KEGG   PATHWAY: sund04350
Entry
sund04350                   Pathway                                
Name
TGF-beta signaling pathway - Sceloporus undulatus (fence lizard)
Description
The transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species ranging from worms and insects to mammals. A wide spectrum of cellular functions such as proliferation, apoptosis, differentiation and migration are regulated by TGF-beta family members. TGF-beta family member binds to the Type II receptor and recruits Type I, whereby Type II receptor phosphorylates and activates Type I. The Type I receptor, in turn, phosphorylates receptor-activated Smads ( R-Smads: Smad1, Smad2, Smad3, Smad5, and Smad8). Once phosphorylated, R-Smads associate with the co-mediator Smad, Smad4, and the heteromeric complex then translocates into the nucleus. In the nucleus, Smad complexes activate specific genes through cooperative interactions with other DNA-binding and coactivator (or co-repressor) proteins.
Class
Environmental Information Processing; Signal transduction
Pathway map
sund04350  TGF-beta signaling pathway
sund04350

Other DBs
GO: 0007179
Organism
Sceloporus undulatus (fence lizard) [GN:sund]
Gene
121914426  SMURF1; E3 ubiquitin-protein ligase SMURF1 [KO:K04678] [EC:2.3.2.26]
121914600  [KO:K04658]
121914766  [KO:K04498] [EC:2.3.1.48]
121914778  E2F4; transcription factor E2F4 isoform X1 [KO:K04682]
121915075  GREM1; gremlin-1 [KO:K23318]
121915301  [KO:K16622]
121915414  [KO:K13376]
121915422  HDAC1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
121915807  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
121915855  [KO:K04668]
121915961  [KO:K04677]
121915996  [KO:K23106]
121916129  ID3; DNA-binding protein inhibitor ID-3 [KO:K17694]
121916287  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
121916299  [KO:K23100]
121916521  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
121916635  GREM2; gremlin-2 isoform X1 [KO:K23318]
121916935  [KO:K04650]
121917072  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
121917280  [KO:K04514] [EC:2.7.11.39]
121917294  [KO:K19383]
121917322  [KO:K19383]
121917336  [KO:K04514] [EC:2.7.11.39]
121917546  [KO:K13375]
121917554  [KO:K21283]
121917598  [KO:K13375]
121917608  [KO:K21283]
121918172  TMEM53; transmembrane protein 53 [KO:K28359]
121918382  ID4; DNA-binding protein inhibitor ID-4 [KO:K17695]
121919051  [KO:K23100]
121919301  ACVR2A; activin receptor type-2A isoform X1 [KO:K04670] [EC:2.7.11.30]
121919380  BMP2; bone morphogenetic protein 2 isoform X1 [KO:K21283]
121919394  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
121919922  BMP5; bone morphogenetic protein 5 [KO:K04663]
121920015  BMP4; bone morphogenetic protein 4 [KO:K04662]
121921188  SMAD4; mothers against decapentaplegic homolog 4 [KO:K04501]
121921293  FST; follistatin isoform X1 [KO:K04661]
121921480  ZFYVE16; zinc finger FYVE domain-containing protein 16 [KO:K04679]
121921506  RHOA; transforming protein RhoA [KO:K04513]
121921541  SMURF2; E3 ubiquitin-protein ligase SMURF2 [KO:K04678] [EC:2.3.2.26]
121921547  INHBE; inhibin beta E chain [KO:K22689]
121921670  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
121921686  SP1; transcription factor Sp1 isoform X1 [KO:K04684]
121922119  [KO:K04382] [EC:3.1.3.16]
121922245  SMAD7; mothers against decapentaplegic homolog 7 isoform X1 [KO:K19631]
121922252  SMAD5; mothers against decapentaplegic homolog 5 isoform X1 [KO:K16790]
121922392  [KO:K04513]
121922394  ACVR1B; activin receptor type-1B [KO:K13567] [EC:2.7.11.30]
121922416  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
121922505  RGMB; repulsive guidance molecule B [KO:K06847]
121922601  BMPR2; bone morphogenetic protein receptor type-2 [KO:K04671] [EC:2.7.11.30]
121922683  [KO:K03156]
121922749  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
121922772  [KO:K03156]
121922855  NOG; noggin [KO:K04658]
121923094  [KO:K04685]
121923188  AMHR2; anti-Muellerian hormone type-2 receptor isoform X1 [KO:K04672] [EC:2.7.11.30]
121923217  [KO:K04685]
121924742  CHRD; chordin isoform X1 [KO:K04657]
121925126  NRROS; transforming growth factor beta activator LRRC33 isoform X1 [KO:K26317]
121925338  TFRC; transferrin receptor protein 1 isoform X1 [KO:K06503]
121925479  GDF7; growth/differentiation factor 7 [KO:K20013]
121925541  SKIL; ski-like protein [KO:K18499]
121925747  TFDP1; transcription factor Dp-1 isoform X1 [KO:K04683]
121925767  SMAD9; mothers against decapentaplegic homolog 9 isoform X1 [KO:K16791]
121926046  INHBB; inhibin beta B chain [KO:K22687]
121926382  LRRC32; transforming growth factor beta activator LRRC32 [KO:K26316]
121926461  NODAL; nodal homolog [KO:K04666]
121926643  BMPR1A; LOW QUALITY PROTEIN: bone morphogenetic protein receptor type-1A [KO:K04673] [EC:2.7.11.30]
121927052  TF; serotransferrin [KO:K14736]
121927513  LTBP1; LOW QUALITY PROTEIN: latent-transforming growth factor beta-binding protein 1 [KO:K19559]
121927852  BMP7; bone morphogenetic protein 7 isoform X1 [KO:K16621]
121928505  ACVR1C; activin receptor type-1C isoform X1 [KO:K13568] [EC:2.7.11.30]
121928598  RBL1; retinoblastoma-like protein 1 isoform X1 [KO:K04681]
121928647  E2F5; transcription factor E2F5 isoform X1 [KO:K04682]
121928698  TGIF2; homeobox protein TGIF2 isoform X1 [KO:K19553]
121928986  ZFYVE9; zinc finger FYVE domain-containing protein 9 [KO:K04679]
121929146  THBS1; thrombospondin-1 isoform X1 [KO:K16857]
121929276  BMP6; bone morphogenetic protein 6 [KO:K16620]
121929441  MYC; myc proto-oncogene protein [KO:K04377]
121929509  GDF6; growth/differentiation factor 6 [KO:K20012]
121929722  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
121929752  GDF5; growth/differentiation factor 5 [KO:K04664]
121929841  FMOD; fibromodulin [KO:K08121]
121929922  [KO:K23318]
121929923  [KO:K23318]
121930473  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
121930750  BMPR1B; bone morphogenetic protein receptor type-1B [KO:K13578] [EC:2.7.11.30]
121931307  LEMD3; inner nuclear membrane protein Man1 [KO:K19410]
121931324  SMAD1; mothers against decapentaplegic homolog 1 isoform X1 [KO:K04676]
121931912  [KO:K28359]
121931968  PITX2; pituitary homeobox 2 isoform X1 [KO:K04686]
121932039  [KO:K04687]
121932051  DCN; decorin [KO:K04660]
121932202  RBX1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
121932531  CUL1; cullin-1 [KO:K03347]
121932578  [KO:K04666]
121932581  TFR2; transferrin receptor protein 2 isoform X1 [KO:K23910]
121932739  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
121933361  NEO1; neogenin isoform X1 [KO:K06766]
121934042  RGMA; LOW QUALITY PROTEIN: repulsive guidance molecule A [KO:K23096]
121934210  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
121934211  ACVR2B; activin receptor type-2B isoform X1 [KO:K13596] [EC:2.7.11.30]
121934436  THSD4; thrombospondin type-1 domain-containing protein 4 isoform X1 [KO:K23377]
121934440  FBN1; fibrillin-1 isoform X1 [KO:K06825]
121934446  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
121934448  SMAD6; mothers against decapentaplegic homolog 6 [KO:K04677]
121934475  ACVR1; activin receptor type-1 isoform X1 [KO:K04675] [EC:2.7.11.30]
121934599  SIN3A; paired amphipathic helix protein Sin3a isoform X1 [KO:K11644]
121934614  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
121934724  INHBA; inhibin beta A chain [KO:K04667]
121935199  EMP3; epithelial membrane protein 3 [KO:K26257]
121935455  BAMBI; BMP and activin membrane-bound inhibitor homolog [KO:K10162]
121935671  HDAC2; LOW QUALITY PROTEIN: histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
121936151  NBL1; neuroblastoma suppressor of tumorigenicity 1 [KO:K19558]
121936371  SKI; ski oncogene isoform X1 [KO:K26503]
121936500  [KO:K21283]
121937062  AMH; muellerian-inhibiting factor [KO:K04665]
121937241  ID2; DNA-binding protein inhibitor ID-2 [KO:K17693]
Compound
C14819  Fe3+
Reference
PMID:12809600
  Authors
Shi Y, Massague J.
  Title
Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
  Journal
Cell 113:685-700 (2003)
DOI:10.1016/S0092-8674(03)00432-X
Reference
PMID:14534577
  Authors
Derynck R, Zhang YE.
  Title
Smad-dependent and Smad-independent pathways in TGF-beta family signalling.
  Journal
Nature 425:577-84 (2003)
DOI:10.1038/nature02006
Reference
PMID:11252892
  Authors
Massague J.
  Title
How cells read TGF-beta signals.
  Journal
Nat Rev Mol Cell Biol 1:169-78 (2000)
DOI:10.1038/35043051
Reference
PMID:14557817
  Authors
Siegel PM, Massague J.
  Title
Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer.
  Journal
Nat Rev Cancer 3:807-21 (2003)
DOI:10.1038/nrc1208
Reference
PMID:14769828
  Authors
Shimasaki S, Moore RK, Otsuka F, Erickson GF.
  Title
The bone morphogenetic protein system in mammalian reproduction.
  Journal
Endocr Rev 25:72-101 (2004)
DOI:10.1210/er.2003-0007
Reference
PMID:11252746
  Authors
De Robertis EM, Larrain J, Oelgeschlager M, Wessely O.
  Title
The establishment of Spemann's organizer and patterning of the vertebrate embryo.
  Journal
Nat Rev Genet 1:171-81 (2000)
DOI:10.1038/35042039
Reference
PMID:12163231
  Authors
Gumienny TL, Padgett RW.
  Title
The other side of TGF-beta superfamily signal regulation: thinking outside the cell.
  Journal
Trends Endocrinol Metab 13:295-9 (2002)
DOI:10.1016/S1043-2760(02)00615-X
Reference
PMID:11836504
  Authors
Hamada H, Meno C, Watanabe D, Saijoh Y.
  Title
Establishment of vertebrate left-right asymmetry.
  Journal
Nat Rev Genet 3:103-13 (2002)
DOI:10.1038/nrg732
Reference
PMID:12466190
  Authors
Chang H, Brown CW, Matzuk MM.
  Title
Genetic analysis of the mammalian transforming growth factor-beta superfamily.
  Journal
Endocr Rev 23:787-823 (2002)
DOI:10.1210/er.2002-0003
Reference
PMID:10021351
  Authors
Morita K, Chow KL, Ueno N.
  Title
Regulation of body length and male tail ray pattern formation of Caenorhabditis elegans by a member of TGF-beta family.
  Journal
Development 126:1337-47 (1999)
Reference
PMID:9847239
  Authors
Krishna S, Maduzia LL, Padgett RW.
  Title
Specificity of TGFbeta signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans.
  Journal
Development 126:251-60 (1999)
Reference
PMID:15063168
  Authors
Chen Y, Mironova E, Whitaker LL, Edwards L, Yost HJ, Ramsdell AF.
  Title
ALK4 functions as a receptor for multiple TGF beta-related ligands to regulate left-right axis determination and mesoderm induction in Xenopus.
  Journal
Dev Biol 268:280-94 (2004)
DOI:10.1016/j.ydbio.2003.12.035
Reference
PMID:10519551
  Authors
Onichtchouk D, Chen YG, Dosch R, Gawantka V, Delius H, Massague J, Niehrs C
  Title
Silencing of TGF-beta signalling by the pseudoreceptor BAMBI.
  Journal
Nature 401:480-5 (1999)
DOI:10.1038/46794
Reference
PMID:19758997
  Authors
Yan X, Lin Z, Chen F, Zhao X, Chen H, Ning Y, Chen YG
  Title
Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-beta signaling.
  Journal
J Biol Chem 284:30097-104 (2009)
DOI:10.1074/jbc.M109.049304
Reference
PMID:8093006
  Authors
Hildebrand A, Romaris M, Rasmussen LM, Heinegard D, Twardzik DR, Border WA, Ruoslahti E
  Title
Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta.
  Journal
Biochem J 302 ( Pt 2):527-34 (1994)
DOI:10.1042/bj3020527
Reference
PMID:10934147
  Authors
Soo C, Hu FY, Zhang X, Wang Y, Beanes SR, Lorenz HP, Hedrick MH, Mackool RJ, Plaas A, Kim SJ, Longaker MT, Freymiller E, Ting K
  Title
Differential expression of fibromodulin, a transforming growth factor-beta modulator, in fetal skin development and scarless repair.
  Journal
Am J Pathol 157:423-33 (2000)
DOI:10.1016/s0002-9440(10)64555-5
Reference
PMID:16642010
  Authors
Anderson GJ, Frazer DM
  Title
Iron metabolism meets signal transduction.
  Journal
Nat Genet 38:503-4 (2006)
DOI:10.1038/ng0506-503
Reference
PMID:26735394
  Authors
Canali S, Core AB, Zumbrennen-Bullough KB, Merkulova M, Wang CY, Schneyer AL, Pietrangelo A, Babitt JL
  Title
Activin B Induces Noncanonical SMAD1/5/8 Signaling via BMP Type I Receptors in Hepatocytes: Evidence for a Role in Hepcidin Induction by Inflammation in Male Mice.
  Journal
Endocrinology 157:1146-62 (2016)
DOI:10.1210/en.2015-1747
Reference
PMID:26160612
  Authors
Ganz T, Nemeth E
  Title
Iron homeostasis in host defence and inflammation.
  Journal
Nat Rev Immunol 15:500-10 (2015)
DOI:10.1038/nri3863
Reference
PMID:15975920
  Authors
Babitt JL, Zhang Y, Samad TA, Xia Y, Tang J, Campagna JA, Schneyer AL, Woolf CJ, Lin HY
  Title
Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor.
  Journal
J Biol Chem 280:29820-7 (2005)
DOI:10.1074/jbc.M503511200
Reference
PMID:15671031
  Authors
Samad TA, Rebbapragada A, Bell E, Zhang Y, Sidis Y, Jeong SJ, Campagna JA, Perusini S, Fabrizio DA, Schneyer AL, Lin HY, Brivanlou AH, Attisano L, Woolf CJ
  Title
DRAGON, a bone morphogenetic protein co-receptor.
  Journal
J Biol Chem 280:14122-9 (2005)
DOI:10.1074/jbc.M410034200
Reference
PMID:33925597
  Authors
Vogt AS, Arsiwala T, Mohsen M, Vogel M, Manolova V, Bachmann MF
  Title
On Iron Metabolism and Its Regulation.
  Journal
Int J Mol Sci 22:ijms22094591 (2021)
DOI:10.3390/ijms22094591
Reference
PMID:20495575
  Authors
Ikushima H, Miyazono K
  Title
TGFbeta signalling: a complex web in cancer progression.
  Journal
Nat Rev Cancer 10:415-24 (2010)
DOI:10.1038/nrc2853
Reference
PMID:38267638
  Authors
Wu M, Wu S, Chen W, Li YP
  Title
The roles and regulatory mechanisms of TGF-beta and BMP signaling in bone and cartilage development, homeostasis and disease.
  Journal
Cell Res 34:101-123 (2024)
DOI:10.1038/s41422-023-00918-9
Related
pathway
sund04010  MAPK signaling pathway
sund04110  Cell cycle
sund04120  Ubiquitin mediated proteolysis
sund04210  Apoptosis
KO pathway
ko04350   

DBGET integrated database retrieval system