KEGG   PATHWAY: sscv00600
Entry
sscv00600                   Pathway                                
Name
Sphingolipid metabolism - Syngnathus scovelli (Gulf pipefish)
Class
Metabolism; Lipid metabolism
Pathway map
sscv00600  Sphingolipid metabolism
sscv00600

Module
sscv_M00066  Lactosylceramide biosynthesis [PATH:sscv00600]
sscv_M00067  Sulfoglycolipids biosynthesis, ceramide/1-alkyl-2-acylglycerol => sulfatide/seminolipid [PATH:sscv00600]
sscv_M00094  Ceramide biosynthesis [PATH:sscv00600]
sscv_M00099  Sphingosine biosynthesis [PATH:sscv00600]
sscv_M00100  Sphingosine degradation [PATH:sscv00600]
Other DBs
GO: 0006665
Organism
Syngnathus scovelli (Gulf pipefish) [GN:sscv]
Gene
125968415  plpp2b; phospholipid phosphatase 2b [KO:K01080] [EC:3.1.3.4]
125968425  sgms2a; phosphatidylcholine:ceramide cholinephosphotransferase 2 [KO:K04714] [EC:2.7.8.27 2.7.8.48 3.1.4.62]
125968472  acer2; alkaline ceramidase 2 [KO:K01441] [EC:3.5.1.23]
125968783  [KO:K01080] [EC:3.1.3.4]
125968884  ugt8; 2-hydroxyacylsphingosine 1-beta-galactosyltransferase [KO:K04628] [EC:2.4.1.47]
125968970  acer1; alkaline ceramidase 1 isoform X1 [KO:K01441] [EC:3.5.1.23]
125969070  [KO:K04718] [EC:2.7.1.91]
125969280  glb1; beta-galactosidase [KO:K12309] [EC:3.2.1.23]
125969327  asah1b; acid ceramidase [KO:K12348] [EC:3.5.1.23]
125970208  smpd3; sphingomyelin phosphodiesterase 3 [KO:K12352] [EC:3.1.4.12]
125970281  [KO:K04715] [EC:2.7.1.138]
125971034  arsa; arylsulfatase A [KO:K01134] [EC:3.1.6.8]
125971080  cers3b; ceramide synthase 2 isoform X1 [KO:K24622]
125971774  sgpp2; sphingosine-1-phosphate phosphatase 2 [KO:K04717] [EC:3.1.3.-]
125972137  plpp3; phospholipid phosphatase 3 isoform X1 [KO:K01080] [EC:3.1.3.4]
125972644  neu4; sialidase-4 [KO:K12357] [EC:3.2.1.18]
125973441  cers4a; ceramide synthase 4a [KO:K24621]
125973569  cers6; ceramide synthase 6 [KO:K23727]
125974215  cers1; ceramide synthase 1 [KO:K04710] [EC:2.3.1.299]
125974951  smpd5; sphingomyelin phosphodiesterase 5 [KO:K12352] [EC:3.1.4.12]
125975151  zgc:153896; ectonucleotide pyrophosphatase/phosphodiesterase family member 7 [KO:K12354] [EC:3.1.4.12]
125975167  [KO:K04714] [EC:2.7.8.27 2.7.8.48 3.1.4.62]
125975318  gba1; lysosomal acid glucosylceramidase [KO:K01201] [EC:3.2.1.45]
125975488  sphk2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
125975754  [KO:K24621]
125976677  b4galnt1b; beta-1,4 N-acetylgalactosaminyltransferase 1 isoform X1 [KO:K00725] [EC:2.4.1.92]
125977308  smpd4; sphingomyelin phosphodiesterase 4 isoform X1 [KO:K12353] [EC:3.1.4.12]
125977634  smpd2b; sphingomyelin phosphodiesterase 2 [KO:K12351] [EC:3.1.4.12]
125977894  cers5; ceramide synthase 5 isoform X1 [KO:K23727]
125978063  psap; prosaposin [KO:K12382]
125978268  sptlc3; serine palmitoyltransferase 3 [KO:K00654] [EC:2.3.1.50]
125978309  [KO:K04714] [EC:2.7.8.27 2.7.8.48 3.1.4.62]
125978391  [KO:K22697] [EC:2.7.8.48 3.1.4.62]
125978425  sgpl1; sphingosine-1-phosphate lyase 1 isoform X1 [KO:K01634] [EC:4.1.2.27]
125978585  degs1; sphingolipid delta(4)-desaturase DES1 [KO:K04712] [EC:1.14.19.17 1.14.18.5]
125979287  hexb; beta-hexosaminidase subunit beta isoform X1 [KO:K12373] [EC:3.2.1.52]
125979496  ugcg; ceramide glucosyltransferase isoform X2 [KO:K00720] [EC:2.4.1.80]
125979582  plpp1a; phospholipid phosphatase 1 isoform X1 [KO:K01080] [EC:3.1.3.4]
125979819  sptlc1; serine palmitoyltransferase 1 isoform X1 [KO:K00654] [EC:2.3.1.50]
125980021  gal3st1b; galactosylceramide sulfotransferase [KO:K01019] [EC:2.8.2.11]
125980123  sftpba; prosaposin [KO:K12382]
125980213  gm2a; ganglioside GM2 activator [KO:K12383]
125980403  degs2; sphingolipid delta(4)-desaturase/C4-monooxygenase DES2 [KO:K04712] [EC:1.14.19.17 1.14.18.5]
125981080  [KO:K01080] [EC:3.1.3.4]
125981794  [KO:K12357] [EC:3.2.1.18]
125981988  acer3; alkaline ceramidase 3 [KO:K04711] [EC:3.5.1.-]
125982666  smpd1; sphingomyelin phosphodiesterase [KO:K12350] [EC:3.1.4.12]
125983232  galcb; galactocerebrosidase [KO:K01202] [EC:3.2.1.46]
125983526  [KO:K04718] [EC:2.7.1.91]
125983611  [KO:K12354] [EC:3.1.4.12]
125983719  gba2; non-lysosomal glucosylceramidase isoform X1 [KO:K17108] [EC:3.2.1.45]
125983888  ppap2d; phosphatidic acid phosphatase type 2D [KO:K01080] [EC:3.1.3.4]
125984497  kdsr; 3-dehydrosphinganine reductase [KO:K04708] [EC:1.1.1.102]
125985426  [KO:K01080] [EC:3.1.3.4]
125986602  neu1; sialidase-1 [KO:K01186] [EC:3.2.1.18]
125986984  [KO:K24621]
125987099  gla; alpha-galactosidase A [KO:K01189] [EC:3.2.1.22]
125987712  [KO:K23727]
125987783  b4galt5; beta-1,4-galactosyltransferase 5 [KO:K09905] [EC:2.4.1.274 2.4.1.-]
125988023  b4galnt1a; beta-1,4 N-acetylgalactosaminyltransferase 1a [KO:K00725] [EC:2.4.1.92]
125989185  zgc:158263; ceramide kinase family protein [KO:K04715] [EC:2.7.1.138]
125990245  sptlc2b; serine palmitoyltransferase 2b [KO:K00654] [EC:2.3.1.50]
125990696  sgpp1a; sphingosine-1-phosphate phosphatase 1 [KO:K04716] [EC:3.1.3.-]
125991098  asah2; neutral ceramidase [KO:K12349] [EC:3.5.1.23]
125991374  [KO:K22697] [EC:2.7.8.48 3.1.4.62]
125991625  [KO:K12354] [EC:3.1.4.12]
125991626  [KO:K12354] [EC:3.1.4.12]
125992378  cerk; ceramide kinase isoform X1 [KO:K04715] [EC:2.7.1.138]
125993537  sftpbb; surfactant protein Bb isoform X1 [KO:K12382]
125993738  [KO:K01080] [EC:3.1.3.4]
125994251  gal3st1a; galactosylceramide sulfotransferase [KO:K01019] [EC:2.8.2.11]
Compound
C00065  L-Serine
C00154  Palmitoyl-CoA
C00195  N-Acylsphingosine
C00319  Sphingosine
C00346  Ethanolamine phosphate
C00550  Sphingomyelin
C00836  Sphinganine
C01120  Sphinganine 1-phosphate
C01190  Glucosylceramide
C01290  Lactosylceramide
C01747  Psychosine
C02686  Galactosylceramide
C02934  3-Dehydrosphinganine
C02960  Ceramide 1-phosphate
C03108  D-Glucosylsphingosine
C03272  Globoside
C03405  Lactosylceramide sulfate
C03640  Sphingosyl-phosphocholine
C04730  GM3
C04737  alpha-D-Galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
C04884  N-Acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C04911  D-Galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C05681  Ceramide 2-aminoethylphosphonate
C06062  Ceramide phosphoethanolamine
C06124  Sphingosine 1-phosphate
C06125  Sulfatide
C06126  Digalactosylceramide
C06127  Digalactosylceramide sulfate
C06128  GM4
C06135  GA2
C06136  GA1
C12126  Dihydroceramide
C12144  Phytosphingosine
C12145  Phytoceramide
C22467  Gangliotriaosylceramide-II3 sulfate
C23072  Oxidized ceramide
Reference
PMID:12011104
  Authors
Merrill AH Jr.
  Title
De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway.
  Journal
J Biol Chem 277:25843-6 (2002)
DOI:10.1074/jbc.R200009200
Reference
PMID:10652340
  Authors
Tani M, Okino N, Mitsutake S, Tanigawa T, Izu H, Ito M.
  Title
Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized.
  Journal
J Biol Chem 275:3462-8 (2000)
DOI:10.1074/jbc.275.5.3462
Reference
PMID:11305904
  Authors
Hannun YA, Luberto C, Argraves KM.
  Title
Enzymes of sphingolipid metabolism: from modular to integrative signaling.
  Journal
Biochemistry 40:4893-903 (2001)
DOI:10.1021/bi002836k
Reference
PMID:1495423
  Authors
Merrill AH Jr, Wang E.
  Title
Enzymes of ceramide biosynthesis.
  Journal
Methods Enzymol 209:427-37 (1992)
DOI:10.1016/0076-6879(92)09053-6
Reference
PMID:8457204
  Authors
Hirschberg K, Rodger J, Futerman AH.
  Title
The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver.
  Journal
Biochem J 290 ( Pt 3):751-7 (1993)
DOI:10.1042/bj2900751
Reference
PMID:10366774
  Authors
Dickson RC, Lester RL.
  Title
Metabolism and selected functions of sphingolipids in the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1438:305-21 (1999)
DOI:10.1016/S1388-1981(99)00068-2
Related
pathway
sscv00260  Glycine, serine and threonine metabolism
sscv00601  Glycosphingolipid biosynthesis - lacto and neolacto series
sscv00603  Glycosphingolipid biosynthesis - globo and isoglobo series
sscv00604  Glycosphingolipid biosynthesis - ganglio series
KO pathway
ko00600   

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