KEGG   PATHWAY: zca04530
Entry
zca04530                    Pathway                                
Name
Tight junction - Zalophus californianus (California sea lion)
Description
Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
zca04530  Tight junction
zca04530

Other DBs
GO: 0005923
Organism
Zalophus californianus (California sea lion) [GN:zca]
Gene
113908051  LLGL2; LLGL scribble cell polarity complex component 2 isoform X1 [KO:K06094]
113908643  [KO:K04393]
113908764  [KO:K06109]
113908913  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
113909046  TJP1; LOW QUALITY PROTEIN: tight junction protein ZO-1 [KO:K05701]
113909120  MPP5; LOW QUALITY PROTEIN: MAGUK p55 subfamily member 5 [KO:K06091]
113909384  RAB8B; ras-related protein Rab-8B isoform X1 [KO:K07902]
113909537  CGNL1; cingulin-like protein 1 [KO:K21110]
113909600  [KO:K07839]
113909646  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
113909650  [KO:K05758]
113909752  [KO:K18584]
113910523  WHAMM; WASP homolog-associated protein with actin, membranes and microtubules [KO:K20479]
113910912  [KO:K05756]
113911393  [KO:K18584]
113911433  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
113911439  SCRIB; protein scribble homolog isoform X1 [KO:K16175]
113911454  CGN; cingulin isoform X1 [KO:K06102]
113911510  PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
113911709  CLDN12; claudin-12 [KO:K06087]
113911768  CFTR; cystic fibrosis transmembrane conductance regulator isoform X1 [KO:K05031] [EC:5.6.1.6]
113912428  NF2; merlin isoform X1 [KO:K16684]
113912439  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
113912440  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
113912551  [KO:K12757]
113912552  [KO:K12757]
113912639  [KO:K07200]
113912842  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
113913200  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
113913263  CLDN5; claudin-5 [KO:K06087]
113913271  PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 isoform X1 [KO:K07199]
113913797  RDX; radixin isoform X1 [KO:K05762]
113913854  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
113913990  DLG2; disks large homolog 2 isoform X1 [KO:K12075]
113914067  AMOTL1; angiomotin-like protein 1 isoform X1 [KO:K06104]
113914083  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
113914305  JAM3; junctional adhesion molecule C isoform X1 [KO:K06785]
113914526  CTTN; src substrate cortactin isoform X1 [KO:K06106]
113915321  CLDN25; putative claudin-25 [KO:K06087]
113916253  CLDN18; claudin-18 isoform X1 [KO:K06087]
113916294  RHOA; transforming protein RhoA [KO:K04513]
113916516  ARHGEF18; rho guanine nucleotide exchange factor 18 isoform X1 [KO:K21066]
113916566  DLG1; disks large homolog 1 isoform X1 [KO:K12076]
113916631  RUNX1; runt-related transcription factor 1 isoform X1 [KO:K08367]
113916637  CRB3; protein crumbs homolog 3 [KO:K06090]
113916638  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
113916665  PRKCI; protein kinase C iota type isoform X1 [KO:K06069] [EC:2.7.11.13]
113916795  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X2 [KO:K04851]
113916807  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
113916866  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
113916973  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
113917017  HCLS1; hematopoietic lineage cell-specific protein [KO:K06106]
113917226  CLDN11; claudin-11 [KO:K06087]
113917239  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
113917250  TJP3; tight junction protein ZO-3 isoform X1 [KO:K06097]
113917379  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
113917434  CLDN8; claudin-8 [KO:K06087]
113917708  AMOTL2; angiomotin-like protein 2 isoform X1 [KO:K06104]
113918054  CLDN16; claudin-16 isoform X1 [KO:K06087]
113918136  CLDN1; claudin-1 [KO:K06087]
113918346  CLDN14; claudin-14 [KO:K06087]
113918397  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
113918435  RAB8A; ras-related protein Rab-8A [KO:K07901]
113918503  IGSF5; immunoglobulin superfamily member 5 isoform X1 [KO:K06786]
113918659  JAM2; junctional adhesion molecule B isoform X2 [KO:K06735]
113918855  CLDN17; claudin-17 [KO:K06087]
113919488  ACTR3; actin-related protein 3 isoform X1 [KO:K18584]
113919585  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
113919929  CLDN10; claudin-10 isoform X1 [KO:K06087]
113919987  [KO:K04392]
113920047  [KO:K04393]
113920067  PRKAG3; 5'-AMP-activated protein kinase subunit gamma-3 [KO:K07200]
113920235  [KO:K05754]
113920316  MPP4; MAGUK p55 subfamily member 4 [KO:K21109]
113920876  [KO:K07374]
113921425  MYH9; myosin-9 [KO:K10352]
113921510  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
113921578  YBX3; Y-box-binding protein 3 isoform X1 [KO:K06099]
113921649  MYL6B; myosin light chain 6B [KO:K12751]
113921650  MYL6; myosin light polypeptide 6 isoform X1 [KO:K12751]
113921668  TUBA8; tubulin alpha-8 chain isoform X1 [KO:K07374]
113921708  PARD3; partitioning defective 3 homolog isoform X2 [KO:K04237]
113921728  TUBAL3; tubulin alpha chain-like 3 isoform X1 [KO:K07374]
113921783  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
113921957  PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
113922330  [KO:K07374]
113922331  [KO:K07374]
113922602  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
113924290  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
113924526  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
113924559  [KO:K06087]
113924645  [KO:K05756]
113924813  CLDN23; claudin-23 [KO:K06087]
113924857  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
113925121  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
113925216  [KO:K05758]
113925631  [KO:K06087]
113925863  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
113925881  GATA4; transcription factor GATA-4 isoform X1 [KO:K09183]
113925887  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
113926169  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
113926219  BVES; blood vessel epicardial substance [KO:K21108]
113926321  TJAP1; tight junction-associated protein 1 isoform X1 [KO:K06105]
113926457  EZR; ezrin isoform X1 [KO:K08007]
113926929  CLDN20; claudin-20 [KO:K06087]
113927218  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
113927317  AFDN; afadin isoform X1 [KO:K05702]
113928541  [KO:K05756]
113928623  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
113928769  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
113928791  RAPGEF6; rap guanine nucleotide exchange factor 6 isoform X7 [KO:K08020]
113928814  SYNPO; synaptopodin isoform X1 [KO:K21112]
113928868  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
113928876  HSPA4; heat shock 70 kDa protein 4 isoform X1 [KO:K09489]
113929021  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
113929208  PRKAA1; LOW QUALITY PROTEIN: 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
113929378  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
113929708  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
113929757  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
113929816  MARVELD2; MARVEL domain-containing protein 2 [KO:K17291]
113929820  OCLN; occludin isoform X1 [KO:K06088]
113930219  PATJ; inaD-like protein isoform X1 [KO:K06092]
113930691  CLDN2; claudin-2 [KO:K06087]
113930697  MSN; moesin [KO:K05763]
113930731  [KO:K04382] [EC:3.1.3.16]
113930768  RAP2C; ras-related protein Rap-2c isoform X1 [KO:K07839]
113930794  WAS; wiskott-Aldrich syndrome protein [KO:K05747]
113930801  [KO:K04513]
113930998  CLDN34; claudin-34 isoform X1 [KO:K06087]
113931044  [KO:K06099]
113931046  DLG3; disks large homolog 3 isoform X1 [KO:K21098]
113931143  [KO:K07374]
113931366  AMOT; angiomotin isoform X2 [KO:K16819]
113931821  PRKACB; LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
113931836  CLDN15; claudin-15 isoform X1 [KO:K06087]
113931995  [KO:K04393]
113932170  ARHGEF2; rho guanine nucleotide exchange factor 2 isoform X1 [KO:K12791]
113932222  ARHGAP17; rho GTPase-activating protein 17 isoform X1 [KO:K20638]
113932225  ARPC1B; actin-related protein 2/3 complex subunit 1B isoform X2 [KO:K05757]
113932378  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
113932390  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
113932394  F11R; junctional adhesion molecule A isoform X1 [KO:K06089]
113932426  [KO:K06448]
113932672  [KO:K06448]
113932675  CD1D; antigen-presenting glycoprotein CD1d [KO:K06448]
113932687  RAB13; ras-related protein Rab-13 isoform X1 [KO:K06109]
113932708  ARPC5; actin-related protein 2/3 complex subunit 5 isoform X1 [KO:K05754]
113932724  CLDN3; claudin-3 [KO:K06087]
113932725  CLDN4; claudin-4 [KO:K06087]
113932833  ACTB; actin, cytoplasmic 1 [KO:K05692]
113932864  [KO:K07374]
113933032  CLDN9; claudin-9 [KO:K06087]
113933055  CLDN6; claudin-6 [KO:K06087]
113933300  [KO:K06448]
113933301  [KO:K06448]
113933526  MICALL2; MICAL-like protein 2 isoform X1 [KO:K21068]
113933555  [KO:K06448]
113933693  MYH11; myosin-11 isoform X1 [KO:K10352]
113934267  MPDZ; multiple PDZ domain protein isoform X1 [KO:K06095]
113934376  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
113934445  TJP2; tight junction protein ZO-2 isoform X1 [KO:K06098]
113934482  PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 isoform X1 [KO:K07199]
113934707  EPB41L4B; LOW QUALITY PROTEIN: band 4.1-like protein 4B [KO:K21111]
113934992  [KO:K04393]
113935276  [KO:K07374]
113935364  MYH14; myosin-14 isoform X1 [KO:K10352]
113935492  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
113935694  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
113935813  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X1 [KO:K03456]
113935927  MARVELD3; MARVEL domain-containing protein 3 isoform X1 [KO:K21099]
113935948  SYMPK; symplekin isoform X1 [KO:K06100]
113936028  CLDN19; claudin-19 isoform X1 [KO:K06087]
113936173  [KO:K04393]
113936392  [KO:K06274]
113936412  [KO:K04393]
113936867  [KO:K07374]
113937046  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
113937156  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.39]
113937273  PRKCE; protein kinase C epsilon type isoform X1 [KO:K18050] [EC:2.7.11.13]
113937323  ACTR2; actin-related protein 2 isoform X1 [KO:K17260]
113937457  PCNA; proliferating cell nuclear antigen [KO:K04802]
113937725  SRC; proto-oncogene tyrosine-protein kinase Src isoform X2 [KO:K05704] [EC:2.7.10.2]
113938288  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
113938488  [KO:K07374]
113938624  [KO:K12757]
113939338  [KO:K12757]
113939365  CLDN7; claudin-7 [KO:K06087]
113939496  MYH10; myosin-10 isoform X1 [KO:K10352]
113939531  LLGL1; lethal(2) giant larvae protein homolog 1 isoform X1 [KO:K06094]
113939569  JUN; transcription factor AP-1 [KO:K04448]
113939578  SLC9A3R1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
113939792  ACTG1; actin, cytoplasmic 2 [KO:K05692]
113939823  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
118356158  [KO:K07374]
118356237  [KO:K07374]
118356266  [KO:K07374]
118356626  [KO:K12757]
118356629  [KO:K12757]
118356749  [KO:K04393]
118357304  [KO:K07374]
118357322  [KO:K07374]
Compound
C00076  Calcium cation
Reference
PMID:27353478
  Authors
Zihni C, Mills C, Matter K, Balda MS
  Title
Tight junctions: from simple barriers to multifunctional molecular gates.
  Journal
Nat Rev Mol Cell Biol 17:564-80 (2016)
DOI:10.1038/nrm.2016.80
Reference
PMID:22169974
  Authors
Martin-Belmonte F, Perez-Moreno M
  Title
Epithelial cell polarity, stem cells and cancer.
  Journal
Nat Rev Cancer 12:23-38 (2011)
DOI:10.1038/nrc3169
Reference
PMID:17525755
  Authors
Weber C, Fraemohs L, Dejana E
  Title
The role of junctional adhesion molecules in vascular inflammation.
  Journal
Nat Rev Immunol 7:467-77 (2007)
DOI:10.1038/nri2096
Reference
PMID:15820555
  Authors
Miyoshi J, Takai Y
  Title
Molecular perspective on tight-junction assembly and epithelial polarity.
  Journal
Adv Drug Deliv Rev 57:815-55 (2005)
DOI:10.1016/j.addr.2005.01.008
Reference
PMID:16650994
  Authors
Mertens AE, Pegtel DM, Collard JG
  Title
Tiam1 takes PARt in cell polarity.
  Journal
Trends Cell Biol 16:308-16 (2006)
DOI:10.1016/j.tcb.2006.04.001
Reference
PMID:16771626
  Authors
Shin K, Fogg VC, Margolis B
  Title
Tight junctions and cell polarity.
  Journal
Annu Rev Cell Dev Biol 22:207-35 (2006)
DOI:10.1146/annurev.cellbio.22.010305.104219
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:17950242
  Authors
Gonzalez-Mariscal L, Tapia R, Chamorro D
  Title
Crosstalk of tight junction components with signaling pathways.
  Journal
Biochim Biophys Acta 1778:729-56 (2008)
DOI:10.1016/j.bbamem.2007.08.018
Reference
PMID:18005931
  Authors
Assemat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D
  Title
Polarity complex proteins.
  Journal
Biochim Biophys Acta 1778:614-30 (2008)
DOI:10.1016/j.bbamem.2007.08.029
Reference
PMID:18946474
  Authors
Iden S, Collard JG
  Title
Crosstalk between small GTPases and polarity proteins in cell polarization.
  Journal
Nat Rev Mol Cell Biol 9:846-59 (2008)
DOI:10.1038/nrm2521
Reference
PMID:20094051
  Authors
Rosse C, Linch M, Kermorgant S, Cameron AJ, Boeckeler K, Parker PJ
  Title
PKC and the control of localized signal dynamics.
  Journal
Nat Rev Mol Cell Biol 11:103-12 (2010)
DOI:10.1038/nrm2847
Reference
PMID:20134025
  Authors
Terry S, Nie M, Matter K, Balda MS
  Title
Rho signaling and tight junction functions.
  Journal
Physiology (Bethesda) 25:16-26 (2010)
DOI:10.1152/physiol.00034.2009
Reference
PMID:21283798
  Authors
Russ PK, Pino CJ, Williams CS, Bader DM, Haselton FR, Chang MS
  Title
Bves modulates tight junction associated signaling.
  Journal
PLoS One 6:e14563 (2011)
DOI:10.1371/journal.pone.0014563
Reference
PMID:21781017
  Authors
Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P
  Title
Regulation of small GTPases at epithelial cell-cell junctions.
  Journal
Mol Membr Biol 28:427-44 (2011)
DOI:10.3109/09687688.2011.603101
Reference
PMID:22896795
  Authors
Lickert H, Van Campenhout CA
  Title
Evolution of the Discs large gene family provides new insights into the establishment of apical epithelial polarity and the etiology of mental retardation.
  Journal
Commun Integr Biol 5:287-90 (2012)
DOI:10.4161/cib.19792
Reference
PMID:22928510
  Authors
Spadaro D, Tapia R, Pulimeno P, Citi S
  Title
The control of gene expression and cell proliferation by the epithelial apical junctional complex.
  Journal
Essays Biochem 53:83-93 (2012)
DOI:10.1042/bse0530083
Reference
PMID:24548561
  Authors
Moleirinho S, Guerrant W, Kissil JL
  Title
The Angiomotins--from discovery to function.
  Journal
FEBS Lett 588:2693-703 (2014)
DOI:10.1016/j.febslet.2014.02.006
Reference
PMID:24651541
  Authors
Rodriguez-Boulan E, Macara IG
  Title
Organization and execution of the epithelial polarity programme.
  Journal
Nat Rev Mol Cell Biol 15:225-42 (2014)
DOI:10.1038/nrm3775
Reference
PMID:25152334
  Authors
Gonzalez-Mariscal L, Dominguez-Calderon A, Raya-Sandino A, Ortega-Olvera JM, Vargas-Sierra O, Martinez-Revollar G
  Title
Tight junctions and the regulation of gene expression.
  Journal
Semin Cell Dev Biol 36:213-23 (2014)
DOI:10.1016/j.semcdb.2014.08.009
Reference
PMID:25469537
  Authors
Mack NA, Georgiou M
  Title
The interdependence of the Rho GTPases and apicobasal cell polarity.
  Journal
Small GTPases 5:10 (2014)
DOI:10.4161/21541248.2014.973768
Reference
PMID:25483301
  Authors
Citi S, Guerrera D, Spadaro D, Shah J
  Title
Epithelial junctions and Rho family GTPases: the zonular signalosome.
  Journal
Small GTPases 5:1-15 (2014)
DOI:10.4161/21541248.2014.973760
Reference
PMID:25757376
  Authors
Zihni C, Terry SJ
  Title
RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer.
  Journal
Int J Biochem Cell Biol 64:120-5 (2015)
DOI:10.1016/j.biocel.2015.02.020
Reference
PMID:22892070
  Authors
Nakano A, Takashima S
  Title
LKB1 and AMP-activated protein kinase: regulators of cell polarity.
  Journal
Genes Cells 17:737-47 (2012)
DOI:10.1111/j.1365-2443.2012.01629.x
Reference
PMID:12042308
  Authors
Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B
  Title
Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.
  Journal
J Biol Chem 277:30183-90 (2002)
DOI:10.1074/jbc.M203072200
Reference
PMID:18094055
  Authors
Yamamura R, Nishimura N, Nakatsuji H, Arase S, Sasaki T
  Title
The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.
  Journal
Mol Biol Cell 19:971-83 (2008)
DOI:10.1091/mbc.E07-06-0551
Reference
PMID:23885123
  Authors
Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA
  Title
JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
  Journal
Mol Biol Cell 24:2849-60 (2013)
DOI:10.1091/mbc.E13-06-0298
Related
pathway
zca04520  Adherens junction
zca04810  Regulation of actin cytoskeleton
KO pathway
ko04530   

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