KEGG   PATHWAY: tst04150
Entry
tst04150                    Pathway                                
Name
mTOR signaling pathway - Trachemys scripta elegans (red-eared slider)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
tst04150  mTOR signaling pathway
tst04150

Organism
Trachemys scripta elegans (red-eared slider) [GN:tst]
Gene
117886493  SLC7A5; large neutral amino acids transporter small subunit 1 [KO:K13780]
117880174  SLC3A2; 4F2 cell-surface antigen heavy chain [KO:K06519]
117879183  SLC38A9; sodium-coupled neutral amino acid transporter 9 isoform X1 [KO:K14995]
117869553  V-type proton ATPase catalytic subunit A-like [KO:K02145] [EC:7.1.2.2]
117886381  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
117878418  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
117872994  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
117875304  ATP6V1C2; V-type proton ATPase subunit C 2 isoform X1 [KO:K02148]
117873729  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
117876886  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
117882696  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
117882291  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
117867133  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
117873485  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
117871346  LAMTOR1; ragulator complex protein LAMTOR1 [KO:K20397]
117869805  LAMTOR2; ragulator complex protein LAMTOR2 [KO:K20398]
117877772  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
117875935  LAMTOR5; ragulator complex protein LAMTOR5 isoform X1 [KO:K16344]
117884054  FLCN; folliculin [KO:K09594]
117881302  FNIP1; folliculin-interacting protein 1 isoform X1 [KO:K20400]
117878483  FNIP2; folliculin-interacting protein 2 isoform X1 [KO:K20401]
117882525  ras-related GTP-binding protein A isoform X1 [KO:K16185]
117868152  RRAGC; ras-related GTP-binding protein C [KO:K16186]
117875108  RRAGD; ras-related GTP-binding protein D isoform X1 [KO:K16186]
117868244  SESN2; sestrin-2 [KO:K20394]
117888014  CASTOR1; cytosolic arginine sensor for mTORC1 subunit 1 isoform X1 [KO:K23080]
117867412  CASTOR2; cytosolic arginine sensor for mTORC1 subunit 2 [KO:K23081]
117872245  MIOS; GATOR complex protein MIOS [KO:K20407]
117884026  WDR24; GATOR complex protein WDR24 [KO:K20408]
117886697  WDR59; GATOR complex protein WDR59 isoform X1 [KO:K20409]
117880807  SEC13; protein SEC13 homolog [KO:K14004]
117887892  DEPDC5; GATOR complex protein DEPDC5 isoform X1 [KO:K20404]
117880133  NPRL2; GATOR complex protein NPRL2 [KO:K20405]
117883606  NPRL3; GATOR complex protein NPRL3 isoform X1 [KO:K20406]
117879165  SKP2; S-phase kinase-associated protein 2 [KO:K03875]
117873069  RNF152; E3 ubiquitin-protein ligase RNF152 [KO:K15705] [EC:2.3.2.27]
117887235  RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
117867798  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
117873777  DEPTOR; DEP domain-containing mTOR-interacting protein isoform X1 [KO:K20402]
117873919  DEP domain-containing mTOR-interacting protein isoform X1 [KO:K20402]
117885347  DEP domain-containing mTOR-interacting protein-like isoform X1 [KO:K20402]
117883816  MLST8; target of rapamycin complex subunit LST8 [KO:K08266]
117884097  TELO2; telomere length regulation protein TEL2 homolog isoform X1 [KO:K11137]
117886050  TTI1; TELO2-interacting protein 1 homolog isoform X1 [KO:K20403]
117888124  CLIP1; CAP-Gly domain-containing linker protein 1 isoform X1 [KO:K10421]
117872655  GRB10; growth factor receptor-bound protein 10 isoform X1 [KO:K20064]
117875309  LPIN1; phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
117873381  LPIN2; phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
117886314  LPIN3; phosphatidate phosphatase LPIN3 [KO:K15728] [EC:3.1.3.4]
117887991  ULK1; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
117867736  ULK2; serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
117873012  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
117881759  EIF4E1B; eukaryotic translation initiation factor 4E type 1B isoform X1 [KO:K03259]
117882773  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
117878011  EIF4E; eukaryotic translation initiation factor 4E isoform X1 [KO:K03259]
117867436  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
117876021  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
117888450  EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
117878914  RPS6; 40S ribosomal protein S6 [KO:K02991]
117869272  STRADA; STE20-related kinase adapter protein alpha [KO:K08271]
117884822  STRADB; STE20-related kinase adapter protein beta [KO:K17532]
117868836  STK11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
117882609  CAB39; calcium-binding protein 39 [KO:K08272]
117870978  CAB39L; calcium-binding protein 39-like [KO:K08272]
117881783  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
117878857  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
117867206  TSC1; hamartin isoform X1 [KO:K07206]
117883582  TSC2; tuberin isoform X1 [KO:K07207]
117873209  TBC1 domain family member 7 isoform X1 [KO:K20396]
117872015  RHEB; GTP-binding protein Rheb isoform X1 [KO:K07208]
117880751  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
117888985  WNT1; proto-oncogene Wnt-1 [KO:K03209]
117876570  WNT2; protein Wnt-2 [KO:K00182]
117877465  WNT2B; protein Wnt-2b isoform X1 [KO:K00182]
117869225  WNT3; LOW QUALITY PROTEIN: proto-oncogene Wnt-3 [KO:K00312]
117871505  WNT3A; protein Wnt-3a [KO:K00312]
117867890  WNT4; protein Wnt-4 isoform X1 [KO:K00408]
117875404  protein Wnt-4-like [KO:K00408]
117880460  WNT5A; protein Wnt-5a [KO:K00444]
117882521  WNT5B; protein Wnt-5b isoform X1 [KO:K00444]
117880932  WNT7A; protein Wnt-7a isoform X1 [KO:K00572]
117870798  WNT7B; protein Wnt-7b isoform X1 [KO:K00572]
117880363  WNT8B; protein Wnt-8b [KO:K00714]
117881833  WNT8A; protein Wnt-8a [KO:K00714]
117869345  WNT9B; protein Wnt-9b [KO:K01064]
117871930  WNT9A; protein Wnt-9a [KO:K01064]
117884911  WNT10A; protein Wnt-10a [KO:K01357]
117883276  protein Wnt-11b-like [KO:K01384]
117871303  WNT11; protein Wnt-11 isoform X1 [KO:K01384]
117876404  WNT16; protein Wnt-16 [KO:K01558]
117872193  FZD1; frizzled-1 [KO:K02432]
117884988  FZD7; frizzled-7 [KO:K02432]
117869169  FZD2; frizzled-2 [KO:K02235]
117875422  FZD3; frizzled-3 [KO:K02329]
117871237  FZD4; frizzled-4 isoform X1 [KO:K02354]
117872066  FZD8; frizzled-8 [KO:K02375]
117885201  FZD5; frizzled-5 [KO:K02375]
117873731  FZD6; frizzled-6 isoform X1 [KO:K02376]
117867605  FZD9; frizzled-9 [KO:K02842]
117888298  FZD10; frizzled-10 [KO:K02842]
117877339  LRP5; low-density lipoprotein receptor-related protein 5 isoform X1 [KO:K03068]
117884177  LRP6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068]
117867885  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
117882795  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
117886617  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
117886471  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
117873054  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
117876752  INS; insulin [KO:K04526]
117881442  IGF1; insulin-like growth factor I [KO:K05459]
117869064  insulin receptor-like isoform X1 [KO:K04527] [EC:2.7.10.1]
117884524  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
117887352  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
117874155  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
117876099  SOS2; son of sevenless homolog 2 [KO:K03099]
117877347  HRAS; GTPase HRas [KO:K02833]
117883516  KRAS; GTPase KRas isoform X1 [KO:K07827]
117875723  NRAS; GTPase NRas [KO:K07828]
117881799  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
117879804  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
117883780  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
117868754  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
117887996  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
117868249  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
117874768  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
117869024  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
117882584  ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
117882685  IRS1; insulin receptor substrate 1 [KO:K16172]
117881251  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
117868848  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
117879552  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
117867910  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
117882413  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
117882483  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
117880573  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
117883619  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
117874665  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
117888624  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
117876213  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
117879818  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
117889445  MAPKAP1; target of rapamycin complex 2 subunit MAPKAP1 isoform X1 [KO:K20410]
117879625  RICTOR; rapamycin-insensitive companion of mTOR isoform X1 [KO:K08267]
117883936  PRR5; proline-rich protein 5 isoform X1 [KO:K20411]
117877002  PRR5L; proline-rich protein 5-like isoform X1 [KO:K20411]
117880295  RHOA; transforming protein RhoA [KO:K04513]
117888631  transforming protein RhoA-like [KO:K04513]
117887796  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
117884391  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
117870501  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
117874915  serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
tst00561  Glycerolipid metabolism
tst04010  MAPK signaling pathway
tst04140  Autophagy - animal
tst04810  Regulation of actin cytoskeleton
tst04910  Insulin signaling pathway
KO pathway
ko04150   
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