ERK signaling |
N00001 |
EGF | → | EGFR | → | GRB2 | → | SOS | → | RAS | → | RAF | → | MEK | → | ERK | → | CCND1 |
N00744 |
| | | | | | HA | → | PRKCA | → | RAF |
| | |
PI3K signaling |
N00033 |
EGF | → | EGFR | → | PI3K | → | PIP3 | → | AKT | ⊣ | BAD |
N00736 |
| | NS1 | → | PI3K |
| | |
NLR signaling |
N00742 |
| | (NLRP3+PYCARD) | → | CASP1 | → | (IL1B,IL18,IL33) |
N00743 |
NS1 | ⊣ | (NLRP3+PYCARD) |
N00515 |
| | OAS | → | 2-5A | → | RNASEL |
N00724 |
NS1 | ⊣ | OAS |
| | |
RLR signaling |
N00469 |
| | RNA | → | RIGI | → | MAVS | → | TRAF3 | → | (TANK+NAP1+SINTBAD.. | → | (TBK1+IKBKE) | → | (IRF7,IRF3) | ⇒ | (IFNA,IFNB1) |
N00727 |
NS1 | ⊣ | TRIM25 | → | RIGI |
N00728 |
| | NS1 | ⊣ | RIGI |
N00732 |
| | | | (PB1F2,PB2) | ⊣ | MAVS |
N00734 |
| | | | | | | | | | (PB1F2+CALCOCO2) | ⊣ | (TBK1+IKBKE) |
N00729 |
| | | | | | | | | | | | NS1 | ⊣ | IRF3 |
N00688 |
| | RNA | → | RIGI | → | MAVS | → | IKK | → | NFKBIA | → | NFKB | ⇒ | (IFNA,IFNB1) |
N00730 |
| | | | | | | | NS1 | ⊣ | NFKB |
| | |
PKR-eIF2alpha signaling |
N00571 |
| | | | | | EIF2AK2 | → | EIF2S1 | ⊣ | EIF2B |
N00726 |
NP | ⊣ | DNAJB1 | ⊣ | DNAJC3 | ⊣ | EIF2AK2 |
N00725 |
| | | | NS1 | ⊣ | EIF2AK2 |
| | |
IFN signaling |
N00150 |
(IFNA,IFNB1) | → | (IFNAR1+IFNAR2) | → | (JAK1,TYK2) | → | (STAT1+STAT2+IRF9) | ⇒ | (IRF7,EIF2AK2) |
N00738 |
| | NS1 | → | SOCS3 | ⊣ | (STAT1+STAT2+IRF9) |
| | |
Cell cycle |
N00066 |
CDKN2A | ⊣ | MDM2 | ⊣ | TP53 | ⇒ | CDKN1A | ⊣ | (CCND+CDK4/6) | → | RB1 | ⌿ | E2F |
N00741 |
| | | | | | M2 | ⊣ | CCND3 |
| | |
Apoptosis |
N00098 |
(PMAIP1,BBC3,BAD,B.. | ⊣ | (BCL2,BCL2L1) | ⊣ | (BAX,BAK1) | → | CYCS | = | APAF1 | → | CASP9 | → | (CASP3,CASP7) |
N00745 |
| | PB1F2 | = | (VDAC1+SLC25A6) | → | CYCS |
| | |
Nuclear export of mRNA |
N00586 |
SRPK1 | → | SRSF1 | = | NXF1 |
N00746 |
| | NS1 | ⊣ | (NXF1+NXT1+HNRNPUL.. |
|