Entry
Name
Wnt signaling pathway - Panthera pardus (leopard)
Description
Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin.
Class
Environmental Information Processing; Signal transduction
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Panthera pardus (leopard) [GN:
ppad ]
Gene
109255421 DKK1; LOW QUALITY PROTEIN: dickkopf-related protein 1 [KO:K02165 ]
109262279 SFRP1; secreted frizzled-related protein 1 isoform X1 [KO:K02166 ]
109268047 SFRP4; secreted frizzled-related protein 4 isoform X1 [KO:K02185 ]
109271278 LGR4; leucine-rich repeat-containing G-protein coupled receptor 4 isoform X1 [KO:K04309 ]
109270514 LGR5; leucine-rich repeat-containing G-protein coupled receptor 5 isoform X1 [KO:K04308 ]
109256363 LGR6; leucine-rich repeat-containing G-protein coupled receptor 6 [KO:K08399 ]
109268615 LRP6; low-density lipoprotein receptor-related protein 6 [KO:K03068 ]
109246877 LRP5; low-density lipoprotein receptor-related protein 5 [KO:K03068 ]
109276344 BAMBI; BMP and activin membrane-bound inhibitor homolog [KO:K10162 ]
109273921 DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353 ]
109275214 DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353 ]
109245979 DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353 ]
109272781 LZTS2; leucine zipper putative tumor suppressor 2 isoform X1 [KO:K26471 ]
109255748 CHD8; chromodomain-helicase-DNA-binding protein 8 isoform X1 [KO:K04494 ] [EC:5.6.2.-]
109277341 CCAR2; cell cycle and apoptosis regulator protein 2 isoform X1 [KO:K25816 ]
109275709 SMAD4; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501 ]
109262802 SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605 ]
109271495 PPARD; peroxisome proliferator-activated receptor delta isoform X1 [KO:K04504 ]
109248273 TBL1X; F-box-like/WD repeat-containing protein TBL1X isoform X1 [KO:K04508 ]
109275152 TBL1XR1; F-box-like/WD repeat-containing protein TBL1XR1 isoform X1 [KO:K04508 ]
109267495 FBXW11; F-box/WD repeat-containing protein 11 isoform X1 [KO:K03362 ]
109272793 BTRC; F-box/WD repeat-containing protein 1A isoform X1 [KO:K03362 ]
109268400 DAAM1; disheveled-associated activator of morphogenesis 1 isoform X1 [KO:K04512 ]
109271577 DAAM2; disheveled-associated activator of morphogenesis 2 isoform X1 [KO:K04512 ]
109251192 RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392 ]
109246661 PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
109274721 PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
109274722 PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
109263166 PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
109264424 CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
109248360 CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
109267916 CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
109247332 PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
109277349 PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
109251747 NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446 ]
109272263 NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332 ]
109270732 NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333 ]
109254966 NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334 ]
Compound
Reference
Authors
Hatsell S, Rowlands T, Hiremath M, Cowin P.
Title
Beta-catenin and Tcfs in mammary development and cancer.
Journal
Reference
Authors
Yang Y.
Title
Wnts and wing: Wnt signaling in vertebrate limb development and musculoskeletal morphogenesis.
Journal
Reference
Authors
Kalderon D.
Title
Similarities between the Hedgehog and Wnt signaling pathways.
Journal
Reference
Authors
Nusse R.
Title
Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface.
Journal
Reference
Authors
Jope RS, Johnson GV.
Title
The glamour and gloom of glycogen synthase kinase-3.
Journal
Reference
Authors
Veeman MT, Axelrod JD, Moon RT.
Title
A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling.
Journal
Reference
Authors
Sun TQ, Lu B, Feng JJ, Reinhard C, Jan YN, Fantl WJ, Williams LT.
Title
PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling.
Journal
Reference
Authors
Saito-Diaz K, Chen TW, Wang X, Thorne CA, Wallace HA, Page-McCaw A, Lee E
Title
The way Wnt works: Components and mechanism.
Journal
Reference
Authors
Carethers JM
Title
Intersection of transforming growth factor-beta and Wnt signaling pathways in colorectal cancer and metastasis.
Journal
Reference
Authors
Lin Z, Gao C, Ning Y, He X, Wu W, Chen YG
Title
The pseudoreceptor BMP and activin membrane-bound inhibitor positively modulates Wnt/beta-catenin signaling.
Journal
Reference
Authors
Niehrs C
Title
The complex world of WNT receptor signalling.
Journal
Reference
Authors
Abou Ziki MD, Mani A
Title
Wnt signaling, a novel pathway regulating blood pressure? State of the art review.
Journal
Reference
Authors
He Y, Ki H, Kim H, Kim K
Title
delta-Catenin interacts with LEF-1 and negatively regulates its transcriptional activity.
Journal
Reference
Authors
Esaki N, Enomoto A, Takagishi M, Mizutani Y, Iida T, Ushida K, Shiraki Y, Mii S, Takahashi M
Title
The Daple-CK1epsilon complex regulates Dvl2 phosphorylation and canonical Wnt signaling.
Journal
Reference
Authors
Yiew NKH, Chatterjee TK, Tang YL, Pellenberg R, Stansfield BK, Bagi Z, Fulton DJ, Stepp DW, Chen W, Patel V, Kamath VM, Litwin SE, Hui DY, Rudich SM, Kim HW, Weintraub NL
Title
A novel role for the Wnt inhibitor APCDD1 in adipocyte differentiation: Implications for diet-induced obesity.
Journal
Related pathway
KO pathway
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