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| Entry | Name | Description | Category | Pathway | Gene |
|---|---|---|---|---|---|
| H00307 | Vibrio parahaemolyticus infection | Vibrio parahaemolyticus is a Gram-negative halophilic bacterium that naturally inhabits marine and estuarine environments. It is a well-recognized pathogen of both aquatic animals and humans. In the case ... | Bacterial infectious disease | ||
| H00308 | Vibrio vulnificus infection | ... in warm coastal waters. It causes two distinct syndromes: a primary septicemia related to seafood consumption and a necrotizing wound infection acquired by exposing open wounds to contaminated seawater. | Bacterial infectious disease | ||
| H00311 |
Legionellosis Legionnaires disease |
... caused by Gram-negative Legionella spp., can be nosocomial, community acquired or travel related. L. pneumophila is the most common cause of LD. The source of LD is potable water systems that become colonized ... | Bacterial infectious disease | hsa05134 Legionellosis | TLR5 [HSA:7100] [KO:K10168] |
| H00312 | Tularemia | ... rare zoonotic infection caused by the bacterium Francisella tularensis. It occurs in North America, Europe, and Asia. The most common clinical presentation is ulceroglandular tularemia with chills, fever ... | Bacterial infectious disease | ||
| H00313 | Multidrug-resistant Pseudomonas aeruginosa infection | Pseudomonas aeruginosa is an opportunistic pathogen that may cause severe invasive diseases in critically ill patients. In the 21st century, when the life expectancy of highly susceptible immunocompromised ... | Bacterial infectious disease | ||
| H00317 | Melioidosis | ... caused by the gram-negative soil-dwelling bacillus Burkholderia pseudomallei. It predominantly affects people in regular contact with soil and water and is endemic in areas of Southeast Asia and Northern Australia ... | Bacterial infectious disease | TLR5 (resistance) [HSA:7100] [KO:K10168] | |
| H00319 |
Pertussis Whooping cough |
Pertussis, or whooping cough, caused by the gram-negative bacillus Bordetella pertussis, is a highly contagious, acute respiratory disease of humans. Despite high vaccination rates, this illness has re-emerged ... | Bacterial infectious disease | hsa05133 Pertussis | |
| H00320 | Helicobacter pylori infection | ... infection varies between different geographical regions; generally, the prevalence is about 30% in developed and up to 80% in developing countries. Although HP may sometimes be eradicated by antibiotics given ... | Bacterial infectious disease | hsa05120 Epithelial cell signaling in Helicobacter pylori infection | |
| H00322 | Epidemic typhus | ... typhus biogroup that are transmitted by infective louse and flea. The disease is widely distributed in tropical and subtropical areas. Most patients present with an acute febrile disease with constitutional ... | Bacterial infectious disease | ||
| H00323 |
Spotted fever Tick-borne rickettsioses |
... the spotted fever group (SFG) of the genus Rickettsia within the family Rickettsiaceae in the order Rickettsiales. The diseases present with high fever, an inoculation eschar, and a maculopapular rash. | Bacterial infectious disease | ||
| H00326 | Bartonellosis | Bartonella species are fastidious gram-negative bacilli. They are usually transmitted by hematophagous insects, such as sandflies, fleas, and lice but can also be transmitted by animal scratches and bites ... | Bacterial infectious disease | ||
| H00327 | Trench fever | ... facultative intracellular gram-negative bacterium Bartonella quintana. It affected several million people worldwide during the two world wars. The incidence of trench fever dramatically decreased after ... | Bacterial infectious disease | ||
| H00331 | Vancomycin-resistant Staphylococcal aureus (VRSA) infection | ... Staphylococcus aureus (VRSA) represents strains of S. aureus that have ability of resistance to the glycopeptide antibiotic vancomycin. S. aureus is the most common cause of nosocomial infections. The glycopeptides-notably ... | Bacterial infectious disease | hsa05150 Staphylococcus aureus infection | |
| H00339 | Botulism | Botulism is an acute neuroparalytic illness caused by a botulinum toxin produced by Clostridium botulinum, an anaerobic, gram-positive bacterium. Botulism occurs in four forms: foodborne, wound, infant ... | Bacterial infectious disease | ||
| H00341 | Mycoplasma pneumonia | Mycoplasmas represent the smallest self-replicating organisms that are most closely related to the gram-positive bacterial group that includes streptococci, bacilli, and lactobacilli. Mycoplasma pneumoniae ... | Bacterial infectious disease | ||
| H00343 | Diphtheria | ... diphtheria still remains endemic in several regions including Africa, India, Bangladesh, Vietnam, the tropics, and South America. Moreover, a large proportion of adults in industrialized countries are now ... | Bacterial infectious disease | ||
| H00348 | Lymphogranuloma venereum | ... L2, L2a and L3 of C. trachomatis are the agents of lymphogranuloma venereum, a disease found in isolated groups of men who have sex with men (MSM) across Western Europe, North America, and Australia. | Bacterial infectious disease | ||
| H00350 |
Psittacosis Parrot fever |
Psittacosis, also known as parrot disease, is an infectious disease caused by Chlamydophila psittaci, a gram-negative intracellular bacterium that is usually transmitted to humans from birds. Symptoms ... | Bacterial infectious disease | ||
| H00351 | Chlamydial pneumonia | Chlamydophila (Cp.) pneumoniae is an obligate intracellular bacteria that causes human respiratory infections. Most acute respiratory infections are asymptomatic or mildly symptomatic. Repeated or prolonged ... | Bacterial infectious disease | ||
| H00352 | Whipple disease | Whipple disease (WD) is a rare chronic multi-system disease associated with the bacterium Tropheryma whipplei that is ubiquitously present in the environment. The clinical features of WD are non-specific ... | Bacterial infectious disease | ||
| H00353 |
Lyme borreliosis Lyme disease |
... variety of peripheral nerve disorders (Lyme neuroborreliosis) can occur as well. Late Lyme borreliosis usually manifests as arthritis or the skin disorder known as acrodermatitis chronica atrophicans. | Bacterial infectious disease | ||
| H00354 | Syphilis | ... spirochete Treponema pallidum subsp. pallidum. It is characterized by genital ulceration, skin rash, and development of serious systemic disease. Syphilis may also alter the course of HIV disease. Effective therapy ... | Bacterial infectious disease | ||
| H00357 |
African trypanosomiasis Sleeping sickness |
... most common serious protozoan infections in sub-Saharan Africa, especially in areas of conflict. Its causative agent is Trypanosoma brucei, whose protein has been shown to induce apoptosis in human brain. | Parasitic infectious disease | hsa05143 African trypanosomiasis | |
| H00358 |
Chagas disease American trypanosomiasis |
... caused by infection with protozoan parasite Trypanosoma cruzi. The infection is transmitted by hematophagous reduviid insect vectors through fecal contamination. The majority of infected individuals live ... | Parasitic infectious disease | hsa05142 Chagas disease | |
| H00359 | Leishmaniasis | Leishmaniasis is a vector-borne disease that affects millions of people especially in developing countries of Africa, the Americas, and Asia. Leishmaniasis is caused by a protozoan parasite of the genus ... | Parasitic infectious disease | hsa05140 Leishmaniasis | |
| H00360 | Amoebiasis | ... gastrointestinal tract caused by Entamoeba histolytica (E. histolytica), an extracellular parasitic protozoan. People living in Central and South America and Africa are at highest risk of infection. Although the majority ... | Parasitic infectious disease | hsa05146 Amoebiasis | |
| H00361 | Malaria | ... common parasitic disease in the world, is caused by Plasmodium parasites that are transmitted by female Anopheline mosquitoes. Plasmodium infections result in a spectrum of clinical effects, including asymptomatic ... | Parasitic infectious disease | hsa05144 Malaria |
ACKR1 (protection) [HSA:2532] [KO:K06574] CD36 (susceptibility/reduced risk) [HSA:948] [KO:K06259] CISH (susceptibility) [HSA:1154] [KO:K04701] CR1 (resistance) [HSA:1378] [KO:K04011] FCGR2A (susceptibility) [HSA:2212] [KO:K06472] FCGR2B (resistance) [HSA:2213] [KO:K12560] G6PD (resistance) [HSA:2539] [KO:K00036] GYPA (resistance) [HSA:2993] [KO:K06575] GYPB (resistance) [HSA:2994] [KO:K20925] GYPC (resistance) [HSA:2995] [KO:K06576] HBB (resistance) [HSA:3043] [KO:K13823] ICAM1 (susceptibility) [HSA:3383] [KO:K06490] NOS2 (resistance) [HSA:4843] [KO:K13241] SLC4A1 (resistance) [HSA:6521] [KO:K06573] TIRAP (protection) [HSA:114609] [KO:K05403] TNF (susceptibility) [HSA:7124] [KO:K03156] |
| H00362 |
Giardiasis Lambliasis |
... transmitted by ingestion of contaminated water or food, or by person-to-person contact, affecting children, pregnant women, the immunocompromised individuals, and people living with poor sanitation facilities. | Parasitic infectious disease | ||
| H00364 | Cryptococcosis | Cryptococcus is a pathogenic yeast that causes opportunistic infection, especially in the immunocompromised patient. It mainly infects the central nervous system and causes meningitis. Cryptococcal lung ... | Fungal infectious disease | ||
| H00365 |
Herpes simplex virus infection HSV infection |
... dsDNA viruses. Humans are the only natural host and reservoir for the HSV virus. HSV are human neurotropic viruses that establish latent infection in dorsal root ganglia (DRG) for the entire life of the ... | Viral infectious disease | hsa05168 Herpes simplex virus 1 infection | |
| H00367 |
Infectious mononucleosis Epstein-Barr virus (EBV) infection |
... manifests as infectious mononucleosis that is defined as a clinical triad of fever, pharyngitis, and adenopathy. EBV establishes a life-long asymptomatic infection in B cells and can contribute to oncogenesis ... | Viral infectious disease | hsa05169 Epstein-Barr virus infection | |
| H00370 | Progressive multifocal leukoencephalopathy | Progressive multifocal leukoencephalopathy (PML) is a fatal neurological disorder characterized by destruction of oligodendrocytes by the JC polyomavirus that occurs in immunosuppressed individuals such ... | Viral infectious disease | ||
| H00371 | Adenovirus infection | ... rarely associated with severe clinical symptoms in healthy individuals. In contrast, in the pediatric population, military recruits, and immunocompromised individuals, Ad infections often result in disseminated ... | Viral infectious disease | ||
| H00372 |
Smallpox Variola |
Smallpox is a contagious disease caused by the variola virus, one of the Orthopoxviruses that causes skin eruption and marked toxemia. The disease was officially declared eradicated in 1979 following intensive ... | Viral infectious disease | ||
| H00373 | Mpox (Monkeypox) | Human monkeypox is a rare viral zoonotic disease caused by Monkeypox virus of the genus Orthopoxvirus. It occurs mostly in the rain forests of central and western Africa. Human monkeypox has a clinical ... | Viral infectious disease | ||
| H00376 |
Acute poliomyelitis Polio |
... serotypes of poliovirus, an enterovirus in the Picornaviridae family of +ssRNA viruses. Only a small proportion of poliovirus infections results in paralytic poliomyelitis due to the viral invasion to the ... | Viral infectious disease | ||
| H00379 | Mosquito-borne viral encephalitis | Mosquito-borne viral encephalitides are infections of the central nervous system caused by arboviruses (arthropod-borne viruses) and transmitted by mosquitoes. Arboviruses are zoonotic viruses and consist of taxonomically ... | Viral infectious disease | ||
| H00380 | Tick-borne viral encephalitis | ... related to yellow fever, dengue, Japanese encephalitis, and West Nile viruses. It is the most important viral tick-borne disease in Europe and is also important in the Far East and in other parts of Asia. | Viral infectious disease | ||
| H00382 | Mosquito-borne viral fever | Mosquito-borne viral fevers are infectious diseases caused by arboviruses (arthropod-borne viruses) and transmitted by mosquitoes. Arboviruses are zoonotic viruses and consist of taxonomically different ... | Viral infectious disease | ||
| H00383 | Arthropod-borne viral fever | Arthropod-borne viral fevers are infectious diseases caused by arboviruses (arthropod-borne viruses) and transmitted by mosquitoes, other insects, mites and ticks. Arboviruses are zoonotic viruses and ... | Viral infectious disease |
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