KEGG   PATHWAY: xla04070
Entry
xla04070                    Pathway                                
Name
Phosphatidylinositol signaling system - Xenopus laevis (African clawed frog)
Class
Environmental Information Processing; Signal transduction
Pathway map
xla04070  Phosphatidylinositol signaling system
xla04070

Organism
Xenopus laevis (African clawed frog) [GN:xla]
Gene
100036841  pip4k2b.S; phosphatidylinositol-5-phosphate 4-kinase, type II, beta S homeolog [KO:K00920] [EC:2.7.1.149]
100137651  impa2.L; inositol(myo)-1(or 4)-monophosphatase 2 L homeolog [KO:K01092] [EC:3.1.3.25]
100158362  pi4k2a.L; phosphatidylinositol 4-kinase type 2-alpha [KO:K13711] [EC:2.7.1.67]
100380949  pik3c2a.L; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha [KO:K00923] [EC:2.7.1.154]
100380968  synj1.S; synaptojanin-1 isoform X3 [KO:K20279] [EC:3.1.3.36]
100380983  dgka.S; diacylglycerol kinase alpha [KO:K00901] [EC:2.7.1.107]
100381066  inpp5b.L; type II inositol 1,4,5-trisphosphate 5-phosphatase isoform X1 [KO:K01099] [EC:3.1.3.36]
100505440  pten.S; uncharacterized protein LOC100505440 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
100653493  pip5k1a.S; uncharacterized protein LOC100653493 [KO:K00889] [EC:2.7.1.68]
100873161  ocrl.L; inositol polyphosphate 5-phosphatase OCRL isoform X1 [KO:K01099] [EC:3.1.3.36]
108695381  pip4p2.S; type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase isoform X1 [KO:K13084] [EC:3.1.3.78]
108695594  impa2.S; inositol monophosphatase 2 [KO:K01092] [EC:3.1.3.25]
108696021  inpp5f.L; phosphatidylinositide phosphatase SAC2 [KO:K21798] [EC:3.1.3.-]
108696106  inpp5a.1.L; inositol polyphosphate-5-phosphatase A isoform X2 [KO:K01106] [EC:3.1.3.56]
108696196  [KO:K05860] [EC:3.1.4.11]
108696776  [KO:K19663] [EC:2.7.11.13]
108697196  [KO:K05860] [EC:3.1.4.11]
108697359  ipmk.S; inositol polyphosphate multikinase [KO:K00915] [EC:2.7.1.140 2.7.1.151]
108697820  [KO:K19663] [EC:2.7.11.13]
108698190  [KO:K20278] [EC:3.1.3.36]
108698262  dgkk.L; diacylglycerol kinase eta isoform X1 [KO:K00901] [EC:2.7.1.107]
108698315  [KO:K15909] [EC:3.1.3.86]
108698369  [KO:K18083] [EC:3.1.3.64 3.1.3.95]
108698426  mtm1.L; myotubularin-like isoform X1 [KO:K01108] [EC:3.1.3.64 3.1.3.95]
108698427  mtmr1.L; myotubularin-related protein 1 isoform X1 [KO:K18081] [EC:3.1.3.64 3.1.3.95]
108698621  mtmr7.L; myotubularin-related protein 7 [KO:K18083] [EC:3.1.3.64 3.1.3.95]
108698651  XB5961849.L; inositol-tetrakisphosphate 1-kinase [KO:K00913] [EC:2.7.1.159 2.7.1.134]
108698710  [KO:K02183]
108699206  itpka.L; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
108699254  plcb2.L; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
108699471  [KO:K00889] [EC:2.7.1.68]
108699497  [KO:K01109] [EC:3.1.3.66]
108699723  itpka.S; inositol-trisphosphate 3-kinase A isoform X1 [KO:K00911] [EC:2.7.1.127]
108700111  ocrl.S; inositol polyphosphate 5-phosphatase OCRL isoform X1 [KO:K01099] [EC:3.1.3.36]
108700127  mtmr1.S; myotubularin-related protein 1 isoform X1 [KO:K18081] [EC:3.1.3.64 3.1.3.95]
108700268  itpkc.S; LOW QUALITY PROTEIN: inositol-trisphosphate 3-kinase C-like [KO:K00911] [EC:2.7.1.127]
108700483  itpk1.S; inositol-tetrakisphosphate 1-kinase-like [KO:K00913] [EC:2.7.1.159 2.7.1.134]
108700620  pi4kb.S; phosphatidylinositol 4-kinase beta-like isoform X1 [KO:K19801] [EC:2.7.1.67]
108700676  XB5961849.S; inositol-tetrakisphosphate 1-kinase-like [KO:K00913] [EC:2.7.1.159 2.7.1.134]
108700851  plcd3.L; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 [KO:K05857] [EC:3.1.4.11]
108701013  dgke.L; diacylglycerol kinase epsilon isoform X1 [KO:K00901] [EC:2.7.1.107]
108701477  [KO:K00921] [EC:2.7.1.150]
108701647  [KO:K19662] [EC:2.7.11.13]
108702159  prkca.S; protein kinase C alpha type isoform X3 [KO:K02677] [EC:2.7.11.13]
108702553  plcd3.S; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X1 [KO:K05857] [EC:3.1.4.11]
108702812  [KO:K01116] [EC:3.1.4.11]
108702938  plcd4.S; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4-like [KO:K05857] [EC:3.1.4.11]
108703204  [KO:K19662] [EC:2.7.11.13]
108703719  dgkq.S; diacylglycerol kinase theta [KO:K00901] [EC:2.7.1.107]
108704339  [KO:K00901] [EC:2.7.1.107]
108704365  [KO:K01109] [EC:3.1.3.66]
108705035  [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
108705528  pik3c3.S; phosphatidylinositol 3-kinase catalytic subunit type 3-like isoform X1 [KO:K00914] [EC:2.7.1.137]
108706556  pi4k2b.S; phosphatidylinositol 4-kinase type 2-beta [KO:K13711] [EC:2.7.1.67]
108706606  [KO:K18083] [EC:3.1.3.64 3.1.3.95]
108706607  [KO:K18083] [EC:3.1.3.64 3.1.3.95]
108706884  pik3r2.S; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
108707045  pip4p1.S; type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase-like [KO:K13084] [EC:3.1.3.78]
108707541  [KO:K00901] [EC:2.7.1.107]
108707879  synj1.L; synaptojanin-1 isoform X3 [KO:K20279] [EC:3.1.3.36]
108708567  dgka.L; diacylglycerol kinase alpha isoform X3 [KO:K00901] [EC:2.7.1.107]
108708590  pip4k2c.L; phosphatidylinositol 5-phosphate 4-kinase type-2 gamma isoform X1 [KO:K00920] [EC:2.7.1.149]
108708714  mtmr6.L; myotubularin-related protein 6 [KO:K18083] [EC:3.1.3.64 3.1.3.95]
108708743  mtmr2.L; myotubularin-related protein 2 [KO:K18081] [EC:3.1.3.64 3.1.3.95]
108708768  inppl1.L; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 [KO:K15909] [EC:3.1.3.86]
108708909  [KO:K00923] [EC:2.7.1.154]
108709322  mtmr4.S; myotubularin-related protein 4-like isoform X1 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
108709441  [KO:K04960]
108709723  inpp4a.S; inositol polyphosphate-4-phosphatase type I A isoform X4 [KO:K01109] [EC:3.1.3.66]
108709786  [KO:K00901] [EC:2.7.1.107]
108710008  mtmr2.S; myotubularin-related protein 2 [KO:K18081] [EC:3.1.3.64 3.1.3.95]
108710178  [KO:K04959]
108711431  ppip5k1.L; inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X5 [KO:K13024] [EC:2.7.4.24]
108711508  calml4.L; calmodulin-like protein 4 isoform X1 [KO:K02183]
108711551  cds2.L; phosphatidate cytidylyltransferase 2 [KO:K00981] [EC:2.7.7.41]
108711571  cds1.L; phosphatidate cytidylyltransferase 1 isoform X1 [KO:K00981] [EC:2.7.7.41]
108712206  [KO:K00889] [EC:2.7.1.68]
108712247  [KO:K00901] [EC:2.7.1.107]
108712508  [KO:K00923] [EC:2.7.1.154]
108712764  cds2.S; phosphatidate cytidylyltransferase 2 [KO:K00981] [EC:2.7.7.41]
108712798  calml4.S; calmodulin-like protein 4 [KO:K02183]
108712873  ppip5k1.S; inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X1 [KO:K13024] [EC:2.7.4.24]
108713027  pik3r2.L; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
108713399  dgkq.L; diacylglycerol kinase theta [KO:K00901] [EC:2.7.1.107]
108713453  [KO:K00901] [EC:2.7.1.107]
108714087  plcg2.L; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
108714575  ippk.L; inositol-pentakisphosphate 2-kinase isoform X1 [KO:K10572] [EC:2.7.1.158]
108714625  [KO:K04958]
108715243  [KO:K00901] [EC:2.7.1.107]
108715313  pik3c2a.S; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha [KO:K00923] [EC:2.7.1.154]
108715809  ippk.S; inositol-pentakisphosphate 2-kinase [KO:K10572] [EC:2.7.1.158]
108715818  ip6k1.S; inositol hexakisphosphate kinase 1 [KO:K07756] [EC:2.7.4.21]
108716048  pi4ka.L; phosphatidylinositol 4-kinase alpha isoform X1 [KO:K00888] [EC:2.7.1.67]
108716399  plcb4.L; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X3 [KO:K05858] [EC:3.1.4.11]
108716400  [KO:K05858] [EC:3.1.4.11]
108716491  [KO:K00911] [EC:2.7.1.127]
108716710  synj2.L; synaptojanin-2-like isoform X1 [KO:K20279] [EC:3.1.3.36]
108717090  [KO:K00901] [EC:2.7.1.107]
108717120  pik3cb.L; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
108717684  [KO:K00911] [EC:2.7.1.127]
108718090  pik3ca.S; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
108718158  [KO:K00901] [EC:2.7.1.107]
108718174  inpp5d.S; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1-like [KO:K03084] [EC:3.1.3.86]
108718190  pik3cb.S; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
108718485  dgkb.L; diacylglycerol kinase beta isoform X1 [KO:K00901] [EC:2.7.1.107]
108718712  plcd1.L; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1 [KO:K05857] [EC:3.1.4.11]
108718800  pip4k2a.L; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform X1 [KO:K00920] [EC:2.7.1.149]
108719261  bpnt2.L; inositol monophosphatase 3-like isoform X1 [KO:K15759] [EC:3.1.3.7]
108719445  [KO:K01116] [EC:3.1.4.11]
108719677  dgkb.S; diacylglycerol kinase beta [KO:K00901] [EC:2.7.1.107]
108719811  plcd1.S; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1 [KO:K05857] [EC:3.1.4.11]
108719862  pip4k2a.S; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha [KO:K00920] [EC:2.7.1.149]
373752  pik3ca.L; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
379701  mtmr3.L; myotubularin related protein 3 homeolog L [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
379828  itpk1.L; inositol-tetrakisphosphate 1-kinase [KO:K00913] [EC:2.7.1.159 2.7.1.134]
379965  mtmr4.L; myotubularin-related protein 4 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
380327  impa1.L; inositol(myo)-1(or 4)-monophosphatase 1 L homeolog [KO:K01092] [EC:3.1.3.25]
380558  calm2.S; calmodulin-2 A [KO:K02183]
397692  plcb3.L; phospholipase C beta 3 L homeolog [KO:K05858] [EC:3.1.4.11]
398359  plcg1.L; phospholipase C gamma 1 L homeolog [KO:K01116] [EC:3.1.4.11]
398360  plcg1.S; phospholipase C gamma 1 S homeolog [KO:K01116] [EC:3.1.4.11]
398687  pip5k1c.S; phosphatidylinositol-4-phosphate 5-kinase, type I, gamma S homeolog [KO:K00889] [EC:2.7.1.68]
398838  inpp1.L; inositol polyphosphate-1-phosphatase L homeolog [KO:K01107] [EC:3.1.3.57]
399051  inpp5d.L; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 [KO:K03084] [EC:3.1.3.86]
399142  pten.L; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
399202  pik3r1.S; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
399254  itpr1.S; inositol 1,4,5-trisphosphate receptor type 1 S homeolog [KO:K04958]
399259  calm2.L; calmodulin-2 B [KO:K02183]
399394  pip4k2b.L; phosphatidylinositol-5-phosphate 4-kinase, type II, beta L homeolog [KO:K00920] [EC:2.7.1.149]
414458  bpnt2.S; inositol monophosphatase 3 [KO:K15759] [EC:3.1.3.7]
414725  MGC81124; uncharacterized protein LOC414725 [KO:K00999] [EC:2.7.8.11]
443837  cdipt.L; CDP-diacylglycerol--inositol 3-phosphatidyltransferase [KO:K00999] [EC:2.7.8.11]
443957  ip6k1.L; inositol hexaphosphate kinase 1 L homeolog [KO:K07756] [EC:2.7.4.21]
443964  pik3r1.L; phosphoinositide-3-kinase regulatory subunit 1 L homeolog [KO:K02649]
444238  pip5k1b.L; phosphatidylinositol-4-phosphate 5-kinase, type I, beta L homeolog [KO:K00889] [EC:2.7.1.68]
444446  pi4kb.L; phosphatidylinositol 4-kinase beta [KO:K19801] [EC:2.7.1.67]
444552  impa1.S; inositol(myo)-1(or 4)-monophosphatase 1 S homeolog [KO:K01092] [EC:3.1.3.25]
444578  sacm1l.L; phosphatidylinositol-3-phosphatase SAC1 isoform 1 [KO:K21797] [EC:3.1.3.-]
444642  ip6k2.S; inositol hexaphosphate kinase 2 S homeolog [KO:K07756] [EC:2.7.4.21]
445848  plcb4.S; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
446671  pik3c3.L; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
446720  pi4ka.S; phosphatidylinositol 4-kinase type 3 alpha [KO:K00888] [EC:2.7.1.67]
446786  pik3r3.S; phosphoinositide-3-kinase regulatory subunit 3 S homeolog [KO:K02649]
446885  pi4k2b.L; phosphatidylinositol 4-kinase type 2-beta [KO:K13711] [EC:2.7.1.67]
447031  prkca.L; protein kinase C, alpha L homeolog [KO:K02677] [EC:2.7.11.13]
447404  dgke.S; diacylglycerol kinase epsilon S homeolog [KO:K00901] [EC:2.7.1.107]
447532  inpp5a.1.S; inositol polyphosphate-5-phosphatase A S homeolog [KO:K01106] [EC:3.1.3.56]
447535  ipmk.L; inositol polyphosphate multikinase L homeolog [KO:K00915] [EC:2.7.1.140 2.7.1.151]
447594  pik3r3.L; phosphoinositide-3-kinase regulatory subunit 3 L homeolog [KO:K02649]
494749  mtmr3.S; myotubularin related protein 3 homeolog S [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
494834  pip4p1.L; type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase [KO:K13084] [EC:3.1.3.78]
494865  itpkc.L; inositol-trisphosphate 3-kinase C L homeolog [KO:K00911] [EC:2.7.1.127]
495012  ppip5k2.L; inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X1 [KO:K13024] [EC:2.7.4.24]
496028  pip4k2c.S; phosphatidylinositol 5-phosphate 4-kinase type-2 gamma [KO:K00920] [EC:2.7.1.149]
606721  calm1.S; calmodulin-1 [KO:K02183]
733258  plcb1.S; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
734343  pip4p2.L; type II phosphatidylinositol 4,5-bisphosphate 4-phosphatase [KO:K13084] [EC:3.1.3.78]
734460  mtm1.S; myotubularin [KO:K01108] [EC:3.1.3.64 3.1.3.95]
734645  inpp4a.L; inositol polyphosphate-4-phosphatase type I A L homeolog [KO:K01109] [EC:3.1.3.66]
734951  mtmr14.S; myotubularin related protein 14 S homeolog [KO:K18086] [EC:3.1.3.64 3.1.3.95]
735225  plcd4.L; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 [KO:K05857] [EC:3.1.4.11]
Compound
C00076  Calcium cation
C00137  myo-Inositol
C00269  CDP-diacylglycerol
C00416  Phosphatidate
C00641  1,2-Diacyl-sn-glycerol
C01177  Inositol 1-phosphate
C01194  1-Phosphatidyl-D-myo-inositol
C01204  Phytic acid
C01220  1D-myo-Inositol 1,4-bisphosphate
C01243  1D-myo-Inositol 1,3,4-trisphosphate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01272  1D-myo-Inositol 1,3,4,5-tetrakisphosphate
C01277  1-Phosphatidyl-1D-myo-inositol 4-phosphate
C01284  1D-myo-Inositol 1,3,4,5,6-pentakisphosphate
C03546  myo-Inositol 4-phosphate
C04006  1D-myo-Inositol 3-phosphate
C04062  D-myo-Inositol 1,3-bisphosphate
C04063  D-myo-Inositol 3,4-bisphosphate
C04477  1D-myo-Inositol 1,3,4,6-tetrakisphosphate
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11174  1-Diphosinositol pentakisphosphate
C11526  5-PP-InsP5
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
C11555  1D-myo-Inositol 1,4,5,6-tetrakisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C11557  1-Phosphatidyl-1D-myo-inositol 5-phosphate
C20690  1D-myo-Inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate
Reference
PMID:19580826
  Authors
Sasaki T, Takasuga S, Sasaki J, Kofuji S, Eguchi S, Yamazaki M, Suzuki A
  Title
Mammalian phosphoinositide kinases and phosphatases.
  Journal
Prog Lipid Res 48:307-43 (2009)
DOI:10.1016/j.plipres.2009.06.001
Reference
PMID:19439500
  Authors
Shears SB
  Title
Diphosphoinositol polyphosphates: metabolic messengers?
  Journal
Mol Pharmacol 76:236-52 (2009)
DOI:10.1124/mol.109.055897
Related
pathway
xla04020  Calcium signaling pathway
xla04144  Endocytosis
xla04510  Focal adhesion
KO pathway
ko04070   

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