KEGG   PATHWAY: rno00830
Entry
rno00830                    Pathway                                
Name
Retinol metabolism - Rattus norvegicus (rat)
Class
Metabolism; Metabolism of cofactors and vitamins
Pathway map
rno00830  Retinol metabolism
rno00830

Other DBs
GO: 0006776
Organism
Rattus norvegicus (rat) [GN:rno]
Gene
100145871  Adh5; alcohol dehydrogenase class-3 [KO:K00121] [EC:1.1.1.284 1.1.1.1]
100361492  Cyp2c55; cytochrome P450 2C55 precursor [KO:K07413] [EC:1.14.14.1]
100361547  Cyp2c7l1; cytochrome P450 2C7-like [KO:K07413] [EC:1.14.14.1]
100911718  [KO:K07413] [EC:1.14.14.1]
100912265  Cyp2c66; cytochrome P450 2C42-like isoform X1 [KO:K07413] [EC:1.14.14.1]
103691072  Cyp2b14; cytochrome P450 2B15 [KO:K07412] [EC:1.14.14.1]
103691092  [KO:K07412] [EC:1.14.14.1]
113992  Ugt1a6; UDP-glucuronosyltransferase 1-6 precursor [KO:K00699] [EC:2.4.1.17]
114106  Bco1; beta,beta-carotene 15,15'-dioxygenase [KO:K00515] [EC:1.13.11.63]
116676  Aldh1a2; retinal dehydrogenase 2 [KO:K07249] [EC:1.2.1.36]
120093077  [KO:K07413] [EC:1.14.14.1]
120098584  [KO:K07413] [EC:1.14.14.1]
120102953  Cyp4a2l1; cytochrome P450, family 4, subfamily a, polypeptide 2 like 1 [KO:K07425] [EC:1.14.14.80]
134478834  [KO:K00699] [EC:2.4.1.17]
134479803  [KO:K13369] [EC:1.1.1.62 1.1.1.105 1.1.1.239]
134483996  [KO:K07413] [EC:1.14.14.1]
134484828  [KO:K07249] [EC:1.2.1.36]
134485234  [KO:K07413] [EC:1.14.14.1]
154516  Ugt1a7c; UDP-glucuronosyltransferase 1A7 precursor [KO:K00699] [EC:2.4.1.17]
154985  Cyp26a1; cytochrome P450, family 26, subfamily a, polypeptide 1 [KO:K07437] [EC:1.14.14.-]
170509  Cyp3a62; cytochrome P450, family 3, subfamily a, polypeptide 62 [KO:K07424] [EC:1.14.14.1]
170635  Dhrs9; dehydrogenase/reductase SDR family member 9 precursor [KO:K11149] [EC:1.1.-.-]
171178  Adh7; all-trans-retinol dehydrogenase [NAD(+)] ADH7 [KO:K13951] [EC:1.1.1.1]
171352  Cyp3a9; cytochrome P450 3A9 [KO:K07424] [EC:1.14.14.1]
171518  Cyp2c22; cytochrome P450 2C70 precursor [KO:K07413] [EC:1.14.14.1]
171521  Cyp2c13; cytochrome P450 2C13, male-specific [KO:K07413] [EC:1.14.14.1]
24172  Adh1c; alcohol dehydrogenase 1 [KO:K13951] [EC:1.1.1.1]
24188  Aldh1a1; aldehyde dehydrogenase 1A1 [KO:K07249] [EC:1.2.1.36]
24296  Cyp1a1; cytochrome P450 1A1 [KO:K07408] [EC:1.14.14.1]
24297  Cyp1a2; cytochrome P450 1A2 [KO:K07409] [EC:1.14.14.1]
24299  Cyp2a3; cytochrome P450 2A3 [KO:K07411] [EC:1.14.14.1]
24300  Cyp2b1; cytochrome P450 2B1 precursor [KO:K07412] [EC:1.14.14.1]
24306  Cyp4a2; cytochrome P450 4A2 [KO:K07425] [EC:1.14.14.80]
246298  Retsat; all-trans-retinol 13,14-reductase precursor [KO:K09516] [EC:1.3.99.23]
24861  Ugt1a1; UDP-glucuronosyltransferase 1A1 precursor [KO:K00699] [EC:2.4.1.17]
24862  Ugt2b; UDP-glucuronosyltransferase 2B2 precursor [KO:K00699] [EC:2.4.1.17]
24894  Cyp2a1; cytochrome P450 2A1 [KO:K07411] [EC:1.14.14.1]
24895  Cyp2a2; cytochrome P450 2A2 [KO:K07411] [EC:1.14.14.1]
25011  Cyp2c12; cytochrome P450 2C12, female-specific precursor [KO:K07413] [EC:1.14.14.1]
252931  Cyp3a18; cytochrome P450 3A18 [KO:K07424] [EC:1.14.14.1]
25642  Cyp3a23-3a1; cytochrome P450 3A1 [KO:K07424] [EC:1.14.14.1]
266603  Aldh1a3; retinaldehyde dehydrogenase 3 [KO:K07249] [EC:1.2.1.36]
266674  Cyp4a8; cytochrome P450 4A12 [KO:K07425] [EC:1.14.14.80]
266682  Cyp3a2; cytochrome P450 3A2 [KO:K07424] [EC:1.14.14.1]
266685  Ugt2b15; UDP-glucuronosyltransferase 2B17 precursor [KO:K00699] [EC:2.4.1.17]
266686  Dhrs4; dehydrogenase/reductase SDR family member 4 [KO:K11147] [EC:1.1.-.-]
286953  Cyp2b3; cytochrome P450 2B3 precursor [KO:K07412] [EC:1.14.14.1]
286954  Ugt2b1; UDP-glucuronosyltransferase 2B1 precursor [KO:K00699] [EC:2.4.1.17]
286964  Hsd17b6; 17-beta-hydroxysteroid dehydrogenase type 6 [KO:K13369] [EC:1.1.1.62 1.1.1.105 1.1.1.239]
286989  Ugt2b7; UDP-glucuronosyltransferase 2B7 precursor [KO:K00699] [EC:2.4.1.17]
288517  Cyp2w1; cytochrome P450, family 2, subfamily w, polypeptide 1 [KO:K07423] [EC:1.14.14.-]
289533  Ugt2a3; UDP-glucuronosyltransferase 2A3 precursor [KO:K00699] [EC:2.4.1.17]
292728  Cyp2b21; cytochrome P450, family 2, subfamily b, polypeptide 21 precursor [KO:K07412] [EC:1.14.14.1]
29277  Cyp2c11; cytochrome P450 2C11 [KO:K07413] [EC:1.14.14.1]
29295  Cyp2b12; cytochrome P450 2B12 precursor [KO:K07412] [EC:1.14.14.1]
29298  Cyp2c7; cytochrome P450 2C7 precursor [KO:K07413] [EC:1.14.14.1]
293989  Cyp2c6v1; cytochrome P450 2C6 precursor [KO:K07413] [EC:1.14.14.1]
29623  Ugt2b37; UDP-glucuronosyltransferase 2B37 precursor [KO:K00699] [EC:2.4.1.17]
29646  Adh4; all-trans-retinol dehydrogenase [NAD(+)] ADH4 [KO:K13980] [EC:1.1.1.1]
297805  Sdr16c5; epidermal retinol dehydrogenase 2 [KO:K15734] [EC:1.1.1.105]
298423  Cyp4a3; cytochrome P450 4A14 [KO:K07425] [EC:1.14.14.80]
299511  Rdh16; retinol dehydrogenase 16 precursor [KO:K11154] [EC:1.1.1.-]
301595  Ugt1a8; UDP-glucuronosyltransferase 1A8 precursor [KO:K00699] [EC:2.4.1.17]
302425  Awat2; acyl-CoA wax alcohol acyltransferase 2 [KO:K11156] [EC:2.3.1.75 2.3.1.76]
305264  Ugt2b10; UDP-glucuronosyltransferase 2B10 precursor [KO:K00699] [EC:2.4.1.17]
308190  Cyp26c1; cytochrome P450 26C1 [KO:K12665] [EC:1.14.14.-]
308445  Cyp2s1; cytochrome P450, family 2, subfamily s, polypeptide 1 precursor [KO:K07420] [EC:1.14.14.1]
310903  Adh6; alcohol dehydrogenase 6 [KO:K13952] [EC:1.1.1.1]
312495  Cyp26b1; cytochrome P450 26B1 [KO:K12664] [EC:1.14.14.-]
313689  Dhrs3; short-chain dehydrogenase/reductase 3 [KO:K11146] [EC:1.1.1.300]
314264  Rdh12; retinol dehydrogenase 12 precursor [KO:K11153] [EC:1.1.1.300]
316421  Aox2; aldehyde oxidase 2 [KO:K00157] [EC:1.2.3.1]
316424  Aox4; aldehyde oxidase 4 [KO:K00157] [EC:1.2.3.1]
353252  Rdh10; retinol dehydrogenase 10 [KO:K11151] [EC:1.1.1.-]
360420  Rdh7; retinol dehydrogenase 7 [KO:K11154] [EC:1.1.1.-]
361504  Rdh13; retinol dehydrogenase 13 precursor [KO:K11161] [EC:1.1.1.300]
361523  Cyp2b2; cytochrome P450 2B2 precursor [KO:K07412] [EC:1.14.14.1]
362757  Rdh11; retinol dehydrogenase 11 precursor [KO:K11152] [EC:1.1.1.300]
363471  Pnpla4; patatin-like phospholipase domain-containing protein 4 isoform a [KO:K11157] [EC:3.1.1.-]
366791  Rdh5; retinol dehydrogenase 5 precursor [KO:K00061] [EC:1.1.1.315]
396527  Ugt1a2; UDP-glucuronosyltransferase 1-2 precursor [KO:K00699] [EC:2.4.1.17]
396551  Ugt1a3; UDP-glucuronosyltransferase 1A3 precursor [KO:K00699] [EC:2.4.1.17]
396552  Ugt1a9; UDP glycosyltransferase 1 family, polypeptide A10 precursor [KO:K00699] [EC:2.4.1.17]
493909  Aox3; aldehyde oxidase 3 [KO:K00157] [EC:1.2.3.1]
499353  Cyp2c24; cytochrome P450, family 2, subfamily c, polypeptide 24 precursor [KO:K07413] [EC:1.14.14.1]
501907  Ugt2b34l1; UDP-glucuronosyltransferase 2B31-like isoform X1 [KO:K00699] [EC:2.4.1.17]
50549  Cyp4a1; cytochrome P450 4A10 [KO:K07425] [EC:1.14.14.80]
54349  Aox1; aldehyde oxidase 1 [KO:K00157] [EC:1.2.3.1]
574523  Ugt1a5; UDP-glucuronosyltransferase 1A5 precursor [KO:K00699] [EC:2.4.1.17]
63867  Ugt2a1; UDP-glucuronosyltransferase 2A1 precursor [KO:K00699] [EC:2.4.1.17]
64047  Lrat; lecithin retinol acyltransferase [KO:K00678] [EC:2.3.1.135]
685222  Cyp2b15; cytochrome P450 2B15 precursor [KO:K07412] [EC:1.14.14.1]
690383  Cyp3a71-ps; cytochrome P450 3A1-like [KO:K07424] [EC:1.14.14.1]
690953  Rdh8; retinol dehydrogenase 8 [KO:K11150] [EC:1.1.1.-]
83790  Cyp2c23; cytochrome P450 2C23 [KO:K07413] [EC:1.14.14.1]
83808  Ugt2b35; UDP-glucuronosyltransferase 2B15 precursor [KO:K00699] [EC:2.4.1.17]
84497  Dgat1; diacylglycerol O-acyltransferase 1 [KO:K11155] [EC:2.3.1.20 2.3.1.75 2.3.1.76]
89826  Rpe65; retinoid isomerohydrolase [KO:K11158] [EC:3.1.1.64 5.3.3.22]
Compound
C00376  Retinal
C00473  Retinol
C00777  Retinoate
C00778  Rhodopsin
C00899  11-cis-Retinol
C02075  Retinyl ester
C02094  beta-Carotene
C02110  11-cis-Retinal
C02588  Retinyl palmitate
C03455  11-cis-Retinyl palmitate
C05914  Bathorhodopsin
C05915  Lumirhodopsin
C05916  Metarhodopsin
C05917  Iodopsin
C11061  all-trans-Retinoyl-beta-glucuronide
C15492  all-trans-13,14-Dihydroretinol
C15493  9-cis-Retinoic acid
C16677  all-trans-4-Hydroxyretinoic acid
C16678  all-trans-4-Oxoretinoic acid
C16679  all-trans-18-Hydroxyretinoic acid
C16680  all-trans-5,6-Epoxyretinoic acid
C16681  9-cis-Retinal
C16682  9-cis-Retinol
C16683  4-Oxoretinol
C21797  all-trans-3,4-Didehydroretinol
Reference
PMID:16968212
  Authors
Travis GH, Golczak M, Moise AR, Palczewski K.
  Title
Diseases caused by defects in the visual cycle: retinoids as potential therapeutic agents.
  Journal
Annu Rev Pharmacol Toxicol 47:469-512 (2007)
DOI:10.1146/annurev.pharmtox.47.120505.105225
Reference
PMID:17618621
  Authors
Muniz A, Villazana-Espinoza ET, Hatch AL, Trevino SG, Allen DM, Tsin AT.
  Title
A novel cone visual cycle in the cone-dominated retina.
  Journal
Exp Eye Res 85:175-84 (2007)
DOI:10.1016/j.exer.2007.05.003
Reference
PMID:11093772
  Authors
Marill J, Cresteil T, Lanotte M, Chabot GG.
  Title
Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites.
  Journal
Mol Pharmacol 58:1341-8 (2000)
DOI:10.1124/mol.58.6.1341
Reference
PMID:17893666
  Authors
Nezzar H, Chiambaretta F, Marceau G, Blanchon L, Faye B, Dechelotte P, Rigal D, Sapin V.
  Title
Molecular and metabolic retinoid pathways in the human ocular surface.
  Journal
Mol Vis 13:1641-50 (2007)
Reference
PMID:16688755
  Authors
Blomhoff R, Blomhoff HK.
  Title
Overview of retinoid metabolism and function.
  Journal
J Neurobiol 66:606-30 (2006)
DOI:10.1002/neu.20242
Reference
PMID:16428379
  Authors
Liden M, Eriksson U.
  Title
Understanding retinol metabolism: structure and function of retinol dehydrogenases.
  Journal
J Biol Chem 281:13001-4 (2006)
DOI:10.1074/jbc.R500027200
KO pathway
ko00830   

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