KEGG   PATHWAY: rno00600
Entry
rno00600                    Pathway                                
Name
Sphingolipid metabolism - Rattus norvegicus (rat)
Class
Metabolism; Lipid metabolism
Pathway map
rno00600  Sphingolipid metabolism
rno00600

Module
rno_M00066  Lactosylceramide biosynthesis [PATH:rno00600]
rno_M00067  Sulfoglycolipids biosynthesis, ceramide/1-alkyl-2-acylglycerol => sulfatide/seminolipid [PATH:rno00600]
rno_M00094  Ceramide biosynthesis [PATH:rno00600]
rno_M00099  Sphingosine biosynthesis [PATH:rno00600]
rno_M00100  Sphingosine degradation [PATH:rno00600]
Other DBs
GO: 0006665
Organism
Rattus norvegicus (rat) [GN:rno]
Gene
366697  Sptlc2; serine palmitoyltransferase 2 [KO:K00654] [EC:2.3.1.50]
361213  Sptlc1; serine palmitoyltransferase 1 [KO:K00654] [EC:2.3.1.50]
296188  Sptlc3; serine palmitoyltransferase 3 [KO:K00654] [EC:2.3.1.50]
360833  Kdsr; 3-ketodihydrosphingosine reductase [KO:K04708] [EC:1.1.1.102]
290658  Cers1; ceramide synthase 1 [KO:K04710] [EC:2.3.1.299]
310667  Cers2; ceramide synthase 2 [KO:K24621] [EC:2.3.1.297]
304208  Cers4; ceramide synthase 4 [KO:K24621] [EC:2.3.1.297]
499174  Cers3; ceramide synthase 3 [KO:K24622] [EC:2.3.1.297 2.3.1.298]
366065  Cers6; ceramide synthase 6 isoform 1 [KO:K23727] [EC:2.3.1.291]
366984  Cers5; ceramide synthase 5 [KO:K23727] [EC:2.3.1.291]
84431  Asah1; acid ceramidase precursor [KO:K12348] [EC:3.5.1.23]
114104  Asah2; neutral ceramidase [KO:K12349] [EC:3.5.1.23]
313339  Acer2; alkaline ceramidase 2 [KO:K01441] [EC:3.5.1.23]
301118  Acer1; alkaline ceramidase 1 [KO:K01441] [EC:3.5.1.23]
499210  Acer3; alkaline ceramidase 3 [KO:K04711] [EC:3.5.1.-]
58970  Degs1; sphingolipid delta(4)-desaturase DES1 [KO:K04712] [EC:1.14.19.17 1.14.18.5]
314438  Degs2; sphingolipid delta(4)-desaturase/C4-monooxygenase DES2 [KO:K04712] [EC:1.14.19.17 1.14.18.5]
289322  Degs1l2; sphingolipid delta(4)-desaturase DES1 [KO:K04712] [EC:1.14.19.17 1.14.18.5]
498300  Degs1l1; sphingolipid delta(4)-desaturase DES1 isoform X2 [KO:K04712] [EC:1.14.19.17 1.14.18.5]
353229  Sgms1; phosphatidylcholine:ceramide cholinephosphotransferase 1 [KO:K04714] [EC:2.7.8.27]
310849  Sgms2; phosphatidylcholine:ceramide cholinephosphotransferase 2 [KO:K04714] [EC:2.7.8.27]
308909  Smpd1; sphingomyelin phosphodiesterase [KO:K12350] [EC:3.1.4.12]
83537  Smpd2; sphingomyelin phosphodiesterase 2 [KO:K12351] [EC:3.1.4.12]
94338  Smpd3; sphingomyelin phosphodiesterase 3 [KO:K12352] [EC:3.1.4.12]
303790  Smpd4; sphingomyelin phosphodiesterase 4 [KO:K12353] [EC:3.1.4.12]
303729  Enpp7; ectonucleotide pyrophosphatase/phosphodiesterase family member 7 precursor [KO:K12354] [EC:3.1.4.12]
300129  Cerk; ceramide kinase [KO:K04715] [EC:2.7.1.138]
64369  Plpp1; phospholipid phosphatase 1 [KO:K01080] [EC:3.1.3.4]
246115  Plpp2; phospholipid phosphatase 2 [KO:K01080] [EC:3.1.3.4]
192270  Plpp3; phospholipid phosphatase 3 [KO:K01080] [EC:3.1.3.4]
81536  Sgpp1; sphingosine-1-phosphate phosphatase 1 [KO:K04716] [EC:3.1.3.-]
301543  Sgpp2; sphingosine-1-phosphate phosphatase 2 [KO:K04717] [EC:3.1.3.-]
308589  Sphk2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
170897  Sphk1; sphingosine kinase 1 isoform b [KO:K04718] [EC:2.7.1.91]
286896  Sgpl1; sphingosine-1-phosphate lyase 1 [KO:K01634] [EC:4.1.2.27]
83626  Ugcg; ceramide glucosyltransferase [KO:K00720] [EC:2.4.1.80]
684536  Gba1; lysosomal acid glucosylceramidase precursor [KO:K01201] [EC:3.2.1.45]
298399  Gba2; non-lysosomal glucosylceramidase [KO:K17108] [EC:3.2.1.45]
65196  B4galt6; beta-1,4-galactosyltransferase 6 [KO:K07553] [EC:2.4.1.274]
316033  Glb1; beta-galactosidase precursor [KO:K12309] [EC:3.2.1.23]
50555  Ugt8; 2-hydroxyacylsphingosine 1-beta-galactosyltransferase precursor [KO:K04628] [EC:2.4.1.47]
314360  Galc; galactocerebrosidase precursor [KO:K01202] [EC:3.2.1.46]
683713  Gal3st1; galactosylceramide sulfotransferase [KO:K01019] [EC:2.8.2.11]
315222  Arsa; arylsulfatase A precursor [KO:K01134] [EC:3.1.6.8]
24591  Neu1; sialidase-1 precursor [KO:K01186] [EC:3.2.1.18]
117185  Neu3; sialidase-3 [KO:K12357] [EC:3.2.1.18]
316642  Neu4; sialidase-4 [KO:K12357] [EC:3.2.1.18]
29204  Neu2; sialidase-2 [KO:K12357] [EC:3.2.1.18]
363494  Gla; alpha-galactosidase A [KO:K01189] [EC:3.2.1.22]
64828  B4galnt1; beta-1,4 N-acetylgalactosaminyltransferase 1 [KO:K00725] [EC:2.4.1.92]
294673  Hexb; beta-hexosaminidase subunit beta precursor [KO:K12373] [EC:3.2.1.52]
300757  Hexa; beta-hexosaminidase subunit alpha precursor [KO:K12373] [EC:3.2.1.52]
282838  Gm2a; ganglioside GM2 activator precursor [KO:K12383]
25524  Psap; prosaposin isoform A preproprotein [KO:K12382]
289720  Psapl1; proactivator polypeptide-like 1 precursor [KO:K12382]
Compound
C00065  L-Serine
C00154  Palmitoyl-CoA
C00195  N-Acylsphingosine
C00319  Sphingosine
C00346  Ethanolamine phosphate
C00550  Sphingomyelin
C00836  Sphinganine
C01120  Sphinganine 1-phosphate
C01190  Glucosylceramide
C01290  Lactosylceramide
C01747  Psychosine
C02686  Galactosylceramide
C02934  3-Dehydrosphinganine
C02960  Ceramide 1-phosphate
C03108  D-Glucosylsphingosine
C03272  Globoside
C03405  Lactosylceramide sulfate
C03640  Sphingosyl-phosphocholine
C04730  GM3
C04737  alpha-D-Galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
C04884  N-Acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C04911  D-Galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C05681  Ceramide 2-aminoethylphosphonate
C06062  Ceramide phosphoethanolamine
C06124  Sphingosine 1-phosphate
C06125  Sulfatide
C06126  Digalactosylceramide
C06127  Digalactosylceramide sulfate
C06128  GM4
C06135  GA2
C06136  GA1
C12126  Dihydroceramide
C12144  Phytosphingosine
C12145  Phytoceramide
C22467  Gangliotriaosylceramide-II3 sulfate
Reference
PMID:12011104
  Authors
Merrill AH Jr.
  Title
De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway.
  Journal
J Biol Chem 277:25843-6 (2002)
DOI:10.1074/jbc.R200009200
Reference
PMID:10652340
  Authors
Tani M, Okino N, Mitsutake S, Tanigawa T, Izu H, Ito M.
  Title
Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized.
  Journal
J Biol Chem 275:3462-8 (2000)
DOI:10.1074/jbc.275.5.3462
Reference
PMID:11305904
  Authors
Hannun YA, Luberto C, Argraves KM.
  Title
Enzymes of sphingolipid metabolism: from modular to integrative signaling.
  Journal
Biochemistry 40:4893-903 (2001)
DOI:10.1021/bi002836k
Reference
PMID:1495423
  Authors
Merrill AH Jr, Wang E.
  Title
Enzymes of ceramide biosynthesis.
  Journal
Methods Enzymol 209:427-37 (1992)
DOI:10.1016/0076-6879(92)09053-6
Reference
PMID:8457204
  Authors
Hirschberg K, Rodger J, Futerman AH.
  Title
The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver.
  Journal
Biochem J 290 ( Pt 3):751-7 (1993)
DOI:10.1042/bj2900751
Reference
PMID:10366774
  Authors
Dickson RC, Lester RL.
  Title
Metabolism and selected functions of sphingolipids in the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1438:305-21 (1999)
DOI:10.1016/S1388-1981(99)00068-2
Related
pathway
rno00260  Glycine, serine and threonine metabolism
rno00601  Glycosphingolipid biosynthesis - lacto and neolacto series
rno00603  Glycosphingolipid biosynthesis - globo and isoglobo series
rno00604  Glycosphingolipid biosynthesis - ganglio series
KO pathway
ko00600   
LinkDB

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