KEGG   Homo sapiens (human): 2559
Entry
2559              CDS       T01001                                 

Gene name
GABRA6
Definition
(RefSeq) gamma-aminobutyric acid type A receptor subunit alpha6
  KO
K05175  gamma-aminobutyric acid receptor subunit alpha
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04723  Retrograde endocannabinoid signaling
hsa04727  GABAergic synapse
hsa04742  Taste transduction
hsa05032  Morphine addiction
hsa05033  Nicotine addiction
Drug target
Abecarnil: D02594
Adinazolam (DG00911): D02770 D02771
Adipiplon: D08840
Alpidem: D02833
Alprazolam: D00225<JP/US>
Aminobutyric acid: D00058<JP>
Amobarbital (DG00916): D00555<JP> D02252
Aprobarbital: D00698
Barbexaclone: D07298
Barbital: D01740
Bretazenil: D03155
Brexanolone: D11149<US>
Bromazepam: D01245<JP>
Brotizolam: D01744<JP>
Butabarbital (DG01308): D00699 D03180
Butobarbital: D02618
Cenobamate: D11150<US>
Chlordiazepoxide (DG00908): D00267<JP> D00693<US>
Cinolazepam: D07328
Clobazam: D01253<JP/US>
Clonazepam: D00280<JP/US>
Clotiazepam: D01328<JP>
Cloxazolam: D01268<JP>
Delorazepam: D07784
Dextofisopam: D03737
Diazepam: D00293<JP/US>
Estazolam: D00311<JP/US>
Eszopiclone: D02624<JP/US>
Ethyl loflazepate: D01293<JP>
Etizolam: D01514<JP>
Fludiazepam: D01354<JP>
Flumazenil: D00697<JP/US>
Flunitrazepam: D01230<JP>
Flurazepam (DG00919): D00329 D00695<US> D01408<JP>
Flutazolam: D01286<JP>
Flutoprazepam: D01279<JP>
Gaboxadol: D04282
Ganaxolone: D04300
Glutethimide: D00532
Halazepam: D00338
Haloxazolam: D01758<JP>
Hexobarbital: D01071
Indiplon: D02640
Iomazenil: D02283<JP>
Ketazolam: D04650
Levotofisopam: D04721
Loprazolam (DG00921): D07326 D08145
Lorazepam: D00365<JP/US>
Lormetazepam: D01657<JP>
Medazepam (DG00909): D01292<JP> D04882
Meprobamate: D00376<US>
Metharbital: D01382
Methylphenobarbital: D00700
Mexazolam: D01316<JP>
Midazolam (DG00920): D00550<JP/US> D00696<US> D05028
Nimetazepam: D01593
Nitrazepam: D00531<JP>
Nordazepam: D08283
Ocinaplon: D02617
Oxazepam: D00464<US>
Oxazolam: D01278<JP>
Pagoclone: D02616
Panadiplon: D05346
Pazinaclone: D05378
Pentobarbital (DG00915): D00499 D00500<US> D02253<JP>
Phenobarbital (DG00845): D00506<JP> D00701<JP> D08356
Potassium clorazepate (DG01218): D00694<JP/US> D03562
Prazepam: D00470
Propofol (DG00797): D00549<JP/US> D04257
Quazepam: D00457<JP/US>
Remimazolam (DG03105): D10194<JP/US> D11788
Rilmazafone (DG01307): D01564<JP> D08481
Sarmazenil: D08507
Secobarbital (DG00917): D00430 D01310<JP/US>
Suritozole: D05980
Talbutal: D06887
Temazepam: D00370<US>
Thiamylal (DG01377): D00713<JP> D06106
Thiopental (DG00790): D00714<JP>
Tofisopam: D01254<JP>
Topiramate: D00537<JP/US>
Triazolam: D00387<JP/US>
Zolpidem (DG00922): D00706<JP/US> D08690
Zopiclone: D01372<JP>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2559 (GABRA6)
 09150 Organismal Systems
  09156 Nervous system
   04727 GABAergic synapse
    2559 (GABRA6)
   04723 Retrograde endocannabinoid signaling
    2559 (GABRA6)
  09157 Sensory system
   04742 Taste transduction
    2559 (GABRA6)
 09160 Human Diseases
  09165 Substance dependence
   05032 Morphine addiction
    2559 (GABRA6)
   05033 Nicotine addiction
    2559 (GABRA6)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2559 (GABRA6)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  GABA-A
   2559 (GABRA6)
SSDB
Motif
Pfam: Neur_chan_LBD Neur_chan_memb DUF4396
Other DBs
NCBI-GeneID: 2559
NCBI-ProteinID: NP_000802
OMIM: 137143
HGNC: 4080
Ensembl: ENSG00000145863
Vega: OTTHUMG00000130351
Pharos: Q16445(Tclin)
UniProt: Q16445
LinkDB
Position
5q34
AA seq 453 aa
MASSLPWLCIILWLENALGKLEVEGNFYSENVSRILDNLLEGYDNRLRPGFGGAVTEVKT
DIYVTSFGPVSDVEMEYTMDVFFRQTWTDERLKFGGPTEILSLNNLMVSKIWTPDTFFRN
GKKSIAHNMTTPNKLFRIMQNGTILYTMRLTINADCPMRLVNFPMDGHACPLKFGSYAYP
KSEIIYTWKKGPLYSVEVPEESSSLLQYDLIGQTVSSETIKSNTGEYVIMTVYFHLQRKM
GYFMIQIYTPCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISARHSLPKVSYA
TAMDWFIAVCFAFVFSALIEFAAVNYFTNLQTQKAKRKAQFAAPPTVTISKATEPLEAEI
VLHPDSKYHLKKRITSLSLPIVSSSEANKVLTRAPILQSTPVTPPPLSPAFGGTSKIDQY
SRILFPVAFAGFNLVYWVVYLSKDTMEVSSSVE
NT seq 1362 nt   +upstreamnt  +downstreamnt
atggcgtcgtctctgccctggctgtgcattattctgtggctagaaaatgccctagggaaa
ctcgaagttgaaggcaacttctactcagaaaacgtcagtcggatcctggacaacttgctt
gaaggctatgacaatcggctgcggccgggatttggaggtgctgtcactgaagtcaaaaca
gacatttatgtgaccagttttgggcccgtgtcagatgtggagatggagtatacgatggat
gtttttttccgccagacctggactgatgagaggttgaagtttggggggccaactgagatt
ctgagtctgaataatttgatggtcagtaaaatctggacgcctgacacctttttcagaaat
ggtaaaaagtccattgctcacaacatgacaactcctaataaactcttcagaataatgcag
aatggaaccattttatacaccatgaggcttaccatcaatgctgactgtcccatgaggctg
gttaactttcctatggatgggcatgcttgtccactcaagtttgggagctatgcttatccc
aaaagtgaaatcatatatacgtggaaaaaaggaccactttactcagtagaagtcccagaa
gaatcttcaagccttctccagtatgatctgattggacaaacagtatctagtgagacaatt
aaatctaacacaggtgaatacgttataatgacagtttacttccacttgcaaaggaagatg
ggctacttcatgatacagatatacactccttgcattatgacagtcattctttcccaggtg
tctttctggattaataaggagtccgtcccagcaagaactgtttttgggatcaccactgtt
ttaactatgaccactttgagcatcagtgcccggcactctttgccaaaagtgtcatatgcc
actgccatggattggttcatagctgtttgctttgcattcgtcttctctgcgcttatcgag
ttcgcagctgtcaactactttaccaatcttcagacacagaaggccaaaaggaaggcacag
tttgcagccccacccacagtgacaatatcaaaagctactgaacctttggaagctgagatt
gttttgcatcctgactccaaatatcatctgaagaaaaggatcacttctctgtctttgcca
atagtttcatcttccgaggccaataaagtgctcacgagagcgcccatcttacaatcaaca
cctgtcacacccccaccactctcgccagcctttggaggcaccagtaaaatagaccagtat
tctcgaattctcttcccagttgcatttgcaggattcaaccttgtgtactgggtagtttat
ctttccaaagatacaatggaagtcagtagcagtgttgaatag

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