KEGG T01001: 2559

Homo sapiens (human): 2559

Entry

2559              CDS       T01001

Symbol

GABRA6

Name

(RefSeq) gamma-aminobutyric acid type A receptor subunit alpha6

K05175

gamma-aminobutyric acid receptor subunit alpha

Organism

hsa Homo sapiens (human)

Pathway

hsa04080

Neuroactive ligand-receptor interaction

hsa04723

Retrograde endocannabinoid signaling

hsa04727

GABAergic synapse

hsa04742

Taste transduction

hsa05032

Morphine addiction

hsa05033

Nicotine addiction

Drug target

Abecarnil:

D02594

Adinazolam (DG00911):

D02770 D02771

Adipiplon:

D08840

Alpidem:

D02833

Alprazolam:

D00225<JP/US>

Aminobutyric acid:

D00058<JP>

Amobarbital (DG00916):

Aprobarbital:

Barbexaclone:

Barbital:

Bretazenil:

Brexanolone:

D11149<US>

Bromazepam:

D01245<JP>

Brotizolam:

D01744<JP>

Butabarbital (DG01308):

D00699 D03180

Butobarbital:

D02618

Cenobamate:

D11150<US>

Chlordiazepoxide (DG00908):

D00267<JP> D00693<US>

Cinolazepam:

D07328

Cipepofol:

D12449

Clobazam:

D01253<JP/US>

Clonazepam:

D00280<JP/US>

Clotiazepam:

D01328<JP>

Cloxazolam:

D01268<JP>

Darigabat:

D12146

Delorazepam:

D07784

Dextofisopam:

D03737

Diazepam:

D00293<JP/US>

Estazolam:

D00311<JP/US>

Eszopiclone:

D02624<JP/US>

Ethyl loflazepate:

D01293<JP>

Etizolam:

D01514<JP>

Fludiazepam:

D01354

Flumazenil:

D00697<JP/US>

Flunitrazepam:

D01230<JP>

Flurazepam (DG00919):

D00329 D00695<US> D01408<JP>

Flutazolam:

D01286<JP>

Flutoprazepam:

D01279

Gaboxadol:

D04282

Ganaxolone:

D04300<US>

Glutethimide:

D00532

Halazepam:

D00338

Haloxazolam:

D01758<JP>

Hexobarbital:

D01071

Indiplon:

D02640

Iomazenil:

D02283<JP>

Ketazolam:

D04650

Levotofisopam:

D04721

Loprazolam (DG00921):

D07326 D08145

Lorazepam:

D00365<JP/US>

Lormetazepam:

D01657<JP>

Medazepam (DG00909):

D01292<JP> D04882

Meprobamate:

D00376<US>

Metharbital:

D01382

Methylphenobarbital:

D00700

Mexazolam:

D01316<JP>

Midazolam (DG00920):

D00550<JP/US> D00696<US> D05028

Nimetazepam:

D01593

Nitrazepam:

D00531<JP>

Nordazepam:

D08283

Ocinaplon:

D02617

Oxazepam:

D00464<US>

Oxazolam:

D01278<JP>

Pagoclone:

D02616

Panadiplon:

D05346

Pazinaclone:

D05378

Pentobarbital (DG00915):

D00499 D00500<US> D02253<JP>

Phenobarbital (DG00845):

D00506<JP> D00701<JP/US> D08356

Potassium clorazepate (DG01218):

D00694<JP/US> D03562

Prazepam:

D00470

Propofol (DG00797):

D00549<JP/US> D04257

Quazepam:

D00457<JP/US>

Remimazolam (DG03105):

D10194<JP/US> D11788

Rilmazafone (DG01307):

D01564<JP> D08481

Sarmazenil:

D08507

Secobarbital (DG00917):

D00430 D01310

Suritozole:

D05980

Talbutal:

D06887

Temazepam:

D00370<US>

Thiamylal (DG01377):

D00713<JP> D06106

Thiopental (DG00790):

D00714<JP>

Tofisopam:

D01254<JP>

Topiramate:

D00537<JP/US>

Triazolam:

D00387<JP/US>

Zolpidem (DG00922):

D00706<JP/US> D08690

Zopiclone:

D01372<JP>

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2559 (GABRA6)
09150 Organismal Systems
  09156 Nervous system
   04727 GABAergic synapse
    2559 (GABRA6)
   04723 Retrograde endocannabinoid signaling
    2559 (GABRA6)
  09157 Sensory system
   04742 Taste transduction
    2559 (GABRA6)
09160 Human Diseases
  09165 Substance dependence
   05032 Morphine addiction
    2559 (GABRA6)
   05033 Nicotine addiction
    2559 (GABRA6)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2559 (GABRA6)
Ion channels [BR:hsa04040]
Ligand-gated channels
  GABA-A
   2559 (GABRA6)

SSDB

Motif

Pfam:

Neur_chan_LBD Neur_chan_memb DUF4396

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

LinkDB

Position

5:161685721..161702592

AA seq 453 aa
MASSLPWLCIILWLENALGKLEVEGNFYSENVSRILDNLLEGYDNRLRPGFGGAVTEVKT
DIYVTSFGPVSDVEMEYTMDVFFRQTWTDERLKFGGPTEILSLNNLMVSKIWTPDTFFRN
GKKSIAHNMTTPNKLFRIMQNGTILYTMRLTINADCPMRLVNFPMDGHACPLKFGSYAYP
KSEIIYTWKKGPLYSVEVPEESSSLLQYDLIGQTVSSETIKSNTGEYVIMTVYFHLQRKM
GYFMIQIYTPCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISARHSLPKVSYA
TAMDWFIAVCFAFVFSALIEFAAVNYFTNLQTQKAKRKAQFAAPPTVTISKATEPLEAEI
VLHPDSKYHLKKRITSLSLPIVSSSEANKVLTRAPILQSTPVTPPPLSPAFGGTSKIDQY
SRILFPVAFAGFNLVYWVVYLSKDTMEVSSSVE

NT seq 1362 nt +upstreamnt +downstreamnt
atggcgtcgtctctgccctggctgtgcattattctgtggctagaaaatgccctagggaaa
ctcgaagttgaaggcaacttctactcagaaaacgtcagtcggatcctggacaacttgctt
gaaggctatgacaatcggctgcggccgggatttggaggtgctgtcactgaagtcaaaaca
gacatttatgtgaccagttttgggcccgtgtcagatgtggagatggagtatacgatggat
gtttttttccgccagacctggactgatgagaggttgaagtttggggggccaactgagatt
ctgagtctgaataatttgatggtcagtaaaatctggacgcctgacacctttttcagaaat
ggtaaaaagtccattgctcacaacatgacaactcctaataaactcttcagaataatgcag
aatggaaccattttatacaccatgaggcttaccatcaatgctgactgtcccatgaggctg
gttaactttcctatggatgggcatgcttgtccactcaagtttgggagctatgcttatccc
aaaagtgaaatcatatatacgtggaaaaaaggaccactttactcagtagaagtcccagaa
gaatcttcaagccttctccagtatgatctgattggacaaacagtatctagtgagacaatt
aaatctaacacaggtgaatacgttataatgacagtttacttccacttgcaaaggaagatg
ggctacttcatgatacagatatacactccttgcattatgacagtcattctttcccaggtg
tctttctggattaataaggagtccgtcccagcaagaactgtttttgggatcaccactgtt
ttaactatgaccactttgagcatcagtgcccggcactctttgccaaaagtgtcatatgcc
actgccatggattggttcatagctgtttgctttgcattcgtcttctctgcgcttatcgag
ttcgcagctgtcaactactttaccaatcttcagacacagaaggccaaaaggaaggcacag
tttgcagccccacccacagtgacaatatcaaaagctactgaacctttggaagctgagatt
gttttgcatcctgactccaaatatcatctgaagaaaaggatcacttctctgtctttgcca
atagtttcatcttccgaggccaataaagtgctcacgagagcgcccatcttacaatcaaca
cctgtcacacccccaccactctcgccagcctttggaggcaccagtaaaatagaccagtat
tctcgaattctcttcccagttgcatttgcaggattcaaccttgtgtactgggtagtttat
ctttccaaagatacaatggaagtcagtagcagtgttgaatag

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