KEGG   PATHWAY: ssc04010
Entry
ssc04010                    Pathway                                
Name
MAPK signaling pathway - Sus scrofa (pig)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
ssc04010  MAPK signaling pathway
ssc04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Sus scrofa (pig) [GN:ssc]
Gene
100037938  CD14; monocyte differentiation antigen CD14 precursor [KO:K04391]
100038019  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
100101471  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
100126861  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100127133  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
100127166  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
100127355  IKBKG; NF-kappa-B essential modulator [KO:K07210]
100127478  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100135662  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
100135663  MAP3K7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
100135665  RELA; transcription factor p65 [KO:K04735]
100144302  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
100144486  FOS; proto-oncogene c-Fos [KO:K04379]
100144493  NTF3; neurotrophin-3 precursor [KO:K04356]
100144501  EFNA1; ephrin-A1 precursor [KO:K05462]
100144518  HSPA1L; heat shock 70 kDa protein 1-like [KO:K03283]
100152116  FGF6; fibroblast growth factor 6 [KO:K04358]
100152223  FGF16; fibroblast growth factor 16 [KO:K04358]
100152555  RAP1B; ras-related protein Rap-1b [KO:K07836]
100152572  MAP3K20; mitogen-activated protein kinase kinase kinase MLT isoform X1 [KO:K04424] [EC:2.7.11.25]
100152927  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
100152997  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
100153199  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
100153248  FGFR1; LOW QUALITY PROTEIN: fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
100153404  MAPKAPK5; MAP kinase-activated protein kinase 5 [KO:K04442] [EC:2.7.11.1]
100153785  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
100153829  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
100153927  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100153986  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
100154002  MAP3K21; mitogen-activated protein kinase kinase kinase MLK4 [KO:K17534] [EC:2.7.11.25]
100154202  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
100154471  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
100154640  CACNA1I; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
100154710  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
100154763  TAOK3; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
100154962  PTPRR; LOW QUALITY PROTEIN: receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
100155053  RET; LOW QUALITY PROTEIN: proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
100155308  [KO:K07830]
100155339  FGF23; fibroblast growth factor 23 [KO:K22428]
100155670  VEGFD; vascular endothelial growth factor D [KO:K05449]
100155720  FGF17; fibroblast growth factor 17 [KO:K04358]
100155753  MAP3K9; mitogen-activated protein kinase kinase kinase 9 isoform X1 [KO:K04417] [EC:2.7.11.25]
100155841  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
100155923  EFNA3; LOW QUALITY PROTEIN: ephrin-A3 [KO:K05462]
100155958  SRF; serum response factor [KO:K04378]
100156182  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
100156242  FGF8; LOW QUALITY PROTEIN: fibroblast growth factor 8 [KO:K04358]
100156404  PGF; placenta growth factor isoform X1 [KO:K16859]
100156602  SOS2; son of sevenless homolog 2 [KO:K03099]
100156630  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
100157144  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
100157221  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X2 [KO:K04349]
100158082  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X4 [KO:K04348] [EC:3.1.3.16]
100170767  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
100192436  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
100192444  CRK; adapter molecule crk [KO:K04438]
100233191  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100233192  MAPKAPK3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
100233194  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 [KO:K04372] [EC:2.7.11.1]
100240743  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
100270820  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
100302504  FGF21; fibroblast growth factor 21 precursor [KO:K22429]
100322894  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
100329127  CDC25B; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
100511085  NTF4; neurotrophin-4 precursor [KO:K12457]
100511102  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X14 [KO:K04851]
100511191  PPM1B; LOW QUALITY PROTEIN: protein phosphatase 1B [KO:K04461] [EC:3.1.3.16]
100511446  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
100511657  NLK; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
100511769  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
100511837  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
100511890  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
100512036  EFNA2; ephrin-A2 isoform X2 [KO:K05462]
100512235  MAP3K6; mitogen-activated protein kinase kinase kinase 6 [KO:K04425] [EC:2.7.11.25]
100512654  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
100512983  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
100513084  CSF1; macrophage colony-stimulating factor 1 precursor [KO:K05453]
100513431  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
100513441  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
100513491  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
100513542  [KO:K04460] [EC:3.1.3.16]
100513645  NRTN; neurturin [KO:K25414]
100513672  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
100513721  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
100513811  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100513834  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
100513840  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
100514115  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
100514316  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X2 [KO:K04862]
100514374  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
100514612  BRAF; serine/threonine-protein kinase B-raf isoform X6 [KO:K04365] [EC:2.7.11.1]
100514745  CACNA1F; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
100514811  PLA2G4E; cytosolic phospholipase A2 epsilon isoform X1 [KO:K16342] [EC:3.1.1.4]
100515267  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
100515286  RPS6KA2; LOW QUALITY PROTEIN: ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
100515363  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
100515414  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
100515445  FLT3; receptor-type tyrosine-protein kinase FLT3 isoform X2 [KO:K05092] [EC:2.7.10.1]
100515448  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
100515978  ANGPT4; angiopoietin-4 [KO:K05467]
100516199  RASGRP4; RAS guanyl-releasing protein 4 [KO:K12363]
100516301  FGF20; fibroblast growth factor 20 [KO:K04358]
100516374  MAP4K1; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase kinase 1 [KO:K04408] [EC:2.7.11.1]
100516558  RRAS; ras-related protein R-Ras [KO:K07829]
100516641  ERBB2; receptor tyrosine-protein kinase erbB-2 precursor [KO:K05083] [EC:2.7.10.1]
100517077  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K04372] [EC:2.7.11.1]
100517086  CSF1R; macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
100517170  MAX; protein max isoform X1 [KO:K04453]
100517317  STK4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
100517409  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X2 [KO:K08018]
100517416  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
100517557  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
100517574  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
100517714  MAP3K12; mitogen-activated protein kinase kinase kinase 12 isoform X1 [KO:K04423] [EC:2.7.11.25]
100518074  PRKCG; protein kinase C gamma type isoform X3 [KO:K19663] [EC:2.7.11.13]
100518179  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
100518237  PSPN; persephin [KO:K25416]
100518251  KRAS; GTPase KRas isoform X2 [KO:K07827]
100518275  MECOM; MDS1 and EVI1 complex locus protein EVI1 isoform X1 [KO:K04462] [EC:2.1.1.367]
100518595  FGF4; fibroblast growth factor 4 [KO:K04358]
100518724  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
100518733  CACNA1C; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
100518950  FGF19; fibroblast growth factor 19 [KO:K22603]
100519006  DUSP9; dual specificity protein phosphatase 9 isoform X1 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
100519127  FGF3; fibroblast growth factor 3 [KO:K04358]
100519209  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
100519412  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X1 [KO:K04405]
100519605  CACNG7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
100519764  PDGFA; platelet-derived growth factor subunit A isoform X5 [KO:K04359]
100519779  CACNG6; voltage-dependent calcium channel gamma-6 subunit isoform X1 [KO:K04871]
100520008  GNG14; uncharacterized LOC105372280 homolog [KO:K04347]
100520100  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X2 [KO:K04430] [EC:2.7.12.2]
100520187  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
100520402  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
100520418  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X5 [KO:K04431] [EC:2.7.12.2]
100520687  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
100521141  ARRB1; beta-arrestin-1 isoform X3 [KO:K04439]
100521453  MAP3K10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
100521473  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
100521718  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X17 [KO:K04436]
100521736  MAPK10; mitogen-activated protein kinase 10 isoform X3 [KO:K04440] [EC:2.7.11.24]
100521837  VEGFB; vascular endothelial growth factor B isoform X2 [KO:K16858]
100521986  MAPKAPK2; LOW QUALITY PROTEIN: MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
100522002  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
100522066  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
100522174  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X4 [KO:K04373] [EC:2.7.11.1]
100522294  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X2 [KO:K04373] [EC:2.7.11.1]
100522469  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
100522721  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
100522792  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
100522873  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
100523716  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 isoform X2 [KO:K04414] [EC:2.7.11.1]
100523919  CACNG4; LOW QUALITY PROTEIN: voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
100523972  RPS6KA1; ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:2.7.11.1]
100524021  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
100524101  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
100524161  PDGFD; LOW QUALITY PROTEIN: platelet-derived growth factor D [KO:K05450]
100524422  PTPN5; tyrosine-protein phosphatase non-receptor type 5 isoform X1 [KO:K18018] [EC:3.1.3.48]
100524741  STK3; serine/threonine-protein kinase 3 isoform X1 [KO:K04412]
100524813  DAXX; death domain-associated protein 6 isoform X1 [KO:K02308]
100525013  FGF18; fibroblast growth factor 18 isoform X2 [KO:K04358]
100525045  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
100525086  FGF10; fibroblast growth factor 10 [KO:K04358]
100525120  HGF; hepatocyte growth factor isoform X3 [KO:K05460]
100525156  GNA12; guanine nucleotide-binding protein subunit alpha-12 isoform X1 [KO:K04346]
100525250  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
100525363  CRKL; crk-like protein [KO:K04438]
100525387  CACNA1A; LOW QUALITY PROTEIN: voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
100525505  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100525607  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
100525766  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
100525789  ERBB4; LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
100526122  LAMTOR3; ragulator complex protein LAMTOR3 isoform X2 [KO:K04370]
100526136  NF1; LOW QUALITY PROTEIN: neurofibromin [KO:K08052]
100620340  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
100620494  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
100620898  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
100620969  EREG; proepiregulin [KO:K09784]
100621090  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
100621234  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
100621398  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
100621675  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
100622149  CACNA1S; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
100622172  TAOK1; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
100622217  MAP3K8; mitogen-activated protein kinase kinase kinase 8 isoform X3 [KO:K04415] [EC:2.7.11.25]
100622259  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
100622609  RELB; transcription factor RelB isoform X1 [KO:K09253]
100622769  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
100622812  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
100622968  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
100623628  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
100623751  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
100624059  TAOK2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
100624603  ARTN; artemin [KO:K25415]
100625117  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
100625946  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
100626093  RASGRP2; RAS guanyl-releasing protein 2 [KO:K12361]
100626141  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
100626270  RPS6KA4; ribosomal protein S6 kinase alpha-4 isoform X1 [KO:K16510] [EC:2.7.11.1]
100626904  IL1R1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
100627123  PDGFRA; platelet-derived growth factor receptor alpha precursor [KO:K04363] [EC:2.7.10.1]
100627149  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
100627579  RASA1; ras GTPase-activating protein 1 isoform X1 [KO:K04352]
100627903  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
100628318  IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
100736741  MAP3K11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
100737448  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100738351  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
100738389  PPM1A; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
100738968  NGF; beta-nerve growth factor [KO:K02582]
100739349  NRAS; GTPase NRas precursor [KO:K07828]
100739450  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
102162529  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
102164336  CACNA1B; LOW QUALITY PROTEIN: voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
102164433  MAPK7; mitogen-activated protein kinase 7 isoform X1 [KO:K04464] [EC:2.7.11.24]
102166564  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
106504126  PTPN7; tyrosine-protein phosphatase non-receptor type 7 isoform X1 [KO:K18019] [EC:3.1.3.48]
106504229  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
110255928  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
110256149  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
110259208  HRAS; GTPase HRas isoform X1 [KO:K02833]
110259213  DUSP8; LOW QUALITY PROTEIN: dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
110259297  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
110259314  JUND; LOW QUALITY PROTEIN: transcription factor jun-D [KO:K04449]
110259378  FGF22; fibroblast growth factor 22 [KO:K04358]
110259950  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
110260602  MAPK8IP2; LOW QUALITY PROTEIN: C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
110260605  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
396565  IL1B2; interleukin 1, beta [KO:K04519]
396585  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 [KO:K04865]
396603  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X3 [KO:K04348] [EC:3.1.3.16]
396606  IRAK1; LOW QUALITY PROTEIN: interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
396609  MAPK9; mitogen-activated protein kinase 9 isoform X4 [KO:K04440] [EC:2.7.11.24]
396610  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
396617  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
396629  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
396646  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
396648  HSP70.2; heat shock 70 kDa protein 1B [KO:K03283]
396665  TGFBR1; TGF-beta receptor type-1 precursor [KO:K04674] [EC:2.7.11.30]
396717  FGF9; fibroblast growth factor 9 [KO:K04358]
396726  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
396729  TEK; angiopoietin-1 receptor isoform X6 [KO:K05121] [EC:2.7.10.1]
396730  ANGPT2; angiopoietin-2 precursor [KO:K05466]
396755  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
396762  FGFR2; fibroblast growth factor receptor 2 precursor [KO:K05093] [EC:2.7.10.1]
396763  FLT1; vascular endothelial growth factor receptor 1 isoform X2 [KO:K05096] [EC:2.7.10.1]
396810  KIT; mast/stem cell growth factor receptor Kit precursor [KO:K05091] [EC:2.7.10.1]
396826  FAS; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390]
396906  HSPA6; heat shock 70 kDa protein [KO:K03283]
396913  JUN; transcription factor AP-1 [KO:K04448]
396916  IGF2; insulin-like growth factor II preproprotein [KO:K13769]
397009  ANGPT1; angiopoietin-1 precursor [KO:K05465]
397020  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A precursor [KO:K03158]
397070  EGFR; epidermal growth factor receptor precursor [KO:K04361] [EC:2.7.10.1]
397078  TGFB1; transforming growth factor beta-1 precursor [KO:K13375]
397083  EGF; pro-epidermal growth factor precursor [KO:K04357]
397084  TGFB2; transforming growth factor beta-2 isoform X1 [KO:K13376]
397086  TNF; tumor necrosis factor [KO:K03156]
397094  IL1A; interleukin-1 alpha precursor [KO:K04383]
397122  IL1B; interleukin-1 beta precursor [KO:K04519]
397157  VEGFA; vascular endothelial growth factor A precursor [KO:K05448]
397184  PRKCA; LOW QUALITY PROTEIN: protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
397241  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
397244  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
397276  TP53; cellular tumor antigen p53 [KO:K04451]
397281  FGF7; fibroblast growth factor 7 [KO:K04358]
397311  KDR; vascular endothelial growth factor receptor 2 isoform X2 [KO:K05098] [EC:2.7.10.1]
397318  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
397350  IGF1R; insulin-like growth factor 1 receptor precursor [KO:K05087] [EC:2.7.10.1]
397377  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 preproprotein [KO:K04858]
397400  TGFB3; transforming growth factor beta-3 precursor [KO:K13377]
397415  INS; insulin precursor [KO:K04526]
397484  TGFA; protransforming growth factor alpha precursor [KO:K08774]
397491  IGF1; insulin-like growth factor I precursor [KO:K05459]
397495  BDNF; brain-derived neurotrophic factor precursor [KO:K04355]
397497  FGF1; fibroblast growth factor 1 [KO:K18496]
397509  KITLG; kit ligand precursor [KO:K05461]
397601  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
397643  FGF2; fibroblast growth factor 2 [KO:K18497]
397652  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
397668  AREG; amphiregulin precursor [KO:K09782]
445013  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
448810  MYC; myc proto-oncogene protein [KO:K04377]
493184  HSPB1; heat shock protein beta-1 [KO:K04455]
494463  STMN1; stathmin [KO:K04381]
574062  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
654328  MET; hepatocyte growth factor receptor precursor [KO:K05099] [EC:2.7.10.1]
733585  FLNA; filamin-A isoform X1 [KO:K04437]
733590  MEF2C; myocyte-specific enhancer factor 2C [KO:K04454]
733669  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
733677  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
751869  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
780428  CDC42; cell division control protein 42 homolog [KO:K04393]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
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Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
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Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
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Trk receptors: roles in neuronal signal transduction.
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Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
ssc04070  Phosphatidylinositol signaling system
ssc04110  Cell cycle
ssc04115  p53 signaling pathway
ssc04210  Apoptosis
ssc04310  Wnt signaling pathway
ssc04668  TNF signaling pathway
KO pathway
ko04010   

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