KEGG   PATHWAY: sati04141
Entry
sati04141                   Pathway                                
Name
Protein processing in endoplasmic reticulum - Sylvia atricapilla (blackcap)
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
sati04141  Protein processing in endoplasmic reticulum
sati04141

Other DBs
GO: 0030433 0034976
Organism
Sylvia atricapilla (blackcap) [GN:sati]
Gene
136357671  HSPH1; heat shock protein 105 kDa isoform X1 [KO:K09485]
136357846  UGGT2; UDP-glucose:glycoprotein glucosyltransferase 2 isoform X1 [KO:K11718] [EC:2.4.1.-]
136357847  DNAJC3; dnaJ homolog subfamily C member 3 isoform X1 [KO:K09523]
136358107  MBTPS2; membrane-bound transcription factor site-2 protease [KO:K07765] [EC:3.4.24.85]
136358621  DNAJC5G; dnaJ homolog subfamily C member 5G [KO:K09525]
136358627  PREB; guanine nucleotide-exchange factor SEC12 isoform X1 [KO:K14003]
136358742  UBXN2A; UBX domain-containing protein 2A isoform X1 [KO:K24349]
136358781  PDIA6; protein disulfide-isomerase A6 [KO:K09584] [EC:5.3.4.1]
136358862  BAG2; BAG family molecular chaperone regulator 2 [KO:K09556]
136358943  UBE2J1; ubiquitin-conjugating enzyme E2 J1 isoform X1 [KO:K10578] [EC:2.3.2.23]
136358993  SEC63; translocation protein SEC63 homolog [KO:K09540]
136359048  MAN1A1; mannosyl-oligosaccharide 1,2-alpha-mannosidase IA [KO:K01230] [EC:3.2.1.113]
136359196  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
136359236  ERO1B; ERO1-like protein beta [KO:K10976] [EC:1.8.4.-]
136359323  PRKN; E3 ubiquitin-protein ligase parkin [KO:K04556] [EC:2.3.2.31]
136359389  CAPN11; calpain-11 [KO:K01367] [EC:3.4.22.52]
136359393  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
136359542  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
136359595  SEC23B; protein transport protein Sec23B isoform X1 [KO:K14006]
136359601  DNAJC1; dnaJ homolog subfamily C member 1 isoform X1 [KO:K09521]
136359608  RRBP1; ribosome-binding protein 1 isoform X1 [KO:K14000]
136359726  ERLEC1; endoplasmic reticulum lectin 1 [KO:K14008]
136359869  TUSC3; tumor suppressor candidate 3 isoform X1 [KO:K19478]
136360186  WFS1; wolframin [KO:K14020]
136360223  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
136360326  MOGS; mannosyl-oligosaccharide glucosidase [KO:K01228] [EC:3.2.1.106]
136360507  SEC24B; protein transport protein Sec24B isoform X1 [KO:K14007]
136360526  OSTC; oligosaccharyltransferase complex subunit OSTC isoform X1 [KO:K26501]
136360540  UBE2D3; ubiquitin-conjugating enzyme E2 D3 isoform X1 [KO:K06689] [EC:2.3.2.23]
136360683  SEC31A; protein transport protein Sec31A [KO:K14005]
136360685  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
136360704  HSPA4L; heat shock 70 kDa protein 4L isoform X1 [KO:K09485]
136360808  SEC24D; protein transport protein Sec24D isoform X1 [KO:K14007]
136361120  SEC61A2; protein transport protein Sec61 subunit alpha isoform X1 [KO:K10956]
136361786  NGLY1; peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase isoform X1 [KO:K01456] [EC:3.5.1.52]
136361791  HSP90B1; endoplasmin [KO:K09487]
136361808  CKAP4; cytoskeleton-associated protein 4 [KO:K13999]
136361837  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
136361865  RBX1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
136362018  STT3B; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B [KO:K07151] [EC:2.4.99.18]
136362138  TMEM258; LOW QUALITY PROTEIN: transmembrane protein 258 [KO:K26502]
136362211  SVIP; small VCP/p97-interacting protein [KO:K14014]
136362655  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
136362736  ERO1A; ERO1-like protein alpha [KO:K10950] [EC:1.8.4.-]
136362866  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
136362867  [KO:K04079]
136362927  ATXN3; ataxin-3 isoform X1 [KO:K11863] [EC:3.4.22.-]
136362959  SEL1L; protein sel-1 homolog 1 isoform X1 [KO:K14026]
136363026  SEC23A; protein transport protein Sec23A [KO:K14006]
136363289  PDIA4; protein disulfide-isomerase A4 [KO:K09582] [EC:5.3.4.1]
136363361  CUL1; cullin-1 [KO:K03347]
136363423  SEC61G; protein transport protein Sec61 subunit gamma [KO:K07342]
136363451  DNAJC10; dnaJ homolog subfamily C member 10 isoform X1 [KO:K09530] [EC:1.8.4.-]
136363467  NFE2L2; nuclear factor erythroid 2-related factor 2 isoform X1 [KO:K05638]
136363576  DNAJB2; dnaJ homolog subfamily B member 2 [KO:K09508]
136363715  UBXN4; UBX domain-containing protein 4 [KO:K24348]
136364206  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
136364220  SEC31B; protein transport protein Sec31B isoform X1 [KO:K14005]
136364255  SEC24C; protein transport protein Sec24C isoform X1 [KO:K14007]
136364361  UBE2D1; ubiquitin-conjugating enzyme E2 D1 isoform X1 [KO:K06689] [EC:2.3.2.23]
136364365  DNAJB12; dnaJ homolog subfamily B member 12 isoform X1 [KO:K09518]
136364368  SAR1A; small COPII coat GTPase SAR1A [KO:K07953] [EC:3.6.5.-]
136364683  EDEM3; ER degradation-enhancing alpha-mannosidase-like protein 3 isoform X1 [KO:K10086]
136364811  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha isoform X1 [KO:K09054]
136364856  TXNDC5; thioredoxin domain-containing protein 5 [KO:K13984] [EC:5.3.4.1]
136364878  SSR1; translocon-associated protein subunit alpha isoform X1 [KO:K13249]
136365350  SEC62; translocation protein SEC62 [KO:K12275]
136365497  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
136365522  UGGT1; UDP-glucose:glycoprotein glucosyltransferase 1 isoform X1 [KO:K11718] [EC:2.4.1.-]
136365550  UBE2G2; ubiquitin-conjugating enzyme E2 G2 isoform X1 [KO:K04555] [EC:2.3.2.23]
136365583  DNAJB11; dnaJ homolog subfamily B member 11 [KO:K09517]
136365852  MARCHF6; E3 ubiquitin-protein ligase MARCHF6 isoform X1 [KO:K10661] [EC:2.3.2.27]
136365941  SEC61A1; protein transport protein Sec61 subunit alpha [KO:K10956]
136365951  RPN1; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 [KO:K12666]
136366216  SEC13; protein SEC13 homolog [KO:K14004]
136366229  EDEM1; LOW QUALITY PROTEIN: ER degradation-enhancing alpha-mannosidase-like protein 1 [KO:K10084]
136366264  BAG1; BAG family molecular chaperone regulator 1 isoform X1 [KO:K09555]
136366509  HERPUD1; homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein isoform X1 [KO:K14027]
136366604  AMFR; E3 ubiquitin-protein ligase AMFR [KO:K10636] [EC:2.3.2.36]
136366612  MBTPS1; membrane-bound transcription factor site-1 protease isoform X1 [KO:K08653] [EC:3.4.21.112]
136366666  DNAJA2; dnaJ homolog subfamily A member 2 [KO:K09503]
136366695  SEC61B; protein transport protein Sec61 subunit beta [KO:K09481]
136366845  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
136366938  SELENOS; selenoprotein S [KO:K14025]
136367346  SIL1; nucleotide exchange factor SIL1 isoform X1 [KO:K14001]
136367377  UBE2D2; ubiquitin-conjugating enzyme E2 D2 [KO:K06689] [EC:2.3.2.23]
136367428  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
136367434  SEC24A; protein transport protein Sec24A isoform X1 [KO:K14007]
136367436  SAR1B; small COPII coat GTPase SAR1B [KO:K07953] [EC:3.6.5.-]
136367465  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
136367475  CANX; calnexin [KO:K08054]
136367591  LMAN2; vesicular integral-membrane protein VIP36 [KO:K10082]
136368030  ERN2; serine/threonine-protein kinase/endoribonuclease IRE2 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
136368086  STUB1; E3 ubiquitin-protein ligase CHIP [KO:K09561] [EC:2.3.2.27]
136368386  EDEM2; ER degradation-enhancing alpha-mannosidase-like protein 2 [KO:K10085]
136368402  RPN2; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform X1 [KO:K12667]
136368519  NSFL1C; NSFL1 cofactor p47 [KO:K14012]
136368537  DNAJC5; dnaJ homolog subfamily C member 5 [KO:K09525]
136368813  [KO:K13989]
136368846  RNF185; E3 ubiquitin-protein ligase RNF185 [KO:K10666] [EC:2.3.2.27]
136368923  UFD1; ubiquitin recognition factor in ER-associated degradation protein 1 isoform X1 [KO:K14016]
136368966  XBP1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
136369018  ERP29; endoplasmic reticulum resident protein 29 [KO:K09586]
136369407  TRAM1; translocating chain-associated membrane protein 1 [KO:K14010]
136369409  P4HB; protein disulfide-isomerase [KO:K09580] [EC:5.3.4.1]
136369448  NPLOC4; nuclear protein localization protein 4 homolog [KO:K14015]
136369505  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
136369647  MAN1B1; endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase [KO:K23741]
136369649  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
136369873  HSPA5; endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
136369999  UBE2G1; ubiquitin-conjugating enzyme E2 G1 isoform X1 [KO:K10575] [EC:2.3.2.23]
136370026  DERL2; derlin-2 [KO:K13989]
136370488  MAGT1; LOW QUALITY PROTEIN: magnesium transporter protein 1 [KO:K19478]
136370493  DNAJC5B; dnaJ homolog subfamily C member 5B [KO:K09525]
136370621  UBE2J2; ubiquitin-conjugating enzyme E2 J2 [KO:K04554] [EC:2.3.2.23]
136370761  FBXO2; F-box only protein 2 isoform X1 [KO:K10099]
136370762  FBXO44; F-box only protein 44 isoform X1 [KO:K10100]
136370838  DDOST; LOW QUALITY PROTEIN: dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit [KO:K12670]
136370895  UBE4B; ubiquitin conjugation factor E4 B [KO:K10597] [EC:2.3.2.27]
136370934  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
136371014  CRYAB; alpha-crystallin B chain [KO:K09542]
136371035  HYOU1; hypoxia up-regulated protein 1 [KO:K09486]
136371083  STT3A; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A [KO:K07151] [EC:2.4.99.18]
136371157  MAN1C1; mannosyl-oligosaccharide 1,2-alpha-mannosidase IC isoform X1 [KO:K01230] [EC:3.2.1.113]
136371540  DERL1; derlin-1 [KO:K11519]
136371590  YOD1; ubiquitin thioesterase OTU1 [KO:K13719] [EC:3.1.2.-]
136371687  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
136371981  UBXN6; UBX domain-containing protein 6 [KO:K14011]
136372163  DAD1; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 [KO:K12668]
136372849  OS9; LOW QUALITY PROTEIN: protein OS-9 [KO:K10088]
136372990  UBQLN4; ubiquilin-4 isoform X1 [KO:K04523]
136373001  KRTCAP2; keratinocyte-associated protein 2 [KO:K28202]
136373022  [KO:K09502]
136373048  [KO:K13250]
136373049  [KO:K13250]
136373323  [KO:K13525]
136373504  DNAJA1; dnaJ homolog subfamily A member 1 [KO:K09502]
136373829  UBQLN1; ubiquilin-1 isoform X1 [KO:K04523]
136374012  RAD23B; UV excision repair protein RAD23 homolog B [KO:K10839]
136374148  VCP; transitional endoplasmic reticulum ATPase [KO:K13525]
136374163  PLAA; phospholipase A-2-activating protein [KO:K14018]
136374327  LMAN1; protein ERGIC-53 [KO:K10080]
136374725  CRYAA; alpha-crystallin A chain [KO:K09541]
136374888  BAX; apoptosis regulator BAX [KO:K02159]
136374996  DNAJB1; dnaJ homolog subfamily B member 1 [KO:K09507]
136375581  MAN1A2; mannosyl-oligosaccharide 1,2-alpha-mannosidase IB [KO:K01230] [EC:3.2.1.113]
Compound
C00076  Calcium cation
G00009  
G00010  
G00011  
G00012  
G10694  
Reference
PMID:19491040
  Authors
Naidoo N
  Title
ER and aging-Protein folding and the ER stress response.
  Journal
Ageing Res Rev 8:150-9 (2009)
DOI:10.1016/j.arr.2009.03.001
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:20347046
  Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  Title
Protein quality control in the ER: the recognition of misfolded proteins.
  Journal
Semin Cell Dev Biol 21:500-11 (2010)
DOI:10.1016/j.semcdb.2010.03.006
Reference
PMID:20219571
  Authors
Stolz A, Wolf DH
  Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  Journal
Biochim Biophys Acta 1803:694-705 (2010)
DOI:10.1016/j.bbamcr.2010.02.005
Reference
PMID:20112977
  Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  Journal
J Proteome Res 9:1763-71 (2010)
DOI:10.1021/pr900900x
Related
pathway
sati00510  N-Glycan biosynthesis
sati03050  Proteasome
sati03060  Protein export
sati04210  Apoptosis
KO pathway
ko04141   

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