KEGG   PATHWAY: umr04810
Entry
umr04810                    Pathway                                
Name
Regulation of actin cytoskeleton - Ursus maritimus (polar bear)
Class
Cellular Processes; Cell motility
Pathway map
umr04810  Regulation of actin cytoskeleton
umr04810

Other DBs
GO: 0030036
Organism
Ursus maritimus (polar bear) [GN:umr]
Gene
103656231  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
103656511  ITGB1; integrin beta-1 [KO:K05719]
103656923  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
103656938  PIP4K2C; phosphatidylinositol 5-phosphate 4-kinase type-2 gamma [KO:K00920] [EC:2.7.1.149]
103657074  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
103657101  FGF21; fibroblast growth factor 21 [KO:K22429]
103657130  RRAS; ras-related protein R-Ras isoform X2 [KO:K07829]
103657269  MYH14; myosin-14 [KO:K10352]
103657535  ARHGEF7; rho guanine nucleotide exchange factor 7 isoform X2 [KO:K13710]
103657720  [KO:K12329]
103657721  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
103657802  FGFR2; LOW QUALITY PROTEIN: fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
103657827  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
103657856  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
103657863  ITGAL; integrin alpha-L isoform X1 [KO:K05718]
103657890  ITGAM; integrin alpha-M isoform X1 [KO:K06461]
103657891  [KO:K06462]
103657892  [KO:K06594]
103658054  PDGFC; platelet-derived growth factor C isoform X2 [KO:K05450]
103658181  DOCK1; LOW QUALITY PROTEIN: dedicator of cytokinesis protein 1 [KO:K13708]
103658858  ITGB8; integrin beta-8 [KO:K06591]
103658995  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
103659029  SCIN; adseverin [KO:K05768]
103659146  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
103659497  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
103659636  ITGA4; integrin alpha-4 [KO:K06483]
103659655  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
103659768  ABI2; abl interactor 2 isoform X1 [KO:K05751]
103659810  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase [KO:K00921] [EC:2.7.1.150]
103659892  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
103659920  NCKAP1; nck-associated protein 1 [KO:K05750]
103660117  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.39]
103660204  IQGAP1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
103660338  PFN1; profilin-1 [KO:K05759]
103660494  MYH10; myosin-10 [KO:K10352]
103660847  EZR; ezrin isoform X2 [KO:K08007]
103660934  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
103660962  ITGA3; LOW QUALITY PROTEIN: integrin alpha-3 [KO:K06482]
103661038  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103661071  ACTN4; alpha-actinin-4 [KO:K05699]
103661079  PAK4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
103661171  ARPC3; actin-related protein 2/3 complex subunit 3 isoform X1 [KO:K05756]
103661240  PIP4K2B; phosphatidylinositol 5-phosphate 4-kinase type-2 beta isoform X1 [KO:K00920] [EC:2.7.1.149]
103661277  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
103661279  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
103661694  CYRIB; CYFIP-related Rac1 interactor B isoform X4 [KO:K27976]
103661742  EGF; pro-epidermal growth factor isoform X2 [KO:K04357]
103661850  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
103662000  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
103662115  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
103662411  RDX; radixin isoform X1 [KO:K05762]
103662491  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
103662543  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
103662651  [KO:K12757]
103662658  [KO:K12757]
103662770  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
103662788  FN1; fibronectin isoform X1 [KO:K05717]
103662842  ROCK1; rho-associated protein kinase 1 isoform X3 [KO:K04514] [EC:2.7.11.39]
103663028  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
103663244  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
103663299  FGD3; FYVE, RhoGEF and PH domain-containing protein 3 [KO:K05722]
103663617  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [KO:K02649]
103663709  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
103663724  DIAPH1; protein diaphanous homolog 1 isoform X1 [KO:K05740]
103663860  IQGAP2; ras GTPase-activating-like protein IQGAP2 [KO:K05767]
103664233  PIP4K2A; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform X1 [KO:K00920] [EC:2.7.1.149]
103664242  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
103664255  ARHGEF4; rho guanine nucleotide exchange factor 4 [KO:K05769]
103664292  FGF9; fibroblast growth factor 9 [KO:K04358]
103664348  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
103664394  SPATA13; spermatogenesis-associated protein 13 isoform X1 [KO:K05769]
103664443  PFN3; LOW QUALITY PROTEIN: profilin-3 [KO:K05759]
103664454  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
103664541  CYFIP2; cytoplasmic FMR1-interacting protein 2 isoform X1 [KO:K05749]
103664600  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
103664633  ITGA2; integrin alpha-2 [KO:K06481]
103664645  FGF10; fibroblast growth factor 10 [KO:K04358]
103664673  C6; complement component C6 [KO:K03995]
103664674  C7; complement component C7 [KO:K03996]
103664686  C9; complement component C9 [KO:K04000]
103664781  FGF18; fibroblast growth factor 18 [KO:K04358]
103664837  ITGA1; integrin alpha-1 isoform X1 [KO:K06480]
103665161  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
103665244  KRAS; GTPase KRas isoform X1 [KO:K07827]
103665349  FGF5; fibroblast growth factor 5 [KO:K04358]
103665409  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
103665592  ITGA2B; integrin alpha-IIb [KO:K06476]
103665670  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
103665746  ITGB4; integrin beta-4 [KO:K06525]
103665813  ACTG1; actin, cytoplasmic 2 [KO:K05692]
103665892  ITGB3; integrin beta-3 [KO:K06493]
103665984  BAIAP2; brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X1 [KO:K05627]
103666008  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
103666200  CFL2; cofilin-2 [KO:K05765]
103666501  WASF2; wiskott-Aldrich syndrome protein family member 2 [KO:K05748]
103666507  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
103666578  CDC42; cell division control protein 42 homolog [KO:K04393]
103666688  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103666874  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
103667204  SSH2; LOW QUALITY PROTEIN: protein phosphatase Slingshot homolog 2 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
103667372  ITGAE; integrin alpha-E [KO:K06524]
103667399  GIT1; ARF GTPase-activating protein GIT1 [KO:K05737]
103667518  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
103667655  ACTR3; actin-related protein 3 [KO:K18584]
103667676  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
103667838  VCL; vinculin isoform X2 [KO:K05700]
103667923  CXCL12; stromal cell-derived factor 1 [KO:K10031]
103668676  INSRR; insulin receptor-related protein [KO:K05086] [EC:2.7.10.1]
103668684  IQGAP3; ras GTPase-activating-like protein IQGAP3 [KO:K05767]
103668838  MYH11; myosin-11 [KO:K10352]
103669054  CHRM2; LOW QUALITY PROTEIN: muscarinic acetylcholine receptor M2 [KO:K04130]
103669072  ENAH; protein enabled homolog isoform X1 [KO:K05746]
103669103  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
103669173  [KO:K02833]
103669230  CRKL; crk-like protein [KO:K04438]
103669286  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
103669422  NRAS; GTPase NRas [KO:K07828]
103669540  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
103669563  BRK1; protein BRICK1 [KO:K05752]
103669571  ARPC4; LOW QUALITY PROTEIN: actin-related protein 2/3 complex subunit 4 [KO:K05755]
103669660  BDKRB2; B2 bradykinin receptor [KO:K03916]
103669776  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
103669791  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
103669942  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
103669983  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
103669984  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
103670054  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
103670086  ACTB; actin, cytoplasmic 1 [KO:K05692]
103670095  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
103670201  MYL10; myosin regulatory light chain 10 [KO:K12756]
103670230  LIMK1; LIM domain kinase 1 isoform X1 [KO:K05743] [EC:2.7.11.1]
103670326  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
103670367  GSN; gelsolin isoform X2 [KO:K05768]
103670372  C5; complement C5 [KO:K03994]
103670589  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
103670671  C8B; complement component C8 beta chain [KO:K03998]
103670672  C8A; complement component C8 alpha chain [KO:K03997]
103670766  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
103671035  HRAS; GTPase HRas isoform X3 [KO:K02833]
103671137  FGF3; fibroblast growth factor 3 [KO:K04358]
103671138  FGF19; fibroblast growth factor 19 [KO:K22603]
103671689  PFN4; profilin-4 [KO:K05759]
103671723  CYRIA; CYFIP-related Rac1 interactor A [KO:K27976]
103671799  ACTR2; actin-related protein 2 [KO:K17260]
103671891  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
103671909  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
103672390  F2; prothrombin [KO:K01313] [EC:3.4.21.5]
103672391  CHRM4; muscarinic acetylcholine receptor M4 [KO:K04132]
103672410  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
103672737  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
103672855  ARHGEF6; rho guanine nucleotide exchange factor 6 isoform X1 [KO:K05729]
103673016  DIAPH2; protein diaphanous homolog 2 isoform X1 [KO:K05741]
103673212  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
103673325  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
103673502  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
103673553  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
103673646  BDKRB1; B1 bradykinin receptor [KO:K03915]
103673818  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
103674291  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
103674343  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
103674429  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
103674660  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
103674685  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
103674825  RHOA; transforming protein RhoA [KO:K04513]
103675138  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
103675162  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
103675192  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
103675247  C8G; complement component C8 gamma chain [KO:K03999]
103675566  NCKAP1L; nck-associated protein 1-like [KO:K05750]
103675667  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
103675680  ITGA5; integrin alpha-5 isoform X1 [KO:K06484]
103675745  FGF23; fibroblast growth factor 23 [KO:K22428]
103675746  FGF6; fibroblast growth factor 6 [KO:K04358]
103675797  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
103675824  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
103675826  FGF16; fibroblast growth factor 16 [KO:K04358]
103676052  KNG1; kininogen-1 isoform X1 [KO:K03898]
103676125  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
103676407  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
103676520  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
103676552  MYH9; LOW QUALITY PROTEIN: myosin-9 [KO:K10352]
103676615  WASL; neural Wiskott-Aldrich syndrome protein isoform X1 [KO:K23612]
103676724  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
103676847  MYL5; myosin light chain 5 [KO:K12753]
103676878  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103676958  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
103677004  WASF1; wiskott-Aldrich syndrome protein family member 1 [KO:K05753]
103677091  CYFIP1; cytoplasmic FMR1-interacting protein 1 isoform X1 [KO:K05749]
103677504  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
103677560  RGCC; regulator of cell cycle RGCC [KO:K26108]
103677666  DIAPH3; protein diaphanous homolog 3 isoform X1 [KO:K05745]
103677944  PFN2; profilin-2 isoform X1 [KO:K05759]
103678069  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
103678244  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
103678302  SSH1; protein phosphatase Slingshot homolog 1 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
103678355  PXN; paxillin isoform X1 [KO:K05760]
103678405  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
103678568  LPAR1; LOW QUALITY PROTEIN: lysophosphatidic acid receptor 1 [KO:K04289]
103678592  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
103678665  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
103678821  ITGB5; integrin beta-5 isoform X1 [KO:K06588]
103678824  MYLK; myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
103678928  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
103679064  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
103679149  ITGA11; integrin alpha-11 [KO:K06587]
103679469  CFL1; cofilin-1 [KO:K05765]
103679510  SSH3; protein phosphatase Slingshot homolog 3 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
103679611  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
103679739  PAK3; serine/threonine-protein kinase PAK 3 [KO:K05733] [EC:2.7.11.1]
103679942  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
103680187  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
103680310  PPP1R12C; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
103680739  ITGB2; integrin beta-2 [KO:K06464]
103680775  ITGA9; integrin alpha-9 isoform X1 [KO:K06585]
103680852  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
103681084  LIMK2; LIM domain kinase 2 isoform X2 [KO:K05744] [EC:2.7.11.1]
103681143  MSN; moesin [KO:K05763]
103681297  FGD1; FYVE, RhoGEF and PH domain-containing protein 1 [KO:K05720]
103681372  FGF20; fibroblast growth factor 20 [KO:K04358]
103681386  [KO:K05759]
103681714  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
103681784  APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
103681825  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
103681834  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
103682158  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 isoform X1 [KO:K04347]
103682372  RRAS2; LOW QUALITY PROTEIN: ras-related protein R-Ras2 [KO:K07830]
121099769  INS; insulin [KO:K04526]
121099774  TMSB4X; thymosin beta-4 [KO:K05764]
121102598  FGF22; fibroblast growth factor 22 [KO:K04358]
121104719  FGF4; fibroblast growth factor 4 [KO:K04358]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
umr04010  MAPK signaling pathway
umr04510  Focal adhesion
umr04520  Adherens junction
KO pathway
ko04810   

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