase kinase kinase 4-like isoform X1 [KO:K04407] [EC:2.7.11.1]
114552600  pak1; LOW QUALITY PROTEIN: serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
114546388  serine/threonine-protein kinase PAK 2-like [KO:K04410] [EC:2.7.11.1]
114561445  pak2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
114554354  serine/threonine-protein kinase 4-like [KO:K04411]
114567693  stk3; serine/threonine-protein kinase 3 [KO:K04412]
114545568  map4k2; mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
114549165  map3k8; mitogen-activated protein kinase kinase kinase 8 isoform X1 [KO:K04415] [EC:2.7.11.25]
114545451  map3k11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
114550986  map3k2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
114569844  map3k3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
114548980  mitogen-activated protein kinase kinase kinase 3-like [KO:K04421] [EC:2.7.11.25]
114547164  map3k9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
114553209  map3k10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
114571694  mitogen-activated protein kinase kinase kinase 21-like [KO:K17534] [EC:2.7.11.25]
114559157  mitogen-activated protein kinase kinase kinase 12-like [KO:K04423] [EC:2.7.11.25]
114554438  mitogen-activated protein kinase kinase kinase 12-like [KO:K04423] [EC:2.7.11.25]
114563712  map3k13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
114565725  tyrosine-protein kinase ABL2-like [KO:K04424] [EC:2.7.11.25]
114564296  map3k20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
114572961  map3k5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
114557214  mitogen-activated protein kinase kinase kinase 5-like [KO:K04426] [EC:2.7.11.25]
114547321  mitogen-activated protein kinase kinase kinase 7-like [KO:K04427] [EC:2.7.11.25]
114573089  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
114572027  map3k4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
114566542  serine/threonine-protein kinase TAO1-like isoform X1 [KO:K04429] [EC:2.7.11.1]
114570274  LOW QUALITY PROTEIN: serine/threonine-protein kinase TAO2-like [KO:K04429] [EC:2.7.11.1]
114547735  taok2; serine/threonine-protein kinase TAO2 [KO:K04429] [EC:2.7.11.1]
114555057  taok3; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
114571069  serine/threonine-protein kinase TAO3-like [KO:K04429] [EC:2.7.11.1]
114550441  serine/threonine-protein kinase TAO1-like [KO:K04429] [EC:2.7.11.1]
114569479  dual specificity mitogen-activated protein kinase kinase 4-like isoform X1 [KO:K04430] [EC:2.7.12.2]
114547952  dual specificity mitogen-activated protein kinase kinase 4-like isoform X1 [KO:K04430] [EC:2.7.12.2]
114570500  map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
114569386  dual specificity mitogen-activated protein kinase kinase 6-like [KO:K04433] [EC:2.7.12.2]
114548455  dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
114559678  C-Jun-amino-terminal kinase-interacting protein 1-like [KO:K04434]
114554444  mapk8ip1; C-Jun-amino-terminal kinase-interacting protein 1 [KO:K04434]
114559913  mapk8ip2; C-Jun-amino-terminal kinase-interacting protein 2 isoform X1 [KO:K04435]
114569112  mapk8ip3; LOW QUALITY PROTEIN: C-Jun-amino-terminal kinase-interacting protein 3 [KO:K04436]
114559340  filamin-A-like isoform X1 [KO:K04437]
114552699  adapter molecule crk-like [KO:K04438]
114566637  adapter molecule crk-like [KO:K04438]
114571390  crkl; crk-like protein isoform X1 [KO:K04438]
114545496  arrestin red cell-like [KO:K04439]
114566520  arrestin red cell isoform X1 [KO:K04439]
114553043  beta-arrestin-1 [KO:K04439]
114570928  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
114547944  mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
114572302  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
114563046  mitogen-activated protein kinase 9-like [KO:K04440] [EC:2.7.11.24]
114558455  mitogen-activated protein kinase 13-like [KO:K04441] [EC:2.7.11.24]
114553663  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
114559432  mitogen-activated protein kinase 14A-like isoform X1 [KO:K04441] [EC:2.7.11.24]
114559764  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
114549914  mitogen-activated protein kinase 11-like isoform X1 [KO:K04441] [EC:2.7.11.24]
114550129  mitogen-activated protein kinase 12-like isoform X1 [KO:K04441] [EC:2.7.11.24]
114558252  mitogen-activated protein kinase 14A-like [KO:K04441] [EC:2.7.11.24]
114555651  mapkapk5; MAP kinase-activated protein kinase 5 [KO:K04442] [EC:2.7.11.1]
114559084  MAP kinase-activated protein kinase 2-like isoform X1 [KO:K04443] [EC:2.7.11.1]
114554459  mapkapk2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
114553593  MAP kinase-activated protein kinase 2-like [KO:K04444] [EC:2.7.11.1]
114554214  MAP kinase-activated protein kinase 2-like isoform X1 [KO:K04444] [EC:2.7.11.1]
114546811  ribosomal protein S6 kinase alpha-5-like isoform X1 [KO:K04445] [EC:2.7.11.1]
114566937  ribosomal protein S6 kinase alpha-4-like [KO:K16510] [EC:2.7.11.1]
114546658  cdc25b; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
114568301  nuclear factor of activated T-cells, cytoplasmic 1-like isoform X1 [KO:K04446]
114557221  nuclear factor of activated T-cells, cytoplasmic 1-like [KO:K04446]
114552936  nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
114559908  nuclear factor of activated T-cells, cytoplasmic 3-like [KO:K17333]
114566085  jun; transcription factor AP-1 [KO:K04448]
114571404  transcription factor AP-1-like [KO:K04448]
114561902  transcription factor AP-1-like [KO:K04448]
114565289  transcription factor jun-D-like [KO:K04449]
114561696  transcription factor jun-D-like [KO:K04449]
114564663  atf2; cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
114545465  cellular tumor antigen p53-like isoform X1 [KO:K04451]
114553920  ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
114546402  protein max-like isoform X1 [KO:K04453]
114572764  protein max isoform X1 [KO:K04453]
114571030  myocyte-specific enhancer factor 2C-like isoform X1 [KO:K04454]
114556017  mef2c; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
114567102  hspb1; heat shock protein beta-1 [KO:K04455]
114571305  heat shock protein beta-1-like [KO:K04455]
114552505  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
114566492  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
114546570  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
114548453  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
114572548  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
114566753  protein phosphatase 1A-like [KO:K04457] [EC:3.1.3.16]
114546472  ppm1a; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
114550214  protein phosphatase 1A-like [KO:K04457] [EC:3.1.3.16]
114549989  ptprr; receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
114559684  ptpn5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
114559087  ptpn7; tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
114562612  dusp1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
114558834  dual specificity protein phosphatase 7-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
114568023  dusp5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
114569813  dual specificity protein phosphatase 8-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
114560288  dusp8; dual specificity protein phosphatase 8 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
114570771  dual specificity protein phosphatase 4-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
114554657  dual specificity protein phosphatase 7-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
114555409  dual specificity protein phosphatase 2-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
114550448  dusp16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
114559907  dusp6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
114572807  dusp10; LOW QUALITY PROTEIN: dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
114570035  dual specificity protein phosphatase 3-like [KO:K17614] [EC:3.1.3.16 3.1.3.48]
114547654  dual specificity protein phosphatase 3-like [KO:K17614] [EC:3.1.3.16 3.1.3.48]
114552396  ppp5c; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
114547868  protein phosphatase 1B-like isoform X1 [KO:K04461] [EC:3.1.3.16]
114571866  ppm1b; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
114552471  heat shock cognate 71 kDa protein [KO:K03283]
114566548  heat shock cognate 70 kDa protein [KO:K03283]
114568872  heat shock 70 kDa protein 1 [KO:K03283]
114556549  LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein-like [KO:K03283]
114558137  heat shock 70 kDa protein-like [KO:K03283]
114553079  mecom; MDS1 and EVI1 complex locus protein isoform X1 [KO:K04462] [EC:2.1.1.367]
114559002  map2k5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
114548107  mapk7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
114559239  nuclear receptor subfamily 4 group A member 1-like [KO:K04465]
114553786  probable nuclear hormone receptor HR38 [KO:K04465]
114570367  mitogen-activated protein kinase kinase kinase 14-like [KO:K04466] [EC:2.7.11.25]
114547852  uncharacterized protein LOC114547852 isoform X1 [KO:K04466] [EC:2.7.11.25]
114548159  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
114571888  inhibitor of nuclear factor kappa-B kinase subunit alpha-like isoform X1 [KO:K04467] [EC:2.7.11.10]
114555052  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
114558815  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
114552634  serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
114569510  serine/threonine-protein kinase NLK2-like [KO:K04468] [EC:2.7.11.24]
114563320  LOW QUALITY PROTEIN: nuclear factor NF-kappa-B p105 subunit-like [KO:K02580]
114572017  nfkb2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
114545913  transcription factor p65-like isoform X1 [KO:K04735]
114550921  relb; transcription factor RelB isoform X1 [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
pflv04070  Phosphatidylinositol signaling system
pflv04110  Cell cycle
pflv04115  p53 signaling pathway
pflv04210  Apoptosis
pflv04310  Wnt signaling pathway
KO pathway
ko04010   
LinkDB

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