KEGG   PATHWAY: aju04115
Entry
aju04115                    Pathway                                
Name
p53 signaling pathway - Acinonyx jubatus (cheetah)
Description
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.
Class
Cellular Processes; Cell growth and death
Pathway map
aju04115  p53 signaling pathway
aju04115

Organism
Acinonyx jubatus (cheetah) [GN:aju]
Gene
106983963  serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
106985461  serine/threonine-protein kinase Chk2 isoform X3 [KO:K06641] [EC:2.7.11.1]
106982261  LOW QUALITY PROTEIN: serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
106976641  serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
106966200  RAB6-interacting golgin isoform X1 [KO:K19748]
106986386  cyclin-dependent kinase inhibitor 2A-like [KO:K06621]
106966348  E3 ubiquitin-protein ligase Mdm2 isoform X3 [KO:K06643] [EC:2.3.2.27]
106972905  protein Mdm4 [KO:K10127]
106972437  cellular tumor antigen p53 [KO:K04451]
106973597  relA-associated inhibitor isoform X1 [KO:K27356]
106972797  cyclin-dependent kinase inhibitor 1 [KO:K06625]
106971167  G1/S-specific cyclin-D1 [KO:K04503]
106965383  G1/S-specific cyclin-D2 [KO:K10151]
106974052  G1/S-specific cyclin-D3 isoform X2 [KO:K10152]
106975871  cyclin-dependent kinase 4 isoform X1 [KO:K02089] [EC:2.7.11.22]
106969949  cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
106974883  G1/S-specific cyclin-E2 [KO:K06626]
106975766  G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
106986916  cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
106977554  14-3-3 protein sigma [KO:K06644]
113598220  protein reprimo [KO:K10128]
106977069  G2/mitotic-specific cyclin-B1 [KO:K05868]
106973791  G2/mitotic-specific cyclin-B2 isoform X2 [KO:K21770]
106989884  cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
106989693  growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
106985200  growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
113594268  growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
106967293  G2 and S phase-expressed protein 1 isoform X3 [KO:K10129]
106989321  zinc finger protein 385A isoform X1 [KO:K26543]
106980953  tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
106988898  p53-induced death domain-containing protein 1 isoform X2 [KO:K10130]
106982854  tumor necrosis factor receptor superfamily member 10B-like isoform X1 [KO:K04722]
106987995  caspase-8 [KO:K04398] [EC:3.4.22.61]
106968455  BH3-interacting domain death agonist [KO:K04726]
106988699  apoptosis regulator BAX isoform X1 [KO:K02159]
106978896  phorbol-12-myristate-13-acetate-induced protein 1 [KO:K10131]
106973568  bcl-2-binding component 3 [KO:K10132]
106985053  apoptosis regulatory protein Siva isoform X2 [KO:K22744]
106986010  bcl-2-like protein 1 [KO:K04570]
106985187  apoptosis regulator Bcl-2 [KO:K02161]
106986711  quinone oxidoreductase PIG3 isoform X1 [KO:K10133] [EC:1.-.-.-]
106976643  etoposide-induced protein 2.4 homolog [KO:K10134]
106979214  protein shisa-5 isoform X3 [KO:K10135]
106982024  p53 apoptosis effector related to PMP-22 [KO:K10136]
106973879  zinc finger matrin-type protein 3 isoform X1 [KO:K10137]
106985846  E3 ubiquitin-protein ligase SIAH1 isoform X1 [KO:K04506] [EC:2.3.2.27]
106982593  E3 ubiquitin-protein ligase SIAH1-like [KO:K04506] [EC:2.3.2.27]
106973875  cytochrome c-like [KO:K08738]
128316364  cytochrome c-like [KO:K08738]
106982840  cytochrome c [KO:K08738]
106986613  cytochrome c-like [KO:K08738]
106973746  apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
106975594  caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
106979326  caspase-3 isoform X3 [KO:K02187] [EC:3.4.22.56]
106967155  ferroptosis suppressor protein 1 isoform X1 [KO:K22745]
106968195  insulin-like growth factor-binding protein 3 [KO:K10138]
106971906  insulin-like growth factor I isoform X4 [KO:K05459]
106988114  plasminogen activator inhibitor 1 [KO:K03982]
113600537  adhesion G protein-coupled receptor B1 isoform X1 [KO:K04596]
106978048  CD82 antigen [KO:K06509]
106979757  thrombospondin-1 [KO:K16857]
106985014  serpin B5 [KO:K10139]
106978021  DNA damage-binding protein 2 isoform X2 [KO:K10140]
106980049  ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
106987069  ribonucleoside-diphosphate reductase subunit M2 isoform X4 [KO:K10808] [EC:1.17.4.1]
106986954  sestrin-3 [KO:K10141]
106968884  sestrin-1 isoform X1 [KO:K10141]
106977533  sestrin-2 [KO:K20394]
106980972  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X4 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
106982748  tuberin isoform X2 [KO:K07207]
106966428  metalloreductase STEAP3 isoform X1 [KO:K10142] [EC:1.16.1.-]
106967964  COP1; E3 ubiquitin-protein ligase COP1 isoform X1 [KO:K10143] [EC:2.3.2.27]
106981721  RING finger and CHY zinc finger domain-containing protein 1 isoform X1 [KO:K10144] [EC:2.3.2.27]
106970382  cyclin-G1 [KO:K10145]
106981545  cyclin-G2 [KO:K10146]
106972698  protein phosphatase 1D [KO:K10147] [EC:3.1.3.16]
106975286  tumor protein p73 [KO:K10148]
Reference
PMID:16557269
  Authors
Levine AJ, Hu W, Feng Z.
  Title
The P53 pathway: what questions remain to be explored?
  Journal
Cell Death Differ 13:1027-36 (2006)
DOI:10.1038/sj.cdd.4401910
Reference
PMID:15838523
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
PMID:11747320
  Authors
Balint E E, Vousden KH.
  Title
Activation and activities of the p53 tumour suppressor protein.
  Journal
Br J Cancer 85:1813-23 (2001)
DOI:10.1054/bjoc.2001.2128
Reference
PMID:11313928
  Authors
Taylor WR, Stark GR.
  Title
Regulation of the G2/M transition by p53.
  Journal
Oncogene 20:1803-15 (2001)
DOI:10.1038/sj.onc.1204252
Reference
PMID:15116721
  Authors
Hofseth LJ, Hussain SP, Harris CC.
  Title
p53: 25 years after its discovery.
  Journal
Trends Pharmacol Sci 25:177-81 (2004)
DOI:10.1016/j.tips.2004.02.009
Reference
PMID:12505356
  Authors
Pietenpol JA, Stewart ZA.
  Title
Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis.
  Journal
Toxicology 181-182:475-81 (2002)
DOI:10.1016/S0300-483X(02)00460-2
Reference
PMID:10714958
  Authors
Tokino T, Nakamura Y.
  Title
The role of p53-target genes in human cancer.
  Journal
Crit Rev Oncol Hematol 33:1-6 (2000)
DOI:10.1016/S1040-8428(99)00051-7
Reference
PMID:16697662
  Authors
Hermeking H, Benzinger A.
  Title
14-3-3 proteins in cell cycle regulation.
  Journal
Semin Cancer Biol 16:183-92 (2006)
DOI:10.1016/j.semcancer.2006.03.002
Reference
PMID:16915296
  Authors
Sherr CJ.
  Title
Divorcing ARF and p53: an unsettled case.
  Journal
Nat Rev Cancer 6:663-73 (2006)
DOI:10.1038/nrc1954
Reference
PMID:17409411
  Authors
Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ.
  Title
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways.
  Journal
Cancer Res 67:3043-53 (2007)
DOI:10.1158/0008-5472.CAN-06-4149
Reference
PMID:26037915
  Authors
Resnick-Silverman L, Manfredi JJ
  Title
Two Faces of SIVA.
  Journal
Cancer Discov 5:581-3 (2015)
DOI:10.1158/2159-8290.CD-15-0484
Reference
PMID:19584092
  Authors
Resch U, Schichl YM, Winsauer G, Gudi R, Prasad K, de Martin R
  Title
Siva1 is a XIAP-interacting protein that balances NFkappaB and JNK signalling to promote apoptosis.
  Journal
J Cell Sci 122:2651-61 (2009)
DOI:10.1242/jcs.049940
Reference
PMID:19240372
  Authors
Barkinge JL, Gudi R, Sarah H, Chu F, Borthakur A, Prabhakar BS, Prasad KV
  Title
The p53-induced Siva-1 plays a significant role in cisplatin-mediated apoptosis.
  Journal
J Carcinog 8:2 (2009)
DOI:10.4103/1477-3163.45389
Reference
PMID:12135761
  Authors
Ohiro Y, Garkavtsev I, Kobayashi S, Sreekumar KR, Nantz R, Higashikubo BT, Duffy SL, Higashikubo R, Usheva A, Gius D, Kley N, Horikoshi N
  Title
A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF).
  Journal
FEBS Lett 524:163-71 (2002)
DOI:10.1016/S0014-5793(02)03049-1
Reference
PMID:26646590
  Authors
Hu Y, Ge W, Wang X, Sutendra G, Zhao K, Dedeic Z, Slee EA, Baer C, Lu X
  Title
Caspase cleavage of iASPP potentiates its ability to inhibit p53 and NF-kappaB.
  Journal
Oncotarget 6:42478-90 (2015)
DOI:10.18632/oncotarget.6478
Related
pathway
aju04110  Cell cycle
aju04210  Apoptosis
aju04218  Cellular senescence
KO pathway
ko04115   
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