KEGG   PATHWAY: tst04010
Entry
tst04010                    Pathway                                
Name
MAPK signaling pathway - Trachemys scripta elegans (red-eared slider)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
tst04010  MAPK signaling pathway
tst04010

Other DBs
GO: 0000165
Organism
Trachemys scripta elegans (red-eared slider) [GN:tst]
Gene
117888655  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
117889392  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
117882551  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
117880097  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
117881590  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
117887252  voltage-dependent T-type calcium channel subunit alpha-1G-like isoform X1 [KO:K04854]
117883762  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
117887606  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
117874908  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
117880201  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 [KO:K04859]
117880385  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
117871167  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
117869289  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
117872151  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
117889270  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
117884730  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
117887626  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
117880921  CACNG2; voltage-dependent calcium channel gamma-2 subunit isoform X1 [KO:K04867]
117884531  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
117887797  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
117887801  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
117870516  CACNG7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
117881601  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
117888473  cAMP-dependent protein kinase catalytic subunit alpha-like isoform X1 [KO:K04345] [EC:2.7.11.11]
117888475  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
117888815  cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
117889034  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
117887796  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
117884391  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
117870501  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
117884213  GNA12; guanine nucleotide-binding protein subunit alpha-12 isoform X1 [KO:K04346]
117881648  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
117877677  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
117872970  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
117880030  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
117874287  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
117884208  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
117879128  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
117876677  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
117880418  RASGRP2; LOW QUALITY PROTEIN: RAS guanyl-releasing protein 2 [KO:K12361]
117874607  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
117889121  RASGRP4; RAS guanyl-releasing protein 4 [KO:K12363]
117878482  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
117867477  NF1; neurofibromin isoform X1 [KO:K08052]
117879624  RASA1; ras GTPase-activating protein 1 [KO:K04352]
117882775  RASA2; ras GTPase-activating protein 2 [KO:K08053]
117877457  RAP1A; ras-related protein Rap-1A [KO:K04353]
117877671  RAP1B; ras-related protein Rap-1b [KO:K07836]
117877887  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
117872910  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
117878185  EREG; proepiregulin [KO:K09784]
117878338  AREG; amphiregulin [KO:K09782]
117881750  FGF1; fibroblast growth factor 1 [KO:K18496]
117880942  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
117868913  FGF22; fibroblast growth factor 22 [KO:K04358]
117882261  FGF18; fibroblast growth factor 18 [KO:K04358]
117876951  FGF3; fibroblast growth factor 3 [KO:K04358]
117876981  FGF4; fibroblast growth factor 4 [KO:K04358]
117882928  FGF16; fibroblast growth factor 16 [KO:K04358]
117870827  FGF6; fibroblast growth factor 6 [KO:K04358]
117871110  FGF9; fibroblast growth factor 9 [KO:K04358]
117871601  FGF17; fibroblast growth factor 17 [KO:K04358]
117884072  FGF7; fibroblast growth factor 7 [KO:K04358]
117878329  FGF5; fibroblast growth factor 5 [KO:K04358]
117878330  FGF20; fibroblast growth factor 20 [KO:K04358]
117879538  FGF10; fibroblast growth factor 10 [KO:K04358]
117877429  FGF19; fibroblast growth factor 19 [KO:K22603]
117888433  FGF21; fibroblast growth factor 21 [KO:K22429]
117884568  FGF23; fibroblast growth factor 23 [KO:K22428]
117875734  NGF; beta-nerve growth factor [KO:K02582]
117877165  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
117884438  NTF3; neurotrophin-3 isoform X1 [KO:K04356]
117876752  INS; insulin [KO:K04526]
117881442  IGF1; insulin-like growth factor I [KO:K05459]
117877300  IGF2; insulin-like growth factor II [KO:K13769]
117883612  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
117880268  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
117871165  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
117877938  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
117875945  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
117878304  KITLG; kit ligand [KO:K05461]
117874588  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
117880839  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K05448]
117876640  PGF; placenta growth factor [KO:K16859]
117888750  snake venom vascular endothelial growth factor toxin ICPP-like [KO:K16859]
117869520  VEGFD; vascular endothelial growth factor D [KO:K05449]
117878402  VEGFC; vascular endothelial growth factor C isoform X1 [KO:K05449]
117874925  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
117873748  ANGPT1; angiopoietin-1 [KO:K05465]
117868219  angiopoietin-2-like isoform X1 [KO:K05466]
117875244  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
117885852  ANGPT4; angiopoietin-4 [KO:K05467]
117868955  EFNA2; ephrin-A2 [KO:K05462]
117888551  EFNA1; ephrin-A1 isoform X1 [KO:K05462]
117888903  EFNA3; ephrin-A3 [KO:K05462]
117888904  EFNA4; ephrin-A4 [KO:K05462]
117879568  GDNF; glial cell line-derived neurotrophic factor [KO:K05452]
117869011  NRTN; neurturin isoform X1 [KO:K25414]
117872619  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
117869182  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
117888990  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
117885003  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
117873025  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
117879776  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
117878458  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
117869333  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
117871922  tumor necrosis factor receptor superfamily member 16-like [KO:K02583]
117869852  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
117879171  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
117869064  insulin receptor-like isoform X1 [KO:K04527] [EC:2.7.10.1]
117884524  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
117878037  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
117881201  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
117878405  KIT; mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
117871082  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
117882473  vascular endothelial growth factor receptor kdr-like isoform X1 [KO:K05096] [EC:2.7.10.1]
117871080  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
117881465  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
117877988  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
117876645  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
117879039  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
117867897  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
117880563  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
117887352  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
117874155  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
117876099  SOS2; son of sevenless homolog 2 [KO:K03099]
117877347  HRAS; GTPase HRas [KO:K02833]
117883516  KRAS; GTPase KRas isoform X1 [KO:K07827]
117875723  NRAS; GTPase NRas [KO:K07828]
117877223  RRAS2; ras-related protein R-Ras2 [KO:K07830]
117884867  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
117881799  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
117879804  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
117883780  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
117868754  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
117877772  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
117887996  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
117868751  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
117881551  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
117868249  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
117874768  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
117869024  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
117882584  ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
117880204  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
117875781  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
117873814  MYC; myc proto-oncogene protein isoform X1 [KO:K04377]
117874152  SRF; serum response factor isoform X1 [KO:K04378]
117876830  FOS; proto-oncogene c-Fos [KO:K04379]
117869222  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
117868334  STMN1; stathmin [KO:K04381]
117881822  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
117876138  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
117876140  LOW QUALITY PROTEIN: cytosolic phospholipase A2 zeta-like [KO:K16342] [EC:3.1.1.4]
117876435  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
117876466  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
117876480  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
117870301  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
117876773  cytosolic phospholipase A2 beta-like isoform X1 [KO:K16342] [EC:3.1.1.4]
117877180  cytosolic phospholipase A2 zeta-like [KO:K16342] [EC:3.1.1.4]
117877371  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
117885909  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
117886015  LOW QUALITY PROTEIN: cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
117886016  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
117886341  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
117872809  interleukin-1 receptor antagonist protein-like [KO:K04519]
117872810  interleukin-1 beta-like [KO:K04519]
117874463  TGFB2; transforming growth factor beta-2 proprotein [KO:K13376]
117876373  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
117886471  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
117870720  interleukin-1 receptor type 1-like isoform X1 [KO:K04386]
117870722  interleukin-1 receptor-like 2 [KO:K04386]
117882923  IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
117872704  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
117872410  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
117885102  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
117882288  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
117880159  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
117883776  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
117880762  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
117867802  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
117886375  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
117877835  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
117867260  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
117871992  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
117877089  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
117877000  TRAF6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
117868995  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
117882130  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
117879556  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
117880237  TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
117874855  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
117874156  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 [KO:K04406] [EC:2.7.11.1]
117882614  NRK; nik-related protein kinase [KO:K04407] [EC:2.7.11.1]
117870718  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
117888691  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 [KO:K04408] [EC:2.7.11.1]
117871281  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
117882800  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
117885822  STK4; serine/threonine-protein kinase 4 [KO:K04411]
117873700  STK3; serine/threonine-protein kinase 3 isoform X1 [KO:K04412]
117880318  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
117872092  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
117878807  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
117880530  MAP3K11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
117884687  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
117869137  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
117871989  mitogen-activated protein kinase kinase kinase 3-like isoform X1 [KO:K04421] [EC:2.7.11.25]
117877194  MAP3K9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
117874706  MAP3K21; mitogen-activated protein kinase kinase kinase 21 isoform X1 [KO:K17534] [EC:2.7.11.25]
117889154  MAP3K12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
117882518  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
117884729  MAP3K20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
117868305  MAP3K6; mitogen-activated protein kinase kinase kinase 6 isoform X1 [KO:K04425] [EC:2.7.11.25]
117874903  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
117875099  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
117874783  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
117867440  TAOK1; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
117888020  TAOK3; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
117887611  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
117888469  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
117883675  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
117887377  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
117876949  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 [KO:K04434]
117873460  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
117883525  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
117867301  CRK; adapter molecule crk isoform X1 [KO:K04438]
117888021  CRKL; crk-like protein [KO:K04438]
117871390  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
117882136  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
117877876  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
117879770  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
117875889  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
117875891  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
117876012  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
117876024  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
117888017  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
117875763  MAPKAPK2; MAP kinase-activated protein kinase 2 isoform X1 [KO:K04443] [EC:2.7.11.1]
117880785  MAPKAPK3; MAP kinase-activated protein kinase 3 isoform X1 [KO:K04444] [EC:2.7.11.1]
117876191  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
117880461  RPS6KA4; ribosomal protein S6 kinase alpha-4 [KO:K16510] [EC:2.7.11.1]
117877866  CDC25B; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
117873284  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
117886489  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
117881919  JUN; transcription factor AP-1 [KO:K04448]
117884769  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
117873113  MAX; protein max isoform X1 [KO:K04453]
117878793  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
117867659  HSPB1; heat shock protein beta-1 [KO:K04455]
117874665  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
117888624  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
117876213  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
117876094  PPM1A; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
117888725  PPM1N; probable protein phosphatase 1N [KO:K04457] [EC:3.1.3.16]
117877860  PTPRR; receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
117877276  tyrosine-protein phosphatase non-receptor type 5-like isoform X1 [KO:K18018] [EC:3.1.3.48]
117875964  PTPN7; tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
117881879  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
117880365  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
117880516  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
117877319  DUSP8; dual specificity protein phosphatase 8 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
117884202  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
117878172  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
117872860  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
117878317  DUSP6; dual specificity protein phosphatase 6 isoform X1 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
117874477  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
117880856  dual specificity protein phosphatase 10-like [KO:K20216] [EC:3.1.3.16 3.1.3.48]
117869371  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
117888690  serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
117874379  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
117868401  heat shock 70 kDa protein II-like [KO:K03283]
117868559  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
117869752  heat shock 70 kDa protein 1A-like [KO:K03283]
117883099  MECOM; histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
117884537  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
117876618  MAPK7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
117888763  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
117869188  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
117879818  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
117873054  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
117867459  NLK; serine/threonine-protein kinase NLK isoform X1 [KO:K04468] [EC:2.7.11.24]
117878027  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
117880223  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
117880425  RELA; LOW QUALITY PROTEIN: transcription factor p65 [KO:K04735]
117889245  RELB; transcription factor RelB isoform X1 [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
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MAP kinases.
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Chem Rev 101:2449-76 (2001)
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Pharmacol Ther 93:193-202 (2002)
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Reference
PMID:12947395
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Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
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MAPK pathways in radiation responses.
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Oncogene 22:5885-96 (2003)
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Reference
PMID:12676795
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Huang EJ, Reichardt LF.
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Trk receptors: roles in neuronal signal transduction.
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Annu Rev Biochem 72:609-42 (2003)
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Reference
PMID:11369511
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Harper SJ, LoGrasso P.
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Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
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Cell Signal 13:299-310 (2001)
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Reference
PMID:12390245
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Takeda K, Ichijo H
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Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
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Genes Cells 7:1099-111 (2002)
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PMID:14597384
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Yang SH, Sharrocks AD, Whitmarsh AJ.
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Transcriptional regulation by the MAP kinase signaling cascades.
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Gene 320:3-21 (2003)
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Reference
PMID:12566928
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Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
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The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
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Neurosignals 11:270-81 (2002)
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Reference
PMID:12849693
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Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
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Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
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PMID:20602996
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Lemmon MA, Schlessinger J
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Cell signaling by receptor tyrosine kinases.
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Cell 141:1117-34 (2010)
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PMID:22367796
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Skaper SD
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The neurotrophin family of neurotrophic factors: an overview.
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Methods Mol Biol 846:1-12 (2012)
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Chu WM
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Tumor necrosis factor.
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Cancer Lett 328:222-5 (2013)
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Reference
PMID:22296764
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Newton K, Dixit VM
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Signaling in innate immunity and inflammation.
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Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
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Gaestel M, Kotlyarov A, Kracht M
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Targeting innate immunity protein kinase signalling in inflammation.
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Nat Rev Drug Discov 8:480-99 (2009)
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Reference
PMID:23664135
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Ajibade AA, Wang HY, Wang RF
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Cell type-specific function of TAK1 in innate immune signaling.
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Trends Immunol 34:307-16 (2013)
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Reference
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Turner MD, Nedjai B, Hurst T, Pennington DJ
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Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
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Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
tst04070  Phosphatidylinositol signaling system
tst04110  Cell cycle
tst04115  p53 signaling pathway
tst04210  Apoptosis
tst04310  Wnt signaling pathway
KO pathway
ko04010   
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