Entry
Name
B cell receptor signaling pathway - Sus scrofa (pig)
Description
B cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor (BCR) is an integral membrane protein complex that is composed of two immunoglobulin (Ig) heavy chains, two Ig light chains and two heterodimers of Ig-alpha and Ig-beta. After BCR ligation by antigen, three main protein tyrosine kinases (PTKs) -the SRC-family kinase LYN, SYK and the TEC-family kinase BTK- are activated. Phosphatidylinositol 3-kinase (PI3K) and phospholipase C-gamma 2 (PLC-gamma 2) are important downstream effectors of BCR signalling. This signalling ultimately results in the expression of immediate early genes that further activate the expression of other genes involved in B cell proliferation, differentiation and Ig production as well as other processes.
Class
Organismal Systems; Immune system
BRITE hierarchy
Pathway map
ssc04662 B cell receptor signaling pathway
Ortholog table
Other DBs
Organism
Sus scrofa (pig) [GN:
ssc ]
Gene
100190992 CD79A; B-cell antigen receptor complex-associated protein alpha chain precursor [KO:K06506 ]
100511898 CD79B; B-cell antigen receptor complex-associated protein beta chain precursor [KO:K06507 ]
100525936 DAPP1; dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide [KO:K12229 ]
100151826 VAV3; LOW QUALITY PROTEIN: guanine nucleotide exchange factor VAV3 [KO:K05730 ]
100151931 VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730 ]
100621675 RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860 ]
110255928 RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861 ]
100525061 BANK1; LOW QUALITY PROTEIN: B-cell scaffold protein with ankyrin repeats [KO:K26239 ]
100518663 PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859 ] [EC:3.1.4.11 ]
397241 PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348 ] [EC:3.1.3.16 ]
100158082 PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X4 [KO:K04348 ] [EC:3.1.3.16 ]
396603 PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X3 [KO:K04348 ] [EC:3.1.3.16 ]
397318 NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446 ]
100134969 NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332 ]
100739450 NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333 ]
110259837 CARD11; caspase recruitment domain-containing protein 11 isoform X1 [KO:K07367 ]
100153830 MALT1; mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform X1 [KO:K07369 ] [EC:3.4.22.-]
751869 NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580 ]
100153486 NFKBIE; LOW QUALITY PROTEIN: NF-kappa-B inhibitor epsilon [KO:K05872 ]
397669 CD19; B-lymphocyte antigen CD19 precursor [KO:K06465 ]
100511937 phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
100739510 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
100623707 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649 ]
100518131 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
100621789 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
100622559 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
613131 FCGR2B; low affinity immunoglobulin gamma Fc region receptor II-b precursor [KO:K12560 ]
100144538 PIGE-108A11.3; leukocyte immunoglobulin-like receptor-like [KO:K06512 ]
100521529 leukocyte immunoglobulin-like receptor subfamily A member 6 isoform X1 [KO:K06512 ]
100517285 leukocyte immunoglobulin-like receptor subfamily A member 6 isoform X2 [KO:K06512 ]
100624191 leukocyte immunoglobulin-like receptor subfamily A member 6 isoform X1 [KO:K06512 ]
100622710 leukocyte immunoglobulin-like receptor subfamily B member 3 isoform X4 [KO:K06512 ]
100622460 leukocyte immunoglobulin-like receptor subfamily A member 2 isoform X1 [KO:K06512 ]
100511639 leukocyte immunoglobulin-like receptor subfamily B member 3-like isoform 1 precursor [KO:K06512 ]
106508173 leukocyte immunoglobulin-like receptor subfamily B member 3 isoform X1 [KO:K06512 ]
100521696 leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512 ]
100522579 LOW QUALITY PROTEIN: leukocyte immunoglobulin-like receptor subfamily B member 3 [KO:K06512 ]
100525227 leukocyte immunoglobulin-like receptor subfamily A member 6 isoform X1 [KO:K06512 ]
Compound
C01245 D-myo-Inositol 1,4,5-trisphosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference
Authors
Niiro H, Clark EA.
Title
Regulation of B-cell fate by antigen-receptor signals.
Journal
Reference
Authors
Kurosaki T.
Title
Genetic analysis of B cell antigen receptor signaling.
Journal
Reference
Authors
Nitschke L.
Title
The role of CD22 and other inhibitory co-receptors in B-cell activation.
Journal
Reference
Authors
Morgan BP, Marchbank KJ, Longhi MP, Harris CL, Gallimore AM.
Title
Complement: central to innate immunity and bridging to adaptive responses.
Journal
Reference
Authors
Kurosaki T.
Title
Regulation of B-cell signal transduction by adaptor proteins.
Journal
Reference
Authors
Nitschke L, Tsubata T.
Title
Molecular interactions regulate BCR signal inhibition by CD22 and CD72.
Journal
Reference
Authors
Jumaa H, Hendriks RW, Reth M.
Title
B cell signaling and tumorigenesis.
Journal
Reference
Authors
Rickert RC.
Title
Regulation of B lymphocyte activation by complement C3 and the B cell coreceptor complex.
Journal
Reference
Authors
Zouali M, Sarmay G
Title
B lymphocyte signaling pathways in systemic autoimmunity: implications for pathogenesis and treatment.
Journal
Reference
Authors
Chiles TC.
Title
Regulation and function of cyclin D2 in B lymphocyte subsets.
Journal
Reference
Authors
Allam A, Marshall AJ
Title
Role of the adaptor proteins Bam32, TAPP1 and TAPP2 in lymphocyte activation.
Journal
Reference
Authors
Gold MR
Title
To make antibodies or not: signaling by the B-cell antigen receptor.
Journal
Reference
Authors
Fu C, Turck CW, Kurosaki T, Chan AC
Title
BLNK: a central linker protein in B cell activation.
Journal
Reference
Authors
Okada T, Maeda A, Iwamatsu A, Gotoh K, Kurosaki T
Title
BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation.
Journal
Reference
Authors
Shinohara H, Maeda S, Watarai H, Kurosaki T
Title
IkappaB kinase beta-induced phosphorylation of CARMA1 contributes to CARMA1 Bcl10 MALT1 complex formation in B cells.
Journal
Related pathway
ssc04610 Complement and coagulation cascades
ssc04810 Regulation of actin cytoskeleton
KO pathway
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