KEGG   PATHWAY: sscv00600
Entry
sscv00600                   Pathway                                
Name
Sphingolipid metabolism - Syngnathus scovelli (Gulf pipefish)
Class
Metabolism; Lipid metabolism
Pathway map
sscv00600  Sphingolipid metabolism
sscv00600

Module
sscv_M00066  Lactosylceramide biosynthesis [PATH:sscv00600]
sscv_M00067  Sulfoglycolipids biosynthesis, ceramide/1-alkyl-2-acylglycerol => sulfatide/seminolipid [PATH:sscv00600]
sscv_M00094  Ceramide biosynthesis [PATH:sscv00600]
sscv_M00099  Sphingosine biosynthesis [PATH:sscv00600]
sscv_M00100  Sphingosine degradation [PATH:sscv00600]
Other DBs
GO: 0006665
Organism
Syngnathus scovelli (Gulf pipefish) [GN:sscv]
Gene
125990245  serine palmitoyltransferase 2b [KO:K00654] [EC:2.3.1.50]
125978268  serine palmitoyltransferase 3 [KO:K00654] [EC:2.3.1.50]
125979819  serine palmitoyltransferase 1 isoform X1 [KO:K00654] [EC:2.3.1.50]
125984497  3-ketodihydrosphingosine reductase [KO:K04708] [EC:1.1.1.102]
125974215  ceramide synthase 1 [KO:K04710] [EC:2.3.1.299]
125975754  ceramide synthase 2 [KO:K24621] [EC:2.3.1.297]
125986984  ceramide synthase 2a [KO:K24621] [EC:2.3.1.297]
125973441  ceramide synthase 4a [KO:K24621] [EC:2.3.1.297]
125971080  ceramide synthase 2 isoform X1 [KO:K24622] [EC:2.3.1.297 2.3.1.298]
125977894  ceramide synthase 5 isoform X1 [KO:K23727] [EC:2.3.1.291]
125987712  ceramide synthase 5-like [KO:K23727] [EC:2.3.1.291]
125973569  ceramide synthase 6 [KO:K23727] [EC:2.3.1.291]
125969327  acid ceramidase [KO:K12348] [EC:3.5.1.23]
125991098  neutral ceramidase [KO:K12349] [EC:3.5.1.23]
125968472  alkaline ceramidase 2 [KO:K01441] [EC:3.5.1.23]
125968970  alkaline ceramidase 1 isoform X1 [KO:K01441] [EC:3.5.1.23]
125981988  alkaline ceramidase 3 [KO:K04711] [EC:3.5.1.-]
125978585  sphingolipid delta(4)-desaturase DES1 [KO:K04712] [EC:1.14.19.17 1.14.18.5]
125980403  sphingolipid delta(4)-desaturase/C4-monooxygenase DES2 [KO:K04712] [EC:1.14.19.17 1.14.18.5]
125968425  phosphatidylcholine:ceramide cholinephosphotransferase 2 [KO:K04714] [EC:2.7.8.27 3.1.4.62]
125975167  phosphatidylcholine:ceramide cholinephosphotransferase 2-like [KO:K04714] [EC:2.7.8.27 3.1.4.62]
125978309  phosphatidylcholine:ceramide cholinephosphotransferase 1 [KO:K04714] [EC:2.7.8.27 3.1.4.62]
125982666  sphingomyelin phosphodiesterase [KO:K12350] [EC:3.1.4.12]
125977634  sphingomyelin phosphodiesterase 2-like [KO:K12351] [EC:3.1.4.12]
125970208  sphingomyelin phosphodiesterase 3 isoform X1 [KO:K12352] [EC:3.1.4.12]
125974951  sphingomyelin phosphodiesterase 5 [KO:K12352] [EC:3.1.4.12]
125977308  sphingomyelin phosphodiesterase 4 isoform X1 [KO:K12353] [EC:3.1.4.12]
125975151  zgc:153896; ectonucleotide pyrophosphatase/phosphodiesterase family member 7 [KO:K12354] [EC:3.1.4.12]
125983611  ectonucleotide pyrophosphatase/phosphodiesterase family member 7-like [KO:K12354] [EC:3.1.4.12]
125991625  ectonucleotide pyrophosphatase/phosphodiesterase family member 7-like [KO:K12354] [EC:3.1.4.12]
125991626  ectonucleotide pyrophosphatase/phosphodiesterase family member 7-like [KO:K12354] [EC:3.1.4.12]
125989185  zgc:158263; ceramide kinase family protein [KO:K04715] [EC:2.7.1.138]
125970281  ceramide kinase-like [KO:K04715] [EC:2.7.1.138]
125992378  ceramide kinase isoform X1 [KO:K04715] [EC:2.7.1.138]
125968415  phospholipid phosphatase 2b [KO:K01080] [EC:3.1.3.4]
125968783  phospholipid phosphatase 3-like isoform X1 [KO:K01080] [EC:3.1.3.4]
125983888  phosphatidic acid phosphatase type 2D [KO:K01080] [EC:3.1.3.4]
125985426  phospholipid phosphatase 3-like isoform X1 [KO:K01080] [EC:3.1.3.4]
125972137  phospholipid phosphatase 3 isoform X1 [KO:K01080] [EC:3.1.3.4]
125979582  phospholipid phosphatase 1 isoform X1 [KO:K01080] [EC:3.1.3.4]
125993738  phospholipid phosphatase 1-like [KO:K01080] [EC:3.1.3.4]
125981080  phospholipid phosphatase 2-like [KO:K01080] [EC:3.1.3.4]
125990696  sphingosine-1-phosphate phosphatase 1-like [KO:K04716] [EC:3.1.3.-]
125971774  sphingosine-1-phosphate phosphatase 2 isoform X1 [KO:K04717] [EC:3.1.3.-]
125975488  sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
125983526  sphingosine kinase 1-like [KO:K04718] [EC:2.7.1.91]
125969070  LOW QUALITY PROTEIN: sphingosine kinase 1-like [KO:K04718] [EC:2.7.1.91]
125978425  sphingosine-1-phosphate lyase 1 isoform X1 [KO:K01634] [EC:4.1.2.27]
125979496  ceramide glucosyltransferase isoform X1 [KO:K00720] [EC:2.4.1.80]
125975318  lysosomal acid glucosylceramidase [KO:K01201] [EC:3.2.1.45]
125983719  non-lysosomal glucosylceramidase isoform X1 [KO:K17108] [EC:3.2.1.45]
125987783  beta-1,4-galactosyltransferase 5 [KO:K09905] [EC:2.4.1.274 2.4.1.-]
125969280  beta-galactosidase [KO:K12309] [EC:3.2.1.23]
125968884  2-hydroxyacylsphingosine 1-beta-galactosyltransferase [KO:K04628] [EC:2.4.1.47]
125983232  galactocerebrosidase [KO:K01202] [EC:3.2.1.46]
125980021  galactosylceramide sulfotransferase [KO:K01019] [EC:2.8.2.11]
125994251  galactosylceramide sulfotransferase [KO:K01019] [EC:2.8.2.11]
125971034  arylsulfatase A [KO:K01134] [EC:3.1.6.8]
125986602  sialidase-1 [KO:K01186] [EC:3.2.1.18]
125972644  sialidase-4 [KO:K12357] [EC:3.2.1.18]
125981794  sialidase-3-like [KO:K12357] [EC:3.2.1.18]
125987099  alpha-galactosidase A [KO:K01189] [EC:3.2.1.22]
125976677  beta-1,4 N-acetylgalactosaminyltransferase 1 [KO:K00725] [EC:2.4.1.92]
125988023  beta-1,4 N-acetylgalactosaminyltransferase 1a [KO:K00725] [EC:2.4.1.92]
125979287  beta-hexosaminidase subunit beta isoform X1 [KO:K12373] [EC:3.2.1.52]
125980213  ganglioside GM2 activator [KO:K12383]
125978063  prosaposin [KO:K12382]
125980123  prosaposin [KO:K12382]
125993537  surfactant protein Bb isoform X1 [KO:K12382]
Compound
C00065  L-Serine
C00154  Palmitoyl-CoA
C00195  N-Acylsphingosine
C00319  Sphingosine
C00346  Ethanolamine phosphate
C00550  Sphingomyelin
C00836  Sphinganine
C01120  Sphinganine 1-phosphate
C01190  Glucosylceramide
C01290  Lactosylceramide
C01747  Psychosine
C02686  Galactosylceramide
C02934  3-Dehydrosphinganine
C02960  Ceramide 1-phosphate
C03108  D-Glucosylsphingosine
C03272  Globoside
C03405  Lactosylceramide sulfate
C03640  Sphingosyl-phosphocholine
C04730  GM3
C04737  alpha-D-Galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
C04884  N-Acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C04911  D-Galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C05681  Ceramide 2-aminoethylphosphonate
C06062  Ceramide phosphoethanolamine
C06124  Sphingosine 1-phosphate
C06125  Sulfatide
C06126  Digalactosylceramide
C06127  Digalactosylceramide sulfate
C06128  GM4
C06135  GA2
C06136  GA1
C12126  Dihydroceramide
C12144  Phytosphingosine
C12145  Phytoceramide
C22467  Gangliotriaosylceramide-II3 sulfate
Reference
PMID:12011104
  Authors
Merrill AH Jr.
  Title
De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway.
  Journal
J Biol Chem 277:25843-6 (2002)
DOI:10.1074/jbc.R200009200
Reference
PMID:10652340
  Authors
Tani M, Okino N, Mitsutake S, Tanigawa T, Izu H, Ito M.
  Title
Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized.
  Journal
J Biol Chem 275:3462-8 (2000)
DOI:10.1074/jbc.275.5.3462
Reference
PMID:11305904
  Authors
Hannun YA, Luberto C, Argraves KM.
  Title
Enzymes of sphingolipid metabolism: from modular to integrative signaling.
  Journal
Biochemistry 40:4893-903 (2001)
DOI:10.1021/bi002836k
Reference
PMID:1495423
  Authors
Merrill AH Jr, Wang E.
  Title
Enzymes of ceramide biosynthesis.
  Journal
Methods Enzymol 209:427-37 (1992)
DOI:10.1016/0076-6879(92)09053-6
Reference
PMID:8457204
  Authors
Hirschberg K, Rodger J, Futerman AH.
  Title
The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver.
  Journal
Biochem J 290 ( Pt 3):751-7 (1993)
DOI:10.1042/bj2900751
Reference
PMID:10366774
  Authors
Dickson RC, Lester RL.
  Title
Metabolism and selected functions of sphingolipids in the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1438:305-21 (1999)
DOI:10.1016/S1388-1981(99)00068-2
Related
pathway
sscv00260  Glycine, serine and threonine metabolism
sscv00601  Glycosphingolipid biosynthesis - lacto and neolacto series
sscv00603  Glycosphingolipid biosynthesis - globo and isoglobo series
sscv00604  Glycosphingolipid biosynthesis - ganglio series
KO pathway
ko00600   
LinkDB

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