KEGG   PATHWAY: prob04530
Entry
prob04530                   Pathway                                
Name
Tight junction - Phodopus roborovskii (desert hamster)
Description
Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
prob04530  Tight junction
prob04530

Other DBs
GO: 0005923
Organism
Phodopus roborovskii (desert hamster) [GN:prob]
Gene
127212994  [KO:K07374]
127213106  [KO:K04513]
127213112  [KO:K07374]
127213370  Cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393]
127213543  Prkcz; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
127213908  Myh14; myosin-14 isoform X1 [KO:K10352]
127214100  [KO:K05692]
127214101  [KO:K05692]
127214184  Cldn12; claudin-12 [KO:K06087]
127214920  Prkce; protein kinase C epsilon type isoform X1 [KO:K18050] [EC:2.7.11.13]
127215051  Map3k5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
127215194  Bves; blood vessel epicardial substance isoform X1 [KO:K21108]
127215341  Cftr; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
127215359  Erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
127215539  [KO:K03456]
127215625  Myl6b; myosin light chain 6B [KO:K12751]
127215626  Myl6; myosin light polypeptide 6 isoform X1 [KO:K12751]
127215685  Cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
127216002  Prkab1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
127216070  Arpc3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
127216106  Myl2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
127216540  Tjp3; tight junction protein ZO-3 [KO:K06097]
127216634  Stk11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
127216799  Crb3; protein crumbs homolog 3 [KO:K06090]
127217264  Rab8a; ras-related protein Rab-8A [KO:K07901]
127217780  [KO:K05692]
127217810  Rap2c; ras-related protein Rap-2c [KO:K07839]
127217869  Msn; moesin [KO:K05763]
127217921  Cldn2; claudin-2 [KO:K06087]
127218003  Amot; angiomotin isoform X1 [KO:K16819]
127218008  Dlg3; disks large homolog 3 isoform X1 [KO:K21098]
127218264  [KO:K06087]
127218386  [KO:K06087]
127218490  [KO:K06087]
127218503  [KO:K06087]
127218993  Nherf1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
127219030  Cldn7; claudin-7 [KO:K06087]
127219092  Myh10; myosin-10 isoform X1 [KO:K10352]
127219189  Llgl1; lethal(2) giant larvae protein homolog 1 [KO:K06094]
127219241  Llgl2; LLGL scribble cell polarity complex component 2 isoform X1 [KO:K06094]
127219278  Rapgef6; rap guanine nucleotide exchange factor 6 isoform X1 [KO:K08020]
127219293  Hspa4; heat shock 70 kDa protein 4 [KO:K09489]
127219312  Ppp2ca; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
127219360  Mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
127219665  [KO:K18584]
127219808  Cldn9; claudin-9 [KO:K06087]
127219809  Cldn6; claudin-6 [KO:K06087]
127219989  Rock2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.39]
127220241  Actg1; actin, cytoplasmic 2 [KO:K05692]
127220412  Ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
127220427  Cldn23; claudin-23 [KO:K06087]
127220545  [KO:K06087]
127220547  [KO:K06087]
127220610  Prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
127220962  Ocln; occludin [KO:K06088]
127220963  Marveld2; MARVEL domain-containing protein 2 [KO:K17291]
127221136  Map3k1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
127221408  Pcna; proliferating cell nuclear antigen [KO:K04802]
127222872  Arpc5l; LOW QUALITY PROTEIN: actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
127223313  Pard6b; partitioning defective 6 homolog beta [KO:K06093]
127223347  Prkci; protein kinase C iota type isoform X1 [KO:K06069] [EC:2.7.11.13]
127223353  Cldn11; claudin-11 [KO:K06087]
127223418  Arpc5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
127223587  F11r; junctional adhesion molecule A [KO:K06089]
127224653  Src; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
127224715  Epb41l4b; LOW QUALITY PROTEIN: band 4.1-like protein 4B [KO:K21111]
127224759  Myl9; myosin regulatory light polypeptide 9 [KO:K12755]
127224901  Mpdz; multiple PDZ domain protein [KO:K06095]
127224952  Jun; transcription factor Jun [KO:K04448]
127224962  Patj; inaD-like protein [KO:K06092]
127224997  Prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
127225273  Cldn19; claudin-19 [KO:K06087]
127225686  Scrib; protein scribble homolog [KO:K16175]
127225735  Myh9; myosin-9 [KO:K10352]
127226041  Prkag1; 5'-AMP-activated protein kinase subunit gamma-1 [KO:K07200]
127226045  [KO:K07374]
127226047  [KO:K07374]
127226048  [KO:K07374]
127226270  Mpp4; MAGUK p55 subfamily member 4 [KO:K21109]
127226427  Arpc2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
127226445  Prkag3; 5'-AMP-activated protein kinase subunit gamma-3 [KO:K07200]
127226461  [KO:K07374]
127226782  [KO:K12757]
127226784  [KO:K12757]
127226838  Cldn16; claudin-16 [KO:K06087]
127226889  Cldn5; claudin-5 [KO:K06087]
127227020  Cldn1; claudin-1 [KO:K06087]
127227052  Dlg1; disks large homolog 1 isoform X1 [KO:K12076]
127227142  Hcls1; hematopoietic lineage cell-specific protein [KO:K06106]
127227379  Cldn14; claudin-14 [KO:K06087]
127227452  Jam2; junctional adhesion molecule B [KO:K06735]
127227463  Tiam1; rho guanine nucleotide exchange factor TIAM1 [KO:K05731]
127227468  Cldn8; claudin-8 [KO:K06087]
127227469  Cldn17; claudin-17 [KO:K06087]
127227534  Runx1; runt-related transcription factor 1 isoform X1 [KO:K08367]
127227556  Igsf5; immunoglobulin superfamily member 5 isoform X1 [KO:K06786]
127227892  Dlg2; disks large homolog 2 isoform X1 [KO:K12075]
127228302  Arhgap17; rho GTPase-activating protein 17 isoform X1 [KO:K20638]
127228482  Ppp2r2d; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354]
127228590  Cttn; src substrate cortactin isoform X1 [KO:K06106]
127228599  Ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
127229737  Tubal3; tubulin alpha chain-like 3 [KO:K07374]
127229872  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
127229917  Prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
127230105  Cldn10; claudin-10 isoform X1 [KO:K06087]
127230233  Ppp2r2a; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
127230284  Gata4; transcription factor GATA-4 [KO:K09183]
127230895  Pals1; protein PALS1 isoform X1 [KO:K06091]
127230913  Actn1; alpha-actinin-1 isoform X1 [KO:K05699]
127231048  [KO:K07839]
127231403  Jam3; junctional adhesion molecule C [KO:K06785]
127231695  Nedd4; E3 ubiquitin-protein ligase NEDD4 [KO:K10591] [EC:2.3.2.26]
127231727  Ppp2r1b; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
127231735  Cldn25; putative claudin-25 [KO:K06087]
127231736  Rdx; radixin [KO:K05762]
127231926  Rab8b; ras-related protein Rab-8B [KO:K07902]
127231946  Cgnl1; cingulin-like protein 1 isoform X1 [KO:K21110]
127232178  Mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
127232633  Cgn; cingulin [KO:K06102]
127232714  Rab13; ras-related protein Rab-13 isoform X1 [KO:K06109]
127232718  Amotl1; angiomotin-like protein 1 [KO:K06104]
127232827  Rapgef2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
127233006  Prkab2; 5'-AMP-activated protein kinase subunit beta-2 isoform X1 [KO:K07199]
127233013  Arhgef2; rho guanine nucleotide exchange factor 2 isoform X1 [KO:K12791]
127233023  Cd1d; antigen-presenting glycoprotein CD1d [KO:K06448]
127233056  Rap1a; ras-related protein Rap-1A [KO:K04353]
127233597  Tjp2; tight junction protein ZO-2 isoform X1 [KO:K06098]
127233639  Ppp2r2c; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
127233792  Nf2; merlin isoform X1 [KO:K16684]
127233840  Actr2; actin-related protein 2 isoform X1 [KO:K17260]
127234114  Ppp2r2b; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
127234262  Synpo; synaptopodin isoform X1 [KO:K21112]
127234264  Nedd4l; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
127234394  [KO:K05692]
127234395  [KO:K05692]
127234396  [KO:K05692]
127234519  Marveld3; MARVEL domain-containing protein 3 isoform X1 [KO:K21099]
127234596  Itgb1; integrin beta-1 [KO:K05719]
127234598  Pard3; partitioning defective 3 homolog [KO:K04237]
127234719  Pard6a; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
127234920  Rock1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
127235063  Pard6g; partitioning defective 6 homolog gamma [KO:K06093]
127235390  Mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
127235572  [KO:K04513]
127235613  Actr3b; actin-related protein 3B isoform X1 [KO:K18584]
127235796  Prkag2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
127236009  Magi1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
127236145  Tuba8; tubulin alpha-8 chain [KO:K07374]
127236228  Arpc4; actin-related protein 2/3 complex subunit 4 isoform X1 [KO:K05755]
127236475  Actr3; actin-related protein 3 [KO:K18584]
127236589  Rhoa; transforming protein RhoA [KO:K04513]
127236610  Tjap1; tight junction-associated protein 1 [KO:K06105]
127236838  Cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
127236921  [KO:K06087]
127236985  Cldn4; claudin-4 [KO:K06087]
127236988  Cldn3; claudin-3 [KO:K06087]
127237005  Cldn15; claudin-15 [KO:K06087]
127237193  Map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
127237213  Actb; actin, cytoplasmic 1 isoform X1 [KO:K05692]
127237261  Micall2; MICAL-like protein 2 [KO:K21068]
127237266  Arhgef18; rho guanine nucleotide exchange factor 18 [KO:K21066]
127237270  Rac1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
127237285  Arpc1b; actin-related protein 2/3 complex subunit 1B [KO:K05757]
127237286  Arpc1a; actin-related protein 2/3 complex subunit 1A [KO:K05757]
127237366  [KO:K05692]
127237632  Cldn20; claudin-20 [KO:K06087]
127237707  Afdn; afadin isoform X1 [KO:K05702]
127237735  Amotl2; angiomotin-like protein 2 isoform X1 [KO:K06104]
127237738  Ezr; ezrin [KO:K08007]
127237938  Cldn18; claudin-18 [KO:K06087]
127238010  Tjp1; tight junction protein ZO-1 isoform X1 [KO:K05701]
127238184  Whamm; WASP homolog-associated protein with actin, membranes and microtubules [KO:K20479]
127238219  Myh11; myosin-11 isoform X1 [KO:K10352]
127238543  Vasp; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
127238821  Actn4; alpha-actinin-4 isoform X1 [KO:K05699]
127238899  Sympk; symplekin [KO:K06100]
127239066  [KO:K03456]
127239125  Ybx3; Y-box-binding protein 3 isoform X1 [KO:K06099]
Compound
C00076  Calcium cation
Reference
PMID:27353478
  Authors
Zihni C, Mills C, Matter K, Balda MS
  Title
Tight junctions: from simple barriers to multifunctional molecular gates.
  Journal
Nat Rev Mol Cell Biol 17:564-80 (2016)
DOI:10.1038/nrm.2016.80
Reference
PMID:22169974
  Authors
Martin-Belmonte F, Perez-Moreno M
  Title
Epithelial cell polarity, stem cells and cancer.
  Journal
Nat Rev Cancer 12:23-38 (2011)
DOI:10.1038/nrc3169
Reference
PMID:17525755
  Authors
Weber C, Fraemohs L, Dejana E
  Title
The role of junctional adhesion molecules in vascular inflammation.
  Journal
Nat Rev Immunol 7:467-77 (2007)
DOI:10.1038/nri2096
Reference
PMID:15820555
  Authors
Miyoshi J, Takai Y
  Title
Molecular perspective on tight-junction assembly and epithelial polarity.
  Journal
Adv Drug Deliv Rev 57:815-55 (2005)
DOI:10.1016/j.addr.2005.01.008
Reference
PMID:16650994
  Authors
Mertens AE, Pegtel DM, Collard JG
  Title
Tiam1 takes PARt in cell polarity.
  Journal
Trends Cell Biol 16:308-16 (2006)
DOI:10.1016/j.tcb.2006.04.001
Reference
PMID:16771626
  Authors
Shin K, Fogg VC, Margolis B
  Title
Tight junctions and cell polarity.
  Journal
Annu Rev Cell Dev Biol 22:207-35 (2006)
DOI:10.1146/annurev.cellbio.22.010305.104219
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:17950242
  Authors
Gonzalez-Mariscal L, Tapia R, Chamorro D
  Title
Crosstalk of tight junction components with signaling pathways.
  Journal
Biochim Biophys Acta 1778:729-56 (2008)
DOI:10.1016/j.bbamem.2007.08.018
Reference
PMID:18005931
  Authors
Assemat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D
  Title
Polarity complex proteins.
  Journal
Biochim Biophys Acta 1778:614-30 (2008)
DOI:10.1016/j.bbamem.2007.08.029
Reference
PMID:18946474
  Authors
Iden S, Collard JG
  Title
Crosstalk between small GTPases and polarity proteins in cell polarization.
  Journal
Nat Rev Mol Cell Biol 9:846-59 (2008)
DOI:10.1038/nrm2521
Reference
PMID:20094051
  Authors
Rosse C, Linch M, Kermorgant S, Cameron AJ, Boeckeler K, Parker PJ
  Title
PKC and the control of localized signal dynamics.
  Journal
Nat Rev Mol Cell Biol 11:103-12 (2010)
DOI:10.1038/nrm2847
Reference
PMID:20134025
  Authors
Terry S, Nie M, Matter K, Balda MS
  Title
Rho signaling and tight junction functions.
  Journal
Physiology (Bethesda) 25:16-26 (2010)
DOI:10.1152/physiol.00034.2009
Reference
PMID:21283798
  Authors
Russ PK, Pino CJ, Williams CS, Bader DM, Haselton FR, Chang MS
  Title
Bves modulates tight junction associated signaling.
  Journal
PLoS One 6:e14563 (2011)
DOI:10.1371/journal.pone.0014563
Reference
PMID:21781017
  Authors
Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P
  Title
Regulation of small GTPases at epithelial cell-cell junctions.
  Journal
Mol Membr Biol 28:427-44 (2011)
DOI:10.3109/09687688.2011.603101
Reference
PMID:22896795
  Authors
Lickert H, Van Campenhout CA
  Title
Evolution of the Discs large gene family provides new insights into the establishment of apical epithelial polarity and the etiology of mental retardation.
  Journal
Commun Integr Biol 5:287-90 (2012)
DOI:10.4161/cib.19792
Reference
PMID:22928510
  Authors
Spadaro D, Tapia R, Pulimeno P, Citi S
  Title
The control of gene expression and cell proliferation by the epithelial apical junctional complex.
  Journal
Essays Biochem 53:83-93 (2012)
DOI:10.1042/bse0530083
Reference
PMID:24548561
  Authors
Moleirinho S, Guerrant W, Kissil JL
  Title
The Angiomotins--from discovery to function.
  Journal
FEBS Lett 588:2693-703 (2014)
DOI:10.1016/j.febslet.2014.02.006
Reference
PMID:24651541
  Authors
Rodriguez-Boulan E, Macara IG
  Title
Organization and execution of the epithelial polarity programme.
  Journal
Nat Rev Mol Cell Biol 15:225-42 (2014)
DOI:10.1038/nrm3775
Reference
PMID:25152334
  Authors
Gonzalez-Mariscal L, Dominguez-Calderon A, Raya-Sandino A, Ortega-Olvera JM, Vargas-Sierra O, Martinez-Revollar G
  Title
Tight junctions and the regulation of gene expression.
  Journal
Semin Cell Dev Biol 36:213-23 (2014)
DOI:10.1016/j.semcdb.2014.08.009
Reference
PMID:25469537
  Authors
Mack NA, Georgiou M
  Title
The interdependence of the Rho GTPases and apicobasal cell polarity.
  Journal
Small GTPases 5:10 (2014)
DOI:10.4161/21541248.2014.973768
Reference
PMID:25483301
  Authors
Citi S, Guerrera D, Spadaro D, Shah J
  Title
Epithelial junctions and Rho family GTPases: the zonular signalosome.
  Journal
Small GTPases 5:1-15 (2014)
DOI:10.4161/21541248.2014.973760
Reference
PMID:25757376
  Authors
Zihni C, Terry SJ
  Title
RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer.
  Journal
Int J Biochem Cell Biol 64:120-5 (2015)
DOI:10.1016/j.biocel.2015.02.020
Reference
PMID:22892070
  Authors
Nakano A, Takashima S
  Title
LKB1 and AMP-activated protein kinase: regulators of cell polarity.
  Journal
Genes Cells 17:737-47 (2012)
DOI:10.1111/j.1365-2443.2012.01629.x
Reference
PMID:12042308
  Authors
Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B
  Title
Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.
  Journal
J Biol Chem 277:30183-90 (2002)
DOI:10.1074/jbc.M203072200
Reference
PMID:18094055
  Authors
Yamamura R, Nishimura N, Nakatsuji H, Arase S, Sasaki T
  Title
The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.
  Journal
Mol Biol Cell 19:971-83 (2008)
DOI:10.1091/mbc.E07-06-0551
Reference
PMID:23885123
  Authors
Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA
  Title
JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
  Journal
Mol Biol Cell 24:2849-60 (2013)
DOI:10.1091/mbc.E13-06-0298
Related
pathway
prob04520  Adherens junction
prob04810  Regulation of actin cytoskeleton
KO pathway
ko04530   

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